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51. 发明申请

US20110118252A1 SUBSTITUTED AMIDE DERIVATIVES AND METHODS OF USE 有权
标题翻译：取代的酰胺衍生物和使用方法
公开(公告)号：US20110118252A1
公开(公告)日：2011-05-19
申请号：US12945575
申请日：2010-11-12
申请人： Tae-Seong Kim , David Bauer , Steven Bellon , Alessandro Boezio , Shon Booker , Deborah Choquette , Derin C. D'Amico , Noel D'Angelo , Celia Dominguez , Ingrid M. Fellows , Julie Germain , Russell Graceffa , Jean-Christophe Harmange , Satoko Hirai , Daniel La , Matthew Lee , Longbin Liu , Mark H. Norman , Michele Potashman , Philip Roveto , Aaron C. Siegmund , Ning Xi , Kevin Yang
发明人： Tae-Seong Kim , David Bauer , Steven Bellon , Alessandro Boezio , Shon Booker , Deborah Choquette , Derin C. D'Amico , Noel D'Angelo , Celia Dominguez , Ingrid M. Fellows , Julie Germain , Russell Graceffa , Jean-Christophe Harmange , Satoko Hirai , Daniel La , Matthew Lee , Longbin Liu , Mark H. Norman , Michele Potashman , Philip Roveto , Aaron C. Siegmund , Ning Xi , Kevin Yang
IPC分类号： A61K31/4709 , C07D401/14 , C07D405/14 , C07D413/14 , C07D401/12 , A61K31/497 , A61K31/5377 , A61K31/506 , A61K31/496 , A61K31/501 , A61P35/00
CPC分类号： C07D413/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D487/04 , C07D495/04
摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译：所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

52. 发明授权

US07915287B2 Substituted heterocycles and methods of use 有权
标题翻译：取代的杂环和使用方法
公开(公告)号：US07915287B2
公开(公告)日：2011-03-29
申请号：US12004153
申请日：2007-12-19
申请人： Steven Bellon , Shon Booker , Noel D'Angelo , Julie Germain , Jean-Christophe Harmange , Tae-Seong Kim , Matthew Lee , Longbin Liu , Mark H. Norman , Elizabeth Rainbeau , Ning Xi , Shimin Xu
发明人： Steven Bellon , Shon Booker , Noel D'Angelo , Julie Germain , Jean-Christophe Harmange , Tae-Seong Kim , Matthew Lee , Longbin Liu , Mark H. Norman , Elizabeth Rainbeau , Ning Xi , Shimin Xu
IPC分类号： A61K31/5377 , A61K31/444 , A61K31/4709 , A61K31/506 , A61P35/00 , C07D413/14 , C07D401/12 , C07D401/14
CPC分类号： C07D213/82 , C07D401/12 , C07D401/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译：所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

53. 发明申请

US20080312232A1 Substituted amide derivatives and methods of use 有权
标题翻译：取代的酰胺衍生物和使用方法
公开(公告)号：US20080312232A1
公开(公告)日：2008-12-18
申请号：US11412302
申请日：2006-04-26
申请人： Tae-Seong Kim , David Bauer , Steven Bellon , Alessandro Boezio , Shon Booker , Deborah Choquette , Derin C. D'Amico , Noel D'Angelo , Celia Dominguez , Ingrid M. Fellows , Julie Germain , Russell Graceffa , Jean-Christophe Harmange , Satoko Hirai , Daniel La , Matthew Lee , Longbin Liu , Mark H. Norman , Michele Potashman , Philip Roveto , Aaron C. Siegmund , Ning Xi , Kevin Yang
发明人： Tae-Seong Kim , David Bauer , Steven Bellon , Alessandro Boezio , Shon Booker , Deborah Choquette , Derin C. D'Amico , Noel D'Angelo , Celia Dominguez , Ingrid M. Fellows , Julie Germain , Russell Graceffa , Jean-Christophe Harmange , Satoko Hirai , Daniel La , Matthew Lee , Longbin Liu , Mark H. Norman , Michele Potashman , Philip Roveto , Aaron C. Siegmund , Ning Xi , Kevin Yang
IPC分类号： A61K31/5377 , C07D413/12 , C07D401/14 , A61K31/4709 , C07D403/12 , A61K31/506 , A61K31/501 , C07D401/12 , A61K31/496
CPC分类号： C07D413/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D487/04 , C07D495/04
摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译：所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

54. 发明申请

US20080200464A1 Substituted heterocycles and methods of use 有权
标题翻译：取代的杂环和使用方法
公开(公告)号：US20080200464A1
公开(公告)日：2008-08-21
申请号：US12004153
申请日：2007-12-19
申请人： Steven Bellon , Shon Booker , Noel D'Angelo , Julie Germain , Jean-Christophe Harmange , Tae-Seong Kim , Matthew Lee , Longbin Liu , Mark H. Norman , Elizabeth Rainbeau , Ning Xi , Shimin Xu
发明人： Steven Bellon , Shon Booker , Noel D'Angelo , Julie Germain , Jean-Christophe Harmange , Tae-Seong Kim , Matthew Lee , Longbin Liu , Mark H. Norman , Elizabeth Rainbeau , Ning Xi , Shimin Xu
IPC分类号： A61K31/5377 , C07D413/14 , C07D401/14 , A61K31/444 , A61K31/4709 , A61K31/506 , C07D401/12 , A61P35/00
CPC分类号： C07D213/82 , C07D401/12 , C07D401/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译：所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

55. 发明授权

US07381625B2 Deterministic process for constructing nanodevices 失效
标题翻译：构建纳米器件的确定性过程
公开(公告)号：US07381625B2
公开(公告)日：2008-06-03
申请号：US11546499
申请日：2006-10-11
申请人： Ning Xi , Guangyong Li , Jiangbo Zhang , Hoyin Chan
发明人： Ning Xi , Guangyong Li , Jiangbo Zhang , Hoyin Chan
IPC分类号： H01L21/76
CPC分类号： H01L51/0048 , B82Y10/00 , H01L51/0587 , Y10S977/70
摘要： A method is provided for constructing a nanodevice. The method includes: fabricating an electrode on a substrate; forming a nanogap across the electrode; dispersing a plurality of nanoobjects onto the substrate using electrophoresis; and pushing one of the nanoobjects onto the electrode using a tip of an atomic force microscope, such that the nanoobject lies across the nanogap formed in the electrode. In addition, remaining nanoobjects may also be pushed away from the electrode using the atomic force microscope, thereby completing construction of a nanodevice.
摘要翻译：提供了一种构造纳米器件的方法。该方法包括：在基板上制造电极; 在电极上形成纳米隙; 使用电泳将多个纳米对象分散到基底上; 并使用原子力显微镜的尖端将一个纳米对象推到电极上，使得纳米对象位于电极中形成的纳米隙上。此外，还可以使用原子力显微镜将剩余的纳米对象推离电极，从而完成纳米器件的构造。

56. 发明授权

US07367242B2 Active sensor for micro force measurement 失效
标题翻译：用于微力测量的主动传感器
公开(公告)号：US07367242B2
公开(公告)日：2008-05-06
申请号：US11366014
申请日：2006-02-27
申请人： Ning Xi , Yantao Shen
发明人： Ning Xi , Yantao Shen
IPC分类号： G01L1/10
CPC分类号： G01L1/08
摘要： An active micro-force sensor is provided for use on a micromanipulation device. The active micro-force sensor includes a cantilever structure having an actuator layer of piezoelectric material and a sensing layer of piezoelectric material bonded together. When an external force is exerted on the sensor, the sensor deforms and an applied force signal is recorded by the sensing layer. The applied force signal is then fed back to the actuating layer of the sensor via a servoed transfer function or servo controller, so that a counteracting deformation can be generated by the bending moment from the servoed actuating layer to quickly balance the deformation caused by the external micro-force. Once balanced, the sensor beam comes back to straight status and the tip will remain in its equilibrium position, thus the sensor stiffness seems to be virtually improved so that the accurate motion control of the sensor tip can be reached, especially, at the same time, the micro-force can also be obtained by solving the counteracting balance voltage applied to the actuating layer.
摘要翻译：提供用于显微操作装置的主动微力传感器。有源微力传感器包括具有压电材料的致动器层和压电材料的感测层结合在一起的悬臂结构。当外力施加在传感器上时，传感器变形，施加的力信号由传感层记录。所施加的力信号然后通过伺服传递函数或伺服控制器反馈到传感器的致动层，使得可以通过来自伺服致动层的弯矩产生抵消变形，以快速平衡由外部引起的变形微力。一旦平衡，传感器光束返回到直线状态，并且尖端将保持在其平衡位置，因此传感器刚度似乎被实际改善，使得可以达到传感器尖端的精确运动控制，特别是同时，也可以通过求解施加到致动层的抵消平衡电压来获得微力。

57. 发明授权

US07262408B2 Process and apparatus for modifying a surface in a work region 有权
标题翻译：用于修改工作区域中的表面的工艺和设备
公开(公告)号：US07262408B2
公开(公告)日：2007-08-28
申请号：US11452891
申请日：2006-06-14
申请人： Jes Asmussen , Timothy Grotjohn , Ning Xi , Timothy P. Hogan
发明人： Jes Asmussen , Timothy Grotjohn , Ning Xi , Timothy P. Hogan
IPC分类号： G01N13/16
CPC分类号： H01J37/32366 , H01J37/32357
摘要： An apparatus and process for manufacturing changes of a substrate in a work region which is 100×100×100 microns or smaller is described. The apparatus uses a plasma source adjacent to the work region to produce radiation or matter which changes the surface. An atomic force microscope or laser can be used in addition. The process and apparatus can be used to produce MEMS devices on a substrate for use in a wide variety of applications.
摘要翻译：描述了用于制造100×100×100微米或更小的工作区域中的衬底的变化的装置和工艺。该设备使用与工作区域相邻的等离子体源产生改变表面的辐射或物质。另外还可以使用原子力显微镜或激光。该方法和装置可用于在基板上制造用于各种应用的MEMS器件。

58. 发明申请

US20060241115A1 Compounds and methods of use 有权
公开(公告)号：US20060241115A1
公开(公告)日：2006-10-26
申请号：US11042634
申请日：2005-01-24
申请人： Michele Potashman , Tae-Seong Kim , Steven Bellon , Shon Booker , Yuan Cheng , Joseph Kim , Andrew Tasker , Ning Xi , Shimin Xu , Jean-Christophe Harmange , George Borg , Matthew Weiss , Brian Hodous , Russell Graceffa , William Buckner , Craig Masse , Deborah Choquette , Matthew Martin , Julie Germain , Lucian DiPietro , Stuart Chaffee , Joseph Nunes , John Buchanan , Gregory Habgood , David McGowan , Douglas Whittington
发明人： Michele Potashman , Tae-Seong Kim , Steven Bellon , Shon Booker , Yuan Cheng , Joseph Kim , Andrew Tasker , Ning Xi , Shimin Xu , Jean-Christophe Harmange , George Borg , Matthew Weiss , Brian Hodous , Russell Graceffa , William Buckner , Craig Masse , Deborah Choquette , Matthew Martin , Julie Germain , Lucian DiPietro , Stuart Chaffee , Joseph Nunes , John Buchanan , Gregory Habgood , David McGowan , Douglas Whittington
IPC分类号： A61K31/517 , A61K31/502 , A61K31/498 , A61K31/4709 , C07D43/02
CPC分类号： C07D213/64 , C07D213/81 , C07D215/233 , C07D215/38 , C07D215/48 , C07D215/54 , C07D237/34 , C07D239/34 , C07D239/47 , C07D239/84 , C07D239/94 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04
摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

59. 发明申请

US20060030148A1 Formation of a tantalum-nitride layer 有权
公开(公告)号：US20060030148A1
公开(公告)日：2006-02-09
申请号：US11240189
申请日：2005-09-30
申请人： Sean Seutter , Michael Yang , Ning Xi
发明人： Sean Seutter , Michael Yang , Ning Xi
IPC分类号： H01L21/44 , H01L21/4763
CPC分类号： C23C16/45553 , C23C16/34 , C23C16/4554 , C23C16/56 , H01L21/28562 , H01L21/28568 , H01L21/76844 , H01L21/76862
摘要： A method of forming a material on a substrate is disclosed. In one embodiment, the method includes forming a tantalum nitride layer on a substrate disposed in a plasma process chamber by sequentially exposing the substrate to a tantalum precursor and a nitrogen precursor, followed by reducing a nitrogen concentration of the tantalum nitride layer by exposing the substrate to a plasma annealing process. A metal-containing layer is subsequently deposited on the tantalum nitride layer.

60. 发明授权

US06920373B2 Synchronization and task control of real-time internet based super-media 有权
标题翻译：实时互联网超媒体同步与任务控制
公开(公告)号：US06920373B2
公开(公告)日：2005-07-19
申请号：US10123044
申请日：2002-04-15
申请人： Ning Xi , Imad Elhajj
发明人： Ning Xi , Imad Elhajj
IPC分类号： B25J9/16 , H04L29/06 , G06F19/00
CPC分类号： H04L29/06 , A63F2300/1037 , A63F2300/407 , B25J9/1689 , G05B2219/40122 , G05B2219/40136 , G05B2219/40147 , H04L29/06027
摘要： A closed-loop control system that remotely controls a device over a distributed communications system includes a device that is connected to the distributed communications system and that generates super-media feedback signals. A computer is connected to the distributed communications system and includes a controller that provides super-media feedback. The computer generates and transmits command signals using the controller to the device and outputs the super-media feedback signals to the controller. The closed-loop control system is event-based to ensure stability and synchronization of the closed-loop system.
摘要翻译：通过分布式通信系统远程控制设备的闭环控制系统包括连接到分布式通信系统并且产生超媒体反馈信号的设备。计算机连接到分布式通信系统，并且包括提供超媒体反馈的控制器。计算机使用控制器生成并发送命令信号到设备，并将超媒体反馈信号输出到控制器。闭环控制系统是基于事件的，以确保闭环系统的稳定性和同步性。

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