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51. 发明授权

US4206140A Novel cyclopropanecarboxylic acids and esters 失效
公开(公告)号：US4206140A
公开(公告)日：1980-06-03
申请号：US910695
申请日：1978-05-30
申请人： Jacques Martel , Chanh Huynh , Jean Buendia
发明人： Jacques Martel , Chanh Huynh , Jean Buendia
IPC分类号： B23D61/02 , B29C37/00 , C07C21/14 , C07C22/04 , C07C35/04 , C07C61/35 , C07D307/45 , C07D307/54 , C07D309/04 , C07D309/10 , C07D309/20 , C07C61/18 , C07C61/28
CPC分类号： C07D307/42 , B23D61/02 , B29C37/00 , C07C21/14 , C07C22/04 , C07C35/045 , C07C61/35 , C07D307/54 , C07D309/04 , C07D309/10 , C07D309/20
摘要： Novel cyclopropanecarboxylic acids and esters of the formula ##STR1## wherein Z.sub.1 and Z.sub.2 are selected from the group consisting of hydrogen, alkyl, aralkyl, aryl, alkenyl non-conjugated with the cyclopropane ring, alkynyl non-conjugated with the cyclopropane ring, cycloalkyl, cycloalkenyl and heterocyclic; R is selected from the group consisting of OH and OR' in which R' is selected from the group consisting of lower alkyl which may be substituted, benzyl which may be substituted on the phenyl or methylene portion, N-methylene-dicarboximide, (5-benzyl-furyl-3) methyl, and a cyclopentene of the formula ##STR2## wherein R" is selected from the group consisting of alkyl, alkynyl, alkenyl, aryl, aralkyl, cycloalkyl, cycloalkenyl and heterocyclic; A is a bivalent alkyl radical selected from the group consisting of ##STR3## wherein R.sub.1 is selected from the group consisting of hydrogen and lower alkyl, R.sub.2 and R.sub.3 are selected from the group consisting of alkyl, alkynyl, alkenyl, aryl, aralkyl, cycloalkyl, cycloalkenyl and heterocyclic and taken together with the carbon atom to which they are attached form a ring selected from the group consisting of carbon homo rings and unsaturated carbon homo rings of 3 to 7 carbon atoms and heterocyclic rings which may be substitued with lower alkyl or lower alkoxy and R.sub.2 and R.sub.3 may together form a polycyclic aromatic radical, R.sub.4 is lower alkyl, R.sub.5 is selected from the group consisting of hydrogen and lower alkyl and R.sub.4 and R.sub.5 together with the carbon atoms to which they are attached may form a saturated or unsaturated carbon homo ring or a heterocyclic ring, Y is selected from the group consisting of methylene and a saturated or unsaturated carbon chain and Y' is selected from the group consisting of methine and a saturated or unsaturated carbon chain with the proviso that when Z.sub.1 and Z.sub.2 are methyl and R.sub.1 is hydrogen, R.sub.2 is other than methyl and their preparation.

52. 发明授权

US4119727A Novel 11-desoxy-prostaglandin F.sub.2 derivatives 失效
标题翻译：新型11-脱氧前列腺素F（HD 2 {B衍生物
公开(公告)号：US4119727A
公开(公告)日：1978-10-10
申请号：US792563
申请日：1977-05-02
申请人： Jean Buendia , Jeanine Nierat , Robert Deroy
发明人： Jean Buendia , Jeanine Nierat , Robert Deroy
IPC分类号： A61K31/19 , A61K31/205 , A61K31/38 , A61K31/381 , A61K31/41 , A61K31/433 , A61K31/557 , A61K31/5575 , A61P1/16 , A61P9/12 , A61P15/04 , A61P43/00 , C07C67/00 , C07C401/00 , C07C405/00 , C07D277/20 , C07D277/34 , C07D285/04 , C07D285/10 , C07D309/12 , C07D333/32 , C07D333/38 , C07F9/38 , C07F9/40 , A01N9/00 , C07D333/24
CPC分类号： C07F9/4006 , C07C405/00 , C07D309/12 , C07D333/32 , C07F9/3808
摘要： Novel 11-desoxy-prostaglandin F.sub.2 derivatives of the formula ##STR1## wherein R is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms, an alkali metal, an equivalent of an alkaline earth metal, magnesium or organic amine base, R.sub.1 and R.sub.2 are individually seleced from the group consisting of hydrogen and methyl and X is selected from the group consisting of ##STR2## and a 5 to 6 membered heterocycle optionally substituted with at least one member of the group consisting of halogen, --CN and alkyl of 1 to 5 carbon atoms and X.sup.1 is a 6 member heterocycle with the wavy lines indicating that the hydroxy may be in either one of the two possible .alpha. and .beta. positions having hypotensive activity and process for their preparation.
摘要翻译：式XI的新型11-脱氧前列腺素F2衍生物，其中R选自氢，1至4个碳原子的烷基，碱金属，当量碱土金属，镁或有机胺碱，R 1和R 2各自独立地选自氢和甲基，X选自由下列组成的组：＆lt; IMAGE＆gt;和5至6元杂环，任选被至少一个以下成员取代的卤素， - CN和1至5个碳原子的烷基，X1是具有波浪线的6元杂环，表示羟基可以是具有降血压活性的两个可能的α和β位置之一，并且其制备方法。

53. 发明授权

US4101574A Cyclopropanecarboxylic acid chlorides 失效
公开(公告)号：US4101574A
公开(公告)日：1978-07-18
申请号：US749402
申请日：1976-12-10
申请人： Jacques Martel , Chanh Huynh , Jean Buendia
发明人： Jacques Martel , Chanh Huynh , Jean Buendia
IPC分类号： B23D61/02 , B29C37/00 , C07C21/14 , C07C22/04 , C07C35/04 , C07C61/35 , C07D307/45 , C07D307/54 , C07D309/04 , C07D309/20 , C07C61/18
CPC分类号： C07D309/20 , B29C37/00 , C07C21/14 , C07C22/04 , C07C35/045 , C07C61/35 , C07D307/42 , C07D307/54 , C07D309/04
摘要： Novel cyclopropanecarboxylic acids and esters of the formula ##STR1## wherein Z.sub.1 and Z.sub.2 are selected from the group consisting of hydrogen, alkyl, aralkyl, aryl, alkenyl non-conjugated with the cyclopropane ring, alkynyl non-conjugated with the cyclopropane ring, cycloalkyl, cycloalkenyl and heterocyclic; R is selected from the group consisting of OH and OR' in which R' is selected from the group consisting of lower alkyl which may be substituted, benzyl which may be substituted on the phenyl or methylene portion, N-methylene-dicarboximide, (5-benzyl-furyl-3) methyl, and a cyclopentene of the formula ##STR2## WHEREIN R" is selected from the group consisting of alkyl, alkynyl, alkenyl, aryl, aralkyl, cycloalkyl, cycloalkenyl and heterocyclic; A is a bivalent alkyl radical selected from the group consisting of ##STR3## WHEREIN R.sub.1 is selected from the group consisting of hydrogen and lower alkyl, R.sub.2 and R.sub.3 are selected from the group consisting of alkyl, alkynyl, alkenyl, aryl, aralkyl, cycloalkyl, cycloalkenyl and heterocyclic and taken together with the carbon atom to which they are attached form a ring selected from the group consisting of carbon homo rings and unsaturated carbon homo rings of 3 to 7 carbon atoms and heterocyclic rings which may be substituted with lower alkyl or lower alkoxy and R.sub.2 and R.sub.3 may together form a polycyclic aromatic radical, R.sub.4 is lower alkyl, R.sub.5 is selected from the group consisting of hydrogen and lower alkyl and R.sub.4 and R.sub.5 together with the carbon atoms to which they are attached may form a saturated or unsaturated carbon homo ring or a heterocyclic ring, Y is selected from the group consisting of methylene and a saturated or unsaturated carbon chain and Y' is selected from the group consisting of methine and a saturated or unsaturated carbon chain with the proviso that when Z.sub.1 and Z.sub.2 are methyl and R.sub.1 is hydrogen, R.sub.2 is other than methyl and their preparation.

54. 发明授权

US4097494A Novel cyclopentanones 失效
标题翻译：新型环戊烷酮
公开(公告)号：US4097494A
公开(公告)日：1978-06-27
申请号：US743507
申请日：1976-11-19
申请人： Jean Buendia , Jeanine Schalbar
发明人： Jean Buendia , Jeanine Schalbar
IPC分类号： C07C67/00 , C07C69/757 , C07C401/00 , C07C405/00 , C07D309/12 , C07C69/74
CPC分类号： C07D309/12
摘要： Novel cyclopentanones of the formula ##STR1## wherein AlK is alkyl of 1 to 4 carbon atoms, R is selected from the group of hydrogen and .alpha.-tetrahydropyranyl and the Ys are hydrogen or together represent a double bond with the proviso that when R is hydrogen, the Ys are hydrogen as well as products of the formula ##STR2## wherein AlK is alkyl of 1 to 4 carbon atoms and products of the formula ##STR3## wherein R and AlK have the above definitions which are useful intermediates in the production of prostaglandins.
摘要翻译：其中AlK是1至4个碳原子的烷基的新型环戊烷酮，R选自氢和α-四氢吡喃基，Y是氢或一起代表双键，条件是当R为氢，Y是氢，以及下式VI的产物，其中AlK是1-4个碳原子的烷基和式的产物，其中R和AlK具有上述定义，它们是有用的中间体生产前列腺素。

55. 发明授权

US4024172A Preparation of prostanoic acid derivatives 失效
标题翻译：前列腺酸衍生物的制备
公开(公告)号：US4024172A
公开(公告)日：1977-05-17
申请号：US176234
申请日：1971-08-30
申请人： Jacques Martel , Jean Buendia , Edmond Toromanoff
发明人： Jacques Martel , Jean Buendia , Edmond Toromanoff
IPC分类号： C07C61/06 , C07C69/74 , C07C405/00 , C07D303/42 , C07D309/12 , C07D521/00 , C07C177/00
CPC分类号： C07D231/12 , C07C405/00 , C07D233/56 , C07D249/08 , C07D303/42 , C07D309/12
摘要： A novel process for the preparation of derivatives of prostanoic acids of the prostaglandin A.sub.2 (PGA.sub.2) group of the formula ##STR1## wherein R is selected from the group consisting of hydrogen and lower alkyl, n is a whole number of 2, 3 or 4 and m is a whole number of 3, 4 or 5 and to novel intermediates produced in the said process.
摘要翻译：用于制备式IMA的前列腺素A2（PGA2）组的前列腺酸衍生物的新方法，其中R选自氢和低级烷基，n是整数2,3或 4和m是3,4或5的整数，以及在所述方法中生产的新型中间体。

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