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51. 发明授权

US07537903B2 FGF21 upregulates expression of GLUT-1 in a βklotho-dependent manner 失效
标题翻译： FGF21以betaklotho依赖性方式上调GLUT-1的表达
公开(公告)号：US07537903B2
公开(公告)日：2009-05-26
申请号：US12107895
申请日：2008-04-23
申请人： Makoto Kuro-o , Yasushi Ogawa , Hiroshi Kurosu , Kevin Rosenblatt
发明人： Makoto Kuro-o , Yasushi Ogawa , Hiroshi Kurosu , Kevin Rosenblatt
IPC分类号： G01N33/53
CPC分类号： G01N33/6872 , G01N33/573 , G01N2333/50 , G01N2333/62 , G01N2333/924 , G01N2500/02
摘要： A method is provided to identify a modulator of βKlotho-dependant glucose transporter-1 (GLUT-1) upregulation that specifically modulates interaction of βKlotho and an FGFR.
摘要翻译：提供了一种方法来鉴定特异性调节βKlotho和FGFR相互作用的βKlotho依赖性葡萄糖转运蛋白-1（GLUT-1）上调的调节剂。

52. 发明申请

US20080228001A1 Process for Producing (Meth)Acrylic Acid or (Meth)Acrolein 审中-公开
标题翻译：生产（甲基）丙烯酸或（甲基）丙烯醛的方法
公开(公告)号：US20080228001A1
公开(公告)日：2008-09-18
申请号：US11597365
申请日：2004-11-05
申请人： Yasushi Ogawa , Shuhei Yada , Yoshiro Suzuki , Kenji Takasaki , Kimikatsu Jinno
发明人： Yasushi Ogawa , Shuhei Yada , Yoshiro Suzuki , Kenji Takasaki , Kimikatsu Jinno
IPC分类号： C07C27/12 , C07C47/22
CPC分类号： B01J23/8876 , B01J23/002 , B01J2523/00 , C07C45/33 , C07C45/35 , C07C51/252 , C07C47/22 , C07C57/04 , B01J2523/12 , B01J2523/13 , B01J2523/22 , B01J2523/305 , B01J2523/41 , B01J2523/54 , B01J2523/68 , B01J2523/842 , B01J2523/845 , B01J2523/847
摘要： An object of the present invention is to provide a method for producing (meth)acrylic acid or (meth)acrolein by conducting a gas phase catalytic oxidation reaction with an oxygen-containing gas using as a raw material at least one substance to be oxidized selected from propylene, propane, isobutylene and (meth)acrolein using a multi-tubular reactor, which enables a high yield and stable production even when operating constantly with supplying the raw material in the maximum supply amount acceptable by the reactor or an amount close thereto.The invention is a method for producing (meth)acrylic acid or (meth)acrolein wherein, at the time of a start-up of the reaction, for a period of at least 20 hours or more after the supply amount of the raw material to the reactor per unit time reached 30% or more of the acceptable maximum supply amount of the raw material per unit time, the supply amount of the raw material per unit time is kept at 30% or more and less than 80% of the acceptable maximum supply amount.
摘要翻译：本发明的目的是提供一种通过与含氧气体进行气相催化氧化反应来生产（甲基）丙烯酸或（甲基）丙烯醛的方法，该方法使用至少一种待氧化物质作为原料使用多管式反应器由丙烯，丙烷，异丁烯和（甲基）丙烯醛组成，即使在以反应器可接受的最大供给量或其附近的量供给原料的情况下，也可以连续运转，能够实现高产率和稳定的生产。本发明是一种生产（甲基）丙烯酸或（甲基）丙烯醛的方法，其中在反应开始时至少20小时以上，在原料供给量至每单位时间的反应器达到每单位时间内可接受的原料最大供应量的30％以上，每单位时间的原料供应量保持在可接受最大值的30％以上且小于80％供应量

53. 发明授权

US07396957B2 Process for producing (meth)acrylic acids and process for distilling the same 有权
公开(公告)号：US07396957B2
公开(公告)日：2008-07-08
申请号：US10817955
申请日：2004-04-06
申请人： Shuhei Yada , Yasushi Ogawa , Yoshiro Suzuki , Kimikatsu Jinno , Hirochika Hosaka , Kenji Takasaki , Masayasu Goriki
发明人： Shuhei Yada , Yasushi Ogawa , Yoshiro Suzuki , Kimikatsu Jinno , Hirochika Hosaka , Kenji Takasaki , Masayasu Goriki
IPC分类号： C07C43/32
CPC分类号： C07C51/44 , B01D3/14 , B01D3/146 , B01D3/42 , B01D3/4211 , C07C67/54 , C07C57/04 , C07C69/54
摘要： In the stopping and starting operations of a distillation column used for producing (meth)acrylic acids according to the present invention, upon stopping the operation of the distillation column, the heating of a reboiler attached thereto is interrupted and then the reboiler is rapidly cooled; and/or upon starting the operation of the distillation column for production of the (meth)acrylic acids, an inner wall surface of the distillation column is heated to a temperature higher than a condensation temperature of the (meth)acrylic acids and the operation of the distillation column is started under the heated condition. According to the present invention, it is possible to early and safely stop the operation of the distillation column while preventing the occurrence of polymerization within the distillation column, and stably perform an operation for distillation of acrylic monomers for a long period of time.

54. 发明申请

US20080014127A1 Pilot test method for multitubular reactor 审中-公开
标题翻译：多管反应堆试点方法
公开(公告)号：US20080014127A1
公开(公告)日：2008-01-17
申请号：US11596293
申请日：2004-10-25
申请人： Yasushi Ogawa , Shuhei Yada , Yoshiro Suzuki , Kenji Takasaki , Kimikatsu Jinno
发明人： Yasushi Ogawa , Shuhei Yada , Yoshiro Suzuki , Kenji Takasaki , Kimikatsu Jinno
IPC分类号： B01J19/00
CPC分类号： B01J23/8876 , B01J8/067 , B01J23/002 , B01J23/887 , B01J23/8885 , B01J23/8892 , B01J2208/00026 , B01J2208/00061 , B01J2208/00212 , B01J2208/00221 , B01J2208/00539 , B01J2219/00009 , B01J2219/002 , B01J2219/00202 , B01J2219/00218 , B01J2219/00234 , B01J2219/00238 , B01J2523/00 , C07C45/33 , C07C45/35 , C07C51/215 , C07C51/252 , C07C47/21 , C07C47/22 , C07C57/04 , B01J2523/12 , B01J2523/13 , B01J2523/22 , B01J2523/30 , B01J2523/41 , B01J2523/54 , B01J2523/68 , B01J2523/842 , B01J2523/845 , B01J2523/847
摘要： An object of the present invention is to provide a pilot test method for suitably setting the reaction conditions for a gas-phase catalytic reaction using a multi-tube reactor, and an apparatus thereof. The present invention is a pilot test method in which a plurality of reaction tubes which are substantially the same as a reaction tube of a multi-tube rector and composed of at least one reaction tube having a means provided for measuring the temperature of a catalyst layer, and remaining reaction tubes having no temperature measuring means, are immersed in a heat medium, a given raw material gas is allowed to flow through the reaction tubes to react, the temperature of the catalyst layer is measured at this stage, the reaction result of the reaction product gas to be discharged is analyzed in the reaction tube having no temperature measuring means, and the reaction conditions of the multi-tube reactor are set so that the reaction at the temperature of the catalyst layer measured generates the reaction result analyzed.
摘要翻译：本发明的目的是提供一种使用多管反应器适当地设定气相催化反应的反应条件的试验方法及其装置。本发明是一种先导试验方法，其中多个反应管与多管反应器的反应管基本相同，并且由至少一个具有用于测量催化剂层的温度的装置的反应管组成，将没有温度测量装置的剩余反应管浸入热介质中，使给定的原料气体流过反应管进行反应，在此阶段测量催化剂层的温度，在没有温度测量装置的反应管中分析要排出的反应产物气体，并且设定多管反应器的反应条件，使得测量的催化剂层的温度下的反应产生分析的反应结果。

55. 发明授权

US07297814B2 Multitube reactor, vapor phase catalytic oxidation method using the multitube reactor, and start up method applied to the multitube reactor 有权
标题翻译：多管反应器，使用多管反应器的气相催化氧化法，以及应用于多管反应器的启动方法
公开(公告)号：US07297814B2
公开(公告)日：2007-11-20
申请号：US11049106
申请日：2005-02-03
申请人： Shuhei Yada , Hirochika Hosaka , Masayasu Goriki , Kimikatsu Jinno , Yasushi Ogawa , Yoshiro Suzuki
发明人： Shuhei Yada , Hirochika Hosaka , Masayasu Goriki , Kimikatsu Jinno , Yasushi Ogawa , Yoshiro Suzuki
IPC分类号： C07C51/16 , C07C45/00 , B01J10/00 , F28D7/00
CPC分类号： B01J35/026 , B01J8/06 , B01J8/067 , B01J23/002 , B01J23/8876 , B01J2208/00221 , B01J2208/0053 , B01J2208/00716 , B01J2523/00 , C07C45/33 , C07C45/35 , C07C51/215 , C07C51/252 , F28D7/1607 , F28D2021/0022 , F28F9/026 , F28F9/028 , F28F9/22 , F28F2265/10 , C07C47/22 , C07C57/04 , B01J2523/12 , B01J2523/13 , B01J2523/22 , B01J2523/305 , B01J2523/41 , B01J2523/54 , B01J2523/68 , B01J2523/842 , B01J2523/845 , B01J2523/847
摘要： A multitube reactor, wherein tubes having smaller tolerance between a nominal size and actual sizes are used as reaction tubes to stably perform a high yield reaction for a long period, a catalyst is filled into the reaction tubes so that the catalyst layer peak temperature portions of the reaction tubes are not overlapped with the connection sites thereof with baffles to effectively prevent hot spots from occurring and stably perform a reaction for a long period without the clogging of the reaction tubes, a heat medium and raw material gas are allowed to flow in the direction of a countercurrent and a specified type of catalyst is filled into the reaction tubes so that activity is increased from the inlet of the raw material gas to the outlet thereof to prevent the autooxidation of products so as to prevent equipment from being damaged due to the reaction, and, at the time of starting, gas with a temperature of 100 to 400° C. is led to the outside of the reaction tubes to increase the temperature of the reaction tubes and, a heat medium, which is solid at the room temperature, is heated to circulate to the outside of the reaction tubes to efficiently start up the reactor without affecting the activity of the catalyst.
摘要翻译：使用多管反应器，其中具有公称尺寸和实际尺寸之间的较小公差的管用作反应管以长期稳定地进行高产率反应，将催化剂填充到反应管中，使得催化剂层峰值温度部分反应管不与其连接位置与挡板重叠，以有效地防止热点发生并且长时间稳定地进行反应而不会使反应管堵塞，允许热介质和原料气体流入将反向的方向和特定类型的催化剂填充到反应管中，使得活性从原料气体的入口到其出口增加，以防止产品的自氧化，从而防止设备因为反应，并且在起始时，将温度为100〜400℃的气体导入反应管的外部以增加反应管的温度和在室温下为固体的热介质被加热以循环到反应管的外部，以有效启动反应器而不影响催化剂的活性。

56. 发明申请

US20070193873A1 Process for producing acrylic acid 审中-公开
标题翻译：丙烯酸生产工艺
公开(公告)号：US20070193873A1
公开(公告)日：2007-08-23
申请号：US11569410
申请日：2004-10-12
申请人： Yasushi Ogawa , Shuhei Yada , Kenji Takasaki , Yuichi Fujita
发明人： Yasushi Ogawa , Shuhei Yada , Kenji Takasaki , Yuichi Fujita
IPC分类号： B01D3/34
CPC分类号： C07C51/44 , C07C51/50 , C07C57/04
摘要： The present invention reduces a cost of a polymerization inhibitor required in purification of high purity acrylic acid through distillation. According to the present invention, a condensate obtained through the distillation of acrylic acid in a distillation column is fed to a flasher, to thereby obtain acrylic acid as a product from a distillate distilled from the flasher.
摘要翻译：本发明降低了通过蒸馏纯化高纯度丙烯酸所需的聚合抑制剂的成本。根据本发明，将通过在蒸馏塔中蒸馏丙烯酸得到的冷凝物供给到闪蒸器中，从而从从闪蒸器蒸馏出的馏出物得到作为产物的丙烯酸。

57. 发明授权

US07241919B2 Storage tank for easily polymerizable compound and method of storage 有权
标题翻译：容易聚合的化合物储存罐和储存方法
公开(公告)号：US07241919B2
公开(公告)日：2007-07-10
申请号：US11133184
申请日：2005-05-20
申请人： Shuhei Yada , Yasushi Ogawa , Yoshiro Suzuki , Kimikatsu Jinno , Hirochika Hosaka , Masayasu Goriki
发明人： Shuhei Yada , Yasushi Ogawa , Yoshiro Suzuki , Kimikatsu Jinno , Hirochika Hosaka , Masayasu Goriki
IPC分类号： C07C57/02
CPC分类号： B01J19/00 , B01J2219/00006 , B01J2219/00083 , B01J2219/00247 , B01J2219/00252 , B01J2219/00254 , Y10T137/0391 , Y10T137/6416 , Y10T137/6579 , Y10T137/85978
摘要： The storage tank of the invention for an easily polymerizable compound is a storage tank having an acceptance piping and a delivery piping and is characterized by having a circulation line which directly connects the acceptance piping to the delivery piping or having circulation lines which respectively connect the acceptance piping to the storage tank and the storage tank to the delivery piping; the method of storing of the invention is characterized by storing an easily polymerizable compound in the storage tank while circulating the compound in the storage tank through the circulation line(s); the method of pipe jointing and apparatus therefor of the invention are a method of jointing pipes fitted to a handling apparatus in a production apparatus, storage apparatus, or the like for the purpose of transporting a corrosive liquid, the method being characterized in that the pipes are jointed with flanges, bolts, and nuts made of a material having resistance to corrosion by the corrosive liquid; the process for (meth)acrylic acid compound production of the invention is a process for producing and/or purifying a (meth)acrylic acid compound, and is characterized in that the temperature of a purified (meth)acrylic acid compound obtained which is being supplied to a storage tank is regulated so as to be not higher than the temperature of the purified (meth)acrylic acid compound residing in the storage tank; and the process of the invention for producing an easily polymerizable compound which is a (meth)acrylic acid compound is characterized in that the temperature of a (meth)acrylic acid compound-containing liquid which has been discharged as an off-specification product and is being supplied to a storage tank is regulated so as to be not higher than the temperature of the off-specification liquid stored in the storage tank.
摘要翻译：用于易聚合化合物的本发明的储罐是具有接受管道和输送管道的储罐，其特征在于，具有将接收管道直接连接到输送管道的循环管线或具有分别连接接收的循环管线管道到储罐和储罐到输送管道; 本发明的储存方法的特征在于，通过在循环管道中使化合物在储罐中循环而将容易聚合的化合物储存在储罐中; 本发明的管接头方法及其设备是在制造装置，储存装置等中装配于处理装置的管道的输送腐蚀性液体的方法，其特征在于，管道与由腐蚀性液体具有腐蚀性的材料制成的法兰，螺栓和螺母接合; 本发明的（甲基）丙烯酸化合物的制造方法是（甲基）丙烯酸化合物的制造和/或纯化方法，其特征在于，得到的纯化的（甲基）丙烯酸化合物的温度为调节供给到储罐的温度不高于存储在储罐中的纯化的（甲基）丙烯酸化合物的温度; 本发明的制备作为（甲基）丙烯酸化合物的易聚合性化合物的方法的特征在于，作为脱离规格的产品排出的（甲基）丙烯酸化合物的液体的温度为被调节为不高于储存在储罐中的不合格液体的温度。

58. 发明申请

US20070118543A1 Full-text search device performing merge processing by using full-text index-for-registration/ deletion storage part with performing registration/deletion processing by using other full-text index-for-registration/deletion storage part 有权
标题翻译：通过使用全文索引登记/删除存储部分，通过使用其他全文索引登记/删除存储部分执行注册/删除处理来执行合并处理的全文搜索装置
公开(公告)号：US20070118543A1
公开(公告)日：2007-05-24
申请号：US11647331
申请日：2006-12-29
申请人： Kensaku Yamamoto , Yasushi Ogawa , Tetsuya Ikeda , Takuya Hiraoka , Hiroshi Takegawa , Kazushige Asada , Futoshi Oseto
发明人： Kensaku Yamamoto , Yasushi Ogawa , Tetsuya Ikeda , Takuya Hiraoka , Hiroshi Takegawa , Kazushige Asada , Futoshi Oseto
IPC分类号： G06F7/00
CPC分类号： G06F17/30622 , G06F17/30613 , G06F17/30631 , Y10S707/99942
摘要： When a number of document data registered in one of full-text index-for-registration/deletion storage parts reaches a predetermined number, or when a capacity of the full-text index-for-registration/deletion storage part reaches a predetermined capacity, a merge processing is performed for merging data from the full-text index-for-registration/deletion storage part to a full-text index-for-search storage part. While this merge processing is performed, a registration/deletion processing is performed by using another full-text index-for-registration/deletion storage part.
摘要翻译：当登记在全文索引登记/删除存储部件中的一个文档数据达到预定数量时，或者当全文索引登记/删除存储部件的容量达到预定容量时，执行用于将来自全文索引登记/删除存储部分的数据合并到全文索引搜索存储部分的合并处理。当执行该合并处理时，通过使用另一全文索引注册/删除存储部分来执行注册/删除处理。

59. 发明申请

US20070043238A1 Process for production of (meth)acrylic acid of (meth)acrolein 审中-公开
标题翻译：（甲基）丙烯醛的（甲基）丙烯酸的制造方法
公开(公告)号：US20070043238A1
公开(公告)日：2007-02-22
申请号：US11451355
申请日：2006-06-13
申请人： Shuhei Yada , Yasushi Ogawa , Yoshiro Suzuki , Kimikatsu Jinno
发明人： Shuhei Yada , Yasushi Ogawa , Yoshiro Suzuki , Kimikatsu Jinno
IPC分类号： C07C51/16
CPC分类号： B01J23/002 , B01J23/8876 , B01J2523/00 , C07C45/33 , C07C45/35 , C07C51/215 , C07C51/252 , C07C47/22 , C07C57/04 , B01J2523/12 , B01J2523/13 , B01J2523/22 , B01J2523/305 , B01J2523/41 , B01J2523/54 , B01J2523/68 , B01J2523/842 , B01J2523/845 , B01J2523/847
摘要： An object of the present invention is to provide that, in a process for the production of (meth)acrolein or (meth)acrylic acid by a gas-phase catalytic oxidation reaction of a substance to be oxidized such as propylene, propane, isobutylene and (meth)acrolein with molecular oxygen or molecular oxygen-containing gas using a multi-tubular reactor equipped with one or more catalyst layer(s) in a direction of tube axis, a sudden rise of temperature is suppressed even after changing the reaction condition for raising the reaction temperature for enhancing the production velocity whereby inactivation of the catalyst is prevented and a stable production is carried out. The present invention relates to a process where a change in the reaction condition for raising the reaction temperature is conducted by changing the temperature of the heat medium for the adjustment of reaction temperature at the inlet equipped with the above-mentioned multi-tubular reactor and, at that time, (1) change in the inlet temperature of the heat medium is conducted at not higher than 2° C. for each changing operation and (2) when another changing operation is continuously conducted, the changing operation is conducted where the time interval from the changing operation immediately before that is made not shorter than 10 minutes.
摘要翻译：本发明的目的是提供在通过气相催化氧化反应生成（甲基）丙烯醛或（甲基）丙烯酸的方法中，例如丙烯，丙烷，异丁烯和（甲基）丙烯醛与分子氧或含分子氧的气体，使用在管轴方向上配备有一个或多个催化剂层的多管式反应器，甚至在改变反应条件之后也抑制了温度的突然升高提高反应温度以提高生产速度，从而防止催化剂的失活并进行稳定的生产。本发明涉及通过改变用于调节装有上述多管式反应器的入口处的反应温度的热介质的温度来进行提高反应温度的反应条件的变化的方法，此时，（1）对于各变化动作，热介质的入口温度的变化不高于2℃，（2）当连续进行其他变更动作时，进行变更动作，在此之前的更改操作的间隔不小于10分钟。

60. 发明申请

US20070021632A1 Gas-phase catalytic oxidation process and process for producing (METH) acrolein or (METH) acrylic acid 审中-公开
标题翻译：气相催化氧化方法和（METH）丙烯醛或（METH）丙烯酸的制备方法
公开(公告)号：US20070021632A1
公开(公告)日：2007-01-25
申请号：US11528395
申请日：2006-09-28
申请人： Shuhei Yada , Yasushi Ogawa , Yoshiro Suzuki , Hirochika Hosaka , Kimikatsu Jinno
发明人： Shuhei Yada , Yasushi Ogawa , Yoshiro Suzuki , Hirochika Hosaka , Kimikatsu Jinno
IPC分类号： C07C45/28 , C07C51/16
CPC分类号： C07C51/215 , C07C45/33 , C07C45/35 , C07C51/252 , C07C47/22 , C07C57/04
摘要： (1) In a gas-phase catalytic oxidation process for conducting gas-phase catalytic oxidation reaction using a fixed bed multipipe type reactor having reaction tubes filled with a catalyst while feeding a reaction raw gas thereinto, the catalyst is filled in each of the reaction tubes of the fixed bed multipipe type reactor to form two or more catalyst layers having different catalytic activities from each other in a direction of the oxidation reaction, and the catalyst layer disposed nearest to a reaction raw gas inlet of the reaction tube has a higher catalytic activity than that of the next catalyst layer adjacent thereto, or (2) in a process for producing (meth)acrolein or (meth)acrylic acid by subjecting a raw material of the (meth)acrolein or (meth)acrylic acid, and molecular oxygen or a molecular oxygen-containing gas to gas-phase catalytic oxidation reaction using a fixed bed multipipe type reactor having two or more catalyst layers in an axial direction of each of reaction tubes provided in the reactor, a difference between maximum and minimum reaction peak temperatures of the respective catalyst layers in the axial direction of the reaction tube is not more than 20° C. According to these processes, formation of hot spots in the catalyst can be efficiently prevented.
摘要翻译：（1）在使用固定床多管式反应器进行气相催化氧化反应的气相催化氧化反应器中，在反应管中装入催化剂，同时向其中加入反应原料气体，在每个反应中填充催化剂固定床多管式反应器的管，在氧化反应的方向上形成具有彼此不同的催化活性的两个以上的催化剂层，最靠近反应管的反应原料气体入口设置的催化剂层具有较高的催化剂活性高于与其相邻的下一催化剂层的活性，或（2）在（甲基）丙烯醛或（甲基）丙烯酸的原料和分子量氧或含分子氧的气体进行气相催化氧化反应，使用在每个反应管的轴向上具有两个以上催化剂层的固定床多管型反应器在反应器中设置反应管的轴向方向上的各催化剂层的最大和最小反应峰值温度之间的差不超过20℃。根据这些方法，可以有效地形成催化剂中的热点防止了

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