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51. 发明授权

US07816371B2 Bicycloheteroaryl compounds as P2X7 modulators and uses thereof 有权
标题翻译：双环杂芳基化合物作为P2X7调节剂及其用途
公开(公告)号：US07816371B2
公开(公告)日：2010-10-19
申请号：US11725153
申请日：2007-03-16
申请人： Michael G. Kelly , John Kincaid , Yunfeng Fang , Jianhua He, legal representative , Yeyu Cao , Carl Kaub , Sumithra Gowlugari , Zhan Wang
发明人： Michael G. Kelly , John Kincaid , Yunfeng Fang , Yeyu Cao , Carl Kaub , Sumithra Gowlugari , Zhan Wang
IPC分类号： C07D217/22 , A61K31/4704
CPC分类号： C07D217/24 , C07D401/06 , C07D403/12 , C07D405/12 , C07D409/12
摘要： Bicycloheteroaryl compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
摘要翻译：公开了具有下列化学式的双杂环芳基化合物：该化合物可以制备成药物组合物，并且可以用于预防和治疗哺乳动物包括人的多种病症，包括作为非限制性实例，疼痛，炎症，创伤性损伤等。

52. 发明申请

US20100022531A1 NOVEL COMPOUNDS AS P2X7 MODULATORS AND USES THEREOF 审中-公开
标题翻译：新型化合物作为P2X7调节剂及其用途
公开(公告)号：US20100022531A1
公开(公告)日：2010-01-28
申请号：US11991485
申请日：2006-09-01
申请人： John Kincaid , Yeyu Cao , Carl Kaub , David Lonergan , Michael G. Kelly
发明人： John Kincaid , Yeyu Cao , Carl Kaub , David Lonergan , Michael G. Kelly
IPC分类号： A61K31/5377 , C07D471/04 , C07D471/12 , C07D265/36 , A61K31/495 , A61K31/519 , A61P25/00 , A61P25/02
CPC分类号： C07D471/04
摘要： Compounds are disclosed that have a formula represented by the following (1), the compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
摘要翻译：公开了具有由下列（1）表示的配方的化合物，该化合物可以制备成药物组合物，并且可用于预防和治疗包括人在内的哺乳动物中的各种病症，包括通过非限制性的方式例如疼痛，炎症，创伤性损伤等。

53. 发明申请

US20090298825A1 Bicycloheteroaryl Compounds as P2x7 Modulators and Uses Thereof 审中-公开
标题翻译：双环杂芳基化合物作为P2x7调节剂及其用途
公开(公告)号：US20090298825A1
公开(公告)日：2009-12-03
申请号：US12225276
申请日：2007-03-16
申请人： Michael G. Kelly , John Kincaid , Yunfeng Fang , Yeyu Cao , Carl Kaub , Sumithra Gowlugari , Zhan Wang
发明人： Michael G. Kelly , John Kincaid , Yunfeng Fang , Yeyu Cao , Carl Kaub , Sumithra Gowlugari , Zhan Wang
IPC分类号： A61K31/4725 , C07D401/04 , C07D413/14 , C07D413/04 , C07D217/24 , C07D453/02 , A61K31/472 , A61K31/5377 , A61P25/00 , A61P11/00 , A61P19/00
CPC分类号： C07D401/04 , C07D217/24 , C07D405/14 , C07D413/04 , C07D413/14 , C07D453/02
摘要： Bicycloheteroaryl compounds are disclosed that have a formula represented by the following: Formula (I). The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
摘要翻译：公开了具有由下式表示的式的双杂芳基化合物：式（I）。化合物可以制备成药物组合物，并且可以用于预防和治疗包括人在内的哺乳动物中的各种病症，包括作为非限制性实例，疼痛，炎症，创伤性损伤等。

54. 发明授权

US07402596B2 Bicycloheteroaryl compounds as P2X7 modulators and uses thereof 失效
标题翻译：双环杂芳基化合物作为P2X7调节剂及其用途
公开(公告)号：US07402596B2
公开(公告)日：2008-07-22
申请号：US11384199
申请日：2006-03-17
申请人： Michael G. Kelly , John Kincaid
发明人： Michael G. Kelly , John Kincaid
IPC分类号： C07D211/74 , A61K31/47
CPC分类号： C07D217/24 , C07D401/06 , C07D405/06 , C07D413/06 , C07D417/06 , C07D471/04 , C07D487/04
摘要： Bicycloheteroaryl compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
摘要翻译：公开了具有下列化学式的双杂环芳基化合物：该化合物可以制备成药物组合物，并且可以用于预防和治疗哺乳动物包括人的多种病症，包括作为非限制性实例，疼痛，炎症，创伤性损伤等。

55. 发明授权

US4425542A Method and apparatus for measuring the surface transfer impedance of a piece of shielded cable 失效
标题翻译：用于测量一根屏蔽电缆的表面传输阻抗的方法和装置
公开(公告)号：US4425542A
公开(公告)日：1984-01-10
申请号：US413603
申请日：1982-09-01
申请人： Anatoly Tsaliovich , John Kincaid
发明人： Anatoly Tsaliovich , John Kincaid
IPC分类号： G01R27/04
CPC分类号： G01R27/04
摘要： A method for measuring surface transfer impedance of shielded cable within a frequency range below about 1 GHz is implemented with a single test fixture. The test fixture provides a conductive cylindrical chamber which opens for installation of a sample of shielded cable. The ends of the chamber are blocked by ferrite toroids to prevent radiation of high frequency electromagnetic energy. One end of the cylindrical chamber may be externally short-circuited to the cable shielding for low frequency measurements. A current source connects between the sample shielding and the conductive chamber boundary at the other end of the chamber. Current flow at low frequencies is limited to the region between the current source and the short circuit. Current flow at high frequency is limited to the region between the toroids. The cable shielding and the fixture body beyond the toroids are short-circuited for high-frequency tests and open-circuited for low frequency tests. The induced voltage in the cable is measured through feed-throughs provided in the test fixture. The current source uses an isolation transformer to avoid ground loops in the low-frequency range.
摘要翻译：一种用于测量屏蔽电缆在低于约1GHz的频率范围内的表面传导阻抗的方法是用单个测试夹具实现的。测试夹具提供一个导电圆柱形腔室，用于安装屏蔽电缆样本。腔室的端部被铁氧体环形物阻挡，以防止高频电磁能的辐射。圆柱形腔室的一端可能外部短路到电缆屏蔽层进行低频测量。电流源在室的另一端连接在样品屏蔽和导电室边界之间。低频电流限制在电流源与短路之间。高频电流限制在环形线圈之间的区域。超出环形线圈的电缆屏蔽和固定体短路，用于高频测试，并开路低频测试。电缆中的感应电压通过测试夹具中提供的馈通来测量。电流源使用隔离变压器来避免低频范围内的接地环路。

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