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    • 51. 发明申请
    • COMBINATION
    • 组合
    • US20130109705A1
    • 2013-05-02
    • US13699077
    • 2011-05-19
    • Tona M. GilmerRakesh Kumar
    • Tona M. GilmerRakesh Kumar
    • A61K31/519A61K31/517
    • A61K31/519A61K9/2018A61K9/2054A61K9/4858A61K31/517A61K2300/00
    • The present invention relates to a method of treating cancer in a human and to pharmaceutical combinations useful in such treatment. In particular, the method relates to a cancer treatment method that includes administering N-{3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methanesulphonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine, or a pharmaceutically acceptable hydrate and/or salt thereof, and N-{3-[3-cyclopropyl-5-(2-fluoro-4-iodo-phenylamino)6,8-dimethy;-2,4,7-trioxo-3,4,6,7-tetrahydro-2H-pyrido[4,3-d]pyrimidin-1-yl]phenyl}acetamide, or a pharmaceutically acceptable salt or solvate thereof, to a human in need thereof.
    • 本发明涉及一种治疗人类癌症的方法和用于治疗的药物组合物。 特别地,该方法涉及一种癌症治疗方法,其包括给予N- {3-氯-4 - [(3-氟苄基)氧基]苯基} -6- [5 - ({[2-(甲磺酰基)乙基]氨基 }甲基)-2-呋喃基] -4-喹唑啉胺或其药学上可接受的水合物和/或盐和N- {3- [3-环丙基-5-(2-氟-4-碘 - 苯基氨基) -2,4,7-三氧代-3,4,6,7-四氢-2H-吡啶并[4,3-d]嘧啶-1-基]苯基}乙酰胺或其药学上可接受的盐或溶剂化物 对有需要的人。