专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

51. 发明申请

US20080305110A1 Novel Ligand of G Protein Coupled Receptor Protein and Use Thereof 失效
标题翻译： G蛋白偶联受体蛋白的新配体及其用途
公开(公告)号：US20080305110A1
公开(公告)日：2008-12-11
申请号：US11578325
申请日：2005-04-11
申请人： Ryo Fujii , Shoichi Okubo , Kazunori Nishi , Shuji Hinuma , Masaaki Mori
发明人： Ryo Fujii , Shoichi Okubo , Kazunori Nishi , Shuji Hinuma , Masaaki Mori
IPC分类号： A61K39/395 , G01N33/566 , A61K31/415 , A61P37/00 , A61K38/00 , A61K31/7088
CPC分类号： G01N33/76 , A61K31/403 , A61K31/4155 , A61K31/4523 , A61K38/1796 , C07K14/705 , G01N2333/726
摘要： The present invention provides a method of screening an agonist or antagonist to a G protein-coupled receptor protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1, or a salt thereof, which comprises using the receptor protein or a salt thereof and the ligand or a salt thereof; etc. The present invention is useful for screening agents for the prevention/treatment of, e.g., leukopenia, leukemia, lymphoma, malignant tumor, ulcerative colitis, rheumatoid arthritis, inflammatory bowel disorders, tonsil disorders, collagen disease, inflammatory disease, leukocytosis, heart failure, inherited muscle disorders, muscular dystrophy, neuromuscular degenerative disease, myocardial infarction, obesity, mellitus diabetes, hyperlipemia, arteriosclerosis, metabolic syndrome, thrombocytopenia, thrombocytosis, cancer, pulmonary edema, multiple organ failure, etc.
摘要翻译：本发明提供筛选G蛋白偶联受体蛋白的激动剂或拮抗剂的方法，其包含与SEQ ID NO：1所示的氨基酸序列相同或基本上相同的氨基酸序列，或其盐，其包含使用受体蛋白或其盐和配体或其盐; 本发明可用于预防/治疗例如白细胞减少症，白血病，淋巴瘤，恶性肿瘤，溃疡性结肠炎，类风湿性关节炎，炎性肠病，扁桃体病，胶原病，炎性疾病，白细胞增多症，心脏病失败，遗传性肌肉疾病，肌营养不良症，神经肌肉退行性疾病，心肌梗死，肥胖症，糖尿病，高脂血症，动脉硬化，代谢综合征，血小板减少症，血小板增多症，癌症，肺水肿，多器官衰竭等。

52. 发明申请

US20080280938A1 Screening Method 失效
标题翻译：筛选方法
公开(公告)号：US20080280938A1
公开(公告)日：2008-11-13
申请号：US11885781
申请日：2006-03-07
申请人： Masaaki Mori , Kimiko Kanehashi
发明人： Masaaki Mori , Kimiko Kanehashi
IPC分类号： A61K31/473 , G01N33/566 , G01N33/53
CPC分类号： A61K31/473 , G01N2500/02
摘要： The present invention provides a medicament for preventing/treating cancer, comprising a tacrine compound, or a compound promoting the binding between the tacrine compound and a protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1.
摘要翻译：本发明提供了用于预防/治疗癌症的药物，其包含他克林化合物或促进他克林化合物与包含与SEQ ID NO所示氨基酸序列相同或基本相同的氨基酸序列的蛋白质之间的结合的化合物：1。

53. 发明授权

US07342105B2 Antibody and use thereof 失效
标题翻译：抗体及其用途
公开(公告)号：US07342105B2
公开(公告)日：2008-03-11
申请号：US10547051
申请日：2004-02-26
申请人： Hirokazu Matsumoto , Eri Hashimoto , Masaaki Mori , Chieko Kitada
发明人： Hirokazu Matsumoto , Eri Hashimoto , Masaaki Mori , Chieko Kitada
IPC分类号： C07K16/00
CPC分类号： C07K7/08 , A61K2039/505 , C07K14/47 , C07K16/18 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/57407 , G01N33/57419
摘要： The antibody of the present invention, which specifically reacts with the N-terminal or C-terminal partial peptide of TGR23-2 ligand, is useful in detecting and quantifying the TGR23-2 ligand. Moreover, it is useful as a preventing/treating agent and a diagnostic agent for cancer, etc.
摘要翻译：与TGR23-2配体的N末端或C-末端部分肽特异性反应的本发明的抗体可用于检测和定量TGR23-2配体。此外，作为癌症等的预防处理剂和诊断剂是有用的

54. 发明申请

US20070117160A1 Novel method of screening 有权
标题翻译：新型筛选方法
公开(公告)号：US20070117160A1
公开(公告)日：2007-05-24
申请号：US11587285
申请日：2005-04-22
申请人： Ryo Fujii , Kazunori Nishi , Yasuhiro Tanaka , Masaaki Mori
发明人： Ryo Fujii , Kazunori Nishi , Yasuhiro Tanaka , Masaaki Mori
IPC分类号： G01N33/567 , G01N33/53
CPC分类号： G01N33/566 , G01N2333/726 , G01N2500/00 , Y10S435/975
摘要： The present invention relates to screening of an agonist/antagonist, etc. Specifically, the present invention provides a method of screening an agonist or antagonist of a G protein-coupled receptor protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1, or a salt thereof, which comprises using the receptor protein or a salt thereof and a cholesterol metabolism-related substance, and so on.
摘要翻译：本发明涉及激动剂/拮抗剂等的筛选。具体而言，本发明提供筛选G蛋白偶联受体蛋白的激动剂或拮抗剂的方法，其包含与氨基酸相同或基本上相同的氨基酸序列由SEQ ID NO：1表示的序列或其盐，其包括使用受体蛋白质或其盐和胆固醇代谢相关物质等。

55. 发明申请

US20070042947A1 Agents for preventing and/or treating uppper digestive tract disorders 审中-公开
标题翻译：用于预防和/或治疗上消化道疾病的药剂
公开(公告)号：US20070042947A1
公开(公告)日：2007-02-22
申请号：US10548817
申请日：2004-03-11
申请人： Hirokazu Matsumoto , Koh Takagi , Masaaki Mori
发明人： Hirokazu Matsumoto , Koh Takagi , Masaaki Mori
IPC分类号： A61K38/17
CPC分类号： A61K38/177 , A61K38/1709 , C12N2310/11 , G01N2800/06
摘要： A compound or its salts that inhibit the activity of the polypeptide or receptor of the present invention and the antibody of the present invention as well as the antisense DNA of the present invention are useful as, e.g., gastric acid secretion inhibitors, mucosa protectants, mineral absorption promoters, etc., which are less toxic and safe, and can be used as, e.g., agents for preventing/treating upper digestive tract disorders, antibacterial agents to Helicobacter pylori, etc. A compound or its salts that promote the activity of the polypeptide or receptor of the present invention, the polypeptide or receptor of the present invention and the DNA of the present invention can be used as, e.g., gastric acid secretion promoters and can be used as, e.g., agents for preventing/treating dyspepsia, bone metabolism disorders, anemia, etc. A compound or its salts that promote the activity of the polypeptide or receptor of the present invention, the polypeptide of the present invention, etc. can also be used as test agents for gastric secretory function. Furthermore, the polypeptide or receptor of the present invention and the DNA of the present invention are also useful for screening the agents for the prevention/treatment described above.
摘要翻译：抑制本发明的多肽或受体和本发明的抗体以及本发明的反义DNA的活性的化合物或其盐可用于例如胃酸分泌抑制剂，粘膜保护剂，矿物质吸收促进剂等，其毒性和安全性较低，并且可以用作例如用于预防/治疗上消化道疾病的药剂，对幽门螺杆菌等的抗菌剂。促进幽门螺杆菌活性的化合物或其盐本发明的多肽或受体，本发明的多肽或受体和本发明的DNA可以用作例如胃酸分泌促进剂，并且可以用作例如用于预防/治疗消化不良，骨骼的药剂代谢紊乱，贫血等。促进本发明的多肽或受体的活性，本发明的多肽等的化合物或其盐。c 也可用作胃分泌功能的试剂。此外，本发明的多肽或受体和本发明的DNA也可用于筛选用于上述预防/治疗的药剂。

56. 发明授权

US07115750B1 Melanin concentrating hormone antagonist 失效
标题翻译：黑色素浓缩激素拮抗剂
公开(公告)号：US07115750B1
公开(公告)日：2006-10-03
申请号：US10088771
申请日：2000-09-19
申请人： Kaneyoshi Kato , Jun Terauchi , Masaaki Mori , Nobuhiro Suzuki , Yukio Shimomura , Shiro Takekawa , Yuji Ishihara
发明人： Kaneyoshi Kato , Jun Terauchi , Masaaki Mori , Nobuhiro Suzuki , Yukio Shimomura , Shiro Takekawa , Yuji Ishihara
IPC分类号： C09B5/00 , A61K3/41 , C07D209/56 , C07D487/00 , C07D491/00
CPC分类号： C07D207/277 , C07C217/74 , C07C219/28 , C07C233/29 , C07C233/44 , C07C233/80 , C07C235/42 , C07C235/50 , C07C235/56 , C07C235/64 , C07C235/84 , C07C237/40 , C07C271/28 , C07C275/42 , C07C311/21 , C07C2602/10 , C07C2602/12 , C07D209/18 , C07D209/22 , C07D209/42 , C07D211/16 , C07D211/18 , C07D211/22 , C07D211/26 , C07D211/32 , C07D211/52 , C07D211/62 , C07D211/70 , C07D213/56 , C07D213/81 , C07D213/82 , C07D215/14 , C07D215/38 , C07D233/24 , C07D239/28 , C07D239/30 , C07D261/18 , C07D263/14 , C07D263/34 , C07D265/28 , C07D271/06 , C07D295/096 , C07D295/13 , C07D295/185 , C07D307/68 , C07D307/81 , C07D311/58 , C07D317/60 , C07D319/20 , C07D333/24 , C07D333/28 , C07D333/38 , C07D335/16 , C07D405/04 , C07D405/12 , C07D413/04 , C07D413/12 , C07D493/04
摘要： A melanin-concentrating hormone antagonist which comprises a compound of the formula: wherein Ar1 is a cyclic group which may have substituents; X is a spacer having a main chain of 1 to 6 atoms; Y is a bond or a spacer having a main chain of 1 to 6 atoms; Ar is a monocyclic aromatic ring which may be condensed with a 4 to 8 membered non-aromatic ring, and may have further substituents; R1 and R2 are independently hydrogen atom or a hydrocarbon group which may have substituents; R1 and R2, together with the adjacent nitrogen atom, may form a nitrogen-containing hetero ring which may have substituents; R2 may form a spiro ring together with Ar; or R2, together with the adjacent nitrogen atom and Y, may form a nitrogen-containing hetero ring which may have substituents; or a salt thereof; which is useful as an agent for preventing or treating obesity, etc.
摘要翻译：一种黑色素浓缩激素拮抗剂，其包含下式化合物：其中Ar 1是可以具有取代基的环状基团; X是具有1至6个原子的主链的间隔物; Y是具有1至6个原子的主链的键或间隔基; Ar是可以与4至8元非芳族环稠合的单环芳环，并且可以具有其它取代基; R 1和R 2独立地是氢原子或可以具有取代基的烃基; R 1和R 2与相邻的氮原子一起可以形成可以具有取代基的含氮杂环; R 2可以与Ar一起形成螺环; 或R 2连同相邻的氮原子和Y可以形成可具有取代基的含氮杂环; 或其盐; 其可用作预防或治疗肥胖症等的药剂。

57. 发明授权

US07053053B2 Humanin-like peptide and use thereof 失效
标题翻译：人类样肽及其用途
公开(公告)号：US07053053B2
公开(公告)日：2006-05-30
申请号：US10481044
申请日：2002-06-14
申请人： Tsukasa Sugo , Masaaki Mori
发明人： Tsukasa Sugo , Masaaki Mori
IPC分类号： A61K38/17 , C07K14/47 , G01N33/50
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00
摘要： A novel polypeptide having a cell death inhibitory activity and use thereof is provided. The polypeptide and the polynucleotide encoding it can be used as a diagnostic, therapeutic or prophylactic agent for various diseases and disorders. Certain suitable diseases and disorders which may be diagnosed, treated, or prevented with the polypeptide and the polynucleotide encoding it are selected from neurodegenerative diseases, brain dysfunctions, cancers, immunological disease, infections, gastrointestinal diseases, circulatory diseases, and endocrine diseases. The polypeptide and the polynucleotide encoding it can be used as a cell death inhibitor.
摘要翻译：提供了具有细胞死亡抑制活性的新型多肽及其用途。多肽和编码它的多核苷酸可以用作各种疾病和病症的诊断，治疗或预防剂。可以用多肽和编码它的多核苷酸诊断，治疗或预防的某些合适的疾病和病症选自神经变性疾病，脑功能障碍，癌症，免疫疾病，感染，胃肠道疾病，循环系统疾病和内分泌疾病。多肽和编码它的多核苷酸可以用作细胞死亡抑制剂。

58. 发明授权

US06991908B1 Antiobestic agents methods for screening antiobestic agents and kits comprising same 失效
标题翻译：用于筛选抗生物剂的抗生物剂方法和包含其的试剂盒
公开(公告)号：US06991908B1
公开(公告)日：2006-01-31
申请号：US09869540
申请日：1999-12-27
申请人： Masaaki Mori , Yukio Shimomura , Shiro Takekawa , Tsukasa Sugo , Yoshihiro Ishibashi , Chieko Kitada , Nobuhiro Suzuki
发明人： Masaaki Mori , Yukio Shimomura , Shiro Takekawa , Tsukasa Sugo , Yoshihiro Ishibashi , Chieko Kitada , Nobuhiro Suzuki
IPC分类号： G01N33/53
CPC分类号： C07K7/08 , A61K38/10 , G01N33/74 , G01N2333/575 , G01N2333/726 , G01N2500/00 , G01N2500/02 , Y10S436/808
摘要： The present invention provides a method for screening a compound or its salt that alters the binding property between MCH or its salt and SLC-1 or its salt, characterized by using MCH or its derivative or a salt thereof and SLC-1 or its salt is useful for screening an SLC-1 agonist which can be used not only as an appetite (eating) promoting agent but also as a prophylactic/therapeutic agent for weak pains, atonic bleeding, before and after expulsion, subinvolution of uterus, cesarean section, induced abortion, galactostasis, and the like, and an SLC-1 antagonist which can be used not only as an antiobestic agents (drug), an appetite (eating) modulator, and the like, but also as a prophylactic/therapeutic agent for hyperstimulation, ankylosing uterine contractions, fetal distress, uterine rupture, cervical laceration, preterm delivery, Prader-Wili syndrome and the like.
摘要翻译：本发明提供一种筛选化合物或其盐的方法，其改变MCH或其盐与SLC-1或其盐之间的结合性质，其特征在于使用MCH或其衍生物或其盐，SLC-1或其盐是可用于筛选SLC-1激动剂，其不仅可以用作食欲（进食）促进剂，而且可用作弱疼痛，无症状出血，驱除前后，子宫切除，剖宫产，诱导流产，半乳糖淀粉酶等，以及不仅可以用作抗生素（药物），食欲调节剂等的SLC-1拮抗剂，而且可以用作过度刺激的预防/治疗剂，强直性子宫收缩，胎儿窘迫，子宫破裂，子宫颈撕裂，早产，Prader-Wili综合征等。

59. 再颁专利

USRE35886E Phosphonic acid derivatives and use thereof 失效
标题翻译：膦酸衍生物及其用途
公开(公告)号：USRE35886E
公开(公告)日：1998-09-01
申请号：US680295
申请日：1996-07-12
申请人： Mitsuhiro Wakimasu , Masaaki Mori , Akira Kawada
发明人： Mitsuhiro Wakimasu , Masaaki Mori , Akira Kawada
IPC分类号： A61K38/00 , A61K38/55 , A61P9/00 , A61P9/12 , A61P13/02 , A61P15/00 , C07K1/06 , C07K1/113 , C07K5/06 , C07F9/22 , A61K33/42
CPC分类号： C07K5/06191 , A61K38/00 , Y02P20/55
摘要： A phosphonic acid derivative compound represented by formula �I ! or a pharmaceutically acceptable salt thereof: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 each represent hydrocarbon groups which may be substituted, except cases in which (1) R.sub.2 is unsubstituted methyl, ( 2 ) R.sub.3 is an unsubstituted hydrocarbon group having 1 to 3 carbon atoms, and (3) R.sub.1 is benzyloxycarbonylaminomethyl, R.sub.2 is isobutyl and R.sub.3 is isobutyl or phenylmethyl, which has endothelin-converting enzyme inhibiting activity and is useful as pharmaceutical drugs such as therapeutic agents for hypertension, cardiac or cerebral circulatory diseases and renal diseases. This is a Reissue of a Patent which was the subject of a Reexamination Certificate No. B1 5,330,978, dated Jun. 18, 1996, Request No. 90/00400, Oct. 18, 1995.
摘要翻译：由式[I]表示的膦酸衍生物或其药学上可接受的盐：其中R 1，R 2和R 3各自表示可以被取代的烃基，除了（1）R 2是未取代的甲基，（2）R3为未取代的碳原子数1〜3的烷基，（3）R1为苄氧羰基氨基甲基，R2为异丁基，R3为异丁基或苯甲基，具有内皮素转化酶抑制活性，可用作药物作为高血压，心脏或脑循环系统疾病和肾脏疾病的治疗剂。 + PR这是1996年10月18日，1996年10月18日申请号90/00400的1996年6月18日的复审证书B1 5,330,978的主题的重新发行。

60. 发明授权

US4748455A System for driving a thermal print head 失效
标题翻译：用于驱动热打印头的系统
公开(公告)号：US4748455A
公开(公告)日：1988-05-31
申请号：US858534
申请日：1986-04-28
申请人： Masaaki Mori
发明人： Masaaki Mori
IPC分类号： B41J2/36 , H04N1/23 , G01D15/10
CPC分类号： B41J2/36
摘要： A system for driving a thermal print head including a plurality of heat-producing elements which are activated selectively in accordance with digital image data obtained from an analog image signal is provided. In one aspect, the driving system is so structured to insert additional data between any two adjacent image data whenever the space between the two exceeds a predetermined level thereby allowing to maintain the dot density at constant when printed. In another aspect, the driving system controls the time period of activation of each of the heat-producing elements in accordance with preheat control data obtained by carrying out AND processing between each of the digital image data of one print line and the corresponding each of the digital image data of the next following print line. In a further aspect, the present driving system has a structure such that a reference point in a print line may be set at a desired location along the print line.
摘要翻译：提供一种用于驱动热打印头的系统，其包括根据从模拟图像信号获得的数字图像数据选择性地激活的多个发热元件。在一个方面，驱动系统如此构造以便每当两者之间的空间超过预定水平时，在任何两个相邻图像数据之间插入附加数据，从而允许在打印时将点密度保持恒定。在另一方面，驱动系统根据通过在一个打印行的每个数字图像数据和每个打印行的每个之间执行AND处理而获得的预热控制数据来控制每个发热元件的激活时间下一个打印行的数字图像数据。在另一方面，本驱动系统具有这样的结构，使得打印线中的参考点可以设置在沿着打印线的期望位置。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式