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    • 52. 发明申请
    • RECONFIGURABLE CHAMBER FOR EMULATING MULTIPATH FADING
    • 用于模拟多路径衰减的可重构室
    • US20100233969A1
    • 2010-09-16
    • US12728730
    • 2010-03-22
    • Jeff FrolikThomas Weller
    • Jeff FrolikThomas Weller
    • H04B17/00
    • H04B17/0082G01R29/0821
    • Disclosed is a compact reconfigurable channel emulator, which may be used to emulate severe fading environments and test wireless systems and subsystems for operation in severe channel environments. Examples include radios, coding schemes, diversity methods and antennas. In particular, the chamber is well suited to test hardware associated with wireless sensor deployments for these tend to be susceptible to severe fading scenarios. Moreover, the invention is significantly smaller than traditional testing instruments, and with its automation, reduces electromagnetic interference and electromagnetic compatibility testing time and costs.
    • 公开了一种紧凑的可重新配置的信道仿真器,可用于模拟严重的衰落环境,并测试无线系统和子系统,以在恶劣的信道环境中运行。 示例包括无线电,编码方案,分集方法和天线。 特别地,该室非常适合于测试与无线传感器部署有关的硬件,因为这些部件往往容易遭受严重的衰落情况。 此外,本发明显着小于传统测试仪器,并且具有自动化功能,可降低电磁干扰和电磁兼容性测试的时间和成本。
    • 55. 发明申请
    • Novel Tetrahydropyridine Derivatives
    • 新型四氢吡啶衍生物
    • US20080234305A1
    • 2008-09-25
    • US10575348
    • 2004-10-05
    • Olivier BezenconDaniel BurWalter FischliLubos RemenSylvia Richard-BildsteinThierry SifferlenThomas Weller
    • Olivier BezenconDaniel BurWalter FischliLubos RemenSylvia Richard-BildsteinThierry SifferlenThomas Weller
    • A61K31/438C07D221/20C07D213/80A61K31/44A61P9/04
    • C07D211/78
    • The invention relates to novel tetrahydropyridine derivatives and use thereof as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin. (I) wherein X and Y represent independently hydrogen, fluorine or a methyl group; X and Y do not represent both hydrogen at the same time or X and Y may together form a cyclopropyl ring; W represents a phenyl or a heteroaryl, the heteroaryl ring being a six-membered and non-fused ring, the phenyl ring and the heteroaryl are substituted with V in position 3 or 4; A and B independently represent —O—; —S—; —SO— or —SO2—; U represents aryl or heteroaryl; T represents —CONR1—; —(CH2)pOCO—; —(CH2)pN(R1)CO—; —(CH2)pN(R1)SO2—; —COO—; —(CH2)pOCONR1— or —(CH2)pN(R2)CONR1—; R1 and R2 independently represent hydrogen; lower alkyl; lower alkenyl; lower alkynil; cycloalkyl; aryl-lower alkyl, heteroaryl-lower alkyl or cycloalkyl-lower alkyl; Q represents lower alkylene or lower alkenylene; M represents hydrogen; cycloalkyl; aryl; heterocyclyl or heteroaryl:
    • 本发明涉及新型四氢吡啶衍生物及其在制备药物组合物中作为活性成分的用途。 本发明还涉及包括制备化合物的方法,含有一种或多种这些化合物的药物组合物,特别是其作为肾素抑制剂的用途的相关方面。 (I)其中X和Y独立地表示氢,氟或甲基; X和Y不同时表示氢或X和Y可以一起形成环丙基环; W表示苯基或杂芳基,杂芳基环为6元和非稠合环,苯环和杂芳基被V 3或4取代; A和B独立地表示-O-; -S-; -SO-或-SO 2 - ; U表示芳基或杂芳基; T表示-CONR <! - SIPO < - (CH 2)2 OCO-; - (CH 2)n - (N) - (CH 2)CO-; - (CH 2)n N(R 1)SO 2 - ; - (CH 2) -COO-; - (CH 2)2 - - - - (CH 2)2 - - - - (CH 2) > N(R 2)CONR 1 - ; R 1和R 2独立地表示氢; 低级烷基 低级链烯基 低级炔 环烷基 芳基 - 低级烷基,杂芳基 - 低级烷基或环烷基 - 低级烷基; Q表示低级亚烷基或低级亚烯基; M表示氢; 环烷基 芳基; 杂环基或杂芳基: