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51. 发明申请

US20120022429A1 OCULAR IMPLANT WITH STIFFNESS QUALITIES, METHODS OF IMPLANTATION AND SYSTEM 有权
公开(公告)号：US20120022429A1
公开(公告)日：2012-01-26
申请号：US13245772
申请日：2011-09-26
申请人： Thomas A. Silvestrini , Eugene de Juang, JR.
发明人： Thomas A. Silvestrini , Eugene de Juang, JR.
IPC分类号： A61F9/00
CPC分类号： A61F9/00781 , A61F2210/0019
摘要： Described herein are devices and methods for treating eye conditions. Described is an ocular implant including an elongate member having an internal lumen forming a flow pathway, at least one inflow port communicating with the flow pathway, and at least one outflow port communicating with the flow pathway. The elongate member is adapted to be positioned in the eye such that at least one inflow port communicates with the anterior chamber, at least one outflow port communicates with the suprachoroidal space to provide a fluid pathway between the anterior chamber and the suprachoroidal space when the elongate member is implanted in the eye. The elongate member has a wall material imparting a stiffness to the elongate member. The stiffness is selected such that after implantation the elongate member deforms eye tissue surrounding the suprachoroidal space forming a tented volume.

52. 发明申请

US20110238173A1 OPHTHALMIC DEVICES HAVING A DEGRADATION RESISTANT POLYMER 有权
标题翻译：具抗降解聚合物的透明设备
公开(公告)号：US20110238173A1
公开(公告)日：2011-09-29
申请号：US13152550
申请日：2011-06-03
申请人： Thomas A. Silvestrini
发明人： Thomas A. Silvestrini
IPC分类号： A61F2/14
CPC分类号： A61F2/145 , A61F2/14 , A61F2/15 , A61F9/0008 , A61F9/00834 , A61L27/16 , A61L2430/16 , G02C7/02 , G02C7/04 , G02C7/165 , C08L27/16
摘要： Disclosed are ophthalmic devices configured to be implanted in an eye of a patient. In one embodiment, the ophthalmic device includes a mask configured to increase the depth of focus of the patient and comprising a highly fluorinated polymeric material in which the number of carbon-fluorine bonds equals or exceeds the number of carbon-hydrogen bonds in the highly fluorinated polymeric material. The highly fluorinated polymeric material can be resistant to degradation upon exposure to ultraviolet light. The mask further includes an aperture configured to transmit light and a portion configured to be substantially opaque to visible light and to surround at least a portion of the aperture.
摘要翻译：公开了被配置为植入患者眼睛的眼科装置。在一个实施例中，眼科装置包括掩模，其被配置为增加患者的焦点深度并且包括高氟化聚合物材料，其中碳 - 氟键的数量等于或超过高氟化物中的碳 - 氢键数聚合材料。高度氟化的聚合物材料可以在暴露于紫外线时耐受降解。掩模还包括被配置为透射光的孔径和被配置为对可见光基本上不透明并且围绕孔的至少一部分的部分。

53. 发明申请

US20110105990A1 ZONAL DRUG DELIVERY DEVICE AND METHOD 审中-公开
标题翻译：区域药物递送装置和方法
公开(公告)号：US20110105990A1
公开(公告)日：2011-05-05
申请号：US12939033
申请日：2010-11-03
申请人： Thomas A. Silvestrini
发明人： Thomas A. Silvestrini
IPC分类号： A61F9/007
CPC分类号： A61F9/00781
摘要： Disclosed herein are ocular implants for treating an eye and methods of implantation including an elongate member having a proximal end with at least one inflow port, a distal end with at least one outflow port, and a longitudinal, internal lumen extending through the elongate member. The distal end of the elongate member is in fluid communication with the suprachoroidal space such that the proximal end of the elongate member remains in fluid communication with the anterior chamber when the elongate member is implanted in the eye. At least one polymeric film surrounds at least a portion of the elongate member, the film comprising a first drug delivery zone embedded with a first drug, wherein the first drug diffuses from the polymeric film over time into the eye at a first anatomical location.
摘要翻译：本文公开了用于治疗眼睛的眼部植入物和植入方法，包括具有近端的细长构件，所述近端具有至少一个流入端口，具有至少一个流出端口的远端和延伸穿过细长构件的纵向内腔。细长构件的远端与脉管外空间流体连通，使得细长构件的近端在细长构件植入眼睛时保持与前房流体连通。至少一个聚合物膜包围细长构件的至少一部分，所述膜包括嵌入第一药物的第一药物递送区，其中第一药物在第一解剖位置随时间从聚合物膜扩散入眼睛。

54. 发明申请

US20110087148A1 OCULAR IMPLANT WITH STIFFNESS QUALITIES, METHODS OF IMPLANTATION AND SYSTEM 有权
标题翻译：具有坚固质量的OCULAR植入物，植入和系统的方法
公开(公告)号：US20110087148A1
公开(公告)日：2011-04-14
申请号：US12970567
申请日：2010-12-16
申请人： Thomas A. Silvestrini , Eugene de Juan, JR.
发明人： Thomas A. Silvestrini , Eugene de Juan, JR.
IPC分类号： A61F9/00
CPC分类号： A61F9/00781 , A61F2210/0019
摘要： Described herein are devices and methods for treating eye conditions. Described is an ocular implant including an elongate member having an internal lumen forming a flow pathway, at least one inflow port communicating with the flow pathway, and at least one outflow port communicating with the flow pathway. The elongate member is adapted to be positioned in the eye such that at least one inflow port communicates with the anterior chamber, at least one outflow port communicates with the suprachoroidal space to provide a fluid pathway between the anterior chamber and the suprachoroidal space when the elongate member is implanted in the eye. The elongate member has a wall material imparting a stiffness to the elongate member. The stiffness is selected such that after implantation the elongate member deforms eye tissue surrounding the suprachoroidal space forming a tented volume.
摘要翻译：本文描述了用于治疗眼睛状况的装置和方法。描述了一种眼部植入物，其包括具有形成流动路径的内部内腔的细长构件，与流动通道连通的至少一个流入口以及与流动通路连通的至少一个流出口。细长构件适于定位在眼睛中，使得至少一个流入端口与前房连通，至少一个流出端口与脉管外空间连通，以在前房和脉管外空间之间提供流体通路，当细长成员植入眼睛。细长构件具有赋予细长构件刚性的壁材料。选择刚度使得在植入之后，细长构件使围绕脉管外空间的眼组织变形，形成帐篷体积。

55. 发明申请

US20100137981A1 OCULAR IMPLANT WITH SHAPE CHANGE CAPABILITIES 有权
标题翻译：具有形状变化能力的OCULAR植入物
公开(公告)号：US20100137981A1
公开(公告)日：2010-06-03
申请号：US12492051
申请日：2009-06-25
申请人： Thomas A. Silvestrini , Steven John , Jose Garcia , Richard S. Lilly
发明人： Thomas A. Silvestrini , Steven John , Jose Garcia , Richard S. Lilly
IPC分类号： A61F2/14 , A61M5/00
CPC分类号： A61F9/00781 , A61M37/00
摘要： Disclosed are devices, methods and systems for treatment of eye disease such as glaucoma. Implants are described herein that enhance aqueous flow through the normal outflow system of the eye with minimal to no complications. The implant can be reversibly deformed to a first shape, such as a generally linear shape conducive to insertion. Upon insertion, the implant can deform to a second shape, such as a generally non-linear shape conducive to retention within the eye. The shape also improves fluid flow from the anterior chamber and prevents or reduces clogging.
摘要翻译：公开了用于治疗诸如青光眼的眼睛疾病的装置，方法和系统。这里描述的植入物增强了通过眼睛的正常流出系统的水流量，而极少到没有并发症。植入物可以可逆地变形为第一形状，例如有利于插入的大致线性形状。在插入时，植入物可以变形为具有有利于保留在眼睛内的大体非线性形状的第二形状。该形状还改善了来自前房的流体流动并防止或减少了堵塞。

56. 发明申请

US20100134759A1 DIGITAL IMAGING SYSTEM FOR EYE PROCEDURES 审中-公开
标题翻译：用于眼睛程序的数字成像系统
公开(公告)号：US20100134759A1
公开(公告)日：2010-06-03
申请号：US12492085
申请日：2009-06-25
申请人： Thomas A. Silvestrini , Steven John , Jose Garcia , Richard S. Lilly
发明人： Thomas A. Silvestrini , Steven John , Jose Garcia , Richard S. Lilly
IPC分类号： A61B3/117 , A61B3/14
CPC分类号： A61B3/117 , A61F9/00781
摘要： Described herein is a hand-held gonioscopic imaging system that can be used to continuously display, capture and record images of the iridocorneal angle within the eye during implantation procedures. The system can be used, for example, during device implantation procedures for the treatment of glaucoma such that landmark identification continues during implantation. Intuitive real-time images viewed through the imaging systems described herein appear to the user to move in the same horizontal orientation as the instrument is actually being moved. The systems described herein also provide independent illumination sources for the camera and the surgical microscope that also have independent illumination controls.
摘要翻译：这里描述的是一种手持式前庭成像系统，其可以用于在植入过程期间连续地显示，捕获和记录眼睛内的虹膜角膜角度的图像。该系统可用于例如在用于治疗青光眼的装置植入过程期间，使得在植入期间继续进行标记识别。通过本文描述的成像系统查看的直观的实时图像对用户来说显示为与仪器实际移动时相同的水平方向移动。本文所述的系统还为摄像机和手术显微镜提供独立的照明源，其也具有独立的照明控制。

57. 发明授权

US07491350B2 Method of making an ocular implant 失效
标题翻译：制造眼部植入物的方法
公开(公告)号：US07491350B2
公开(公告)日：2009-02-17
申请号：US11000562
申请日：2004-12-01
申请人： Thomas A. Silvestrini
发明人： Thomas A. Silvestrini
IPC分类号： B29D11/00
CPC分类号： A61F2/142 , A61F2/15 , A61F9/00834 , A61F2240/002 , C23C14/0005 , G02C7/04 , G02C7/165
摘要： A method is provided for making a mask configured to improve the depth of focus of an eye of a patient. A substrate is provided with a mask forming feature. The mask forming feature comprises an annular surface that has a curved profile that corresponds to the curvature of a corneal layer of the eye. A release layer is formed on the annular surface. A mask layer of a biocompatible metal is formed above the release layer. The mask layer is separated from the substrate.
摘要翻译：提供了一种用于制造掩模的方法，所述掩模被配置为改善患者眼睛的焦点深度。衬底具有掩模形成特征。掩模形成特征包括具有对应于眼睛的角膜层的曲率的弯曲轮廓的环形表面。释放层形成在环形表面上。生物相容性金属的掩模层形成在剥离层的上方。掩模层与基板分离。

58. 发明授权

US6125294A Method and apparatus for measuring corneal incisions 失效
标题翻译：用于测量角膜切口的方法和装置
公开(公告)号：US6125294A
公开(公告)日：2000-09-26
申请号：US907112
申请日：1997-08-06
申请人： John Anthony Scholl , Thomas A. Silvestrini , Isidro Matias Gandionco , William P. Kuhn , Phillip C. Baker
发明人： John Anthony Scholl , Thomas A. Silvestrini , Isidro Matias Gandionco , William P. Kuhn , Phillip C. Baker
IPC分类号： A61B3/10 , A61B8/10 , A61B19/00 , A61F9/007 , A61F9/013 , A61B5/00
CPC分类号： A61F9/0133 , A61B8/10 , A61B90/06 , A61B2090/062 , A61F9/013
摘要： A method and apparatus for performing a surgical procedure on a patient is described. An incision is made into tissue of the patient to create a tissue pocket. The tissue has an anterior surface. Preferably, the tissue is corneal tissue of an eye. A reflective element is inserted into the pocket. An energy source generates a radiant energy signal, which is directed toward the reflective element. Reflected energy is received from the reflective element. A detector determines the depth of the reflective element below the anterior surface based upon the energy reflected by the reflective element. The speed of transmission of the radiant energy in the reflective element is different (preferably slower) than the speed of transmission of the radiant energy in the tissue. The reflective element may be in the form of a tool on which is disposed a biocompatible polymer layer, the layer comprising trapped air spaces, or a tool having an open space for containing trapped air. The radiant energy may take the form of ultrasound generated by an ultrasonic probe, or light generated by a confocal microscope. The confocal microscope may employ longitudinal chromatic aberration to measure the depth of the reflective element. When employing a confocal microscope, the depth of the reflective element is a function of the reflected energy from the anterior surface and the reflected energy from the reflective element.
摘要翻译：描述了一种用于对患者进行外科手术的方法和装置。将切口制成患者的组织以产生组织袋。组织具有前表面。优选地，组织是眼睛的角膜组织。将反射元件插入口袋中。能量源产生朝向反射元件的辐射能信号。从反射元件接收反射能量。检测器基于由反射元件反射的能量确定反射元件在前表面下方的深度。反射元件中的辐射能的传输速度与组织中的辐射能的传递速度不同（优选地较慢）。反射元件可以是工具的形式，其上设置有生物相容性聚合物层，该层包括被捕获的空气空间，或具有用于容纳被捕获的空气的开放空间的工具。辐射能可以采用由超声波探头产生的超声或由共聚焦显微镜产生的光的形式。共焦显微镜可以采用纵向色差来测量反射元件的深度。当使用共焦显微镜时，反射元件的深度是来自前表面的反射能量和来自反射元件的反射能量的函数。

59. 发明授权

US4834755A Triaxially-braided fabric prosthesis 失效
标题翻译：三轴编织布假体
公开(公告)号：US4834755A
公开(公告)日：1989-05-30
申请号：US707724
申请日：1985-03-04
申请人： Thomas A. Silvestrini , Joseph E. Laptewicz, Jr.
发明人： Thomas A. Silvestrini , Joseph E. Laptewicz, Jr.
IPC分类号： A61F2/06 , A61F2/08 , A61F2/24
CPC分类号： A61F2/2412 , A61F2/06 , A61F2/08
摘要： A novel prosthesis for use in repairing or replacing soft tissue is disclosed, which comprises a triaxially-braided fabric element having interwoven first, second and third sets of fibers, with the fibers of the second and third sets being oriented at substantially the same acute braiding angle with respect to the fibers of the first set. An elongated ligament prosthesis exhibiting the desired properties of high strength and high elasticity may be prepared by selecting high elasticity fibers for the first set, orienting said first set of fibers in the longitudinal direction of the prosthesis and selecting fibers having high yield strength and high Young's modulus for the second and third sets. A tubular prosthesis in which high elasticity fibers are oriented in the longitudinal direction is highly suitable for use as a vascular prosthesis. A prosthesis of the invention may also be manufactured in the form of a prosthetic heart valve leaflet.
摘要翻译：公开了一种用于修复或更换软组织的新型假体，其包括具有交织的第一，第二和第三组纤维的三轴编织织物元件，第二和第三组的纤维被定向成基本上相同的尖锐编织相对于第一组的纤维的角度。可以通过选择第一组的高弹性纤维，在假体的纵向方向上定向所述第一组纤维并选择具有高屈服强度的纤维和高杨氏硬度的纤维来制备具有高强度和高弹性所需性质的细长韧带假体第二和第三组的模数。其中高弹性纤维沿纵向定向的管状假体非常适合用作血管假体。本发明的假体也可以以假体心脏瓣膜小叶的形式制造。

60. 发明授权

US4621638A Hard elastic sutures 失效
标题翻译：硬弹性缝线
公开(公告)号：US4621638A
公开(公告)日：1986-11-11
申请号：US754716
申请日：1985-07-15
申请人： Thomas A. Silvestrini
发明人： Thomas A. Silvestrini
IPC分类号： A61B17/06 , A61L17/04 , A61B17/00
CPC分类号： A61L17/04 , A61B2017/0618
摘要： A surgical suture made of a polymer filament having the "hard" elastic properties of reversible elasticity and retention of diameter on stretching.
摘要翻译：由聚合物长丝制成的手术缝合线，其具有可逆弹性和直径保持在拉伸状态的“硬”弹性特性。

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