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51. 发明授权

US07989638B2 Conjugates of biological substances 有权
标题翻译：生物物质结合物
公开(公告)号：US07989638B2
公开(公告)日：2011-08-02
申请号：US12804065
申请日：2010-07-12
申请人： Zhenjun Diwu , Jianheng Zhang , Yi Tang , Xiang Guobing
发明人： Zhenjun Diwu , Jianheng Zhang , Yi Tang , Xiang Guobing
IPC分类号： C07D209/02 , C07D209/04 , C07D209/56 , C12Q1/68
CPC分类号： C09B23/06 , C07D487/14 , C07D487/22 , C07D498/22 , C09B23/0066 , C09B23/02 , G01N33/52 , G01N33/533 , Y10T436/143333
摘要： Chemically reactive carbocyanine dyes that are intramolecularly crosslinked between the 1-position and 3′-position, their bioconjugates and their uses are described. 1,3′-crosslinked carbocyanines are superior to those of conjugates of spectrally similar 1,1′-crosslinked or non-crosslinked dyes. The invention includes derivative compounds having one or more benzo nitrogens.
摘要翻译：描述了在1位和3'-位之间分子内交联的化学反应性碳菁染料，它们的生物缀合物及其用途。 1,3'-交联的碳氰酸酯优于光谱相似的1,1'-交联或非交联染料的共轭物。本发明包括具有一个或多个苯并氮的衍生化合物。

52. 发明申请

US20110045585A1 Kit for fluorometric analysis 有权
标题翻译：用于荧光分析的试剂盒
公开(公告)号：US20110045585A1
公开(公告)日：2011-02-24
申请号：US12925505
申请日：2010-10-21
申请人： Zhenjun Diwu , Jianheng Zhang , Yi Tang , Xiang Guobing
发明人： Zhenjun Diwu , Jianheng Zhang , Yi Tang , Xiang Guobing
IPC分类号： C12N5/071 , C07D487/14 , C12N1/20 , C07K2/00 , C08H1/00 , C07H99/00 , C07H19/00 , C07H21/00
CPC分类号： C09B23/06 , C07D487/14 , C07D487/22 , C07D498/22 , C09B23/0066 , C09B23/02 , G01N33/52 , G01N33/533 , Y10T436/143333
摘要： Chemically reactive carbocyanine dyes that are intramolecularly crosslinked between the 1-position and 3′-position, their bioconjugates and their uses are described. 1,3′-crosslinked carbocyanines are superior to those of conjugates of spectrally similar 1,1′-crosslinked or non-crosslinked dyes. The invention includes derivative compounds having one or more benzo nitrogens.
摘要翻译：描述了在1位和3'-位之间分子内交联的化学反应性碳菁染料，它们的生物缀合物及其用途。 1,3'-交联的碳氰酸酯优于光谱相似的1,1'-交联或非交联染料的共轭物。本发明包括具有一个或多个苯并氮的衍生化合物。

53. 发明申请

US20100331543A1 Cyanine dyes and their applications as luminescence quenching compounds 有权
标题翻译：花青染料及其作为发光淬灭剂的应用
公开(公告)号：US20100331543A1
公开(公告)日：2010-12-30
申请号：US12807180
申请日：2010-08-30
申请人： Zhenjun Diwu , Jianheng Zhang , Yi Tang
发明人： Zhenjun Diwu , Jianheng Zhang , Yi Tang
IPC分类号： C07D471/04 , C07D403/14 , C07D417/14 , C07F9/28
CPC分类号： C07D409/14 , C07D209/60 , C07D403/14 , C07D409/04 , C07D409/06 , C07D417/14 , C07D471/04 , C07H21/04 , C07J43/00 , G01N33/542 , G01N33/582
摘要： The quenching compounds of the invention are weakly luminescent cyanines that are substituted by one or more heteroaromatic quenching moieties. The quenching compounds of the invention exhibit little or no observable luminescence and efficiently quench a broad spectrum of luminescent compounds. The chemically reactive quenching compounds possess utility for labeling a wide variety of substances, including biomolecules. These labeled substances are highly useful for a variety of energy-transfer assays and applications.
摘要翻译：本发明的淬灭化合物是被一个或多个杂芳族猝灭部分取代的弱发光花青素。本发明的淬灭化合物表现出很少或不可观察到的发光，并有效地淬灭广谱的发光化合物。化学反应猝灭化合物具有用于标记各种物质（包括生物分子）的效用。这些标记的物质对于各种能量转移测定和应用是非常有用的。

54. 发明申请

US20090221790A1 METHOD FOR STABILIZATION OF PROTEINS USING NON-NATURAL AMINO ACIDS 审中-公开
标题翻译：使用非天然氨基酸稳定蛋白质的方法
公开(公告)号：US20090221790A1
公开(公告)日：2009-09-03
申请号：US12247119
申请日：2008-10-07
申请人： David A. Tirrell , Yi Tang
发明人： David A. Tirrell , Yi Tang
IPC分类号： C07K14/00 , C07K1/00
CPC分类号： C12N9/96 , C07K1/107 , C07K2/00 , C07K14/47 , C07K14/4705 , C12P21/02
摘要： The present invention provides a method for producing modified stable polypeptides introducing at least one non-natural amino acid into the hydrophobic region of the polypeptide. The thermal and chemical stability of such polypeptides is improved compared to those properties of its corresponding wild type proteins.The invention further provides purified leucine zipper and coiled-coil proteins in which the leucine residues have been replaced with 5,5,5-trifluoroleucines, and the modified proteins so produced demonstrate increased thermal and chemical stability compared to their corresponding wild-type natural proteins.
摘要翻译：本发明提供了一种制备将至少一个非天然氨基酸引入多肽疏水区的修饰稳定多肽的方法。与其相应的野生型蛋白质的那些性质相比，这些多肽的热和化学稳定性得到改善。本发明还提供纯化的亮氨酸拉链和卷曲螺旋蛋白，其中亮氨酸残基已经被5,5,5-三氟色氨酸替代，并且与其相应的野生型天然蛋白相比，所产生的修饰的蛋白质表现出增加的热和化学稳定性。

55. 发明申请

US20090191602A1 Methods and Materials for Making Simvastatin and Related Compounds 有权
标题翻译：辛伐他汀及相关化合物的制备方法与材料
公开(公告)号：US20090191602A1
公开(公告)日：2009-07-30
申请号：US12227671
申请日：2007-05-24
申请人： Yi Tang , Xinkai Xie
发明人： Yi Tang , Xinkai Xie
IPC分类号： C12P17/06 , C12N9/10 , C12N1/14
CPC分类号： C12P17/06 , C12N9/1025 , C12N9/1029 , C12P7/42 , C12P7/62
摘要： The invention disclosed herein relates to methods and materials for producing simvastatin and related compounds such as huvastatin.
摘要翻译：本文公开的本发明涉及用于生产辛伐他汀和相关化合物如胡伐他汀的方法和材料。

56. 发明授权

US07449443B2 Method for stabilization of proteins using non-natural amino acids 失效
标题翻译：使用非天然氨基酸稳定蛋白质的方法
公开(公告)号：US07449443B2
公开(公告)日：2008-11-11
申请号：US10851564
申请日：2004-05-21
申请人： David A. Tirrell , Yi Tang
发明人： David A. Tirrell , Yi Tang
IPC分类号： C07K14/00 , C07K14/39
CPC分类号： C12N9/96 , C07K1/107 , C07K2/00 , C07K14/47 , C07K14/4705 , C12P21/02
摘要： The present invention provides a method for producing modified stable polypeptides introducing at least one non-natural amino acid into the hydrophobic region of the polypeptide. The thermal and chemical stability of such polypeptides is improved compared to those properties of its corresponding wild type proteins.The invention further provides purified leucine zipper and coiled-coil proteins in which the leucine residues have been replaced with 5,5,5-trifluoroleucines, and the modified proteins so produced demonstrate increased thermal and chemical stability compared to their corresponding wild-type natural proteins.
摘要翻译：本发明提供了一种制备将至少一个非天然氨基酸引入多肽疏水区的修饰稳定多肽的方法。与其相应的野生型蛋白质的那些性质相比，这些多肽的热和化学稳定性得到改善。本发明还提供纯化的亮氨酸拉链和卷曲螺旋蛋白，其中亮氨酸残基已经被5,5,5-三氟色氨酸替代，并且与其相应的野生型天然蛋白相比，所产生的修饰的蛋白质表现出增加的热和化学稳定性。

57. 发明申请

US20060121503A1 Reactive 1,3'-crosslinked carbocyanines and their BIOCONJUGATE 有权
标题翻译：反应性1,3'-交联的碳氰胺及其生物活性剂
公开(公告)号：US20060121503A1
公开(公告)日：2006-06-08
申请号：US11256581
申请日：2005-10-21
申请人： Zhenjun Diwu , Jianheng Zhang , Yi Tang , Xiang Guobing
发明人： Zhenjun Diwu , Jianheng Zhang , Yi Tang , Xiang Guobing
IPC分类号： C12Q1/68 , G01N33/00 , C07F15/00 , C07D487/22 , C07D498/22
CPC分类号： C09B23/06 , C07D487/14 , C07D487/22 , C07D498/22 , C09B23/0066 , C09B23/02 , G01N33/52 , G01N33/533 , Y10T436/143333
摘要： Chemically reactive carbocyanine dyes that are intramolecularly crosslinked between the 1-position and 3′-position, their bioconjugates and their uses are described. 1,3′-crosslinked carbocyanines are superior to those of conjugates of spectrally similar 1,1′-crosslinked or non-crosslinked dyes. The invention includes derivative compounds having one or more benzo nitrogens.
摘要翻译：描述了在1位和3'-位之间分子内交联的化学反应性碳菁染料，它们的生物缀合物及其用途。 1,3'-交联的碳氰酸酯优于光谱相似的1,1'-交联或非交联染料的共轭物。本发明包括具有一个或多个苯并氮的衍生化合物。

58. 发明授权

US09673732B2 Power converter circuit 有权
公开(公告)号：US09673732B2
公开(公告)日：2017-06-06
申请号：US13599964
申请日：2012-08-30
申请人： Gerald Deboy , Yi Tang
发明人： Gerald Deboy , Yi Tang
IPC分类号： H02J1/00 , H02M7/49 , H02M1/00
CPC分类号： H02M7/49 , H02M2001/0077 , Y10T307/707
摘要： A circuit arrangement includes a number of DC power sources. Each DC power source includes a rechargeable battery. The circuit arrangement also includes a number converter units. Each converter unit has input terminals and output terminals. The input terminals are coupled to one DC power source. The converter units form a series circuit between load terminals.

59. 发明授权

US09461474B2 Power converter circuit with AC output 有权
标题翻译：电源转换器电路，交流输出
公开(公告)号：US09461474B2
公开(公告)日：2016-10-04
申请号：US13440629
申请日：2012-04-05
申请人： Gerald Deboy , Yi Tang
发明人： Gerald Deboy , Yi Tang
IPC分类号： H02J1/00 , H02J3/38 , H02J3/40 , H02M1/00
CPC分类号： H02J3/385 , H02H7/1227 , H02J3/387 , H02J3/40 , H02J3/44 , H02M7/53871 , H02M2001/007 , H02M2001/0077 , H02M2001/0083 , Y02E10/563 , Y02E10/58 , Y10T307/707
摘要： A power converter circuit includes output terminals configured to receive an external voltage. A series circuit with a number of converter units is connected between the output terminals of the power converter circuit. Each converter unit includes input terminals configured to be coupled to a DC power source and output terminals configured to provide an output current. At least one converter unit of the converter units includes a signal generator configured to receive a synchronization signal and to generate a continuous synchronization signal from the synchronization signal. The power converter circuit can be operated in a normal operation mode. In the normal operation mode, the at least one converter unit is configured to regulate generation of the output current such that a frequency and/or a phase of the output current are dependent on the continuous synchronization signal.
摘要翻译：电源转换器电路包括被配置为接收外部电压的输出端子。具有多个转换器单元的串联电路连接在功率转换器电路的输出端子之间。每个转换器单元包括被配置为耦合到DC电源的输入端子和被配置为提供输出电流的输出端子。转换器单元的至少一个转换器单元包括被配置为接收同步信号并从同步信号产生连续同步信号的信号发生器。电源转换器电路可以在正常工作模式下工作。在正常操作模式中，至少一个转换器单元被配置为调节输出电流的产生，使得输出电流的频率和/或相位取决于连续同步信号。

60. 发明授权

US08981056B2 Variant LovD polypeptide 有权
标题翻译：变体LovD多肽
公开(公告)号：US08981056B2
公开(公告)日：2015-03-17
申请号：US13499356
申请日：2010-10-08
申请人： Yi Tang , Xue Gao , Xinkai Xie
发明人： Yi Tang , Xue Gao , Xinkai Xie
IPC分类号： A61K38/00 , C12N9/10 , C12P7/62 , C12P17/06
CPC分类号： C12N9/1029 , C12P7/62 , C12P17/06
摘要： The invention disclosed herein relates to methods and materials for producing simvastatin and related compounds such as huvastatin. In particular, the disclosure teaches that variants of the LovD acyltransferase polypeptide can be engineered to exhibit properties that facilitate their use in the production of simvastatin and/or huvastatin. The materials and processes disclosed herein are designed so that fermentation facilities currently producing lovastatin can be converted to producing simvastatin and related compounds with minimal modifications.
摘要翻译：本文公开的本发明涉及用于生产辛伐他汀和相关化合物如胡伐他汀的方法和材料。特别地，本公开内容指出，LovD酰基转移酶多肽的变体可被工程化以显示有利于其用于生产辛伐他汀和/或胡伐他汀的性质。本文公开的材料和方法设计成使得目前生产洛伐他汀的发酵设备可以转化为以最少的修饰生产辛伐他汀和相关化合物。

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