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51. 发明授权

US08452394B2 Implantable medical device crosstalk evaluation and mitigation 有权
公开(公告)号：US08452394B2
公开(公告)日：2013-05-28
申请号：US12362768
申请日：2009-01-30
申请人： John E. Burnes , Paul G. Krause , William T. Donofrio , James D. Reinke , Gerald P. Arne , David J. Peichel , Xiaohong Zhou , Timothy Davis
发明人： John E. Burnes , Paul G. Krause , William T. Donofrio , James D. Reinke , Gerald P. Arne , David J. Peichel , Xiaohong Zhou , Timothy Davis
IPC分类号： A61N1/00
CPC分类号： A61N1/36114 , A61N1/3622 , A61N1/37247 , A61N1/37258 , A61N1/3962 , A61N2001/083
摘要： Electrical crosstalk between two implantable medical devices or two different therapy modules of a common implantable medical device may be evaluated, and, in some examples, mitigated. In some examples, one of the implantable medical devices or therapy modules delivers electrical stimulation to a nonmyocardial tissue site or a nonvascular cardiac tissue site, and the other implantable medical device or therapy module delivers cardiac rhythm management therapy to a heart of the patient.

52. 发明授权

US08437837B2 Method and apparatus for induced T-wave alternans assessment 有权
标题翻译：诱导T波交替评估的方法和装置
公开(公告)号：US08437837B2
公开(公告)日：2013-05-07
申请号：US11536946
申请日：2006-09-29
申请人： Xiaohong Zhou
发明人： Xiaohong Zhou
IPC分类号： A61B5/04 , A61N1/00
CPC分类号： A61B5/0456 , A61B5/0452 , A61N1/365 , G16H40/63
摘要： An implantable medical device and associated method assesses T-wave alternans. The method includes sensing a cardiac signal from implanted electrodes subsequent to a premature contraction; measuring a T-wave parameter from the sensed cardiac signal for a plurality of cardiac cycles; and determining a T-wave alternans metric corresponding to the measured T-wave parameter.
摘要翻译：可植入医疗器械和相关方法评估T波交替。该方法包括在过早收缩之后感测来自植入电极的心脏信号; 从感测的心脏信号中测量多个心动周期的T波参数; 以及确定对应于所测量的T波参数的T波交替量度。

53. 发明授权

US08396539B2 Implantable medical device having optical fiber for sensing electrical activity 有权
标题翻译：具有用于感测电活动的光纤的可植入医疗装置
公开(公告)号：US08396539B2
公开(公告)日：2013-03-12
申请号：US11676128
申请日：2007-02-16
申请人： Vinod Sharma , Xiaohong Zhou
发明人： Vinod Sharma , Xiaohong Zhou
IPC分类号： A61B5/04
CPC分类号： A61B5/0071 , A61B5/0084 , A61B5/0452
摘要： An implantable medical device for optically sensing action potential signals in excitable body tissue. The device includes an elongated tubular lead body carrying an optical fiber extending from a proximal lead end to a distal lead end to position the optical fiber at a target site. The lead body additionally carries a conduit for dispensing a voltage-sensitive fluorescent dye into tissue surrounding the target site. The optical fiber transmits excitation light to the fluorescent dye to cause the dye to fluoresce with varying intensity as the transmembrane potentials of local tissue cells vary due to passing depolarization wavefronts. The optical fiber transmits the fluorescence signal to the device to generate an action potential signal or fiducial points of an action potential signal for use in accurately measuring and characterizing electrical activity of excitable tissue.
摘要翻译：一种用于在可兴奋的身体组织中光学感测动作电位信号的可植入医疗装置。该装置包括细长的管状引线体，其承载从近侧引线端延伸到远端引线端的光纤，以将光纤定位在目标部位。引线体还带有用于将电压敏感的荧光染料分配到靶区域周围的组织中的导管。光纤将激发光透射到荧光染料，以使得染料以不同的强度发荧光，因为局部组织细胞的跨膜电位由于通过去极化波前而变化。光纤将荧光信号传输到设备以产生动作电位信号或动作电位信号的基准点，用于精确测量和表征可兴奋组织的电活动。

54. 发明授权

US08301263B2 Therapy module crosstalk mitigation 有权
标题翻译：治疗模块串扰减轻
公开(公告)号：US08301263B2
公开(公告)日：2012-10-30
申请号：US12363180
申请日：2009-01-30
申请人： William T. Donofrio , Paul G. Krause , Gerald P. Arne , John E. Burnes , David J. Peichel , Xiaohong Zhou
发明人： William T. Donofrio , Paul G. Krause , Gerald P. Arne , John E. Burnes , David J. Peichel , Xiaohong Zhou
IPC分类号： A61N1/00
CPC分类号： A61N1/37288 , A61N1/36114
摘要： A first implantable medical device (IMD) implanted within a patient may communicate with a second IMD implanted within the patient by encoding information in an electrical stimulation signal. The delivery of the electrical stimulation signal may provide therapeutic benefits to the patient. The second IMD may sense the electrical stimulation signal, which may be presented as an artifact in a sensed cardiac signal, and process the sensed signal to retrieve the encoded information. The second IMD may modify its operation based on the received therapy information. Crosstalk between the first and second IMDs may be reduced using various techniques described herein. For example, the first IMD may generate the electrical stimulation signal to include a spread spectrum energy distribution or a predetermined signal signature. The second IMD may effectively remove a least some of the signal artifact in a sensed cardiac signal based on the predetermined signal signature.
摘要翻译：植入在患者体内的第一可植入医疗装置（IMD）可以通过对电刺激信号中的信息进行编码来与植入患者内的第二IMD进行通信。电刺激信号的传递可以为患者提供治疗益处。第二IMD可以感测电刺激信号，其可以被呈现为感测到的心脏信号中的伪像，并且处理感测到的信号以检索经编码的信息。第二IMD可以基于接收到的治疗信息修改其操作。可以使用本文所述的各种技术来减少第一和第二IMD之间的串扰。例如，第一IMD可以产生电刺激信号以包括扩频能量分布或预定信号特征。基于预定的信号签名，第二IMD可以有效地去除感测到的心脏信号中的至少一些信号伪像。

55. 发明申请

US20120185007A1 VAGAL STIMULATION 有权
标题翻译： VAGAL刺激
公开(公告)号：US20120185007A1
公开(公告)日：2012-07-19
申请号：US13353802
申请日：2012-01-19
申请人： Paul D. Ziegler , Lillian Kornet , Xiaohong Zhou , Richard Cornelussen , Robert Stadler , Eduardo Warman , Karen J. Kleckner , Alberto Della Scala
发明人： Paul D. Ziegler , Lillian Kornet , Xiaohong Zhou , Richard Cornelussen , Robert Stadler , Eduardo Warman , Karen J. Kleckner , Alberto Della Scala
IPC分类号： A61N1/365
CPC分类号： A61N1/36139 , A61N1/36053 , A61N1/36114 , A61N1/3621 , A61N1/3627 , A61N1/36564 , A61N1/3682 , A61N1/3702 , A61N1/37235 , A61N1/3962
摘要： The disclosure herein relates generally to methods for treating heart conditions using vagal stimulation, and further to systems and devices for performing such treatment. Such methods may include monitoring physiological parameters of a patient, detecting cardiac conditions, and delivering vagal stimulation (e.g., electrical stimulation to the vagus nerve or neurons having parasympathetic function) to the patient to treat the detected cardiac conditions.
摘要翻译：本文的公开内容一般涉及使用迷走神经刺激治疗心脏病症的方法，还涉及用于进行这种治疗的系统和装置。这样的方法可以包括监测患者的生理参数，检测心脏状况，以及向患者输送迷走神经刺激（例如，对迷走神经或具有副交感神经功能的神经元的电刺激）以治疗检测到的心脏状况。

56. 发明授权

US08126539B2 Method and apparatus for monitoring T-wave alternans 有权
标题翻译：用于监测T波交替的方法和装置
公开(公告)号：US08126539B2
公开(公告)日：2012-02-28
申请号：US11871405
申请日：2007-10-12
申请人： Xiaohong Zhou , Jeffrey M. Gillberg
发明人： Xiaohong Zhou , Jeffrey M. Gillberg
IPC分类号： A61B5/0402
CPC分类号： A61B5/0452 , A61B5/021 , A61N1/3702
摘要： An implantable medical device and associated method assess T-wave alternans by sensing a cardiac electrogram (EGM) signal and selecting a pair of consecutive T-wave signals from the EGM signal. A first amplitude and a second amplitude from each of the consecutive T-wave signals are determined. The differences between the first amplitudes and the second amplitudes of the consecutive T-wave signal pairs are used to compute a T-wave alternans metric.
摘要翻译：可植入医疗装置和相关方法通过感测心电图（EGM）信号和从EGM信号中选择一对连续的T波信号来评估T波交替。确定来自每个连续T波信号的第一幅度和第二幅度。使用连续T波信号对的第一幅度和第二幅度之间的差异来计算T波交替量度。

57. 发明申请

US20110245700A1 DETECTION OF T-WAVE ALTERNANS PHASE REVERSAL FOR ARRHYTHMIA PREDICTION AND SUDDEN CARDIAC DEATH RISK STRATIFICATION 有权
标题翻译： T-WAVE ALTERNANS相关检测ARRHYTHMIA预测和SUDDEN CARDIAC死亡风险分析
公开(公告)号：US20110245700A1
公开(公告)日：2011-10-06
申请号：US12749753
申请日：2010-03-30
申请人： Raja N. Ghanem , Xiaohong Zhou
发明人： Raja N. Ghanem , Xiaohong Zhou
IPC分类号： A61B5/0452
CPC分类号： A61B5/0452 , A61B5/02405 , A61B5/7264 , A61B5/7275 , A61N1/36507 , G06F19/00
摘要： An implantable medical device and associated method for classifying a patient's risk for arrhythmias by sensing a cardiac electrogram (EGM) signal and selecting a first pair of T-wave signals and a second pair of T-wave signals. A first difference between the two T-wave signals of the first pair is compared to a second difference between the two T-wave signals of the second pair. A T-wave alternans phase reversal is detected in response to comparing the first difference and the second difference, and the patient's arrhythmia risk is classified in response to detecting the phase reversal.
摘要翻译：一种用于通过感测心电图（EGM）信号和选择第一对T波信号和第二对T波信号来分类患者心律失常风险的可植入医疗装置和相关方法。将第一对的两个T波信号之间的第一个差异与第二对的两个T波信号之间的第二个差值进行比较。响应于比较第一个差异和第二个差异，检测到T波交替相位逆转，并且响应于检测相位反转来分类患者的心律失常风险。

58. 发明申请

US20100198284A1 DETECTING AND TREATING ELECTROMECHANICAL DISSOCIATION OF THE HEART 有权
标题翻译：检测和治疗心脏的机械分离
公开(公告)号：US20100198284A1
公开(公告)日：2010-08-05
申请号：US12697019
申请日：2010-01-29
申请人： Xiaohong Zhou , Paul G. Krause , William T. Donofrio
发明人： Xiaohong Zhou , Paul G. Krause , William T. Donofrio
IPC分类号： A61N1/365 , A61N1/39
CPC分类号： A61N1/3627 , A61N1/0551 , A61N1/36114 , A61N1/36557 , A61N1/36564 , A61N1/3962
摘要： In some examples, an electromechanical disassociation state (EMD) of a heart of a patient can be treated by delivering electrical stimulation to a tissue site to at least one of modulate afferent nerve activity or inhibit efferent nerve activity upon determining that the heart is in an electromechanical dissociation state, where the tissue site comprises at least one of a nonmyocardial tissue site or a nonvascular cardiac tissue site. The delivery of electrical stimulation may effectively treat the EMD state of the heart, e.g., by enabling effective mechanical contraction of the heart. In another example, an electromechanical disassociation state of a heart of a patient can be treated by determining autonomic nervous system activity associated with a detected EMD state of the heart of a patient, and delivering electrical stimulation therapy to the patient based on the determined autonomic nervous system activity of the patient associated with the EMD state.
摘要翻译：在一些示例中，可以通过将电刺激递送至组织部位至少调整传入神经活动或抑制传出神经活动的至少一种来治疗患者心脏的机电解离状态（EMD），确定心脏处于机电解离状态，其中组织部位包含非心肌组织部位或非血管心脏组织部位中的至少一个。电刺激的递送可以有效地治疗心脏的EMD状态，例如通过使心脏有效的机械收缩。在另一个示例中，可以通过确定与患者的心脏的检测到的EMD状态相关联的自主神经系统活动来治疗患者的心脏的机电解离状态，并且基于确定的自主神经向患者输送电刺激疗法与EMD状态相关的患者的系统活动。

59. 发明申请

US20100114208A1 IMPLANTABLE MEDICAL DEVICE CROSSTALK EVALUATION AND MITIGATION 有权
公开(公告)号：US20100114208A1
公开(公告)日：2010-05-06
申请号：US12362792
申请日：2009-01-30
申请人： William T. Donofrio , John E. Burnes , Paul G. Krause , Gerald P. Arne , David J. Peichel , Xiaohong Zhou , James D. Reinke , Timothy Davis
发明人： William T. Donofrio , John E. Burnes , Paul G. Krause , Gerald P. Arne , David J. Peichel , Xiaohong Zhou , James D. Reinke , Timothy Davis
IPC分类号： A61N1/08
CPC分类号： A61N1/0551 , A61N1/36114 , A61N1/3621 , A61N1/36521 , A61N1/37 , A61N1/37247 , A61N1/37282 , A61N1/3962 , A61N2001/083
摘要： Electrical crosstalk between two implantable medical devices or two different therapy modules of a common implantable medical device may be evaluated, and, in some examples, mitigated. In some examples, one of the implantable medical devices or therapy modules delivers electrical stimulation to a nonmyocardial tissue site or a nonvascular cardiac tissue site, and the other implantable medical device or therapy module delivers cardiac rhythm management therapy to a heart of the patient.

60. 发明申请

US20100114202A1 IMPLANTABLE MEDICAL DEVICE CROSSTALK EVALUATION AND MITIGATION 有权
公开(公告)号：US20100114202A1
公开(公告)日：2010-05-06
申请号：US12362842
申请日：2009-01-30
申请人： William T. Donofrio , John E. Burnes , Paul G. Krause , Xiaohong Zhou , Gerald P. Arne , David J. Peichel , James D. Reinke
发明人： William T. Donofrio , John E. Burnes , Paul G. Krause , Xiaohong Zhou , Gerald P. Arne , David J. Peichel , James D. Reinke
IPC分类号： A61N1/362 , A61B5/00 , A61N1/39
CPC分类号： A61N1/3706 , A61B5/04288 , A61B5/7217 , A61N1/025 , A61N1/0551 , A61N1/36114 , A61N1/36185 , A61N1/3686 , A61N1/3702 , A61N1/3718 , A61N1/37247 , A61N1/37288 , A61N1/3962
摘要： Electrical crosstalk between two implantable medical devices or two different therapy modules of a common implantable medical device may be evaluated, and, in some examples, mitigated. In some examples, one of the implantable medical devices or therapy modules delivers electrical stimulation to a nonmyocardial tissue site or a nonvascular cardiac tissue site, and the other implantable medical device or therapy module delivers cardiac rhythm management therapy to a heart of the patient.

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