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    • 55. 发明授权
    • Biomarker specific for cancer
    • 针对癌症的生物标志物
    • US08309687B2
    • 2012-11-13
    • US12531358
    • 2008-03-13
    • Ai WakamatsuJunichi YamamotoTakao Isogai
    • Ai WakamatsuJunichi YamamotoTakao Isogai
    • C07K1/00C07K14/00C07K17/00C07K4/00C07K7/00A61K38/00
    • G01N33/574A01K2227/105C07K14/4748C12Q1/6886C12Q2600/136C12Q2600/178
    • It is an object of the present invention to provide diagnostic reagents, pharmaceuticals and the like for particular diseases, and providing means that are useful in developing such reagents, pharmaceuticals and the like. The present invention provides a novel polypeptide and a specific partial peptide thereof, as well as a novel polynucleotide and a specific partial nucleotide thereof, that can be used as cancer-specific biomarkers; an expression vector for such a polynucleotide and a specific partial peptide thereof; a transformant incorporating such an expression vector; an antisense molecule, RNAi-inducing nucleic acid (e.g., siRNA), aptamer, or antibody for a cancer-specific biomarker, and a composition comprising the same; a mammalian cell or non-human mammal wherein the expression or a function of a cancer-specific biomarker is regulated; a measuring means (e.g., primer set, nucleic acid probe, antibody, aptamer) for a cancer-specific biomarker, and a reagent comprising them and the like.
    • 本发明的目的是为特定疾病提供诊断试剂,药物等,并提供可用于开发这些试剂,药物等的方法。 本发明提供了可用作癌症特异性生物标志物的新型多肽及其特异性部分肽,以及其新型多核苷酸及其特定部分核苷酸; 这种多核苷酸及其特定部分肽的表达载体; 包含这种表达载体的转化体; 用于癌特异性生物标志物的反义分子,RNAi诱导核酸(例如siRNA),适体或抗体,以及包含其的组合物; 哺乳动物细胞或非人哺乳动物,其中调节癌特异性生物标志物的表达或功能; 用于癌特异性生物标志物的测量装置(例如,引物组,核酸探针,抗体,适体)和包含它们的试剂等。