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51. 发明授权

US06997942B2 Disposable cassette for intravascular heat exchange catheter 失效
标题翻译：一次性用于血管内热交换导管
公开(公告)号：US06997942B2
公开(公告)日：2006-02-14
申请号：US10752324
申请日：2004-01-05
申请人： Timothy R. Machold , Nicole Denise Bloom , Alex T. Roth , Dave J. Scott , Jose Alejandro , Ed Oliver
发明人： Timothy R. Machold , Nicole Denise Bloom , Alex T. Roth , Dave J. Scott , Jose Alejandro , Ed Oliver
IPC分类号： A61F7/00
CPC分类号： A61F7/12 , A61B2017/00119 , A61B2017/00123 , A61B2017/22051 , A61F7/0085 , A61F7/10 , A61F7/123 , A61F2007/0054 , A61F2007/0096 , A61F2007/126 , A61M5/44 , A61M25/1011 , A61M2025/1072 , A61M2025/1086 , A61M2205/127
摘要： A heat exchange fluid supply system for supplying a heat exchange fluid to an intravascular heat exchange catheter includes a disposable cassette having a bulkhead and an external heat exchanger, and which is configured to operate in combination with a reusable master control unit The bulkhead includes a reservoir section and a pump section. The reservoir section is provided with a means to monitor the amount of heat exchange fluid that is in the system. The bulkhead provides the mechanism for priming the system with heat exchange fluid from an external source and for circulating fluid to the catheter in a closed circuit. The pump section is configured to allow for pumping of heat exchange fluid at a constant pressure.
摘要翻译：用于将热交换流体供应到血管内热交换导管的热交换流体供应系统包括具有隔板和外部热交换器的一次性盒，其被构造成与可重复使用的主控制单元结合操作。隔板包括储存器部分和泵部分。储存器部分设置有用于监测系统中的热交换流体的量的装置。隔板提供了使用来自外部源的热交换流体并且用于在闭合回路中将流体循环到导管的系统引发系统的机构。泵部分构造成允许在恒定压力下泵送热交换流体。

52. 发明授权

US06866650B2 System for cardiac procedures 失效
标题翻译：心脏手术系统
公开(公告)号：US06866650B2
公开(公告)日：2005-03-15
申请号：US09776336
申请日：2001-02-02
申请人： John H. Stevens , Wesley D. Sterman , Hanson S. Gifford, III , Timothy R. Machold
发明人： John H. Stevens , Wesley D. Sterman , Hanson S. Gifford, III , Timothy R. Machold
IPC分类号： A61B17/00 , A61F2/24 , A61F2/958 , A61M1/36 , A61M25/00 , A61M25/01 , A61M25/06 , A61M29/02 , A61M29/00
CPC分类号： A61M25/0147 , A61B2017/00243 , A61B2018/00232 , A61B2018/00261 , A61F2/2427 , A61M1/3653 , A61M1/3659 , A61M25/0032 , A61M25/0041 , A61M25/0125 , A61M25/0152 , A61M25/0662 , A61M25/10 , A61M25/1002 , A61M2025/0031 , A61M2025/0078 , A61M2025/015 , A61M2025/0161 , A61M2025/028 , A61M2025/1047 , A61M2025/1052 , A61M2025/1077 , A61M2025/1095 , A61M2202/047 , A61M2205/11 , A61M2205/366 , A61M2210/125 , A61M2210/127
摘要： A system for accessing a patient's cardiac anatomy which includes an endovascular aortic partitioning device that separates the coronary arteries and the heart from the rest of the patient's arterial system. The endovascular device for partitioning a patient's ascending aorta comprises a flexible shaft having a distal end, a proximal end, and a first inner lumen therebetween with an opening at the distal end. The shaft may have a preshaped distal portion with a curvature generally corresponding to the curvature of the patient's aortic arch. An expandable means, e.g. a balloon, is disposed near the distal end of the shaft proximal to the opening in the first inner lumen for occluding the ascending aorta so as to block substantially all blood flow therethrough for a plurality of cardiac cycles, while the patient is supported by cardiopulmonary bypass. The endovascular aortic partitioning device may be coupled to an arterial bypass cannula for delivering oxygenated blood to the patient's arterial system. The heart muscle or myocardium is paralyzed by the retrograde delivery of a cardioplegic fluid to the myocardium through patient's coronary sinus and coronary veins, or by antegrade delivery of cardioplegic fluid through a lumen in the endovascular aortic partitioning device to infuse cardioplegic fluid into the coronary arteries. The pulmonary trunk may be vented by withdrawing liquid from the trunk through an inner lumen of an elongated catheter. The cardiac accessing system is particularly suitable for removing the aortic valve and replacing the removed valve with a prosthetic valve.
摘要翻译：一种用于访问患者心脏解剖结构的系统，其包括将冠状动脉和心脏与患者动脉系统的其余部分分离的血管内主动脉分配装置。用于分隔患者升主动脉的血管内装置包括具有远端，近端和其间的第一内腔的柔性轴，在远端具有开口。轴可以具有预先形成的远端部分，其曲率通常对应于患者主动脉弓的曲率。可膨胀装置，例如靠近靠近第一内腔中的开口的轴的远端附近的气囊，用于闭塞升主动脉，以便阻止基本上所有的血液通过其进行多个心动周期，同时患者由体外循环。血管内主动脉分配装置可以联接到动脉旁路套管，用于将氧合血液输送到患者的动脉系统。通过患者的冠状窦和冠状静脉逆行递送心脏停搏液到心肌，或者通过血管内主动脉分配装置的内腔顺序递送心脏停跳液，将心肌或心肌瘫痪，将心脏停搏液注入冠状动脉。可以通过从细长的导管的内腔中抽出液体来排出肺动脉干。心脏存取系统特别适用于去除主动脉瓣并用假体瓣替换去除的瓣膜。

53. 发明授权

US06800068B1 Intra-aortic balloon counterpulsation with concurrent hypothermia 有权
标题翻译：主动脉内气囊反搏与并发低温
公开(公告)号：US06800068B1
公开(公告)日：2004-10-05
申请号：US10015220
申请日：2001-10-26
申请人： Michael W. Dae , Timothy R. Machold
发明人： Michael W. Dae , Timothy R. Machold
IPC分类号： A61F712
CPC分类号： A61M1/1086 , A61F7/10 , A61F7/123 , A61F2007/0056 , A61F2007/0095 , A61F2007/126 , A61M1/106 , A61M1/107 , A61M1/1072 , A61M1/1074 , A61M1/125 , A61M19/00 , A61M2205/3606 , A61M2230/04
摘要： Devices, systems and methods for treating disorders characterized by low cardiac output. The devices, systems and methods use intra-aortic balloon counterpulsation in combination with hypothermia of all or a portion of a human or veterinary patient's body to improve coronary perfusion and cardiac output. To effect the hypothermia, a heat exchange catheter may be positioned in the a patent's vasculature separately from the intra-aortic balloon counterpulsation catheter. Alternatively, a combination Intra-aortic balloon counterpulsation/heat exchange catheter may be utilized. Such combination catheter comprises a) a catheter sized for insertion into the aorta, b) a counterpulsation balloon and c) a heat exchanger. A drive/control system receives temperature and eletrocardiograph signals and drives the inflation/deflation of the counterpulsation balloon as well as the heating/cooling of the heat exchanger.
摘要翻译：用于治疗以低心输出量为特征的疾病的装置，系统和方法。装置，系统和方法使用主动脉内气囊反搏与人或兽医患者身体的全部或一部分的低体温结合，以改善冠状动脉灌注和心输出量。为了降低体温，可以将热交换导管与主动脉内气囊反搏导管分开设置在专利的脉管系统中。或者，可以使用主动脉内球囊反搏/热交换导管的组合。这种组合导管包括a）尺寸适于插入主动脉的导管，b）反力气囊和c）热交换器。驱动/控制系统接收温度和电子心电图仪信号并驱动反力气囊的充气/放气以及热交换器的加热/冷却。

54. 发明授权

US5792094A Method of delivering cardioplegic fluid to a patient's heart 失效
标题翻译：将心脏停跳液输送到患者心脏的方法
公开(公告)号：US5792094A
公开(公告)日：1998-08-11
申请号：US535676
申请日：1995-09-28
申请人： John H. Stevens , Wesley D. Sterman , Hanson S. Gifford, III , Philip C. Evard , Timothy R. Machold
发明人： John H. Stevens , Wesley D. Sterman , Hanson S. Gifford, III , Philip C. Evard , Timothy R. Machold
IPC分类号： A61B17/00 , A61B17/28 , A61B17/32 , A61F2/24 , A61F2/958 , A61M1/36 , A61M25/00 , A61M25/01 , A61M25/06 , A61M29/02 , A61M37/00
CPC分类号： A61F2/2427 , A61B17/29 , A61F2/2433 , A61M1/3653 , A61M1/3659 , A61M25/0041 , A61M25/0147 , A61M25/0152 , A61M25/0662 , A61M25/10 , A61B17/320016 , A61B2017/00243 , A61B2018/00232 , A61B2018/00261 , A61F2/2436 , A61M2025/0031 , A61M2025/0078 , A61M2025/015 , A61M2025/0161 , A61M2025/028 , A61M2025/1047 , A61M2025/1052 , A61M2025/1077 , A61M2025/1095 , A61M2205/11 , A61M2205/366 , A61M2210/125 , A61M2210/127 , A61M25/0032 , A61M25/0125 , A61M25/1002
摘要： A system for accessing a patient's cardiac anatomy which includes an endovascular aortic partitioning device that separates the coronary arteries and the heart from the rest of the patient's arterial system. The endovascular device for partitioning a patient's ascending aorta comprises a flexible shaft having a distal end, a proximal end, and a fist inner lumen therebetween with an opening at the distal end. The shaft may have a preshaped distal portion with a curvature generally corresponding to the curvature of the patient's aortic arch. An expandable means, e.g. a balloon, is disposed near the distal end of the shaft proximal to the opening in the first inner lumen for occluding the ascending aorta so as to block substantially all blood flow therethrough for a plurality of cardiac cycles, while the patient is supported by cardiopulmonary bypass. The endovascular aortic partitioning device may be coupled to an arterial bypass cannula for delivering oxygenated blood to the patient's arterial system. The heart muscle or myocardium is paralyzed by the retrograde delivery of a cardioplegic fluid to the myocardium through patient's coronary sinus and coronary veins, or by antegrade delivery of cardioplegic fluid through a lumen in the endovascular aortic partitioning device to infuse cardioplegic fluid into the coronary arteries. The pulmonary trunk may be vented by withdrawing liquid from the trunk through an inner lumen of an elongated catheter. The cardiac accessing system is particularly suitable for removing the aortic valve and replacing the removed valve with a prosthetic valve.
摘要翻译：一种用于访问患者心脏解剖结构的系统，其包括将冠状动脉和心脏与患者动脉系统的其余部分分离的血管内主动脉分配装置。用于分隔患者升主动脉的血管内装置包括具有远端，近端和其中的第一内腔的柔性轴，在其前端具有开口。轴可以具有预先形成的远端部分，其曲率通常对应于患者主动脉弓的曲率。可膨胀装置，例如靠近靠近第一内腔中的开口的轴的远端附近的气囊，用于闭塞升主动脉，以便阻止基本上所有的血液通过其进行多个心动周期，同时患者由体外循环。血管内主动脉分配装置可以联接到动脉旁路套管，用于将氧合血液输送到患者的动脉系统。通过患者的冠状窦和冠状静脉逆行递送心脏停搏液到心肌，或者通过血管内主动脉分配装置的内腔顺序递送心脏停跳液，将心肌或心肌瘫痪，将心脏停搏液注入冠状动脉。可以通过从细长的导管的内腔中抽出液体来排出肺动脉干。心脏存取系统特别适用于去除主动脉瓣并用假体瓣替换去除的瓣膜。

55. 发明授权

US5588949A Stereoscopic percutaneous visualization system 失效
标题翻译：立体经皮可视化系统
公开(公告)号：US5588949A
公开(公告)日：1996-12-31
申请号：US227366
申请日：1994-04-13
申请人： Charles S. Taylor , Brian S. Donlon , Timothy R. Machold
发明人： Charles S. Taylor , Brian S. Donlon , Timothy R. Machold
IPC分类号： A61B1/00 , A61B1/002 , A61B1/313 , A61B1/317 , A61B17/00 , A61B17/34 , A61B19/00 , G02B21/22 , G02B23/24
CPC分类号： G02B21/22 , A61B1/00193 , A61B1/002 , A61B17/3421 , G02B23/2415 , A61B1/3132 , A61B1/317 , A61B2017/00243 , A61B2017/3492 , A61B2090/3616 , A61B90/361 , A61B90/50
摘要： The invention provides a percutaneous visualization system for direct, stereoscopic visualization of a body cavity during minimally-invasive surgical procedures. The visualization system includes a cannula having a distal end, a proximal end, and a passage extending therebetween. The passage is configured to allow stereoscopic vision therethrough, and is preferably tapered from the proximal end to the distal end. A sleeve is positionable in the passage of the cannula, the sleeve having an optical passage also configured to allow stereoscopic vision, preferably by tapering. A lens may be disposed in the optical passage of the sleeve tier wide-angle viewing. Magnification means may be positioned in optical alignment with the optical passage to provide a magnified image of a surgical site.
摘要翻译：本发明提供了一种经皮可视化系统，用于在微创外科手术过程中直接立体显示体腔。可视化系统包括具有远端，近端和在其间延伸的通道的套管。该通道构造成允许通过其的立体视觉，并且优选地从近端到远端是锥形的。套管可定位在套管的通道中，套筒具有光学通道，其还构造成允许立体视觉，优选通过锥形化。透镜可以设置在袖子层广角视角的光学通道中。放大装置可以定位成与光学通道光学对准以提供手术部位的放大图像。

56. 发明授权

US5425705A Thoracoscopic devices and methods for arresting the heart 失效
标题翻译：胸腔镜装置和止血方法
公开(公告)号：US5425705A
公开(公告)日：1995-06-20
申请号：US173899
申请日：1993-12-27
申请人： Philip C. Evard , Timothy R. Machold , Hanson S. Gifford, III , Alex T. Roth , Wesley D. Sterman , Lawrence C. Siegel , Jeffry J. Grainger
发明人： Philip C. Evard , Timothy R. Machold , Hanson S. Gifford, III , Alex T. Roth , Wesley D. Sterman , Lawrence C. Siegel , Jeffry J. Grainger
IPC分类号： A61B1/00 , A61B17/00 , A61B17/02 , A61B17/04 , A61B17/06 , A61B17/064 , A61B17/068 , A61B17/12 , A61B17/122 , A61B17/128 , A61B17/28 , A61B17/30 , A61B17/34 , A61B18/14 , A61B19/00 , A61F2/24 , A61F2/958 , A61M1/00 , A61M25/00 , A61M25/01
CPC分类号： A61B17/0218 , A61B17/00234 , A61B17/0469 , A61B17/06061 , A61B17/12013 , A61B17/122 , A61B17/1227 , A61B17/1285 , A61B18/1442 , A61B18/1492 , A61B90/50 , A61F2/2427 , A61M25/01 , A61M39/0247 , A61B17/0057 , A61B17/0467 , A61B17/064 , A61B17/068 , A61B17/29 , A61B17/2909 , A61B17/295 , A61B17/30 , A61B17/34 , A61B17/3403 , A61B2017/00243 , A61B2017/00247 , A61B2017/00353 , A61B2017/00544 , A61B2017/00637 , A61B2017/00663 , A61B2017/0243 , A61B2017/047 , A61B2017/0472 , A61B2017/0474 , A61B2017/0475 , A61B2017/2905 , A61B2017/2933 , A61B2017/2943 , A61B2017/2945 , A61B2017/2946 , A61B2017/306 , A61B2017/3405 , A61B2017/3427 , A61B2017/3445 , A61B2017/3492 , A61B2018/00214 , A61B2018/00232 , A61B2018/00261 , A61B2018/00291 , A61B2018/00363 , A61B2018/00392 , A61B2018/00577 , A61B2018/1432 , A61B2090/064 , A61M2025/0003 , A61M2025/0089 , A61M2025/028 , A61M2039/0279 , A61M2202/047 , A61M2205/3344 , A61M2205/3355 , A61M2205/366 , A61M2210/127 , A61M25/1011 , Y10S128/26
摘要： The invention provides devices and methods for thoracoscopically arresting the heart and establishing cardiopulmonary bypass, thus facilitating a variety of less-invasive surgical procedures on and within the heart and great vessels of the thorax. In one embodiment, the invention provides a thoracoscopic system for arresting a patient's heart including a clamp configured for introduction into the patient's thoracic cavity through a percutaneous intercostal penetration in the patient's chest. The clamp is positionable about the patient's ascending aorta between the coronary arteries and the brachiocephalic artery. The clamp is coupled to the distal end of an elongated handle means for manipulating the clamp from a location outside of the patient's thoracic cavity. A means for actuating the clamp is coupled to the proximal end of the handle means. When actuated, the clamp blocks blood flow through the ascending aorta. A delivery cannula may be used to deliver cardioplegic fluid into the ascending aorta upstream from the clamp to arrest cardiac function.
摘要翻译：本发明提供了用于胸腔镜阻塞心脏并建立心肺旁路的装置和方法，从而促进在胸部和/或胸部的心脏和大血管内部和内部的多种较小侵入性的外科手术。在一个实施例中，本发明提供了一种用于阻止患者心脏的胸腔镜系统，包括构造成通过患者胸部经皮肋间穿透引入患者胸腔的夹具。夹具可以围绕冠状动脉和头臂动脉之间的患者升主动脉定位。夹具联接到细长手柄的远端，用于从患者胸腔外部的位置操纵夹具。用于致动夹具的装置联接到手柄装置的近端。当启动时，夹具阻止血流通过升主动脉。输送插管可用于将心脏停搏液输送到夹钳上游的升主动脉以阻止心脏功能。

57. 发明授权

US5034001A Method of repairing a damaged blood vessel with an expandable cage catheter 失效
标题翻译：用可膨胀笼导管修复受损血管的方法
公开(公告)号：US5034001A
公开(公告)日：1991-07-23
申请号：US404815
申请日：1989-09-08
申请人： Michi E. Garrison , Timothy R. Machold
发明人： Michi E. Garrison , Timothy R. Machold
IPC分类号： A61F2/00 , A61F2/06 , A61F2/84 , A61M25/04 , A61M29/00 , A61M29/02
CPC分类号： A61F2/966 , A61F2/95 , A61M25/04 , A61M29/02 , A61F2250/0059 , A61F2250/0098 , A61M2025/0063 , A61M2025/0183 , A61M2025/107
摘要： A vascular catheter having an expandable cage mounted on the distal end of a tubular member which is radially expanded and contracted by means of a control wire which is secured to the distal end of the expandable cage. The control wire extends through a first inner lumen within the tubular member which extends along essentially the entire length thereof. A second inner lumen is provided in the distal portion of the tubular member which has a proximal port at least 15 but not more than 60 cm from the distal end of the catheter and a distal port which opens into the interior of the expandable cage. A guidewire or a low-profile steerable catheter is slidably disposed within the second lumen and a tubular member such as a slightly expanded coil through the expandable cage interior to facilitate the rapid exchange of the catheter. The catheter assembly is particularly adapted to hold open a blood vessel after a vascular procedure therein such as an angioplasty.

58. 发明授权

US08551151B2 Method and apparatus for regional and whole body temperature modification 有权
标题翻译：区域和全身温度改变的方法和装置
公开(公告)号：US08551151B2
公开(公告)日：2013-10-08
申请号：US13101000
申请日：2011-05-04
申请人： Timothy R. Machold , Nicole Denise Bloom , Alex T. Roth , Dave J. Scott , Jose Alejandro , Edward A. Oliver
发明人： Timothy R. Machold , Nicole Denise Bloom , Alex T. Roth , Dave J. Scott , Jose Alejandro , Edward A. Oliver
IPC分类号： A61F7/12
CPC分类号： A61F7/12 , A61B2017/00119 , A61B2017/00123 , A61B2017/22051 , A61F7/0085 , A61F7/10 , A61F7/123 , A61F2007/0054 , A61F2007/0096 , A61F2007/126 , A61M5/44 , A61M25/1011 , A61M2025/1072 , A61M2025/1086 , A61M2205/127
摘要： A heat exchange fluid supply system for supplying a heat exchange fluid to an intravascular heat exchange catheter includes a disposable cassette having a bulkhead and an external heat exchanger, and which is configured to operate in combination with a reusable master control unit. The bulkhead includes a reservoir section and a pump section. The reservoir section is provided with a means to monitor the amount of heat exchange fluid that is in the system. The bulkhead provides the mechanism for priming the system with heat exchange fluid from an external source and for circulating fluid to the catheter in a closed circuit. The pump section is configured to allow for pumping of heat exchange fluid at a constant pressure.
摘要翻译：用于将热交换流体供应到血管内热交换导管的热交换流体供应系统包括具有隔板和外部热交换器的一次性盒，其被配置为与可重复使用的主控制单元结合操作。舱壁包括储存段和泵段。储存器部分设置有用于监测系统中的热交换流体的量的装置。隔板提供了使用来自外部源的热交换流体并且用于在闭合回路中将流体循环到导管的系统引发系统的机构。泵部分构造成允许在恒定压力下泵送热交换流体。

59. 发明授权

US08409265B2 Multiple lumen heat exchange catheters 有权
公开(公告)号：US08409265B2
公开(公告)日：2013-04-02
申请号：US12511015
申请日：2009-07-28
申请人： Wade A. Keller , Timothy R. Machold
发明人： Wade A. Keller , Timothy R. Machold
IPC分类号： A61F7/12 , A61M5/44
CPC分类号： A61F7/12 , A61B18/00 , A61B18/082 , A61B18/245 , A61B2017/00084 , A61B2017/22051 , A61B2018/00095 , A61F7/007 , A61F7/10 , A61F7/123 , A61F2007/0054 , A61F2007/0056 , A61F2007/0086 , A61F2007/0095 , A61F2007/0096 , A61F2007/126 , A61M25/00 , A61M25/1002 , A61M25/1011 , A61M2025/0078 , A61M2025/1072 , A61M2025/1086 , A61M2205/366 , A61M2206/10 , A61M2230/50
摘要： Catheter devices and methods for intravascular heating and/or cooling of human or veterinary patients. The catheter devices generally comprise catheters having inflow and outflow lumens and at least one curvilinear balloon connected to the inflow and outflow lumens such that heat exchange fluid may be circulated through the balloon(s). The catheter is inserted into the vasculature and heated or cooled fluid is circulated through the balloon(s) to heat or cool blood flowing in heat-exchange proximity to the balloon(s), thereby effecting heating or cooling of all or a portion of the patient's body.

60. 发明申请

US20120185040A1 DEVICES, SYSTEMS, AND METHODS FOR RETAINING A NATIVE HEART VALVE LEAFLET 审中-公开
标题翻译：用于保持原位心脏瓣膜的装置，系统和方法
公开(公告)号：US20120185040A1
公开(公告)日：2012-07-19
申请号：US13431430
申请日：2012-03-27
申请人： DAVID A. RAHDERT , John A. Macoviak , Timothy R. Machold , Robert T. Chang , Rick A. Soss
发明人： DAVID A. RAHDERT , John A. Macoviak , Timothy R. Machold , Robert T. Chang , Rick A. Soss
IPC分类号： A61F2/24
CPC分类号： A61F2/2445 , A61F2/2418 , A61F2/2454
摘要： Devices, systems and methods retain a native heart valve leaflet to prevent retrograde flow. The devices, systems, and methods employ an implant that, in use, rests adjacent a valve annulus and includes a retaining structure that is sized and shaped to overlay at least a portion of one or more native valve leaflets. The retaining structure retains the leaflet or leaflets it overlays, to resist leaflet eversion and/or prolapse. In this way, the implant prevents or reduces regurgitation. The implant does not interfere significantly with the opening of and blood flow through the leaflets during periods of antegrade flow.
摘要翻译：装置，系统和方法保留天然心脏瓣膜瓣以防止逆行流动。装置，系统和方法采用植入物，其在使用中邻近瓣膜环并且包括保持结构，该保持结构的尺寸和形状可覆盖一个或多个天然瓣膜的至少一部分。保留结构保留了覆盖的小叶或传单，以抵抗小叶外翻和/或脱垂。以这种方式，植入物防止或减少反流。植入物在顺行流动期间不会明显干扰通过传单的血液流通。

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