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51. 发明申请

US20060216289A1 GFRalpha3 and its uses 审中-公开
标题翻译： GFRalpha3及其用途
公开(公告)号：US20060216289A1
公开(公告)日：2006-09-28
申请号：US11448387
申请日：2006-06-06
申请人： Frederic de Sauvage , Robert Klein , Heidi Phillips , Arnon Rosenthal
发明人： Frederic de Sauvage , Robert Klein , Heidi Phillips , Arnon Rosenthal
IPC分类号： G01N33/53 , C07H21/04 , C12P21/06 , A61K39/395 , C07K14/71 , C07K16/28
CPC分类号： C07K16/2863 , C07K14/71 , C07K2317/75 , C07K2319/00 , C12Q1/485 , G01N33/573 , G01N33/74 , G01N2500/04 , G01N2500/10
摘要： The present invention relates to nucleotide sequences, including expressed sequence tags (ESTs), oligonucleotide probes, polypeptides, vectors and host cells expressing, and immunoadhesions and antibodies to mammalian GFRα3, a novel α-subunit receptor of the GDNF (i.e. GFR) receptor family. It further relates to an assay for measuring activation of an α-subunit receptor by detecting tyrosine kinase receptor activation (i.e., autophosphorylation) or other activities related to ligand-induced α-subunit receptor homo-dimerization or homo-oligomerization.
摘要翻译：本发明涉及核苷酸序列，包括表达序列标签（EST），寡核苷酸探针，多肽，载体和宿主细胞，其表达和免疫粘附和抗体对哺乳动物GFRalpha3，GDNF（即GFR）受体家族的新型α-亚单位受体。它进一步涉及通过检测酪氨酸激酶受体激活（即自身磷酸化）或与配体诱导的α-亚基受体均二聚化或同型寡聚化相关的其他活性来测量α-亚单位受体活化的测定法。

52. 发明申请

US20060142196A1 Uses of GDNF and GDNF receptor 有权
公开(公告)号：US20060142196A1
公开(公告)日：2006-06-29
申请号：US11336555
申请日：2006-01-20
申请人： Robert Klein , Mark Moore , Arnon Rosenthal , Anne Ryan
发明人： Robert Klein , Mark Moore , Arnon Rosenthal , Anne Ryan
IPC分类号： A61K38/17 , C07K14/705 , C07H21/04 , C12P21/06
CPC分类号： C07K14/71 , A01K2217/05 , A61K38/00 , C07K16/22 , C07K2319/00
摘要： GDNFRα, GDNFRα extracellular domain (ECD), GDNFRα variants, chimeric GDNFRα (e.g., GDNFRα immunoadhesin), and antibodies which bind thereto (including agonist and neutralizing antibodies) are disclosed. Various uses for these molecules are described, including methods to modulate cell activity and survival by response to GDNFRα-ligands, for example GDNF, by providing GDNFRα to the cell. Also provided are methods for using GDNFRα, GDNF, or agonists thereof, separately or in complex, to treat kidney diseases.

53. 发明申请

US20060079488A1 Methods of treating and preventing bone loss 审中-公开
公开(公告)号：US20060079488A1
公开(公告)日：2006-04-13
申请号：US11286237
申请日：2005-11-23
申请人： John Allard , Robert Klein , Gary Peltz
发明人： John Allard , Robert Klein , Gary Peltz
IPC分类号： A61K31/66 , C12Q1/68
CPC分类号： C12Q1/26 , A61K31/167 , A61K31/192 , A61K31/404 , A61K31/407 , A61K31/56 , A61K31/663 , A61K38/23 , A61K38/30 , G01N2333/90241 , G01N2500/04 , G01N2800/108 , A61K2300/00
摘要： Methods of treating and preventing bone loss and/or enhancing bone formation are disclosed. The methods utilize 15-lipoxygenase inhibitors. These molecules can be delivered alone or in combination with agents which inhibit bone resorption or additional agents that regulate calcium resorption from bone or enhances bone accumulation. The invention additionally provides methods of diagnosing a predisposition to bone loss.

54. 发明申请

US20050244035A1 Image quality assurance system and methodologies in a post-image capture document processing environment 有权
标题翻译：图像捕获文档处理环境中的图像质量保证系统和方法
公开(公告)号：US20050244035A1
公开(公告)日：2005-11-03
申请号：US10837345
申请日：2004-04-30
申请人： Robert Klein , Craig Lapan , George Reasoner
发明人： Robert Klein , Craig Lapan , George Reasoner
IPC分类号： G06K9/00 , G06K9/40 , H04N1/00
CPC分类号： G06K9/036 , G06Q20/042 , H04N1/00002 , H04N1/00005 , H04N1/00034 , H04N1/00037 , H04N1/0009
摘要： An image quality assurance method for identifying image defects in a plurality of previously-imaged documents, where each previously-imaged document includes at least one image rendition stored in at least one image rendition file according to type of image rendition. The image renditions are analyzed to provide selected image metrics, the latter of which are compared against preselected image quality metric threshold values. An image quality flag is generated for any image rendition if at least one of the selected image metrics for that image rendition does not successfully compare against the preselected image quality metric threshold values. A record entry is created in an image quality flag file for those documents having at least one flagged image rendition, the record entry including information about the selected image metrics of the at least one flagged image rendition for that imaged document. Image defects in a plurality of imaged documents can be identified by examining the record entries in the image quality flag file.
摘要翻译：一种用于识别多个先前成像的文档中的图像缺陷的图像质量保证方法，其中每个先前成像的文档根据图像再现的类型包括存储在至少一个图像再现文件中的至少一个图像再现。分析图像再现以提供所选择的图像度量，其中后者与预选图像质量度量阈值进行比较。如果图像再现的所选择的图像度量中的至少一个没有成功地与预先选择的图像质量度量阈值进行比较，则为任何图像再现生成图像质量标志。在具有至少一个标记图像再现的那些文档的图像质量标志文件中创建记录条目，该记录条目包括关于该成像文档的至少一个标记图像再现的所选图像度量的信息。可以通过检查图像质量标志文件中的记录条目来识别多个成像文档中的图像缺陷。

55. 发明申请

US20050243379A1 Document processing system with improved image quality assurance 有权
标题翻译：文件处理系统具有改进的图像质量保证
公开(公告)号：US20050243379A1
公开(公告)日：2005-11-03
申请号：US10837344
申请日：2004-04-30
申请人： Robert Klein , Craig Lapan , George Reasoner
发明人： Robert Klein , Craig Lapan , George Reasoner
IPC分类号： G06K15/00 , G07F19/00
CPC分类号： G06Q20/042 , G06Q20/1085 , G07F19/202 , Y10S707/99931 , Y10S707/99937 , Y10S707/99945
摘要： A document processing system comprising an image capture subsystem for capturing selected image metrics and at least one image rendition from a plurality of documents and for determining if at least one of the selected image metrics for any of the at least one image rendition does not successfully compare against preselected image quality metric threshold values. An image quality flag is generated for any of the at least one image rendition if it does not successfully compare, and a record entry for each imaged document having at least one flagged image rendition is created in an image quality flag file. An image index file for individually accessing the image renditions is modified to include a reference to the corresponding image quality flag file record entry The document processing system may optionally compare selected document metrics against preselected document metrics in a similar manner. Image defects in the plurality of documents can be identified by examining the record entries in the image quality flag file.
摘要翻译：一种文档处理系统，包括用于从多个文档捕获所选择的图像度量和至少一个图像再现的图像捕获子系统，并且用于确定所述至少一个图像再现中的任一个的所选图像度量中的至少一个是否未成功比较针对预选图像质量度量阈值。如果没有成功比较，则生成用于至少一个图像再现的任何图像质量标记，并且在图像质量标记文件中创建具有至少一个标记图像再现的每个成像文档的记录条目。用于单独访问图像再现的图像索引文件被修改为包括对相应图像质量标志文件记录条目的引用。文档处理系统可以可选地以类似的方式将所选择的文档度量与预先选择的文档度量进行比较。可以通过检查图像质量标志文件中的记录条目来识别多个文档中的图像缺陷。

56. 发明授权

US06413936B1 Glycomimetics as selectin antagonists and pharmaceuticals having antiinflammatory activity 失效
标题翻译：作为选择素拮抗剂的Glycomimetics和具有抗炎活性的药物
公开(公告)号：US06413936B1
公开(公告)日：2002-07-02
申请号：US08739855
申请日：1996-10-30
申请人： Wolfgang Schmidt , Ulrich Sprengard , Gerhard Kretzschmar , Robert Klein , Horst Kunz
发明人： Wolfgang Schmidt , Ulrich Sprengard , Gerhard Kretzschmar , Robert Klein , Horst Kunz
IPC分类号： A61K3170
CPC分类号： C07D405/10 , A61K38/00 , C07D307/20 , C07D309/10 , C07D407/06 , C07K9/001
摘要： The invention relates to novel mimetics of the tetrasaccharides sialyl-Lewis-X and sialyl-Lewis-A having an improved action as inhibitors of cell adhesion, to a process for the preparation of these compounds and to their use as pharmacological active compounds and diagnostic agents.
摘要翻译：本发明涉及具有作为细胞粘附抑制剂的改善作用的四糖唾液酸 - 路易斯-X和唾液酸 - 路易斯-A的新型模拟物，制备这些化合物的方法及其作为药物活性化合物和诊断剂的用途。

57. 发明授权

US11782726B1 Serial bootstrap 有权
公开(公告)号：US11782726B1
公开(公告)日：2023-10-10
申请号：US17036604
申请日：2020-09-29
申请人： Barak Wasserstrom , Idan Saar , Robert Klein
发明人： Barak Wasserstrom , Idan Saar , Robert Klein
IPC分类号： G06F9/4401
CPC分类号： G06F9/4401
摘要： Approaches in accordance with various embodiments can be used to provide bootstrap data for a computing device, such as a system on chip (SoC). In particular, various embodiments can use one or more shift registers to receive bits of a sequence of bootstrap data in parallel. Individual bits of this bootstrap data sequence can then be provided to the SoC, from the shift register(s), serially and using a single input. Such an approach prevents the need for multiple bootstrap pins on the SoC, as well as the need to multiplex those pins for use with other external devices.

58. 发明授权

US09084171B2 Predictive hard and soft handover 有权
标题翻译：预测硬和软切换
公开(公告)号：US09084171B2
公开(公告)日：2015-07-14
申请号：US12557254
申请日：2009-09-10
申请人： Robert Klein
发明人： Robert Klein
IPC分类号： H04W36/00 , H04W36/30 , H04W36/24 , H04W72/08 , H04B17/00
CPC分类号： H04W36/30 , H04B17/10 , H04B17/15 , H04B17/318 , H04B17/336 , H04W36/00 , H04W36/24 , H04W72/085
摘要： Methods and apparatus that facilitate predictive hard and soft handover are presented herein. A measurement component can measure signal strength data associated with a source cell and one or more target cells. One or more linear regression lines can be computed based on the signal strength data. Rates of at least one of an increase or a decrease in the signal strength data per unit of time can be determined based on a slope of the one or more linear regression lines—the slope can comprise a change in signal strength data per unit of time. A time to trigger at least one of a hard or soft handover can be triggered based on the rates.
摘要翻译：本文介绍了促进预测性硬切换和软切换的方法和装置。测量组件可以测量与源小区和一个或多个目标小区相关联的信号强度数据。可以基于信号强度数据来计算一个或多个线性回归线。可以基于一个或多个线性回归线的斜率来确定每单位时间的信号强度数据的增加或减少中的至少一个的速率 - 该斜率可以包括每单位时间的信号强度数据的变化。可以基于速率触发触发硬切换或软切换中的至少一个的时间。

59. 发明授权

US08688387B2 Method for the determination of intra- and intermolecular interactions in aqueous solution 有权
标题翻译：测定水溶液中分子间和分子间相互作用的方法
公开(公告)号：US08688387B2
公开(公告)日：2014-04-01
申请号：US13366491
申请日：2012-02-06
申请人： Gudrun Lange , Robert Klein , Juergen Albrecht , Matthias Rarey , Ingo Reulecke
发明人： Gudrun Lange , Robert Klein , Juergen Albrecht , Matthias Rarey , Ingo Reulecke
IPC分类号： G01N33/48 , G06G7/58
CPC分类号： G06F19/701 , G06F19/16 , Y10T436/143333
摘要： The present invention relates to the determination of intra- or intermolecular interaction between molecules in aqueous solution, the method comprising the steps of: (a) determining the dehydration of all atoms in the intermolecular interface, (b) adding the vacuum hydrogen bond energy, and (c) further adding the change in the free enthalpy of the interacting partners upon their interaction. The obtained results can be used for the prediction if and to what extent two molecules of various origin fit to each other.
摘要翻译：本发明涉及水溶液中分子间或分子间相互作用的测定，该方法包括以下步骤：（a）测定分子间界面中所有原子的脱水，（b）加入真空氢键能，和（c）进一步增加相互作用的伙伴在互动时的自由焓的变化。获得的结果可以用于预测各种来源的两个分子如何以及在何种程度上相互适应。

60. 发明申请

US20110141887A1 SITE BASED MEDIA STORAGE IN A WIRELESS COMMUNICATION NETWORK 有权
标题翻译：基于站点的媒体存储在无线通信网络中
公开(公告)号：US20110141887A1
公开(公告)日：2011-06-16
申请号：US12639766
申请日：2009-12-16
申请人： Robert Klein , Arthur Brisebois
发明人： Robert Klein , Arthur Brisebois
IPC分类号： H04L1/00 , G06F17/30 , G06F15/173 , G06F15/16
CPC分类号： H04W4/00 , H04L67/2842 , H04L67/325 , H04W88/08
摘要： A system and methodology that facilitates efficient utilization of bandwidth on a transmission link between a base station and a core mobility network, during content delivery is provided. Moreover, the system includes a data storage device, adjunct to, or integrated within, the base station for storing content locally. Typically, the data storage device is updated by downloading content from the core network at an optimal time. For example, content can be downloaded to the data storage device when the core network-to-base station link is idle, under utilized and/or has sufficient bandwidth for the download. On receiving a request for content from a user equipment (UE), the base station can directly deliver the content to the UE from the data storage device, over an air interface, when the requested content is locally available.
摘要翻译：提供了一种在内容传送期间促进基站和核心移动网络之间的传输链路上的带宽的有效利用的系统和方法。此外，该系统包括用于在本地存储内容的基站中的附件或集成在其中的数据存储设备。通常，通过在最佳时间从核心网络下载内容来更新数据存储设备。例如，当核心网络到基站链路空闲时被使用和/或具有用于下载的足够带宽时，可以将内容下载到数据存储设备。当接收到来自用户设备（UE）的内容请求时，当所请求的内容在本地可用时，基站可以通过空中接口从数据存储设备直接传递内容给UE。

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