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    • 51. 发明授权
    • Applicator systems for applying a localized amount of coating material
to top edges of containers
    • 用于将局部涂覆材料施加到容器的顶部边缘的涂覆器系统
    • US5242497A
    • 1993-09-07
    • US783692
    • 1991-10-29
    • Richard A. MillerOnisim Krasnokutsky
    • Richard A. MillerOnisim Krasnokutsky
    • B05C1/02
    • B05C1/027B05C1/022Y10S118/03
    • An assembly for applying coating material to top edges of containers is provided with a porous applicator which may be saturated with the molten coating material. The applicator assembly is especially adapted to contact the top curl of paperboard containers so that an amount of the molten coating material which saturates the porous applicator may be transferred to the top curl and thereby increase the top curl's circumferential rigidity upon solidification. The applicator assembly is preferably positioned laterally parallel of a linear treatment path along which the containers are conveyed in an inverted manner. Each container is rotated during conveyance along the linear treatment path such that the entire circumference of the top curl is brought into contact with the elongate porous applicator saturated with molten coating material. The container may also be rotated in contact with the applicator a successive number of turns so that a corresponding successive number of coating layers may be applied to the top curl. The coating material will thus be transferred to the top curl due to the contact that occurs between the top curl and the applicator.
    • 用于将涂料施加到容器的顶部边缘的组件设置有可被熔融涂覆材料饱和的多孔施加器。 施用器组件特别适于接触纸板容器的顶部卷曲,使得使多孔施加器饱和的熔融涂层材料的量可以转移到顶部卷曲,从而在凝固时增加顶部卷曲的周向刚度。 涂抹器组件优选地定位成横向平行于线性处理路径,容器以反向方式沿着该处理路径被传送。 每个容器沿着线性处理路径传送期间旋转,使得顶部卷曲的整个周边与被熔融涂覆材料饱和的细长多孔施加器接触。 容器也可以与涂抹器相接触地旋转数次,使相应的连续数量的涂层可以施加到顶部卷曲。 因此,涂层材料由于顶部卷曲和涂抹器之间的接触而被转移到顶部卷曲。
    • 52. 发明授权
    • Anti-idiotype antibodies reactive with shared idiotopes expressed by B
cell lymphomas and autoantibodies
    • 与B细胞淋巴瘤和自身抗体表达的共有特异性反应的抗独特型抗体
    • US5227159A
    • 1993-07-13
    • US898246
    • 1992-06-12
    • Richard A. Miller
    • Richard A. Miller
    • C07K16/42C12N5/12C12N5/20
    • C07K16/4266C12N5/12
    • B-cell lymphomas express surface immunoglobulin (immunoglobulin) containing unique idiotypic (idiotype) determinants which may be exploited as tumor specific markers. The inventor has produced murine monoclonal antibodies (MAbs) reactive with the idiotype marker derived from 67 patients with low grade, follicular, small cleaved cell lymphoma. Out of 199 monoclonal antibodies, 47 (24%) were found to react with pooled normal human serum immunoglobulin in concentrations ranging from 0.6 .mu.g/ml to 160 .mu.g/ml. Of these 40 monoclonal antibodies, 90% cross-reacted with idiotype present in normal serum in levels
    • B细胞淋巴瘤表达含有独特特异性(独特型)决定簇的表面免疫球蛋白(免疫球蛋白),其可被用作肿瘤特异性标志物。 本发明人已经产生了与来自67名患有低等级,滤泡,小切割细胞淋巴瘤的患者的独特型标志物反应的鼠单克隆抗体(MAb)。 在199个单克隆抗体中,发现47(24%)与浓度范围为0.6μg/ ml至160μg/ ml的合并的正常人血清免疫球蛋白反应。 在这40种单克隆抗体中,90%的交联反应具有存在于正常血清中的独特型,水平<50μg/ ml。 其中三十二种抗独特型针对在另一患者淋巴瘤细胞上表达的共有特异性。 由每种抗体定义的共有特异性表达的频率范围为测试的B细胞淋巴瘤的0.26%至3.9%。 一组五种抗独特型抗体与80%的AIDS相关淋巴瘤反应。 基于与这些单克隆抗体的反应性,肿瘤可以分成不同的家族。 总之,这32种单克隆抗体与共有108例332例B细胞淋巴瘤病例(32.5%)反应,其中包括35例116例滤泡性小切割细胞淋巴瘤(30%)。 许多这些抗共享的特异性反应与多于一种淋巴瘤的组织病理学亚型反应。 抗独特型已被用于B细胞淋巴瘤诊断和治疗。 此外,申请人已发现至少七种与自身抗体交叉反应的抗共享独特型抗体,例如16.6和RF。 发展与独立反应的反特异型图书馆应该促进这些临床研究,从而避免需要为每个患者开发定制的杂交瘤。