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51. 发明申请

US20080132800A1 NOVEL MEDICAL METHODS AND SYSTEMS INCORPORATING WIRELESS MONITORING 有权
标题翻译：新型医疗方法与系统无线监控
公开(公告)号：US20080132800A1
公开(公告)日：2008-06-05
申请号：US11565283
申请日：2006-11-30
申请人： Douglas A. Hettrick , Kenneth C. Gardeski , H. Toby Markowitz , Sameh Sowelam
发明人： Douglas A. Hettrick , Kenneth C. Gardeski , H. Toby Markowitz , Sameh Sowelam
IPC分类号： A61B5/04 , A61B5/00
CPC分类号： A61B5/076 , A61B5/0031 , A61B5/1107 , A61B5/686 , A61B90/39 , A61B2017/00411 , A61B2090/3908 , A61B2090/397 , A61B2090/3975 , A61B2562/0209 , A61B2562/046
摘要： Medical systems and methods incorporate monitoring of at least two implanted markers, each of which is adapted to wirelessly transmit a signal in response to a wirelessly transmitted excitation signal; the response signals are converted into positional information for the two markers. The systems and methods further incorporate both, or one of, an implanted sensing member and/or an implanted therapy delivery device. Signals received from the sensing member may be collated with the positional information. A therapy delivered from the therapy delivery device may be adjusted according to the positional information.
摘要翻译：医疗系统和方法包括至少两个植入标记的监测，每个植入标记适于响应于无线发送的激励信号无线地发送信号; 响应信号被转换成两个标记的位置信息。所述系统和方法还包括植入的感测构件和/或植入的治疗递送装置中的一个或其中之一。从感测构件接收到的信号可以与位置信息进行整理。可以根据位置信息调整从治疗输送装置输送的治疗。

52. 发明授权

US06434424B1 Regularization of ventricular rate during atrial tachyarrhythmia 有权
标题翻译：房性心律失常期心室率正常化
公开(公告)号：US06434424B1
公开(公告)日：2002-08-13
申请号：US09470120
申请日：1999-12-22
申请人： David A. Igel , H. Toby Markowitz , Robert A. Betzold , Karen J. Kleckner , Jeremy A. Schroetter
发明人： David A. Igel , H. Toby Markowitz , Robert A. Betzold , Karen J. Kleckner , Jeremy A. Schroetter
IPC分类号： A61N1362
CPC分类号： A61N1/3622
摘要： A pacing system provided with a mode switching feature and ventricular rate regularization (VRR) function adapted to stabilize or regularize ventricular heart rate during chronic or paroxysmal atrial tachyarrhythmia. In a preferred embodiment, the pacing system nominally operates in an atrial synchronized pacing mode such as DDD or DDDR pacing mode. In response to detection of atrial rhythm characteristics consistent with an atrial tachyarrhythmia, e.g., atrial fibrillation, a mode switch into a non-atrial synchronized, ventricular rate regularization pacing mode, e.g. DDIR or VDIR pacing mode, is made. If the VRR function is programmed on, the ventricular pacing rate based upon a rate responsive sensor derived ventricular pacing rate modulated on a beat by beat basis by preceding intrinsic or paced ventricular events, the stability of the intrinsic ventricular heart rate, and any atrial pace events to regularize the ventricular pacing rate. The pacing system may also be permanently programmed to the DDIR pacing mode with the VRR feature functioning continuously. The pacing system may also be permanently programmed to the VVIR pacing mode with VRR function activated, but without consideration of atrial pace events.
摘要翻译：具有模式切换特征和心室率正常化（VRR）功能的起搏系统适于在慢性或阵发性房性快速性心律失常期间稳定或规范心室心率。在优选实施例中，起搏系统名义地以心房同步起搏模式操作，例如DDD或DDDR起搏模式。响应于检测与房性快速性心律失常（例如心房颤动）一致的心房节律特征，模式切换到非心房同步的心室速率正则化起搏模式，例如心房颤动。 DDIR或VDIR起搏模式。如果VRR功能被编程，则基于速率响应传感器导出的心室起搏速率的心室起搏速率通过前进的内在或节奏心室事件，内部心室心率的稳定性和任何心房起搏事件来规范心室起搏率。起搏系统也可以永久编程到DDIR起搏模式，VRR功能连续工作。起搏系统也可以被永久编程到VVIR起搏模式，VRR功能被激活，但不考虑心房速度事件。

53. 发明授权

US06238429B1 Biologic cabling 失效
标题翻译：生物布线
公开(公告)号：US06238429B1
公开(公告)日：2001-05-29
申请号：US09072819
申请日：1998-05-05
申请人： H. Toby Markowitz , Maura G. Donovan , Khawar Mehdi
发明人： H. Toby Markowitz , Maura G. Donovan , Khawar Mehdi
IPC分类号： A61N105
CPC分类号： A61N1/05
摘要： A length of living conductive cells may be injected directly or may be grown to be attached to a fibrous matrix of material that provides for flexible structure so as to deliver a stimulation signal from one end of the biologic cable to the other to induce a physiologic reaction in body tissue.
摘要翻译：活体导电细胞的长度可以直接注射或者可以生长以附着到提供柔性结构的材料的纤维基质上，以将刺激信号从生物电缆的一端传递到另一端以诱导生理反应在身体组织。

54. 发明授权

US5174287A Airway feedback measurement system responsive to detected inspiration and obstructive apnea event 失效
标题翻译：对检测到的启发和阻碍APNEA事件的航空反馈测量系统
公开(公告)号：US5174287A
公开(公告)日：1992-12-29
申请号：US706165
申请日：1991-05-28
申请人： Michael J. Kallok , H. Toby Markowitz
发明人： Michael J. Kallok , H. Toby Markowitz
IPC分类号： A61B5/08 , A61N1/36 , A61N1/365
CPC分类号： A61N1/3601
摘要： An improved apparatus for and method of providing feedback to an implantable pulse generator to treat obstructive sleep apnea. Sensors monitor the electrical activity associated with contractions of the diaphragm. The pressure within the thorax and the upper airway are also measured. Whenever electrical activity of the diaphragm suggests that an inspiration cycle is in progress and the pressure sensors show an abnormal pressure differential across the airway, the presence of obstructive sleep apenea is assumed and electrical stimulation is applied to the musculature of the upper airway.
摘要翻译：一种用于向可植入脉冲发生器提供反馈以治疗阻塞性睡眠呼吸暂停的改进的装置和方法。传感器监测与隔膜收缩相关的电活动。也测量胸腔和上呼吸道内的压力。无论何时隔膜的电活动表明启动循环正在进行，压力传感器显示气道两侧的异常压力差异，则假设存在阻塞性睡眠apenea，并且电刺激应用于上呼吸道的肌肉组织。

55. 发明授权

US11065422B2 Devices, systems, and methods useful to engage tissue using suction and to perform medical procedures during suctional engagement 有权
公开(公告)号：US11065422B2
公开(公告)日：2021-07-20
申请号：US15821825
申请日：2017-11-23
申请人： Ghassan S. Kassab , Matthew Phillips , H. Toby Markowitz
发明人： Ghassan S. Kassab , Matthew Phillips , H. Toby Markowitz
IPC分类号： A61M25/00 , A61B17/34 , A61B17/00 , A61M25/09 , A61M25/06 , A61B17/30 , A61B18/02 , A61B18/00 , A61B18/14
摘要： Devices, systems, and methods useful to engage tissue using suction and to perform medical procedures during sectional engagement. The present disclosure includes disclosure of a tension apparatus, comprising an elongated portion; and a head portion at a distal end of the elongated portion, the head portion comprising one or more arms, whereby a suction lumen extending along the elongated portion and the one or more arms terminates at one or more suction openings at each of the one or more arms.

56. 发明授权

US09655666B2 Catheter with coronary sinus ostium anchor 有权
公开(公告)号：US09655666B2
公开(公告)日：2017-05-23
申请号：US12915327
申请日：2010-10-29
申请人： H. Toby Markowitz , Amy E. Thompson-Nauman
发明人： H. Toby Markowitz , Amy E. Thompson-Nauman
IPC分类号： A61B18/14 , A61B18/02 , A61B5/042 , A61B18/00 , A61M25/04 , A61B90/00
CPC分类号： A61B18/02 , A61B5/042 , A61B18/1492 , A61B2018/00023 , A61B2018/00214 , A61B2018/00273 , A61B2018/00285 , A61B2018/00755 , A61B2018/00875 , A61B2018/00898 , A61B2090/0811 , A61M25/04
摘要： A method of treating cardiac tissue is provided, including positioning a first chamber of a medical device adjacent an atrial wall; directing a cryogenic coolant into the first chamber; anchoring the first chamber to the atrial wall through cryoadhesion; directing a distal portion of the medical device into the coronary sinus; and positioning a cardiac lead through at least a portion of the coronary sinus with the distal portion. The method may include measuring a temperature of the first chamber; removing the first chamber from the atrial wall once a predetermined threshold temperature of the first chamber is reached; anchoring a second chamber of the medical device to a portion of the coronary sinus; and/or perfusing blood flow through at least a portion of the second chamber.

57. 发明授权

US08843189B2 Interference blocking and frequency selection 有权
标题翻译：干扰阻塞和频率选择
公开(公告)号：US08843189B2
公开(公告)日：2014-09-23
申请号：US12423487
申请日：2009-04-14
申请人： H. Toby Markowitz , Mustafa Karamanoglu , Pooja Mehta , Ioana Fleming , David A. Scanlon , Michael Kryger , Sean Campbell-Massa , Chad Giese , Steven L. Waldhauser , Shangqian Peter Zhang , Jeff Jannicke , Phillip Falkner , Don Hefner , Eduardo N. Warman , James Steeves , Rogier Receveur , Koen Michels , Olaf Eick , Vincent Larik
发明人： H. Toby Markowitz , Mustafa Karamanoglu , Pooja Mehta , Ioana Fleming , David A. Scanlon , Michael Kryger , Sean Campbell-Massa , Chad Giese , Steven L. Waldhauser , Shangqian Peter Zhang , Jeff Jannicke , Phillip Falkner , Don Hefner , Eduardo N. Warman , James Steeves , Rogier Receveur , Koen Michels , Olaf Eick , Vincent Larik
IPC分类号： A61B5/04 , A61B19/00 , A61B5/042 , A61B5/053 , A61B17/00 , A61B5/06 , A61B8/00 , A61B5/05 , A61B8/06
CPC分类号： A61B5/061 , A61B5/0422 , A61B5/04288 , A61B5/0432 , A61B5/044 , A61B5/05 , A61B5/053 , A61B5/0538 , A61B5/06 , A61B5/062 , A61B5/063 , A61B5/066 , A61B5/4836 , A61B5/742 , A61B8/06 , A61B8/4472 , A61B34/20 , A61B34/25 , A61B2017/00022 , A61B2017/00026 , A61B2017/00053 , A61B2017/00084 , A61B2017/00243 , A61B2017/00336 , A61B2017/22051 , A61B2034/105 , A61B2090/376 , A61B2090/378 , A61B2090/3983
摘要： A volume of a patient can be mapped with a system operable to identify a plurality of locations and save a plurality of locations of a mapping instrument. The mapping instrument can include one or more electrodes that can sense a voltage that can be correlated to a three dimensional location of the electrode at the time of the sensing or measurement. Therefore, a map of a volume can be determined based upon the sensing of the plurality of points without the use of other imaging devices. An implantable medical device can then be navigated relative to the mapping data.
摘要翻译：可以利用可操作以识别多个位置并且存储映射仪器的多个位置的系统来映射患者体积。映射仪器可以包括一个或多个电极，其可以感测在感测或测量时可以与电极的三维位置相关联的电压。因此，可以基于多个点的感测而不使用其它成像装置来确定体积的映射。然后可以相对于映射数据导航可植入医疗装置。

58. 发明授权

US08839798B2 System and method for determining sheath location 有权
标题翻译：用于确定护套位置的系统和方法
公开(公告)号：US08839798B2
公开(公告)日：2014-09-23
申请号：US12421375
申请日：2009-04-09
申请人： H. Toby Markowitz , Chad Giese , Jeff Jannicke , Steven L. Waldhauser
发明人： H. Toby Markowitz , Chad Giese , Jeff Jannicke , Steven L. Waldhauser
IPC分类号： A61B19/00
CPC分类号： A61B5/06 , A61B5/0215 , A61B5/0422 , A61B5/053 , A61B5/0538 , A61B5/063 , A61B6/12 , A61B34/20 , A61B2034/2046 , A61B2034/2051 , A61B2034/2053 , A61B2034/2072 , G06K2209/05 , G06K2209/057
摘要： A system for determining a location of an instrument within an anatomy is provided. The system can include a first instrument, which can define at least one lumen. The system can further include a second instrument, which can be received through the at least one lumen. The system can include at least one electrode, which can be coupled to a distal end of the first instrument. The electrode can be responsive to electrical activity to generate at least one signal. The system can include a sensing unit, which can be in contact with the anatomy to sense electrical activity within the anatomy at a location near the instrument. The sensing unit can be in communication with the electrode to receive the signal. The system can further include a control module that can determine, based on the sensed electrical activity and the signal, the location of the first instrument.
摘要翻译：提供了一种用于确定在解剖结构内的仪器的位置的系统。该系统可以包括可以限定至少一个内腔的第一仪器。该系统还可以包括可以通过至少一个内腔接收的第二仪器。该系统可以包括至少一个电极，其可以联接到第一仪器的远端。电极可以响应于电活动以产生至少一个信号。系统可以包括感测单元，其可以与解剖结构接触以感测在仪器附近的位置处的解剖结构内的电活动。感测单元可以与电极连通以接收信号。该系统还可以包括控制模块，该控制模块可以基于检测到的电活动和信号来确定第一仪器的位置。

59. 发明授权

US08457371B2 Method and apparatus for mapping a structure 有权
标题翻译：用于映射结构的方法和装置
公开(公告)号：US08457371B2
公开(公告)日：2013-06-04
申请号：US12117549
申请日：2008-05-08
申请人： H. Toby Markowitz , Karl Evan Nowak , Mustafa Karamanoglu , Pooja Mehta , Ioana Fleming , David Scanlon , Michael Kryger , Sean Campbell-Massa , Chad Giese , Victoria Interrante , Phillip Falkner
发明人： H. Toby Markowitz , Karl Evan Nowak , Mustafa Karamanoglu , Pooja Mehta , Ioana Fleming , David Scanlon , Michael Kryger , Sean Campbell-Massa , Chad Giese , Victoria Interrante , Phillip Falkner
IPC分类号： G06K9/00 , A61B5/05
CPC分类号： A61B5/063 , A61B5/0215 , A61B5/0422 , A61B5/053 , A61B5/0536 , A61B5/06 , A61B5/066 , A61B5/742 , A61B6/12 , A61B34/20 , A61B2034/2046 , A61B2034/2051 , A61B2034/2072 , G06K2209/05 , G06K2209/057
摘要： An area of a patient can be mapped with a system operable to identify a plurality of locations and save a plurality of locations of a mapping instrument. The mapping instrument can include one or more electrodes that can sense a voltage that can be correlated to a three dimensional location of the electrode at the time of the sensing or measurement. Therefore, a map of an area or volume can be determined based upon the sensing of the plurality of points without the use of an imaging device. An implantable medical device can then be navigated relative to the mapping data.
摘要翻译：可以利用可操作以识别多个位置并且存储映射仪器的多个位置的系统来映射患者的区域。映射仪器可以包括一个或多个电极，其可以感测在感测或测量时可以与电极的三维位置相关联的电压。因此，可以基于多个点的感测而不使用成像装置来确定面积或体积的图。然后可以相对于映射数据导航可植入医疗装置。

60. 发明授权

US08340751B2 Method and apparatus for determining tracking a virtual point defined relative to a tracked member 有权
标题翻译：用于确定跟踪相对于被跟踪的成员定义的虚拟点的方法和装置
公开(公告)号：US08340751B2
公开(公告)日：2012-12-25
申请号：US12422689
申请日：2009-04-13
申请人： H. Toby Markowitz , Mustafa Karamanoglu , Pooja Mehta , Ioana Fleming , David A. Scanlon , Michael Kryger , Sean Campbell-Massa , Chad Giese , Steven L. Waldhauser , Shangqian Peter Zhang , Jeff Jannicke , Phillip Falkner , Don Hefner , Eduardo N. Warman , James Steeves , Rogier Receveur , Koen Michels , Olaf Eick , Vincent Larik
发明人： H. Toby Markowitz , Mustafa Karamanoglu , Pooja Mehta , Ioana Fleming , David A. Scanlon , Michael Kryger , Sean Campbell-Massa , Chad Giese , Steven L. Waldhauser , Shangqian Peter Zhang , Jeff Jannicke , Phillip Falkner , Don Hefner , Eduardo N. Warman , James Steeves , Rogier Receveur , Koen Michels , Olaf Eick , Vincent Larik
IPC分类号： A61B5/042
CPC分类号： A61B5/0422 , A61B5/0215 , A61B5/053 , A61B5/06 , A61B5/062 , A61B5/066 , A61B5/068 , A61B6/12 , A61B34/20 , A61B2034/2046 , A61B2034/2051 , A61B2034/2072 , G06K9/00201 , G06K2209/057
摘要： An volume of a patient can be mapped with a system operable to identify a plurality of locations and save a plurality of locations of a mapping instrument. The mapping instrument can include one or more electrodes that can sense a voltage that can be correlated to a three dimensional location of the electrode at the time of the sensing or measurement. Therefore, a map of a volume can be determined based upon the sensing of the plurality of points without the use of other imaging devices. An implantable medical device can then be navigated relative to the mapping data.
摘要翻译：可以用可操作以识别多个位置并且存储映射仪器的多个位置的系统来映射患者体积。映射仪器可以包括一个或多个电极，其可以感测在感测或测量时可以与电极的三维位置相关联的电压。因此，可以基于多个点的感测而不使用其它成像装置来确定体积的映射。然后可以相对于映射数据导航可植入医疗装置。

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