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51. 发明申请

US20090247856A1 POLYMER MEMBRANES FOR CONTINUOUS ANALYTE SENSORS 审中-公开
公开(公告)号：US20090247856A1
公开(公告)日：2009-10-01
申请号：US12413231
申请日：2009-03-27
申请人： Robert Boock , Monica A. Rixman , Huashi Zhang , Michael J. Estes , Kristina Lawrence
发明人： Robert Boock , Monica A. Rixman , Huashi Zhang , Michael J. Estes , Kristina Lawrence
IPC分类号： A61B5/1468
CPC分类号： C12Q1/002 , A61B5/14532 , A61B5/14546 , A61B5/1486 , A61B5/14865 , C12Q1/006
摘要： Devices and methods are described for providing continuous measurement of an analyte concentration. In some embodiments, the device has a sensing mechanism and a sensing membrane that includes at least one surface-active group-containing polymer and that is located over the sensing mechanism. The sensing membrane may have a bioprotective layer configured to substantially block the effect and/or influence of non-constant noise-causing species.

52. 发明申请

US20090247855A1 POLYMER MEMBRANES FOR CONTINUOUS ANALYTE SENSORS 审中-公开
标题翻译：用于连续分析仪传感器的聚合物膜
公开(公告)号：US20090247855A1
公开(公告)日：2009-10-01
申请号：US12413166
申请日：2009-03-27
申请人： Robert Boock , Monica A. Rixman , Huashi Zhang , Michael J. Estes , Kristina Lawrence
发明人： Robert Boock , Monica A. Rixman , Huashi Zhang , Michael J. Estes , Kristina Lawrence
IPC分类号： A61B5/1468
CPC分类号： C12Q1/002 , A61B5/14532 , A61B5/14546 , A61B5/1486 , A61B5/14865 , C12Q1/006
摘要： Devices and methods are described for providing continuous measurement of an analyte concentration. In some embodiments, the device has a sensing mechanism and a sensing membrane that includes at least one surface-active group-containing polymer and that is located over the sensing mechanism. The sensing membrane may have a bioprotective layer configured to substantially block the effect and/or influence of non-constant noise-causing species.
摘要翻译：描述了用于提供分析物浓度的连续测量的装置和方法。在一些实施例中，该装置具有感测机构和感测膜，其包括至少一个含表面活性基团的聚合物并且位于感测机构上方。感测膜可以具有生物保护层，其被配置为基本上阻挡非恒定噪声产生物质的影响和/或影响。

53. 发明申请

US20090131768A1 ANALYTE SENSOR 有权
公开(公告)号：US20090131768A1
公开(公告)日：2009-05-21
申请号：US12267547
申请日：2008-11-07
申请人： Peter C. Simpson , Michael J. Estes , Paul V. Neale , Robert Boock , Jacob S. Leach , Richard C. Yang
发明人： Peter C. Simpson , Michael J. Estes , Paul V. Neale , Robert Boock , Jacob S. Leach , Richard C. Yang
IPC分类号： A61B5/145
CPC分类号： C12Q1/001 , A61B5/0031 , A61B5/145 , A61B5/14532 , A61B5/14539 , A61B5/14542 , A61B5/14546 , A61B5/14865 , A61B5/1495 , A61B5/412 , A61B5/4839 , A61B5/6848 , A61B5/6849 , A61B5/7275 , A61B5/743 , A61B2560/0223 , A61B2560/04 , A61B2562/085 , A61M5/14 , A61M5/16804 , A61M5/1723 , A61M25/007 , A61M2005/14296 , A61M2230/201 , C12Q1/006 , G06F19/3468 , G16H40/40 , Y02A90/26
摘要： Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes a vascular access device, a sensor and sensor electronics, the system being configured for insertion into communication with a host's circulatory system.

54. 发明申请

US20070104752A1 Aneurysm embolization material and device 审中-公开
标题翻译：动脉瘤栓塞材料及装置
公开(公告)号：US20070104752A1
公开(公告)日：2007-05-10
申请号：US10967667
申请日：2004-10-18
申请人： Jeffrey Lee , Marie Calabria , Aurthur Bertelson , Robert Boock
发明人： Jeffrey Lee , Marie Calabria , Aurthur Bertelson , Robert Boock
IPC分类号： A61F13/00
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/1214 , A61B17/1219 , A61B2017/00022 , A61B2017/0003 , A61B2017/00477 , A61B2017/12054 , A61B2017/12068 , A61B2017/12072 , A61M2205/36
摘要： The present invention includes a method for treating an aneurysm. The method includes providing a biocompatible polymeric string or hollow tube and transporting the string or hollow tube to the aneurysm. The aneurysm is filled with the string. The string is cut when the aneurysm is substantially filled.
摘要翻译：本发明包括一种治疗动脉瘤的方法。该方法包括提供生物相容性聚合物线或中空管并且将线或中空管输送到动脉瘤。动脉瘤充满了字符串。当动脉瘤基本上被填满时，切割该绳。

55. 发明申请

US20220211301A1 Electrochemical Sensing System 有权
公开(公告)号：US20220211301A1
公开(公告)日：2022-07-07
申请号：US17577544
申请日：2022-01-18
申请人： Jeff T. Suri , Robert Boock
发明人： Jeff T. Suri , Robert Boock
IPC分类号： A61B5/1468 , G01N27/28 , G01N27/327 , G01N27/416
摘要： In some embodiments, an electrochemical sensing system includes a working electrode and a reference electrode. At least a portion of the working electrode includes rhodium. An electrical circuit is electronically coupled to the working electrode and the reference electrode. The electrical circuit is configured to bias the working electrode at voltage of less than about 0.4 V which is sufficient to electrochemically decompose a target analyte, and to measure a current corresponding to the concentration of the target analyte. In some embodiments, a biosensing molecule can be disposed on the working electrode and is operative to catalytically decompose a non-electroactive target analyte to yield and an electroactive by-product. In some embodiment, the reference electrode can include rhodium and its oxides.

56. 发明授权

US09237864B2 Analyte sensors and methods of manufacturing same 有权
公开(公告)号：US09237864B2
公开(公告)日：2016-01-19
申请号：US12829306
申请日：2010-07-01
申请人： Peter C. Simpson , Robert Boock , Paul V. Neale , Sebastian Bohm , Matthew Wightlin , Jack Pryor , Jason Mitchell , Jeff Jackson , Kaushik Patel , Antonio C. Llevares
发明人： Peter C. Simpson , Robert Boock , Paul V. Neale , Sebastian Bohm , Matthew Wightlin , Jack Pryor , Jason Mitchell , Jeff Jackson , Kaushik Patel , Antonio C. Llevares
IPC分类号： A61B5/00 , A61B5/1473 , A61B5/145 , A61B5/1486 , B05C3/10
CPC分类号： A61B5/1473 , A61B5/14503 , A61B5/1451 , A61B5/14517 , A61B5/14532 , A61B5/14546 , A61B5/14865 , A61B2560/0223 , A61B2562/0209 , A61B2562/043 , A61B2562/125 , B05C3/10
摘要： Analyte sensors and methods of manufacturing same are provided, including analyte sensors comprising multi-axis flexibility. For example, a multi-electrode sensor system 800 comprising two working electrodes and at least one reference/counter electrode is provided. The sensor system 800 comprises first and second elongated bodies E1, E2, each formed of a conductive core or of a core with a conductive layer deposited thereon, insulating layer 810 that separates the conductive layer 820 from the elongated body, a membrane layer deposited on top of the elongated bodies E1, E2, and working electrodes 802′, 802″ formed by removing portions of the conductive layer 820 and the insulating layer 810, thereby exposing electroactive surface of the elongated bodies E1, E2.

57. 发明授权

US08583204B2 Polymer membranes for continuous analyte sensors 有权
公开(公告)号：US08583204B2
公开(公告)日：2013-11-12
申请号：US12718299
申请日：2010-03-05
申请人： Robert Boock , Monica A. Rixman , Huashi Zhang , Michael J. Estes , Kristina Lawrence
发明人： Robert Boock , Monica A. Rixman , Huashi Zhang , Michael J. Estes , Kristina Lawrence
IPC分类号： A61B5/05 , A61B5/00
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/14546 , A61B5/1468 , A61B5/1473 , A61B5/1486 , A61B5/7203 , B33Y70/00 , C12Q1/006 , G01N27/40
摘要： Devices and methods are described for providing continuous measurement of an analyte concentration. In some embodiments, the device has a sensing mechanism and a sensing membrane that includes at least one surface-active group-containing polymer and that is located over the sensing mechanism. The sensing membrane may have a bioprotective layer configured to substantially block the effect and/or influence of non-constant noise-causing species.

58. 发明授权

US08543184B2 Silicone based membranes for use in implantable glucose sensors 有权
公开(公告)号：US08543184B2
公开(公告)日：2013-09-24
申请号：US13277997
申请日：2011-10-20
申请人： Robert Boock , Monica Rixman
发明人： Robert Boock , Monica Rixman
IPC分类号： A61B5/05 , A61B5/00
CPC分类号： A61B5/14532 , A61B5/14865 , A61B5/6848 , B33Y70/00 , C08G77/12 , C08G77/20 , C08G77/46 , C08L83/04 , C08L2666/14
摘要： Membrane systems incorporating silicone polymers are described for use in implantable analyte sensors. Some layers of the membrane system may comprise a blend of a silicone polymer with a hydrophilic polymer, for example, a triblock poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) polymer. Such polymeric blends provide for both high oxygen solubility and aqueous analyte solubility.

59. 发明申请

US20120310281A1 SUTURE ANCHOR WITH IMPROVED DRIVE HEAD 审中-公开
标题翻译：具有改进的驱动头的固定锚
公开(公告)号：US20120310281A1
公开(公告)日：2012-12-06
申请号：US13589468
申请日：2012-08-20
申请人： Robert Boock , Nathan Cauldwell
发明人： Robert Boock , Nathan Cauldwell
IPC分类号： A61B17/04
CPC分类号： A61B17/0401 , A61B2017/0409 , A61B2017/0414 , A61B2017/044
摘要： A suture anchor is provided including an elongate shank defining a longitudinal axis and having at least one bone-engaging thread formed thereon, and a drive head having a proximal end and a distal end mated to the elongate shank. The drive head has a substantially oval shape and includes at least one suture attachment member formed in a portion of the drive head. The configuration of the drive head is particularly advantages in that it provides a suture anchor having improved physical properties, including a high failure torque and a high stripping strength.
摘要翻译：提供了缝合锚，其包括限定纵向轴线的细长柄，并且具有形成在其上的至少一个骨接合螺纹，以及具有与所述细长柄配合的近端和远端的驱动头。驱动头具有大致椭圆形并且包括形成在驱动头的一部分中的至少一个缝合线附接构件。驱动头的构造是特别的优点，因为它提供了具有改进的物理性能的缝合锚，其包括高故障扭矩和高剥离强度。

60. 发明申请

US20110077490A1 TRANSCUTANEOUS ANALYTE SENSOR 有权
标题翻译： TRANSCUTANEOUS分析仪传感器
公开(公告)号：US20110077490A1
公开(公告)日：2011-03-31
申请号：US12893850
申请日：2010-09-29
申请人： Peter C. Simpson , Robert Boock , Sebastian Bohm , James H. Brauker , Paul V. Neale
发明人： Peter C. Simpson , Robert Boock , Sebastian Bohm , James H. Brauker , Paul V. Neale
IPC分类号： A61B5/1473
CPC分类号： A61B5/14865 , A61B5/14503 , A61B5/14532 , A61B5/14546 , A61B5/1468 , A61B5/1473 , A61B5/1486 , A61B5/6843 , A61B5/6848 , A61B5/6849 , A61B2560/0443 , A61B2562/0209 , A61B2562/04
摘要： A transcutaneous sensor device configured for continuously measuring analyte concentrations in a host is provided. In some embodiments, the transcutaneous sensor device 100 comprises an in vivo portion 160 configured for insertion under the skin 180 of the host and an ex vivo portion 170 configured to remain above the surface of the skin 180 of the host after sensor insertion of the in vivo portion. The in vivo portion may comprise a tissue piercing element 110 configured for piercing the skin 180 of the host and a sensor body 120 comprising a material or support member 130 that provides sufficient column strength to allow the sensor body to be pushable in a host tissue without substantial buckling. The ex vivo portion 170 may be configured to comprise (or operably connect to) a sensor electronics unit and may comprise a mounting unit 150. Also described here are various configurations of the sensor body and the tissue piercing element that may be used to protect the membrane of the sensor body.
摘要翻译：提供了经配置以连续测量宿主中的分析物浓度的经皮传感器装置。在一些实施例中，经皮传感器装置100包括构造成用于插入主体皮肤180下方的体内部分160，以及配置成在传感器插入入口之后保留在主体的皮肤180的表面上方的离体部分170 体内部分。体内部分可以包括构造成用于刺穿主体的皮肤180的组织刺穿元件110和传感器主体120，传感器主体120包括提供足够的柱强度的材料或支撑构件130，以允许传感器主体能够在主机组织中推动而没有实质屈曲。离体部分170可以被配置为包括（或可操作地连接）传感器电子单元，并且可以包括安装单元150.这里还描述了传感器主体和组织刺穿元件的各种构造，其可以用于保护传感器体的膜。

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