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51. 发明申请

US20110307025A1 SYSTEMS AND METHODS FOR AVOIDING NEURAL STIMULATION HABITUATION 有权
标题翻译：用于避免神经刺激症状的系统和方法
公开(公告)号：US20110307025A1
公开(公告)日：2011-12-15
申请号：US13217794
申请日：2011-08-25
申请人： Imad Libbus , Andrew P. Kramer
发明人： Imad Libbus , Andrew P. Kramer
IPC分类号： A61N1/365 , A61N1/36
CPC分类号： A61N1/36117 , A61N1/36053 , A61N1/36057 , A61N1/36114 , A61N1/36167 , A61N1/37235
摘要： An embodiment relates to a method for delivering a vagal stimulation therapy to a vagus nerve, including delivering a neural stimulation signal to non-selectively stimulate both afferent axons and efferent axons in the vagus nerve according to a predetermined schedule for the vagal stimulation therapy, and selecting a value for at least one parameter for the predetermined schedule for the vagal stimulation therapy to control the neural stimulation therapy to avoid physiological habituation to the vagal stimulation therapy. The parameter(s) include at least one parameter selected from the group of parameters consisting of a predetermined therapy duration parameter for a predetermined therapy period, and a predetermined intermittent neural stimulation parameter associated with on/off timing for the intermittent neural stimulation parameter.
摘要翻译：一个实施方案涉及一种用于将迷走神经刺激治疗递送至迷走神经的方法，包括递送神经刺激信号以根据迷走神经刺激治疗的预定时间表非迷走神经中的输入轴突和传出轴突两者非选择性地刺激，以及选择用于迷走神经刺激治疗的预定时间表的至少一个参数的值以控制神经刺激疗法以避免迷走神经刺激治疗的生理习惯。该参数包括从由用于预定治疗期间的预定治疗持续时间参数组成的参数组中选择的至少一个参数以及与用于间歇神经刺激参数的开启/关闭定时相关联的预定间歇神经刺激参数。

52. 发明授权

US08032215B2 Method and apparatus for controlling autonomic balance using neural stimulation 有权
标题翻译：使用神经刺激来控制自主神经平衡的方法和装置
公开(公告)号：US08032215B2
公开(公告)日：2011-10-04
申请号：US12483031
申请日：2009-06-11
申请人： Imad Libbus , Andrew P. Kramer , Julio C. Spinelli
发明人： Imad Libbus , Andrew P. Kramer , Julio C. Spinelli
IPC分类号： A61N1/362
CPC分类号： A61N1/36057 , A61N1/36114 , A61N1/36139 , A61N1/3621 , A61N1/3627 , A61N1/36585
摘要： A neural stimulation system senses autonomic activities and applies neural stimulation to sympathetic and parasympathetic nerves to control autonomic balance. The neural stimulation system is capable of delivering neural stimulation pulses for sympathetic excitation, sympathetic inhibition, parasympathetic excitation, and parasympathetic inhibition.
摘要翻译：神经刺激系统感知自主活动，并将神经刺激应用于交感神经和副交感神经以控制自主神经平衡。神经刺激系统能够传递交感神经激励，交感神经抑制，副交感神经激动和副交感神经抑制的神经刺激脉冲。

53. 发明授权

US08010198B2 Systems and methods for avoiding neural stimulation habituation 有权
标题翻译：避免神经刺激习惯的系统和方法
公开(公告)号：US08010198B2
公开(公告)日：2011-08-30
申请号：US12231372
申请日：2008-09-02
申请人： Imad Libbus , Andrew P. Kramer
发明人： Imad Libbus , Andrew P. Kramer
IPC分类号： A61N1/00
CPC分类号： A61N1/36117 , A61N1/36053 , A61N1/36057 , A61N1/36114 , A61N1/36167 , A61N1/37235
摘要： An embodiment relates to a method for delivering a vagal stimulation therapy to a vagus nerve, including delivering a neural stimulation signal to non-selectively stimulate both afferent axons and efferent axons in the vagus nerve according to a predetermined schedule for the vagal stimulation therapy, and selecting a value for at least one parameter for the predetermined schedule for the vagal stimulation therapy to control the neural stimulation therapy to avoid physiological habituation to the vagal stimulation therapy. The parameter(s) include at least one parameter selected from the group of parameters consisting of a predetermined therapy duration parameter for a predetermined therapy period, and a predetermined intermittent neural stimulation parameter associated with on/off timing for the intermittent neural stimulation parameter.
摘要翻译：一个实施方案涉及一种用于将迷走神经刺激治疗递送至迷走神经的方法，包括递送神经刺激信号以根据迷走神经刺激治疗的预定时间表非迷走神经中的输入轴突和传出轴突两者非选择性地刺激，以及选择用于迷走神经刺激治疗的预定时间表的至少一个参数的值以控制神经刺激疗法以避免迷走神经刺激治疗的生理习惯。该参数包括从由用于预定治疗期间的预定治疗持续时间参数组成的参数组中选择的至少一个参数以及与用于间歇神经刺激参数的开启/关闭定时相关联的预定间歇神经刺激参数。

54. 发明授权

US08005543B2 Heart failure management system 有权
标题翻译：心力衰竭管理系统
公开(公告)号：US08005543B2
公开(公告)日：2011-08-23
申请号：US11382128
申请日：2006-05-08
申请人： Imad Libbus , Krzysztof Z. Siejko , Marina V. Brockway , Robert J. Sweeney
发明人： Imad Libbus , Krzysztof Z. Siejko , Marina V. Brockway , Robert J. Sweeney
IPC分类号： A61N1/362
CPC分类号： A61B5/0205 , A61B5/0031 , A61B5/0215 , A61B5/02158 , A61B5/0402 , A61B5/0488 , A61N1/36114 , A61N1/36117 , A61N1/36128 , A61N1/36139 , A61N1/3627 , A61N1/36514 , A61N1/36521 , A61N1/36542 , A61N1/36564 , A61N1/36578 , A61N1/36585 , A61N1/36592 , A61N1/372 , A61N1/37288
摘要： Various system embodiments comprise a stimulator adapted to deliver a stimulation signal for a heart failure therapy, a number of sensors adapted to provide at least a first measurement of a heart failure status and a second measurement of the heart failure status, and a controller. The controller is connected to the stimulator and to the number of sensors. The controller is adapted to use the first and second measurements to create a heart failure status index, and control the stimulator to modulate the signal using the index. Other aspects and embodiments are provided herein.
摘要翻译：各种系统实施例包括适于递送用于心力衰竭治疗的刺激信号的刺激器，适于提供心力衰竭状态的至少第一测量和心力衰竭状态的第二测量的多个传感器以及控制器。控制器连接到刺激器和传感器的数量。控制器适于使用第一和第二测量来创建心力衰竭状态指数，并且使用该索引来控制刺激器来调制信号。本文提供了其它方面和实施例。

55. 发明授权

US08000793B2 Automatic baroreflex modulation based on cardiac activity 有权
标题翻译：基于心脏活动的自动压力反射调制
公开(公告)号：US08000793B2
公开(公告)日：2011-08-16
申请号：US12126182
申请日：2008-05-23
申请人： Imad Libbus
发明人： Imad Libbus
IPC分类号： A61N1/05
CPC分类号： A61N1/36139 , A61B5/0215 , A61B5/0452 , A61B5/1118 , A61B5/4035 , A61B5/4047 , A61N1/3611 , A61N1/36117
摘要： An aspect relates to a system for providing baroreflex stimulation. An embodiment of the system comprises a cardiac activity monitor to sense cardiac activity and provide a signal indicative of the cardiac activity, and a baroreflex stimulator. The stimulator includes a pulse generator and a modulator. The pulse generator provides a baroreflex stimulation signal adapted to provide a baroreflex therapy. The modulator receives the signal indicative of the cardiac activity and modulates the baroreflex stimulation signal based on the signal indicative of the cardiac activity to change the baroreflex therapy from a first baroreflex therapy to a second baroreflex therapy.
摘要翻译：一个方面涉及一种用于提供压力反射刺激的系统。系统的一个实施例包括用于感测心脏活动并提供指示心脏活动的信号的心脏活动监测器和压力反射刺激器。刺激器包括脉冲发生器和调制器。脉冲发生器提供适于提供压力反射疗法的压力反射刺激信号。调制器接收指示心脏活动的信号，并且基于指示心脏活动的信号调节压力反射刺激信号，以将压力反射治疗从第一压力反射治疗改变为第二压力反射治疗。

56. 发明申请

US20110112592A1 NEURAL STIMULATION SYSTEM TO PREVENT SIMULTANEOUS ENERGY DISCHARGES 有权
标题翻译：神经刺激系统，以防止同时进行的能量消耗
公开(公告)号：US20110112592A1
公开(公告)日：2011-05-12
申请号：US13007739
申请日：2011-01-17
申请人： Imad Libbus , Andrew P. Kramer , William J. Linder , Jeffrey E. Stahmann
发明人： Imad Libbus , Andrew P. Kramer , William J. Linder , Jeffrey E. Stahmann
IPC分类号： A61N1/36 , A61N1/362 , A61N1/39
CPC分类号： A61N1/36114 , A61N1/3962
摘要： Various aspects of the present subject matter relate to a system. Various embodiments of the system comprise at least one port to connect to at least one lead with at least one electrode, at least one stimulator circuit and at least one controller. The at least one stimulator circuit is connected to the at least one port and is adapted to deliver neural stimulation to a neural stimulation target using the at least one electrode. The at least one controller is adapted to determine when another energy discharge other than the neural stimulation to the neural stimulation target is occurring and to prevent delivery of the neural stimulation simultaneously with the other energy discharge. Other aspects and embodiments are provided herein.
摘要翻译：本主题的各个方面涉及系统。系统的各种实施例包括至少一个端口，以连接至少一个引线与至少一个电极，至少一个刺激器电路和至少一个控制器。所述至少一个刺激器电路连接到所述至少一个端口，并且适于使用所述至少一个电极将神经刺激递送到神经刺激靶。所述至少一个控制器适于确定何时发生除了对神经刺激靶的神经刺激以外的其他能量放电，并且防止神经刺激与另一能量放电同时传送。本文提供了其它方面和实施例。

57. 发明申请

US20100324620A1 PERCUTANEOUS NEUROSTIMULATOR FOR MODULATING CARDIOVASCULAR FUNCTION 有权
标题翻译：用于调节心脏功能的PERCUTANEOUS神经调节器
公开(公告)号：US20100324620A1
公开(公告)日：2010-12-23
申请号：US12869579
申请日：2010-08-26
申请人： Imad Libbus , Anthony V. Caparso , Andrew P. Kramer
发明人： Imad Libbus , Anthony V. Caparso , Andrew P. Kramer
IPC分类号： A61N1/36
CPC分类号： A61N1/05 , A61N1/36014 , A61N1/36017 , A61N1/36114 , A61N1/365 , A61N1/37211 , A61N1/37252 , A61N1/37288
摘要： A neurostimulation device includes an external neurostimulator worn by a patient using a bracing element that braces a portion of the patient's body. The external neurostimulator delivers neurostimulation to modulate a cardiovascular function of the patient. In one embodiment, the external stimulator delivers neurostimulation percutaneously to a stimulation target in the patient's body using at least one percutaneous stimulation electrode having a distal end lodged on or near the stimulation target.
摘要翻译：神经刺激装置包括由患者佩戴的外部神经刺激器，其使用支撑患者身体的一部分的支撑元件。外部神经刺激仪提供神经刺激来调节患者的心血管功能。在一个实施例中，外部刺激器使用至少一个经皮刺激电极将刺激神经刺激经皮刺激到患者体内的刺激目标，所述经皮刺激电极具有放置在刺激靶上或附近的远端。

58. 发明申请

US20100298898A1 BAROREFLEX ACTIVATION FOR ARRHYTHMIA TREATMENT 审中-公开
标题翻译： BAROREFLEX激活ARRHYTHMIA治疗
公开(公告)号：US20100298898A1
公开(公告)日：2010-11-25
申请号：US12850245
申请日：2010-08-04
申请人： Imad Libbus
发明人： Imad Libbus
IPC分类号： A61N1/365 , A61N1/36 , A61N1/39
CPC分类号： A61N1/36117 , A61N1/36139 , A61N1/3627 , A61N1/36564
摘要： An aspect of the present subject matter relates to a system for providing baroreflex stimulation. An embodiment of the system comprises an adverse event detector to sense an adverse event and provide a signal indicative of the adverse event, and a baroreflex stimulator. The stimulator includes a pulse generator to provide a baroreflex stimulation signal adapted to provide a baroreflex therapy, and a modulator to receive the signal indicative of the adverse event and modulate the baroreflex stimulation signal based on the signal indicative of the adverse event to change the baroreflex therapy from a first baroreflex therapy to a second baroreflex therapy. Other aspects are provided herein.
摘要翻译：本主题的一个方面涉及一种用于提供压力反射刺激的系统。系统的实施例包括用于感测不利事件并提供指示不利事件的信号的不利事件检测器和压力反射激励器。刺激器包括脉冲发生器以提供适于提供压力反射治疗的压力反射刺激信号，以及调制器，用于接收指示不利事件的信号，并且基于指示不利事件的信号来调节压力反射刺激信号以改变压力反射从第一次压力反射治疗到第二次压力反射治疗。本文提供了其他方面。

59. 发明授权

US07761151B2 Intermittent high-energy cardiac stimulation for therapeutic effect 有权
标题翻译：间歇性高能心脏刺激治疗效果
公开(公告)号：US07761151B2
公开(公告)日：2010-07-20
申请号：US11466679
申请日：2006-08-23
申请人： Joseph M. Pastore , Imad Libbus , Andrew P. Kramer , Julio C. Spinelli
发明人： Joseph M. Pastore , Imad Libbus , Andrew P. Kramer , Julio C. Spinelli
IPC分类号： A61N1/00
CPC分类号： A61N1/3627 , A61N1/3622
摘要： A device and method for delivering high-energy electrical stimulation to the heart in order to improve cardiac function in heart failure patients. The high-energy stimulation mimics the effects of exercise and improves symptoms even in patients who are exercise intolerant. The high-energy stimulation may be delivered on an intermittent basis either as pacing pulses in accordance with a programmed pacing mode and with a higher pacing pulse energy than used for conventional pacing or as low energy shock pulses.
摘要翻译：用于向心脏递送高能电刺激以改善心力衰竭患者的心脏功能的装置和方法。高能量刺激模拟运动的影响，即使在运动不耐受的患者中也能改善症状。高能量刺激可以间歇地作为起搏脉冲递送，或者作为起搏脉冲根据编程的起搏模式和较高的起搏脉冲能量而不是用于常规起搏或低能量冲击脉冲。

60. 发明授权

US07643875B2 Baroreflex stimulation system to reduce hypertension 有权
标题翻译： Baroreflex刺激系统可以降低高血压
公开(公告)号：US07643875B2
公开(公告)日：2010-01-05
申请号：US10746134
申请日：2003-12-24
申请人： Ronald W. Heil, Jr. , Avram Scheiner , Imad Libbus
发明人： Ronald W. Heil, Jr. , Avram Scheiner , Imad Libbus
IPC分类号： A61N1/36
CPC分类号： A61N1/36117 , A61N1/3627 , A61N1/36564
摘要： Various aspects of the present subject matter provide an implantable medical device. In various embodiments, the device comprises a pulse generator, a lead, a sensor, and a controller. The pulse generator generates a baroreflex stimulation signal as part of a baroreflex therapy. The lead is adapted to be electrically connected to the pulse generator and to be intravascularly fed into a heart. The lead includes an electrode to be positioned in or proximate to the heart to deliver the baroreflex signal to a baroreceptor region in or proximate to the heart. The sensor senses a physiological parameter regarding an efficacy of the baroreflex therapy and provides a signal indicative of the efficacy. The controller is connected to the pulse generator to control the baroreflex stimulation signal and to the sensor to receive the signal indicative of the efficacy of the baroreflex therapy. Other aspects are provided herein.
摘要翻译：本主题的各个方面提供可植入医疗装置。在各种实施例中，装置包括脉冲发生器，引线，传感器和控制器。脉冲发生器产生压力反射刺激信号作为压力反射治疗的一部分。引线适于电连接到脉冲发生器并且被血管内馈送到心脏中。引线包括位于心脏中或靠近心脏的电极，以将压力反射信号传递到心脏中或心脏附近的压力感受器区域。传感器感测关于压力反射治疗的功效的生理参数，并提供指示功效的信号。控制器连接到脉冲发生器以控制压力反射刺激信号和传感器以接收指示压力反射治疗功效的信号。本文提供了其他方面。

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