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51. 发明授权

US09396446B2 Modeling properties of data and events as transformations of document data and system values 有权
标题翻译：将数据和事件的属性建模为文档数据和系统值的转换
公开(公告)号：US09396446B2
公开(公告)日：2016-07-19
申请号：US13284020
申请日：2011-10-28
申请人： Gerd Ritter , Rene Gross , Tim Kornmann , Steffen Tatzel , Dirk Stumpf , Dirk Giebel
发明人： Gerd Ritter , Rene Gross , Tim Kornmann , Steffen Tatzel , Dirk Stumpf , Dirk Giebel
IPC分类号： G06F3/048 , G06Q10/06 , G06Q10/10
CPC分类号： G06Q10/06 , G06Q10/10
摘要： A system and method for modeling properties of data and events of a business application is presented. The system include a user interface frontend system that displays a user interface, and a user interface backend system that hosts a business application that generates the user interface for display in the user interface frontend system. The system further includes an enterprise service framework comprising one or more data processors that define one or more properties of data and/or events related to the business application, and model each of the one or more properties as a data field of the business application. A dynamic properties calculator includes one or more data processors that access a set of transformation logic representing data transformation rules for each of the data fields of the business application, and apply the transformation rules to the data fields that represent the one or more properties.
摘要翻译：介绍了一种用于建模业务应用程序的数据和事件属性建模的系统和方法。该系统包括显示用户界面的用户界面前端系统，以及主机业务应用程序的用户界面后端系统，用于生成用户界面以在用户界面前端系统中显示。所述系统还包括企业服务框架，其包括一个或多个数据处理器，所述数据处理器定义与所述业务应用相关的数据和/或事件的一个或多个属性，以及将所述一个或多个属性中的每个属性建模为所述业务应用的数据字段。动态属性计算器包括访问代表业务应用的每个数据字段的数据变换规则的一组变换逻辑的一个或多个数据处理器，并将转换规则应用于表示一个或多个属性的数据字段。

52. 发明授权

US08694397B2 Consistent set of interfaces derived from a business object model 有权
标题翻译：从业务对象模型派生的一组接口
公开(公告)号：US08694397B2
公开(公告)日：2014-04-08
申请号：US11155368
申请日：2005-06-17
申请人： Michael Seubert , Jochen Rasch , Axel Kuehl , Stefan Adelmann , Gabriel Alvarez , Markus Biehler , Daniel Bock , Andreas Bold , Andreas Brossler , Daniel Buchmann , Renzo Colle , Robert Doerner , Stefan Elfner , Stefan Franke , Werner Gnan , Antonia Gross , Toralf Grossmann , Gerhard Gschwender , Joerg Hendricks , Wolf Hengevoss , Stephan Hetzer , Christine Hofmann , Volker Jaeck , Bernhard Kelnberger , Johann Kemmer , Joachim Kenntner , Adam Kiwon , Karsten Koetter , Thilo Kraehmer , Corinne Kuster , Christoph Lehner , Werner Liebold , Thomas Maag , Otto Makris , Andreas Morsch , Wolfgang Nieswand , Thomas Nitschke , Dietmar Nowotny , Markus Peter , Georg Podhajsky , Dominic Poetschke , Uwe Pyka , Ruediger Radcke , Gregor Rieken , Volker Ripp , Gerd Ritter , Paola Sala , Daniela Schapler , Matthias Schmitt , Andreas Schneider , Arnulf Schueler , Dagmar Schultze , Reiner Seyler , Ralf Sievers , Gunther Stuhec , Frank Thome , Andre Wagner , Rudolf Winkel , Tao Yu , Jens Zachmann , Renato Zadro , Theo Zimmerman , Michael Zoeller
发明人： Michael Seubert , Jochen Rasch , Axel Kuehl , Stefan Adelmann , Gabriel Alvarez , Markus Biehler , Daniel Bock , Andreas Bold , Andreas Brossler , Daniel Buchmann , Renzo Colle , Robert Doerner , Stefan Elfner , Stefan Franke , Werner Gnan , Antonia Gross , Toralf Grossmann , Gerhard Gschwender , Joerg Hendricks , Wolf Hengevoss , Stephan Hetzer , Christine Hofmann , Volker Jaeck , Bernhard Kelnberger , Johann Kemmer , Joachim Kenntner , Adam Kiwon , Karsten Koetter , Thilo Kraehmer , Corinne Kuster , Christoph Lehner , Werner Liebold , Thomas Maag , Otto Makris , Andreas Morsch , Wolfgang Nieswand , Thomas Nitschke , Dietmar Nowotny , Markus Peter , Georg Podhajsky , Dominic Poetschke , Uwe Pyka , Ruediger Radcke , Gregor Rieken , Volker Ripp , Gerd Ritter , Paola Sala , Daniela Schapler , Matthias Schmitt , Andreas Schneider , Arnulf Schueler , Dagmar Schultze , Reiner Seyler , Ralf Sievers , Gunther Stuhec , Frank Thome , Andre Wagner , Rudolf Winkel , Tao Yu , Jens Zachmann , Renato Zadro , Theo Zimmerman , Michael Zoeller
IPC分类号： G06Q40/00
CPC分类号： G06Q40/00 , G06Q10/06 , G06Q10/10
摘要： Methods and systems consistent with the present invention provide a data processing system having a business object model reflecting the data used during a business transaction. Consistent interfaces are generated from the business object model. These interfaces are suitable for use across industries, across businesses, and across different departments within a business during a business transaction.
摘要翻译：与本发明一致的方法和系统提供了一种数据处理系统，其具有反映业务交易中使用的数据的业务对象模型。从业务对象模型生成一致的接口。这些接口适合在业务交易期间跨行业，跨企业以及业务中的不同部门使用。

53. 发明申请

US20120231035A1 METHOD FOR INDUCING CELL LYSIS WITH IMMUNOGENIC PORTIONS OF NY-ESO-1 PROTEIN 有权
标题翻译：用于诱导NY-ESO-1蛋白质免疫原性细胞分析的方法
公开(公告)号：US20120231035A1
公开(公告)日：2012-09-13
申请号：US13404633
申请日：2012-02-24
申请人： Alexander Knuth , Elke Jäger , Yao-tseng Chen , Matthew Scanlan , Ali Gure , Gerd Ritter , Lloyd J. Old , Jan W. Drijfhout
发明人： Alexander Knuth , Elke Jäger , Yao-tseng Chen , Matthew Scanlan , Ali Gure , Gerd Ritter , Lloyd J. Old , Jan W. Drijfhout
IPC分类号： A61K39/00 , A61P37/04 , A61P35/00
CPC分类号： C07K14/4748 , A61K38/00 , Y10S435/81
摘要： The invention relates to peptides which bind to MHC Class I and to MHC Class II molecules. These peptides are useful in different therapeutic and diagnostic contexts.
摘要翻译：本发明涉及结合MHC I类和MHC II类分子的肽。这些肽可用于不同的治疗和诊断情境。

54. 发明申请

US20120183471A1 SPECIFIC BINDING PROTEINS AND USES THEREOF 有权
标题翻译：特异性结合蛋白及其用途
公开(公告)号：US20120183471A1
公开(公告)日：2012-07-19
申请号：US13201061
申请日：2010-02-17
申请人： Lloyd J. Old , Constance Old , Andrew Mark Scott , Gerd Ritter , Achim Jungbluth , Elisabeth Stockert , Stephen Stockert , Vincent Peter Collins , Webster K. Cavenee , Huei-Jen Su Huang , Antony Wilks Burgess , Edouard Collins Nice , Anne Murray , George Mark , Terrance Grant Johns , Con Panousis , Christoph Renner
发明人： Lloyd J. Old , Constance Old , Andrew Mark Scott , Gerd Ritter , Achim Jungbluth , Elisabeth Stockert , Stephen Stockert , Vincent Peter Collins , Webster K. Cavenee , Huei-Jen Su Huang , Antony Wilks Burgess , Edouard Collins Nice , Anne Murray , George Mark , Terrance Grant Johns , Con Panousis , Christoph Renner
IPC分类号： A61K39/395 , A61P35/00 , C12N1/19 , G01N33/574 , C12N5/10 , C12N1/21 , C07K16/30 , A61K51/00
CPC分类号： C07K16/40 , A61K31/495 , A61K39/39541 , A61K39/39558 , A61K47/6871 , A61K51/103 , A61K51/1045 , A61K51/1078 , A61K2039/505 , A61K2300/00 , C07K16/2863 , C07K16/30 , C07K16/4258 , C07K2317/24 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/77 , C07K2317/92
摘要： The present invention relates to specific binding members, particularly antibodies and fragments thereof, which bind to amplified epidermal growth factor receptor (EGFR) and to the de2-7 EGFR truncation of the EGFR. In particular, the epitope recognized by the specific binding members, particularly antibodies and fragments thereof, is enhanced or evident upon aberrant post-translational modification. These specific binding members are useful in the diagnosis and treatment of cancer. The binding members of the present invention may also be used in therapy in combination with chemotherapeutics or anti-cancer agents and/or with other antibodies or fragments thereof.
摘要翻译：本发明涉及结合扩增的表皮生长因子受体（EGFR）和EGFR的de2-7 EGFR截短的特异性结合成员，特别是抗体及其片段。特别地，特异性结合成员识别的表位，特别是其抗体及其片段，在异常翻译后修饰时增强或明显。这些特异性结合成员可用于癌症的诊断和治疗。本发明的结合成员也可用于与化学治疗剂或抗癌剂和/或与其它抗体或其片段组合的治疗中。

55. 发明申请

US20110313230A1 SPECIFIC BINDING PROTEINS AND USES THEREOF 审中-公开
标题翻译：特异性结合蛋白及其用途
公开(公告)号：US20110313230A1
公开(公告)日：2011-12-22
申请号：US13078764
申请日：2011-04-01
申请人： Terrance Grant Johns , Andrew Mark Scott , Gerd Ritter , Achim Jungbluth , Elizabeth Stockert , Stephen Stockert , Vincent Peter Collins , Webster K. Cavenee , Huei-Jen Su Huang , Antony Wilks Burgess , Edouard Collins Nice , Anne Murray , George Mark , Lloyd J. Old , Edward B. Reilly , Andrew C. Phillips , Jonathan A. Meulbroek , Fritz G. Buchanan
发明人： Terrance Grant Johns , Andrew Mark Scott , Gerd Ritter , Achim Jungbluth , Elizabeth Stockert , Stephen Stockert , Vincent Peter Collins , Webster K. Cavenee , Huei-Jen Su Huang , Antony Wilks Burgess , Edouard Collins Nice , Anne Murray , George Mark , Lloyd J. Old , Edward B. Reilly , Andrew C. Phillips , Jonathan A. Meulbroek , Fritz G. Buchanan
IPC分类号： A61N5/00 , A61K38/19 , A61P35/00 , A61K51/00 , A61K38/21 , A61K39/395 , A61K38/20
CPC分类号： A61K39/3955 , A61K39/39541 , A61K39/39558 , A61K45/06 , A61K51/103 , A61K51/1045 , A61K51/1078 , A61K2039/505 , A61K2039/507 , C07K16/22 , C07K16/2863 , C07K16/30 , C07K16/4241 , C07K16/4258 , C07K16/4266 , C07K2299/00 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/77 , C07K2317/90 , C07K2317/92 , A61K2300/00
摘要： The present invention relates to specific binding members, particularly antibodies and fragments thereof, which bind to EGFR on tumor cells that overexpress EGFR, and on tumor cells that express the truncated version of the EGFR receptor, de2-7 EGF. In particular, the epitope recognized by the specific binding members, particularly antibodies and fragments thereof, is enhanced or evident upon aberrant post-translational modification. These specific binding members are useful in the diagnosis and treatment of cancer. The binding members of the present invention may also be used in therapy in combination with chemotherapeutics or anti-cancer agents and/or with other antibodies or fragments thereof.
摘要翻译：本发明涉及在过表达EGFR的肿瘤细胞上结合EGFR的特异性结合成员，特别是抗体及其片段，以及表达EGFR受体截短型de2-7EGF的肿瘤细胞。特别地，特异性结合成员识别的表位，特别是其抗体及其片段，在异常翻译后修饰时增强或明显。这些特异性结合成员可用于癌症的诊断和治疗。本发明的结合成员也可用于与化学治疗剂或抗癌剂和/或与其它抗体或其片段组合的治疗中。

56. 发明授权

US08039670B2 Analogs of alpha galactosyceramide and uses thereof 有权
标题翻译： α半乳糖苷酰胺的类似物及其用途
公开(公告)号：US08039670B2
公开(公告)日：2011-10-18
申请号：US12083673
申请日：2006-10-25
申请人： Vincenzo Cerundolo , Richard Schmidt , Gopal Reddy , Rengarajan Balamurugan , Gerd Ritter , Gurdyal Besra , Mariolina Salio , Jonathan Silk
发明人： Vincenzo Cerundolo , Richard Schmidt , Gopal Reddy , Rengarajan Balamurugan , Gerd Ritter , Gurdyal Besra , Mariolina Salio , Jonathan Silk
IPC分类号： C07C233/18 , C07C233/20 , C07C305/20 , C07F9/09 , A61K31/66 , A61K31/661 , A61K31/16
CPC分类号： C07H15/00
摘要： There are disclosed compound of formula I, in which R1 represents a hydrophobic moiety adapted to occupy the C′ channel of human CDId, R2 represents a hydrophobic moiety adapted to occupy the A′ channel of human CDId, such that R1 fills at least at least 30% of the occupied volume of the C′ channel compared to the volume occupied by the terminal nC14H29 of the sphingosine chain of α-galactosylceramide when bound to human CDId and R2 fills at least 30% of the occupied volume of the A′ channel compared to the volume occupied by the terminal nC25H51 of the acyl chain of α-galactosylceramide when bound to human CDId R3 represents hydrogen or OH, Ra and Rb each represent hydrogen and in addition, when R3 represents hydrogen, Ra and Rb together may form a single bond, X represents or —CHA(CHOH)nY or —P(=0)(0−)0CH2(CH0H)mY, in which Y represents CHB1B2, n represents an integer from 1 to 4, m represents 0 or 1, A årepresents hydrogen, one of B1 and B2 represents H, OH or phenyl, and the other represents hydrogen or one of B1 and B2 represents hydroxyl and the other represents phenyl, in addition, when n represents 4, then A together with one of B1 and B2 together forms a single bond and the other of B1 and B2 represents H, OH or OSO3H and pharmaceutically acceptable salts thereof; the compounds of formula I are indicted for use in the treatment of a virus, microbial infection, parasite, an autoimmune disease, cancer, allergy or asthma.
摘要翻译：公开了式I的化合物，其中R 1表示适于占据人CD1d的C'通道的疏水性部分，R 2表示适于占据人CDId的A'通道的疏水部分，使得R1至少填充至少比较C'通道的占据体积的30％，与结合人CD1d和R2的α-半乳糖神经酰胺的鞘氨醇链末端nC14H29占据的体积相比，填充了A'通道占据体积的至少30％与α-galactosylceramide的酰基链末端nC25H51所占的体积结合到人CDID R3表示氢或OH，Ra和Rb各自表示氢，另外，当R 3表示氢时，R a和R b可以一起形成单键，X表示或-CHA（CHOH）nY或-P（= O）（0-）0CH 2（CHOH）mY，其中Y表示CHB1B2，n表示1至4的整数，m表示0或1，A 表示氢，B1和B2之一表示H，OH或苯基另一个代表氢或B1和B2之一表示羟基，另一个表示苯基，另外，当n表示4时，则A与B1和B2中的一个一起形成单键，而B1和B2中的另一个表示H，OH或OSO 3 H及其药学上可接受的盐; 式I的化合物被指示用于治疗病毒，微生物感染，寄生虫，自身免疫疾病，癌症，变态反应或哮喘。

57. 发明申请

US20110076232A1 SPECIFIC BINDING PROTEINS AND USES THEREOF 审中-公开
标题翻译：特异性结合蛋白及其用途
公开(公告)号：US20110076232A1
公开(公告)日：2011-03-31
申请号：US12890029
申请日：2010-09-24
申请人： Lloyd J. Old , Terrance Grant Johns , Con Panousis , Andrew Mark Scott , Christoph Renner , Achim Jungbluth , Elizabeth Stockert , Vincent Peter Collins , Webster K. Cavenee , Huei-Jen Su Huang , Antony Wilks Burgess , Edouard Collins Nice , Anne Murray , George Mark , Gerd Ritter
发明人： Lloyd J. Old , Terrance Grant Johns , Con Panousis , Andrew Mark Scott , Christoph Renner , Achim Jungbluth , Elizabeth Stockert , Vincent Peter Collins , Webster K. Cavenee , Huei-Jen Su Huang , Antony Wilks Burgess , Edouard Collins Nice , Anne Murray , George Mark , Gerd Ritter
IPC分类号： A61K51/10 , C07K16/28 , A61K39/395 , A61P35/00
CPC分类号： C07K16/2863 , A61K39/39558 , A61K51/103 , A61K51/1045 , A61K2039/505 , A61K2039/507 , A61K2039/545 , C07K16/30 , C07K16/4266 , C07K2317/24 , C07K2317/32 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2317/94 , A61K2300/00
摘要： The present invention relates to specific binding members, particularly antibodies and fragments thereof, which bind to amplified epidermal growth factor receptor (EGFR) and to the de2-7 EGFR truncation of the EGFR. In particular, the epitope recognized by the specific binding members, particularly antibodies and fragments thereof, is enhanced or evident upon aberrant post-translational modification. These specific binding members are useful in the diagnosis and treatment of cancer. The binding members of the present invention may also be used in therapy in combination with chemotherapeutics or anti-cancer agents and/or with other antibodies or fragments thereof.
摘要翻译：本发明涉及结合扩增的表皮生长因子受体（EGFR）和EGFR的de2-7 EGFR截短的特异性结合成员，特别是抗体及其片段。特别地，特异性结合成员识别的表位，特别是其抗体及其片段，在异常翻译后修饰时增强或明显。这些特异性结合成员可用于癌症的诊断和治疗。本发明的结合成员也可用于与化学治疗剂或抗癌剂和/或与其它抗体或其片段组合的治疗中。

58. 发明申请

US20090164932A1 Logging And Evaluating Manual Interactions By Users To Support Optimizing And Streamlining Business Processes 有权
标题翻译：记录和评估用户手动交互以支持优化和优化业务流程
公开(公告)号：US20090164932A1
公开(公告)日：2009-06-25
申请号：US11960666
申请日：2007-12-19
申请人： Gerd Ritter
发明人： Gerd Ritter
IPC分类号： G06F3/048
CPC分类号： G06F17/243 , G06Q10/06 , G06Q10/103 , G06Q30/0224 , G06Q30/0244
摘要： The subject matter disclosed herein provides methods and apparatus, including computer program products, for logging and evaluating activity to support optimizing and streamlining a process, such as a business process. In one aspect, there is provided a computer-implemented method. The method include receiving information representative of activity at a user interface. The received information may be aggregated to form aggregated data. The received information may be evaluated to determine one or more proposals. The evaluation may use the context of a task being performed at the user interface and the activity at the user interface. The one or more proposals may be provided to enable a configuration of a system or a business process with at least one of the proposals. Related apparatus, systems, methods, and articles are also described.
摘要翻译：本文公开的主题提供了用于记录和评估活动以支持优化和简化诸如业务过程之类的过程的计算机程序产品的方法和装置。一方面，提供了一种计算机实现的方法。该方法包括在用户界面处接收表示活动的信息。所收到的信息可以被聚合以形成聚合数据。可以评估所接收的信息以确定一个或多个提案。评估可以使用在用户界面处执行的任务的上下文以及在用户界面处的活动。可以提供一个或多个提案以使得能够利用至少一个提案来配置系统或业务流程。还描述了相关装置，系统，方法和制品。

59. 发明申请

US20070022081A1 Record of data repository access 审中-公开
标题翻译：数据存储库访问记录
公开(公告)号：US20070022081A1
公开(公告)日：2007-01-25
申请号：US11184613
申请日：2005-07-19
申请人： Gerd Ritter
发明人： Gerd Ritter
IPC分类号： G06F17/30
CPC分类号： G06F16/20
摘要： The disclosure relates to computer systems that include 1) a data repository containing several data records and 2) several executable application processes that can cause the computer system to access the data records. A method includes accessing a data record in a data repository, the access of the data record being caused by an application process that is being executed. An electronic record of the data record access is generated, indicating the data record that was accessed and the application process that caused the data record access to occur. The record may reflect data repository access(es) performed during a client-server roundtrip. User behavior may be registered to generate recommendations for improving a data repository access strategy.
摘要翻译：本公开涉及计算机系统，其包括1）包含若干数据记录的数据存储库和2）可使计算机系统访问数据记录的几个可执行应用程序进程。一种方法包括访问数据存储库中的数据记录，由正在执行的应用进程引起的数据记录的访问。生成数据记录访问的电子记录，指示访问的数据记录和导致数据记录访问的应用程序进程发生。该记录可能反映了在客户端 - 服务器往返期间执行的数据存储库访问。可以注册用户行为以产生改进数据存储库访问策略的建议。

60. 发明申请

US20060015878A1 Command entry portal navigation 审中-公开
标题翻译：命令入口门户导航
公开(公告)号：US20060015878A1
公开(公告)日：2006-01-19
申请号：US10890778
申请日：2004-07-14
申请人： Gerd Ritter
发明人： Gerd Ritter
IPC分类号： G06F13/00
CPC分类号： G06F3/0489
摘要： Methods and computer program products that enable command entry portal navigation (CEPN) permit a portal user to navigate directly to a desired tile of information by entering a textual navigation command (TNC) into an input field associated with the portal. The TNC may include a command directing the computer system to interpret the TNC to determine which of a plurality of application programs is to be accessed and displayed on the portal. The TNC may also allow the user to directly perform some action within the target application by entering a single textual command. In some embodiments, the TNC may include additional commands that may be interpreted according to predefined grammar rules. In response to the TNC, the computer system may send information generated by the access to be displayed in a tile within the portal frame.
摘要翻译：启用命令入口门户导航（CEPN）的方法和计算机程序产品允许门户用户通过将文本导航命令（TNC）输入到与门户相关联的输入字段中直接导航到期望的信息块。 TNC可以包括指示计算机系统解释TNC以确定要在门户上访问和显示多个应用程序中的哪一个的命令。 TNC还可以允许用户通过输入单个文本命令直接在目标应用程序中执行某些操作。在一些实施例中，TNC可以包括可以根据预定义的语法规则来解释的附加命令。响应于TNC，计算机系统可以发送由门禁帧内的瓦片中显示的访问生成的信息。

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