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51. 发明授权

US06559318B1 Method for producing (2S,4R,9S)-octahydro-1H-indole-2-carboxylic acid and intermediate products therefor 有权
标题翻译：（2S，4R，9S） - 八氢-1H-吲哚-2-羧酸及其中间产物的制备方法
公开(公告)号：US06559318B1
公开(公告)日：2003-05-06
申请号：US09869651
申请日：2002-02-05
申请人： Klaus Ebel , Frank Ohlbach , Christoph Nübling
发明人： Klaus Ebel , Frank Ohlbach , Christoph Nübling
IPC分类号： C07D20904
CPC分类号： C07D209/42
摘要： Described is a process for the preparation of (2S, 4R, 9S)-octahydro-1H-indole-2-carboxylic acid, comprising a) reacting a compound of the formula I (R1O)2CH—CH2—CH(OR2)2 I wherein R1 and R2 may be the same or different and represent each a C1-4-alkyl group, with water in the presence of an acidic catalyst, b) subjecting the obtained 3,3-dialkoxypropionaldehyde of formula II (R2O)2CH—CH2—CHO II to a Henry-reaction with nitromethane, c) subjecting the obtained 4,4-dialkoxy-1-nitro-4-butanol of formula III (R1O)2CH—CH2—CHOH—CH2—NO2 III to a dehydration d) converting the obtained nitroolefin IV with the aid of a Diels-Alder reaction into the corresponding trans-4-(2,2-dialkoxyethyl)-5-nitro-1-caclohexene V e) hydrogenating the obtained substance V into the corresponding trans-4-(2,2-dialkoxyethyl)-5-amino-1-cyclohexane VI f) subjecting the compound VI to a resolution of racemate and obtaining the (1S, 2R)-1-amino-2-(2,2-dialkoxyethyl)-cyclohexane VII in enantiomerically pure form by enzymatic racemate resolution, g) hydrolysing the obtained compound VII to the corresponding aldehyde VIII h) converting the obtained aldehyde into the corresponding nitrite IX by reaction with cyanide ions and i) saponifying this nitrile to the (2S, 4R, 9S)-octahydro-1H-indole-2-carboxylic acid.
摘要翻译：描述了制备（2S，4R，9S） - 八氢-1H-吲哚-2-羧酸的方法，该方法包括：a）使式Ⅰ化合物，其中R 1和R 2可以相同或不同，在酸性催化剂存在下与水反应，b）将得到的式Ⅱ的3,3-二烷氧基丙醛与硝基甲烷进行亨利反应，c）将得到的4,4'-二烷氧基-1 式Ⅱ的硝基-4-丁醇脱水）将所得的硝基烯烃IV用Diels-Alder反应转化成相应的反式-4-（2,2-二烷氧基乙基）-5-硝基-1-环己烯Ve ）将所得物质V氢化成相应的反式-4-（2,2-二烷氧基乙基）-5-氨基-1-环己烷VIf），使化合物VI拆分外消旋体，得到（1S，2R）-1- 氨基-2-（2,2-二烷氧基乙基） - 环己烷Ⅶ，通过酶促消旋物拆分的对映异构体纯形式，g）将获得的化合物VII水解成对应物通过与氰化物离子反应将所得醛转化成相应的亚硝酸根IX，并且将该腈皂化成（2S，4R，9S） - 八氢-1H-吲哚-2-羧酸。

52. 发明授权

US06531629B1 Method of producing alkanesulfonic acid 有权
标题翻译：烷基磺酸的生产方法
公开(公告)号：US06531629B1
公开(公告)日：2003-03-11
申请号：US09831362
申请日：2001-05-15
申请人： Matthias Eiermann , Christian Tragut , Klaus Ebel
发明人： Matthias Eiermann , Christian Tragut , Klaus Ebel
IPC分类号： C07C30316
CPC分类号： C07C303/16 , C07C309/04
摘要： The invention relates to a process for the prepartaion of alkanesulfonic acids, comprising the following steps: (a) oxidation of alkylmercaptans and/or dialkyl disulfides and/or dialkyl polysulfides having from three to nine sulfur atoms with nitric acid to form alkanesulfonic acids, water, nitrogen oxides and other byproducts, (b) regeneration of the nitrogen oxides obtained from step (a) with oxygen to give nitric acid and recycling of the nitric acid to step (a), where steps (a) and (b) are carried out in reaction chambers separate from one another.
摘要翻译：本发明涉及一种预聚烷基磺酸的方法，包括以下步骤：（a）用硝酸将具有3-9个硫原子的烷基硫醇和/或二烷基二硫化物和/或二烷基多硫化物氧化形成烷烃磺酸，水，氮氧化物和其它副产物，（b）用氧气再生由步骤（a）获得的氮氧化物，得到硝酸并将硝酸再循环至步骤（a），其中步骤（a）和（b）在反应室中彼此分离。

53. 发明授权

US06320055B1 Process for preparing hydantoins or cyclic anhydrides of an amino acid 失效
标题翻译：制备氨基酸的乙内酰脲或环状酸酐的方法
公开(公告)号：US06320055B1
公开(公告)日：2001-11-20
申请号：US09559046
申请日：2000-04-27
申请人： Michael Slany , Michael Schulz , Martin Schäfer , Edgar Zeller , Klaus Ebel
发明人： Michael Slany , Michael Schulz , Martin Schäfer , Edgar Zeller , Klaus Ebel
IPC分类号： C07D26344
CPC分类号： C07D233/76
摘要： Process for preparing compounds of the formula I in which R is alkyl or aryl, in each case unsubstituted or substituted, R3 is hydrogen, alkyl or aryl, in each case unsubstituted or substituted, and X═O or NH, which comprises reacting an aldehyde R—CHO with CO and a compound of the formula II in which R2 is a group which reacts with a —CO2H group, which is formed during the reaction, with ring-closure to give compounds of the formula I, in the presence of a transition metal catalyst described.
摘要翻译：制备式Iin化合物的方法，其中R是烷基或芳基，在每种情况下是未取代或取代的，R 3是氢，烷基或芳基，在每种情况下是未取代或取代的，X = O或NH，其包括使醛R -CHO与CO和式II化合物反应，其中R2是与反应期间形成的-CO 2 H基团反应的基团，其中闭环以在过渡金属存在下进行闭环以得到式I化合物催化剂描述。

54. 发明授权

US06222059B1 Process for the manufacture of aliphatic alpha, omega amino nitriles 有权
标题翻译：用于制造脂肪族α，ω-氨基腈的方法
公开(公告)号：US06222059B1
公开(公告)日：2001-04-24
申请号：US09254570
申请日：1999-03-10
申请人： Klaus Ebel , Rolf Fischer , Klemens Flick , Martin Merger , Guido Voit
发明人： Klaus Ebel , Rolf Fischer , Klemens Flick , Martin Merger , Guido Voit
IPC分类号： C07C25504
CPC分类号： C07C255/24 , C07C209/48 , C07C211/12 , C07C253/30
摘要： A process for preparing aliphatic alpha,omega-amino nitrites by partial hydrogenation of aliphatic alpha,omega-dinitriles in the presence of a catalyst, wherein the catalyst used for the partial hydrogenation comprises (a) iron or a compound based on iron or mixtures thereof and (b) from 0.01 to 5% by weight, based on (a), of a promoter based on 2,3,4 or 5 elements selected from the group consisting of aluminum, silicon, zirconium, titanium and vanadium and (c) from 0 to 5% by weight, based on (a), of a compound based on an alkali metal or alkaline earth metal.
摘要翻译：在催化剂存在下通过部分氢化脂族α，ω-二腈制备脂族α，ω-氨基亚硝酸盐的方法，其中用于部分氢化的催化剂包括（a）铁或基于铁或其混合物的化合物和（b）基于（a）0.01至5重量％的基于2,3,4或5个选自铝，硅，锆，钛和钒的元素的促进剂，和（c）基于（a）的0至5重量％的基于碱金属或碱土金属的化合物。

55. 发明授权

US5972856A Reaction products of polyisobutenes and oxides of nitrogen or mixtures of oxides of nitrogen and oxygen and their use as fuel and lubricant additives 有权
公开(公告)号：US5972856A
公开(公告)日：1999-10-26
申请号：US208448
申请日：1998-12-10
申请人： Rudolf Kropp , Eckhard Hickmann , Klaus Ebel , Wolfgang Gunther , Hans Peter Rath , Harald Schwahn
发明人： Rudolf Kropp , Eckhard Hickmann , Klaus Ebel , Wolfgang Gunther , Hans Peter Rath , Harald Schwahn
IPC分类号： C10L1/234 , C08F8/30 , C08F10/10 , C10L1/14 , C10L1/18 , C10L1/22 , C10L1/222 , C10L1/23 , C10L1/236 , C10L1/238 , C10L10/00 , C10L10/08 , C10M133/02 , C10M133/52 , C10M133/54 , C10M149/14 , C10M159/12 , C10N40/25
CPC分类号： C10M133/54 , C08F8/30 , C10L1/143 , C10L1/221 , C10L1/222 , C10L1/231 , C10L1/238 , C10L10/06 , C10M133/52 , C10L1/1852 , C10L1/188 , C10L1/19 , C10L1/1905 , C10L1/191 , C10L1/1985 , C10L1/2222 , C10L1/2225 , C10L1/223 , C10L1/2235 , C10L1/224 , C10L1/232 , C10L1/2383 , C10L1/2387 , C10M2215/04 , C10M2215/202 , C10M2215/26 , C10N2240/10 , C10N2240/101 , C10N2240/104 , C10N2240/106
摘要： Reaction products of polyisobutenes having an average degree of polymerization P of from 10 to 100 and a content E of from 60 to 90% of double bonds which can react with maleic anhydride, E=100% corresponding to the theoretical value for the case where each molecule of the polyisobutene has such a reactive double bond, with oxides of nitrogen or mixtures of oxides of nitrogen and oxygen, are suitable as additives for fuels, in particular for gasoline engines, and for lubricants.

56. 发明授权

US5962596A Polyformamides and polyamines 失效
标题翻译：聚甲酰胺和多胺
公开(公告)号：US5962596A
公开(公告)日：1999-10-05
申请号：US839801
申请日：1997-04-18
申请人： Klaus Ebel , Hans-Joachim Hahnle
发明人： Klaus Ebel , Hans-Joachim Hahnle
IPC分类号： C07C233/03 , C08F8/00 , C08F8/12 , C08F20/42
CPC分类号： C08F8/04
摘要： A process for obtaining polymers containing N-substituted formamide structural units, in which nitrile-containing polymers are reacted in the presence of 1) hydrogen, and 2) carbon monoxide and/or carbon monoxide-releasing compounds.
摘要翻译：一种获得含有N-取代甲酰胺结构单元的聚合物的方法，其中含腈聚合物在1）氢存在下反应，和2）一氧化碳和/或一氧化碳释放化合物。

57. 发明授权

US5767325A Preparation of enol ethers 失效
标题翻译：烯醇醚的制备
公开(公告)号：US5767325A
公开(公告)日：1998-06-16
申请号：US755299
申请日：1996-11-22
申请人： Jurgen Schroder , Stefan Bock , Klaus Ebel
发明人： Jurgen Schroder , Stefan Bock , Klaus Ebel
IPC分类号： B01J21/04 , B01J21/06 , B01J21/08 , C07B61/00 , C07C41/28 , C07C43/16 , C07C43/166 , C07C43/176 , C07C67/327 , C07C69/734
CPC分类号： C07C41/28 , C07C67/327
摘要： A process for the preparation of enol ethers of the general formula I ##STR1## in which R.sup.1,R.sup.2,R.sup.3,R.sup.4,R.sup.5 denote C.sub.1 -C.sub.20 alkyl, C.sub.1 -C.sub.20 alkenyl, or C.sub.7 -C.sub.20 phenylalkyl, R.sup.2,R.sup.3,R.sup.4 denote hydrogen, aryl, cyano, --COOR.sup.5, C.sub.1 -C.sub.12 alkyl monosubstituted to trisubstituted or interrupted by --COOR.sup.5, --C.dbd.O, cyano, or C.sub.1 -C.sub.12 alkoxy, C.sub.1 -C.sub.12 alkyl monosubstituted to trisubstituted by --COOR.sup.5, --C.dbd.O, cyano, or C.sub.1 -C.sub.12 alkyl, or C.sub.7 -C.sub.20 phenylalkyl and R.sup.2 and R.sup.4 or R.sup.3 and R.sup.4 together form a C.sub.3 -C.sub.10 alkylene chain or a C.sub.2 -C.sub.20 alkylidene chain, from acetals or ketals.
摘要翻译：制备通式Ⅰ（I）的烯醇醚的方法，其中R 1，R 2，R 3，R 4，R 5表示C 1 -C 20烷基，C 1 -C 20链烯基或C 7 -C 20苯基烷基，R 2，R 3 ，R4表示氢，芳基，氰基，-COOR5，被-COOR5，-C = O，氰基或C1-C12烷氧基单取代或中断的C1-C12烷基，被-COOR5单取代至三取代的C1-C12烷基， C = O，氰基或C 1 -C 12烷基或C 7 -C 20苯基烷基，R 2和R 4或R 3和R 4一起由缩醛或缩酮形成C 3 -C 10亚烷基链或C 2 -C 20亚烷基链。

58. 发明授权

US5292894A Preparation of benzo[b]thiophenes 失效
标题翻译：苯并[b]噻吩的制备
公开(公告)号：US5292894A
公开(公告)日：1994-03-08
申请号：US18499
申请日：1993-02-17
申请人： Klaus Ebel , Juergen Schroeder
发明人： Klaus Ebel , Juergen Schroeder
IPC分类号： C07C319/14 , C07C323/22 , C07D333/54
CPC分类号： C07D333/54 , C07C319/14
摘要： A process for the preparation of benzo[b]thiophenes of the general formula I ##STR1## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4 independently denote hydrogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 haloalkyl, nitro, cyano, halo, C.sub.1 -C.sub.4 alkylcarbonyl, benzoyl, C.sub.1 -C.sub.4 alkylcarbonylamino, benzoylamino,N-(C.sub.1 -C.sub.4 alkyl)phenylamino, C.sub.1 -C.sub.4 alkoxycarbonyl, C.sub.1 -C.sub.4 alkylsulfonyl, phenylsulfonyl, aminosulfonyl, aminocarbonyl, C.sub.1 -C.sub.4 phenylalkyl and nitrobenzyl or R.sup.1 +R.sup.2 or R.sup.2 +R.sup.3 or R.sup.3 +R.sup.4 denote a butadienediyl chain optionally substituted by R.sup.1 to R.sup.4, in whicha) thiophenols of the general formula II ##STR2## in which the substituents R.sup.1 to R.sup.4 have the aforementioned meanings, are reacted with chloroacetaldehyde at a temperature ranging from 0.degree. to 150.degree. C. andb) the resulting (arylthio)acetaldehydes of the general formula III ##STR3## in which the substituents R.sup.1 to R.sup.4 have the aforementioned meanings, are cyclized by passing them into polyphosphoric acid or a mixture of phosphoric acid and phosphorus pentoxide at a temperature ranging from 100.degree. to 300.degree. C. and a pressure ranging from 0.001 to 1 bar.
摘要翻译：制备通式Ⅰ（I）的苯并[b]噻吩的方法，其中R 1，R 2，R 3，R 4独立地表示氢，C 1 -C 4烷基，C 1 -C 4烷氧基，C 1 -C 4卤代烷基，硝基，氰基，卤素，C 1 -C 4烷基羰基，苯甲酰基，C 1 -C 4烷基羰基氨基，苯甲酰氨基，N-（C 1 -C 4烷基）苯基氨基，C 1 -C 4烷氧基羰基，C 1 -C 4烷基磺酰基，苯基磺酰基，氨基磺酰基，氨基羰基，C 1 -C 4苯基并且硝基苄基或R 1 + R 2或R 2 + R 3或R 3 + R 4表示任选被R 1至R 4取代的亚乙二基链，其中a）通式II的苯硫酚（II），其中取代基R 1至R 4具有上述含义与氯乙醛在0℃至150℃的温度下反应，和b）得到的通式III（III）的（芳硫基）乙醛其中取代基R 1至R 4具有上述含义通过将它们聚合成多磷酸或磷酸和磷的戊氧基化合物的混合物而环化在100℃至300℃的温度和0.001至1巴的压力范围内。

59. 发明授权

US4670558A Aminoalkylmelamines 失效
标题翻译：氨基烷基三聚氰胺
公开(公告)号：US4670558A
公开(公告)日：1987-06-02
申请号：US788466
申请日：1985-10-17
申请人： Klaus Ebel , Wolfgang Reuther
发明人： Klaus Ebel , Wolfgang Reuther
IPC分类号： C07D251/70
CPC分类号： C07D251/70 , Y02P20/55
摘要： Preparation of amidoalkylmelamines and aminoalkylmelamines of the formula I ##STR1## where R.sup.1 is an amidoalkyl group --(CH.sub.2).sub.n --NHZ or an aminoalkyl group --(CH.sub.2).sub.n --NH.sub.2, n is from 2 to 10, preferably from 2 to 6, Z is an amino protective group and R.sup.2 and R.sup.3 independently of one another are each hydrogen or have the same meanings as R.sup.1, are prepared by a process in which a chlorotriazine is reacted with a diamine of the formula H.sub.2 N--(CH.sub.2).sub.n --NHZ, where n and Z have the above meanings, to give an amidoalkylmelamine, and, if required, the group Z is eliminated.
摘要翻译：制备式I的酰氨基烷基三聚氰胺和氨基烷基三聚氰胺其中R1是酰氨基烷基 - （CH2）n-NHZ或氨基烷基 - （CH2）n-NH2，n为2-10，优选为2-6 Z是氨基保护基，R 2和R 3彼此独立地各自为氢或具有与R 1相同的含义，通过其中氯代三嗪与式H2N-（CH2）n- NHZ，其中n和Z具有上述含义，得到酰氨基烷基三聚氰胺，并且如果需要，除去基团Z。

60. 发明授权

US08957260B2 Process for the oxidation of mesitol 有权
标题翻译：仲醇的氧化方法
公开(公告)号：US08957260B2
公开(公告)日：2015-02-17
申请号：US13364532
申请日：2012-02-02
申请人： Martine Weis , Joaquim Henrique Teles , Klaus Ebel , Peter Deglmann , Vivien Ellinor Weyrauch , Gunhild Weyrauch
发明人： Jan Philipp Weyrauch , Martine Weis , Joaquim Henrique Teles , Klaus Ebel , Peter Deglmann
IPC分类号： C07C37/07 , C07C37/60 , C07C39/08 , C07C45/28
CPC分类号： C07C37/07 , C07C45/28 , C07C2101/16 , C07C2601/16 , C07C39/08 , C07C49/713
摘要： The invention relates to a process for the oxidation of mesitol with singlet oxygen, which is released from hydrogen peroxide, this release taking place in the presence of a bismuth compound as catalyst. In the process, 2,4,6-trimethylquinol is formed in high yield and selectivity as product, which can be used in further reactions for the synthesis of vitamins and in particular of vitamin A and vitamin E.
摘要翻译：本发明涉及一种氧化来自过氧化氢释放的单线态氧的仲醇的方法，该释放是在铋化合物作为催化剂的存在下进行的。在此过程中，2,4,6-三甲基喹啉以高产率和选择性形成作为产品，可用于合成维生素，特别是维生素A和维生素E的进一步反应。

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