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51. 发明授权

US5967847A Lampsocket with means to reject incorrectly dimensioned lamps 失效
标题翻译：灯泡具有排除尺寸不正确的灯具的方法
公开(公告)号：US5967847A
公开(公告)日：1999-10-19
申请号：US960157
申请日：1997-10-29
申请人： Walter Newman
发明人： Walter Newman
IPC分类号： H01R33/22
CPC分类号： H01R33/22
摘要： A lampsocket is provided with a body having an extension both of which contain a continuous bore of a first predetermined diameter dimension to prevent the seating and electrical connection of an electrical lamp having a neck dimension in excess of first predetermined dimension to thereby reject inappropriate lamps and only permit the seating and electrical connection of suitable lamps.
摘要翻译：灯泡设置有具有延伸部的主体，两个延伸部都包含第一预定直径尺寸的连续孔，以防止具有超过第一预定尺寸的颈部尺寸的电灯的就座和电连接，从而排除不适当的灯和只允许合适的灯具的座位和电气连接。

52. 发明授权

US5874800A Lampholder system with mogul base 失效
标题翻译：灯座系统与大底座
公开(公告)号：US5874800A
公开(公告)日：1999-02-23
申请号：US978925
申请日：1997-11-26
申请人： Walter Newman
发明人： Walter Newman
IPC分类号： H01K1/46 , H01R13/652 , H01R33/22 , H01J5/48 , H01J5/50 , H01R13/44
CPC分类号： H01R33/22 , H01K1/46 , H01R13/652 , H01J61/34 , H01J61/827
摘要： A lampholder for shrouded low-wattage metal halide lamps which include a contact button on an extension of the lamp base to distinguish them from unshrouded lamps. A hub with walls and top is placed about the entrance to an additional cavity in the lampholder body. A socket contact is arranged to only make contact with the contact button at the end of an extension which is able to enter the cavity and not make contact with a contact button not an extension which is prevented from entering the cavity.
摘要翻译：一种用于被覆盖的低功率金属卤化物灯的灯座，其包括在灯座的延伸部上的接触按钮以将其与无罩灯相区别。具有墙壁和顶部的轮毂围绕灯座主体中的附加空腔的入口放置。插座触点被布置成仅在能够进入空腔的延伸端处与接触按钮接触，而不与接触按钮接触而不是防止其进入腔的延伸部。

53. 发明授权

US4637671A Theft-resistant device for fluorescent lamp 失效
标题翻译：荧光灯防盗装置
公开(公告)号：US4637671A
公开(公告)日：1987-01-20
申请号：US790661
申请日：1985-10-28
申请人： George E. Johnson , Walter Newman
发明人： George E. Johnson , Walter Newman
IPC分类号： H01R33/08 , H01R33/97 , H01R13/62
CPC分类号： H01R33/97 , H01R33/08
摘要： A removable locking system for a fluorescent U-tube electrically connected to a mounting body connected to a surface. The mounting body has a flange extending over the coupling member of the connecting end of the U-tube at the mounting body. A locking screw member is threaded through a hole in the flange into pressing contact with the top of the coupling member of the U-tube. A self-locking washer is positioned between the head element of the screw and the top surface of the flange. The locking screw can be rotated to lock or free the U-tube from its mounted association with the mounting body.
摘要翻译：用于与连接到表面的安装体电连接的荧光U形管的可移除锁定系统。安装体在安装体上具有在U形管的连接端的连接构件上延伸的凸缘。锁定螺钉构件穿过凸缘中的孔与U形管的联接构件的顶部压接。自锁垫圈位于螺钉的头元件和法兰的顶表面之间。锁定螺钉可以旋转以锁定或释放U形管与其与安装体的安装关联。

54. 发明授权

US4429942A Threaded lamp adapter 失效
标题翻译：螺纹灯适配器
公开(公告)号：US4429942A
公开(公告)日：1984-02-07
申请号：US420202
申请日：1982-09-20
申请人： George E. Johnson , Walter Newman
发明人： George E. Johnson , Walter Newman
IPC分类号： H01R33/94 , H01R13/02
CPC分类号： H01R33/94
摘要： An adapter for permitting a lamp to be threaded into a light socket while preventing damage to the socket through application of excessive threading force includes a threaded sleeve rotatably mounted on a cylindrical body and conductive securing means for preventing longitudinal movement of the sleeve with respect to the body, the securing means being urged nto sliding electrical contact with the sleeve and being connected to an electrical conductor for maintaining electrical continuity between the sleeve and an energizing terminal of the lamp. A cam on the ring cooperates with an opening in the sleeve for permitting relative rotation between the sleeve and body in one direction when a threshold torque is exceeded to prevent damage to the socket but preventing relative rotation in the other direction so that the lamp and adapter can be threaded out of the socket.
摘要翻译：一种用于允许灯被穿入灯座的适配器，同时通过施加过度的穿透力来防止对插座的损坏，包括可旋转地安装在圆柱形主体上的螺纹套筒和用于防止套筒相对于套筒的纵向移动的导电固定装置固定装置被推动以与套筒滑动电接触并连接到电导体，用于保持套管和灯的激励端子之间的电连续性。环上的凸轮与套筒中的开口配合，当超过阈值扭矩时允许套筒和主体在一个方向上的相对旋转，以防止对插座的损坏，但防止在另一个方向上的相对旋转，使得灯和适配器可以从插座中拔出。

55. 发明授权

US4306758A Lamp holder with self-locking device 失效
标题翻译：带自锁装置的灯座
公开(公告)号：US4306758A
公开(公告)日：1981-12-22
申请号：US15570
申请日：1979-02-26
申请人： George E. Johnson , Walter Newman
发明人： George E. Johnson , Walter Newman
IPC分类号： H01R33/08 , H01R17/22
CPC分类号： H01R33/0854
摘要： A lamp holder of the type used to removably hold a fluorescent lamp in a lighting fixture has a housing in which there are defined channels for inserting pins protruding from the end of the lamp and a tiltable locking member rotatable between an open position permitting the pins to enter the channels and a closed position preventing withdrawal of the pins from the channels. The locking member is held in the closed position by cooperating means on the housing and locking member.
摘要翻译：用于可拆卸地将荧光灯保持在照明器具中的灯座具有壳体，其中具有用于插入从灯的端部突出的销的限定通道，以及可倾斜锁定构件，其可在允许销钉到进入通道和关闭位置，防止引脚从通道中撤出。锁定构件通过壳体和锁定构件上的配合装置保持在关闭位置。

56. 发明授权

US08846047B2 Monoclonal antibodies against HMGB1 有权
标题翻译：针对HMGB1的单克隆抗体
公开(公告)号：US08846047B2
公开(公告)日：2014-09-30
申请号：US12897453
申请日：2010-10-04
申请人： Walter Newman , Shixin Qin , Theresa L. O'Keefe , Robert A. Obar
发明人： Walter Newman , Shixin Qin , Theresa L. O'Keefe , Robert A. Obar
IPC分类号： A61K39/395 , C07K16/24 , C07K14/47 , A61K39/00
CPC分类号： C07K14/4718 , A61K2039/505 , C07K16/24 , C07K2317/34 , C07K2317/565 , C07K2317/76 , Y10S435/81
摘要： In various embodiments, the present invention is drawn to antibodies or antigen-binding fragments thereof that bind to a vertebrate high mobility group box (HMGB) polypeptide, methods of detecting and/or identifying an agent that binds to an HMGB polypeptide, methods of treating a condition in a subject characterized by activation of an inflammatory cytokine cascade and methods of detecting an HMGB polypeptide in a sample.
摘要翻译：在各种实施方案中，本发明涉及结合脊椎动物高迁移率组盒（HMGB）多肽的抗体或其抗原结合片段，检测和/或鉴定与HMGB多肽结合的试剂的方法，治疗方法特征在于激活炎性细胞因子级联的受试者的病症以及检测样品中的HMGB多肽的方法。

57. 发明申请

US20090285835A1 Antibodies which bind human CXCR3 有权
标题翻译：结合人CXCR3的抗体
公开(公告)号：US20090285835A1
公开(公告)日：2009-11-19
申请号：US12214891
申请日：2008-06-23
申请人： Shixin Qin , Nasim Kassam , Walter Newman
发明人： Shixin Qin , Nasim Kassam , Walter Newman
IPC分类号： A61K39/395 , C07K16/28 , C12N5/06 , C07H21/00
CPC分类号： C07K16/2866 , A61K47/6849 , A61K2039/505 , C07K2317/21 , C07K2317/565 , C07K2317/76
摘要： Antibodies and antigen-binding fragments of antibodies that bind human CXCR3 are disclosed. In preferred embodiments, the antibodies are human. Nucleic acids and vectors encoding the antibodies or portions thereof, recombinant cells that contain the nucleic acids, and compositions comprising the antibodies or antigen-binding fragments are also disclosed. The invention also provides therapeutic and diagnostic methods which employ the antibodies and antigen-binding fragments.
摘要翻译：公开了结合人CXCR3的抗体的抗体和抗原结合片段。在优选的实施方案中，抗体是人。还公开了编码抗体或其部分的核酸和载体，含有核酸的重组细胞，以及包含抗体或抗原结合片段的组合物。本发明还提供了使用抗体和抗原结合片段的治疗和诊断方法。

58. 发明授权

US07423129B2 Antibodies to human eotaxin 失效
标题翻译：人类嗜酸性粒细胞趋化因子的抗体
公开(公告)号：US07423129B2
公开(公告)日：2008-09-09
申请号：US11900700
申请日：2007-09-13
申请人： Paul D. Ponath , Shixin Qin , Douglas J. Ringler , Walter Newman , Charles Mackay
发明人： Paul D. Ponath , Shixin Qin , Douglas J. Ringler , Walter Newman , Charles Mackay
IPC分类号： C07K16/24 , C12N5/12
CPC分类号： C07K16/24 , A61K38/00 , A61K47/642 , C07K14/523 , C07K14/7158 , C07K2317/76 , C07K2319/00
摘要： The invention relates to isolated and/or recombinant nucleic acids which encode a human chemotactic cytokine designated human eotaxin, and to isolated and/or recombinant human eotaxin proteins or polypeptides, including synthetic polypeptides. The invention further relates to recombinant nucleic acid constructs, comprising a nucleic acid which encodes a human eotaxin, a portion thereof, or a variant; to host cells comprising such constructs, useful for the production of recombinant human eotaxin; and to antibodies reactive with human eotaxin, useful in in vitro methods, diagnosis and/or therapy. Also provided are methods of use of the eotaxin proteins, e.g., in the recruitment of eosinophils to a particular site or in the treatment of allergic conditions. Human eotaxins can be used to identify inhibitors (e.g., antagonists) or promoters (agonists) of human eotaxin, which can be used to selectively modulate leukocyte function, in inflammatory and autoimmune diseases, or in infections.
摘要翻译：本发明涉及编码人类趋化性细胞因子（命名为人类嗜酸细胞活化趋化因子）的分离和/或重组核酸，以及包含合成多肽的分离和/或重组人类嗜酸细胞活化趋化因子蛋白或多肽。本发明还涉及重组核酸构建体，其包含编码人类嗜酸细胞活化趋化因子，其部分或变体的核酸; 包含可用于生产重组人类嗜酸性粒细胞趋化因子的这种构建体的宿主细胞; 以及可用于体外方法，诊断和/或治疗的与人嗜酸细胞活化趋化因子反应的抗体。还提供了使用嗜酸细胞活化趋化因子蛋白质的方法，例如将嗜酸性粒细胞募集到特定部位或用于治疗过敏性病症。人类嗜酸性粒细胞趋化因子可用于鉴定可用于选择性调节白细胞功能，炎性和自身免疫疾病或感染的人类嗜酸细胞活化趋化因子的抑制剂（例如拮抗剂）或启动子（激动剂）。

59. 发明授权

US07405275B2 Antibodies which bind human CXCR3 有权
标题翻译：结合人CXCR3的抗体
公开(公告)号：US07405275B2
公开(公告)日：2008-07-29
申请号：US10949135
申请日：2004-09-24
申请人： Shixin Qin , Nasim Kassam , Walter Newman
发明人： Shixin Qin , Nasim Kassam , Walter Newman
IPC分类号： C07K16/00 , C12P21/08 , A61K39/395 , C12N5/06
CPC分类号： C07K16/2866 , A61K47/6849 , A61K2039/505 , C07K2317/21 , C07K2317/565 , C07K2317/76
摘要： Antibodies and antigen-binding fragments of antibodies that bind human CXCR3 are disclosed. In preferred embodiments, the antibodies are human. Nucleic acids and vectors encoding the antibodies or portions thereof, recombinant cells that contain the nucleic acids, and compositions comprising the antibodies or antigen-binding fragments are also disclosed. The invention also provides therapeutic and diagnostic methods which employ the antibodies and antigen-binding fragments.
摘要翻译：公开了结合人CXCR3的抗体的抗体和抗原结合片段。在优选的实施方案中，抗体是人。还公开了编码抗体或其部分的核酸和载体，含有核酸的重组细胞，以及包含抗体或抗原结合片段的组合物。本发明还提供了使用抗体和抗原结合片段的治疗和诊断方法。

60. 发明申请

US20080075728A1 Combination Therapies Of Hmgb And Complement Inhibitors Against Inflammation 审中-公开
标题翻译： Hmgb和补体抑制剂对炎症的联合治疗
公开(公告)号：US20080075728A1
公开(公告)日：2008-03-27
申请号：US11632257
申请日：2005-07-20
申请人： Walter Newman
发明人： Walter Newman
IPC分类号： A61K39/395 , A61K31/22 , A61K38/02 , A61P1/18 , A61P11/06 , A61P17/06 , A61P25/00 , A61P29/00 , A61P19/02 , A61P17/02 , A61P11/00 , A61P1/00 , A61K38/17
CPC分类号： C07K16/24 , A61K38/1703 , A61K45/06 , A61K2300/00
摘要： Compositions and methods are disclosed for treating a condition characterized by activation of an inflammatory cytokine cascade in a patient. The compositions comprise an HMGB A box and an inhibitor of complement biological activity, and/or an antibody that binds an HMGB polypeptide or biologically active fragment thereof and an inhibitor of complement biological activity, and/or an inhibitor of HMGB receptor binding and an inhibitor of complement biological activity. The methods comprise treating a cell or a patient with sufficient amounts of the composition to inhibit the release of proinflammatory cytokine(s) and/or inhibit the inflammatory cytokine cascade.
摘要翻译：公开了用于治疗特征在于患者中炎性细胞因子级联活化的病症的组合物和方法。组合物包含HMGB A盒和补体生物活性抑制剂，和/或结合HMGB多肽或其生物活性片段和补体生物活性抑制剂的抗体，和/或HMGB受体结合抑制剂和抑制剂的补体生物活性。所述方法包括用足够量的组合物治疗细胞或患者以抑制促炎细胞因子的释放和/或抑制炎性细胞因子级联。

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