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51. 发明授权

US07792569B2 Cavity-filling biopsy site markers 有权
标题翻译：腔填充活检部位标记
公开(公告)号：US07792569B2
公开(公告)日：2010-09-07
申请号：US10990327
申请日：2004-11-16
申请人： Fred H. Burbank , Paul Lubock , Michael L. Jones
发明人： Fred H. Burbank , Paul Lubock , Michael L. Jones
IPC分类号： A61B19/00
CPC分类号： A61B8/481 , A61B6/12 , A61B8/0833 , A61B10/02 , A61B90/39 , A61B2017/00004 , A61B2090/3908 , A61B2090/392 , A61B2090/3925 , A61B2090/395 , A61B2090/3954 , A61B2090/3966 , A61B2090/3987 , A61B2090/3995 , A61K49/006 , A61K49/222 , A61M37/0069
摘要： The invention provides materials, devices and methods for marking biopsy sites for a limited time. The biopsy-marking materials are ultrasound-detectable bio-resorbable powders, with powder particles typically between about 20 microns and about 800 microns in maximum dimension, more preferably between about 300 microns and about 500 microns. The powders may be formed of polymeric materials containing cavities sized between about 10 microns and about 500 microns, and may also contain binding agents, anesthetic agents, hemostatic agents, and radiopaque markers. Devices for delivering the powders include tubes configured to contain the powders and to fit within a biopsy cannula, the powders being ejected by action of a syringe. Systems may include a tube containing powder, and a syringe containing sterile saline. The tube may be configured to fit within a biopsy cannula such as a Mammotome® or SenoCor 360™ cannula.
摘要翻译：本发明提供用于在有限时间内标记活检部位的材料，装置和方法。活检标记材料是可超声检测的生物可再吸收粉末，粉末颗粒通常在最大尺寸为约20微米至约800微米之间，更优选为约300微米至约500微米。粉末可以由含有大约10微米至约500微米的空腔的聚合材料形成，并且还可以含有粘合剂，麻醉剂，止血剂和不透射线的标记物。用于递送粉末的装置包括被配置为容纳粉末并且装配在活检插管内的管，粉末通过注射器的作用喷射。系统可以包括含有粉末的管和含有无菌盐水的注射器。管可以被配置成装配在活检插管内，例如Mammotome或SenoCor 360 TM插管。

52. 发明授权

US06996433B2 Imageable biopsy site marker 有权
标题翻译：可成像的活检部位标记
公开(公告)号：US06996433B2
公开(公告)日：2006-02-07
申请号：US10719448
申请日：2003-11-21
申请人： Fred H. Burbank , Paul Lubock , Michael L. Jones , Nancy Forcier
发明人： Fred H. Burbank , Paul Lubock , Michael L. Jones , Nancy Forcier
IPC分类号： A61B1/00 , A61B1/04 , A61B6/00
CPC分类号： A61K49/006 , A61B10/02 , A61B90/39 , A61B2017/00004 , A61B2090/3908 , A61B2090/3933 , A61B2090/395 , A61B2090/3987 , A61M37/0069
摘要： A biopsy site marker comprises small bodies or pellets of gelatin which enclose substantially in their interior a radio (X-ray) opaque object. The gelatin pellets are deposited into the biopsy site, typically a cylindrical opening in the tissue created by the recent use of a vacuum assisted large core biopsy device, by an applicator device that includes an elongated cylindrical body that forms a flexible tube and a piston slidable in the tube. One end of the tube is placed into the biopsy site. Typically, several gelatin pellets, only some of which typically do, but all of which may contain the radio opaque object, are deposited sequentially into the site through the tube. The radio opaque objects contained in the gelatin bodies are of a non-biological configuration and readily identifiable as man-made object, so that in observation by typical mammography equipment they do not assume the shape of a line, whereby they are readily distinguishable from granules and lines of calcification.
摘要翻译：活检部位标记物包括明胶的小体或小丸，其基本上在其内部封闭无线电（X射线）不透明物体。凝胶颗粒沉积到活检部位，通常是通过最近使用真空辅助的大芯活检装置产生的组织中的圆柱形开口，该施用装置包括形成柔性管的细长圆柱形主体和可滑动的活塞在管中。将管的一端放入活检部位。通常，几个明胶丸粒，其中仅一些通常可以，但都可以包含无线电不透明物体，通过管子依次沉积到该部位。包含在明胶体中的无线电不透明物体具有非生物构型，并且易于被识别为人造物体，因此在通过典型的乳房X射线摄影术设备的观察中，它们不呈现线的形状，由此它们容易与颗粒区分开和钙化线。

53. 发明授权

US06716179B2 Sentinel node location and biopsy 失效
标题翻译：前哨淋巴结位置和活检
公开(公告)号：US06716179B2
公开(公告)日：2004-04-06
申请号：US10061706
申请日：2002-01-30
申请人： Fred H. Burbank , Paul Lubock
发明人： Fred H. Burbank , Paul Lubock
IPC分类号： A61B1000
CPC分类号： A61B10/0266 , A61B6/4258 , A61B10/02 , A61B17/00491 , A61B18/1477 , A61B18/1482 , A61B18/1487 , A61B18/1815 , A61B90/39 , A61B2010/0208 , A61B2017/3488 , A61B2018/00208 , A61B2018/00273 , A61B2018/00333 , A61B2018/00577 , A61B2018/00916 , A61B2018/1407 , A61B2018/1425 , A61B2018/1475 , A61B2090/378 , A61B2090/3904 , A61B2090/3908 , A61B2090/392
摘要： A device and system for accessing and anchoring a patient's sentinel lymph node after a radiopharmaceutical is injected at or near a lesion site within a patient's body. The migration of and accumulation of the radiopharmaceutical in a sentinel node of the patient is monitored from outside the patient's body. The sentinel node can then be accessed through a cannula and an anchoring device may be employed to fix the location of the sentinel node. The anchoring device has at least one radially extending members which penetrate into the sentinel node. Preferably, the radially extending members are RF powered to facilitate entry into the sentinel node. With the anchor device secured to the sentinel node as a locator, subsequent procedures may be performed.
摘要翻译：在放射性药物在患者体内的病变部位处或附近注射放射性药物后，用于访问和锚定患者前哨淋巴结的装置和系统。从患者身体外部监测放射性药物在患者前哨淋巴结中的迁移和积累。然后可以通过套管访问前哨节点，并且可以采用锚定装置来固定前哨节点的位置。锚定装置具有至少一个径向延伸的构件，其穿透到前哨节点中。优选地，径向延伸的构件被RF供电以便于进入前哨节点。锚定装置作为定位器固定到前哨节点，可以执行随后的过程。

54. 发明授权

US06662041B2 Imageable biopsy site marker 有权
公开(公告)号：US06662041B2
公开(公告)日：2003-12-09
申请号：US10001043
申请日：2001-10-31
申请人： Fred H. Burbank , Paul Lubock , Michael L. Jones , Nancy Forcier
发明人： Fred H. Burbank , Paul Lubock , Michael L. Jones , Nancy Forcier
IPC分类号： A61B1900
CPC分类号： A61K49/006 , A61B10/02 , A61B90/39 , A61B2017/00004 , A61B2090/3908 , A61B2090/3933 , A61B2090/395 , A61B2090/3987 , A61M37/0069
摘要： A biopsy site marker comprises small bodies or pellets of gelatin which enclose substantially in their interior a radio (X-ray) opaque object. The gelatin pellets are deposited into the biopsy site, typically a cylindrical opening in the tissue created by the recent use of a vacuum assisted large core biopsy device, by an applicator device that includes an elongated cylindrical body that forms a flexible tube and a piston slidable in the tube. One end of the tube is placed into the biopsy site. Typically, several gelatin pellets, only some of which typically do, but all of which may contain the radio opaque object, are deposited sequentially into the site through the tube. The radio opaque objects contained in the gelatin bodies are of a non-biological configuration and readily identifiable as man -made object, so that in observation by typical mammography equipment they do not assume the shape of a line, whereby they are readily distinguishable from granules and lines of calcification.

55. 发明授权

US08636734B2 Tissue specimen isolating and damaging device and method 有权
标题翻译：组织样本分离和破坏装置及方法
公开(公告)号：US08636734B2
公开(公告)日：2014-01-28
申请号：US12082509
申请日：2008-04-11
申请人： Fred H. Burbank , Paul Lubock
发明人： Fred H. Burbank , Paul Lubock
IPC分类号： A61B18/14
CPC分类号： A61B10/0266 , A61B10/0041 , A61B10/02 , A61B10/0233 , A61B17/00234 , A61B17/00491 , A61B17/221 , A61B17/32056 , A61B17/320725 , A61B17/3417 , A61B18/0206 , A61B18/06 , A61B18/14 , A61B18/148 , A61B18/1482 , A61B18/1487 , A61B18/1492 , A61B18/20 , A61B90/37 , A61B2010/0208 , A61B2017/00287 , A61B2017/2212 , A61B2017/320733 , A61B2017/3488 , A61B2018/00208 , A61B2018/00214 , A61B2018/00267 , A61B2018/00333 , A61B2018/00577 , A61B2018/00601 , A61B2018/00898 , A61B2018/0091 , A61B2018/00916 , A61B2018/1253 , A61B2018/126 , A61B2018/1407 , A61B2018/1425 , A61B2018/144 , A61B2018/1475 , A61B2018/162 , A61B2018/1861 , A61B2090/3908 , A61N5/1007 , A61N5/1027
摘要： A device and method for treatment of a tissue specimen disposed in surrounding tissue has a tissue specimen isolating toot and a tissue specimen damager. The tissue specimen isolating tool isolates the tissue specimen from the surrounding tissue. The tissue specimen damager damages the tissue, with a possible end result being necrosis. The severing tool may have a cutting member that is extendable to an outwardly radially bowed position about device. The tissue specimen is isolated by rotating the cutting member about the tissue specimen. The cutting member may be functionally connected to a cutting member radio frequency generation source. The tissue specimen damager may damage the tissue specimen using ionizing radiation, cutting devices, thermal treatment devices, chemical treatment devices, or sealing an outer boundary of the tissue specimen.
摘要翻译：用于处理设置在周围组织中的组织样本的装置和方法具有组织样本分离齿和组织样本容器。组织标本分离工具将组织标本与周围组织隔离。组织标本损伤组织，可能的最终结果是坏死。切割工具可以具有切割构件，该切割构件可延伸到关于装置的向外径向弯曲的位置。通过围绕组织样本旋转切割构件来分离组织样本。切割构件可以功能地连接到切割构件射频发生源。组织样本容器可能会使用电离辐射，切割装置，热处理装置，化学处理装置或密封组织标本的外边界来损伤组织标本。

56. 发明授权

US08219182B2 Cavity-filling biopsy site markers 有权
标题翻译：腔填充活检部位标记
公开(公告)号：US08219182B2
公开(公告)日：2012-07-10
申请号：US12852286
申请日：2010-08-06
申请人： Fred H. Burbank , Paul Lubock , Michael L. Jones
发明人： Fred H. Burbank , Paul Lubock , Michael L. Jones
IPC分类号： A61B8/00 , A61B6/00 , A61B8/14
CPC分类号： A61B8/481 , A61B6/12 , A61B8/0833 , A61B10/02 , A61B90/39 , A61B2017/00004 , A61B2090/3908 , A61B2090/392 , A61B2090/3925 , A61B2090/395 , A61B2090/3954 , A61B2090/3966 , A61B2090/3987 , A61B2090/3995 , A61K49/006 , A61K49/222 , A61M37/0069
摘要： An ultrasound-detectable biopsy marker mass has a detectable in-vivo lifetime during which the marker mass remains readily detectable by ultrasound imaging. The ultrasound-detectable biopsy marker mass is formed of particles of a bio-resorbable material having bubble cavities and having a particle size between about 200 microns and about 500 microns.
摘要翻译：超声检测的活检标记物质具有可检测的体内寿命，在此期间，通过超声成像可以容易地检测出标记物质。可超声检测的活检标记物质由具有气泡腔并具有约200微米至约500微米的粒度的生物可吸收材料的颗粒形成。

57. 发明申请

US20110092815A1 MARKER OR FILLER FORMING FLUID 有权
标题翻译：标记或填充液形成流体
公开(公告)号：US20110092815A1
公开(公告)日：2011-04-21
申请号：US12967639
申请日：2010-12-14
申请人： Fred H. Burbank , Michael L. Jones , Frank Louw , Paul Lubock
发明人： Fred H. Burbank , Michael L. Jones , Frank Louw , Paul Lubock
IPC分类号： A61B6/00 , A61M5/31
CPC分类号： A61B90/39 , A61B2090/3908 , A61B2090/3925 , A61B2090/3933 , A61B2090/3987 , A61K49/226
摘要： A system for at least partially filling and marking a cavity at a site within a patient's body includes a marker delivery device having a chamber configured to contain a marking substance and having a mechanism configured to expel the marking substance. A quantity of the marking substance is contained within the chamber of the marker delivery device. The marking substance is configured to at least partially fill the cavity and form therein a porous bioabsorbable body. A delivery tube is coupled in fluid communication with the chamber of the marker delivery device. The delivery tube has a distal end with a discharge port through which the marking substance is expelled. A releasable remotely detectable distal tip is coupled to the distal end of the delivery tube and is configured to be released to remain within the porous bioabsorbable body within the cavity upon the formation thereof.
摘要翻译：一种用于至少部分地填充和标记患者体内的部位的空腔的系统包括标记物输送装置，其具有被配置为容纳标记物质并具有被配置为排出标记物质的机构的室。标记物质的量被容纳在标记物输送装置的室内。标记物质构造成至少部分地填充空腔并在其中形成多孔生物可吸收体。输送管与标记物递送装置的腔室流体连通地联接。输送管具有远端，其具有排出口，排出标记物质。可释放的可远程检测的远侧末端联接到输送管的远端，并且构造成在其形成时被释放以保持在腔内的多孔生物可吸收体内。

58. 发明授权

US07322938B2 Breast biopsy system and methods 有权
标题翻译：乳腺活检系统及方法
公开(公告)号：US07322938B2
公开(公告)日：2008-01-29
申请号：US09929371
申请日：2001-08-13
申请人： Fred H. Burbank , Michael L. Jones , Paul Lubock
发明人： Fred H. Burbank , Michael L. Jones , Paul Lubock
IPC分类号： A61B10/00 , A61B18/18
CPC分类号： A61B10/0266 , A61B10/02 , A61B17/00491 , A61B17/32056 , A61B17/320725 , A61B17/3417 , A61B18/14 , A61B18/1487 , A61B18/1492 , A61B90/17 , A61B90/37 , A61B2017/3488 , A61B2018/00208 , A61B2018/00214 , A61B2018/00267 , A61B2018/00333 , A61B2018/00898 , A61B2018/0091 , A61B2018/00916 , A61B2018/1253 , A61B2018/126 , A61B2018/1407 , A61B2018/1475 , A61B2018/162 , A61B2090/3908
摘要： An apparatus and method are provided for precisely isolating a target lesion in a patient's body tissue, resulting in a high likelihood of “clean” margins about the lesion when it is removed for diagnosis and/or therapy. This approach advantageously will often result in the ability to both diagnose and treat a malignant lesion with only a single percutaneous procedure, with no follow-up percutaneous or surgical procedure required, while minimizing the risk of migration of possibly cancerous cells from the lesion to surrounding tissue or the bloodstream. In particular, the apparatus comprises a biopsy instrument having a distal end adapted for entry into the patient's body, a longitudinal shaft, and a cutting element disposed along the shaft. The cutting element is actuatable between a radially retracted position and a radially extended position. Advantageously, the instrument is rotatable about its axis in the radially extended position to isolate a desired tissue specimen from surrounding tissue by defining a peripheral margin about the tissue specimen. The specimen may be encapsulated and removed as an intact piece.
摘要翻译：提供了一种用于精确地分离患者体内组织中的靶病变的装置和方法，导致当其被去除用于诊断和/或治疗时，对病变的“清洁”边缘的高可能性。这种方法有利地经常导致仅使用单一经皮手术来诊断和治疗恶性病变的能力，而不需要随访的经皮或外科手术，同时最小化可能的癌细胞从病变迁移到周围的风险组织或血液。特别地，该装置包括具有适于进入患者身体的远端的活检器械，纵向轴和沿轴设置的切割元件。切割元件可在径向缩回位置和径向延伸位置之间致动。有利地，仪器可以在其径向延伸位置中绕其轴线旋转，以通过围绕组织样本限定周边边界来将期望的组织样本与周围组织隔离。样品可以作为完整的片段被包封和去除。

59. 发明授权

US07229439B2 Apparatus and method for accessing a body site 有权
标题翻译：用于访问身体部位的装置和方法
公开(公告)号：US07229439B2
公开(公告)日：2007-06-12
申请号：US10851342
申请日：2004-05-21
申请人： Fred H. Burbank , Paul Lubock , Martin Shabaz , Frank Louw
发明人： Fred H. Burbank , Paul Lubock , Martin Shabaz , Frank Louw
IPC分类号： A61F18/18
CPC分类号： A61B10/0266 , A61B10/02 , A61B10/0275 , A61B10/0283 , A61B10/04 , A61B17/32056 , A61B17/320725 , A61B17/3417 , A61B18/14 , A61B18/148 , A61B18/1482 , A61B18/1487 , A61B18/1492 , A61B90/37 , A61B2010/0208 , A61B2018/00208 , A61B2018/00214 , A61B2018/00267 , A61B2018/00291 , A61B2018/00333 , A61B2018/00898 , A61B2018/0091 , A61B2018/00916 , A61B2018/1253 , A61B2018/126 , A61B2018/1407 , A61B2018/1412 , A61B2018/1425 , A61B2018/1455 , A61B2018/1475 , A61B2018/162 , A61B2090/3908
摘要： A device and method of using the device to access a desired tissue site within a patient's body and separating a tissue specimen from the tissue site suitable for evaluation. The device includes a probe member having an arcuate tissue-cutting RF powered electrode secured to and distally spaced from the distal end of the probe and a small dimensioned distal extremity which when an inner lumen thereof is subjected to a vacuum, secured tissue for the specimen to the surface of the distal extremity. A circular tissue-cutting blade preferably secured to the distal end of a supporting tube is configured to rotate and move longitudinally along the shaft of the probe member effective to sever a tissue specimen from tissue secured to the surface of the distal extremity of the probe member. The supporting tube covers the separated specimen, and may be disposed within an accessing cannula.
摘要翻译：一种使用该装置来访问患者体内期望的组织部位并将组织标本与适于评估的组织部位分离的装置和方法。该装置包括探针构件，该探针构件具有固定到探针的远端并远离间隔开的弓形组织切割RF供电的电极，以及小尺寸的远端，当其内腔经受真空时，用于样本的固定的组织到远端的表面。优选地固定到支撑管的远端的圆形组织切割刀片构造成沿着探针构件的轴线旋转并纵向移动，其有效地从固定到探针构件的远端的表面的组织切断组织样本。支撑管覆盖分离的样本，并且可以设置在进入的插管内。

60. 发明授权

US06758848B2 Apparatus and method for accessing a body site 有权
公开(公告)号：US06758848B2
公开(公告)日：2004-07-06
申请号：US10179933
申请日：2002-06-21
申请人： Fred H. Burbank , Paul Lubock , Martin Shabaz , Frank Louw
发明人： Fred H. Burbank , Paul Lubock , Martin Shabaz , Frank Louw
IPC分类号： A61B1818
CPC分类号： A61B10/0266 , A61B10/02 , A61B10/0275 , A61B10/0283 , A61B10/04 , A61B17/32056 , A61B17/320725 , A61B17/3417 , A61B18/14 , A61B18/148 , A61B18/1482 , A61B18/1487 , A61B18/1492 , A61B90/37 , A61B2010/0208 , A61B2018/00208 , A61B2018/00214 , A61B2018/00267 , A61B2018/00291 , A61B2018/00333 , A61B2018/00898 , A61B2018/0091 , A61B2018/00916 , A61B2018/1253 , A61B2018/126 , A61B2018/1407 , A61B2018/1412 , A61B2018/1425 , A61B2018/1455 , A61B2018/1475 , A61B2018/162 , A61B2090/3908
摘要： A device and method of using the device to access a desired tissue site within a patient's body and separating a tissue specimen from the tissue site suitable for evaluation. The device includes a probe member having an arcuate tissue-cutting RF powered electrode secured to and distally spaced from the distal end of the probe and a small dimensioned distal extremity which when an inner lumen thereof is subjected to a vacuum, secured tissue for the specimen to the surface of the distal extremity. A circular tissue-cutting blade preferably secured to the distal end of a supporting tube is configured to rotate and move longitudinally along the shaft of the probe member effective to sever a tissue specimen from tissue secured to the surface of the distal extremity of the probe member. The supporting tube covers the separated specimen, and may be disposed within an accessing cannula.

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