专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

51. 发明申请

US20050102007A1 Nerve stimulation for treating spasticity, tremor, muscle weakness, and other motor disorders 有权
公开(公告)号：US20050102007A1
公开(公告)日：2005-05-12
申请号：US10981939
申请日：2004-11-05
申请人： Shai Ayal , Ehud Cohen , Ron Dabby
发明人： Shai Ayal , Ehud Cohen , Ron Dabby
IPC分类号： A61N1/18 , A61N1/34 , A61N1/36 , A61N1/372
CPC分类号： A61N1/36021 , A61N1/36003 , A61N1/36007 , A61N1/36067 , A61N1/36071 , A61N1/37205
摘要： A method for treating spasticity of a subject is provided, including driving a current into a nerve of the subject that includes one or more sensory fibers, and configuring the current so as to inhibit propagation of action potentials in one or more of the sensory fibers, so as to treat the spasticity. In a preferred embodiment, the sensory fibers include one or more Ia sensory fibers, and configuring the current includes configuring the current so as to inhibit propagation of the action potentials in at least one of the Ia sensory fibers.

52. 发明申请

US20050065553A1 Applications of vagal stimulation 审中-公开
标题翻译：迷走神经刺激的应用
公开(公告)号：US20050065553A1
公开(公告)日：2005-03-24
申请号：US10866601
申请日：2004-06-10
申请人： Omry Ben Ezra , Ehud Cohen , Tamir Ben David
发明人： Omry Ben Ezra , Ehud Cohen , Tamir Ben David
IPC分类号： A61N20060101 , A61N1/18 , A61N1/36 , A61N1/362 , A61N1/365 , A61N1/39
CPC分类号： A61N1/36114 , A61N1/36053 , A61N1/36117 , A61N1/3621 , A61N1/395 , A61N1/3962
摘要： A method is provided for treating a subject, including applying a current to a site of the subject selected from the list consisting of: a vagus nerve of the subject, an epicardial fat pad of the subject, a pulmonary vein of the subject, a carotid artery of the subject, a carotid sinus of the subject, a vena cava vein of the subject, and an internal jugular vein of the subject. The method also includes configuring the current so as to treat a condition of the subject selected from the list consisting of: an autoimmune disease, an autoimmune inflammatory disease, multiple sclerosis, encephalitis, myelitis, immune-mediated neuropathy, myositis, dermatomyositis, polymyositis, inclusion body myositis, inflammatory demyelinating polyradiculoneuropathy, Guillain Barre syndrome, myasthenia gravis, inflammation of the nervous system, inflammatory bowel disease, Crohn's disease, ulcerative colitis, SLE (systemic lupus erythematosus), rheumatoid arthritis, vasculitis, polyarteritis nodosa, Sjogren syndrome, mixed connective tissue disease, glomerulonephritis, thyroid autoimmune disease, sepsis, meningitis, a bacterial infection, a viral infection, a fungal infection, sarcoidosis, hepatitis, and portal vein hypertension.
摘要翻译：提供了一种用于治疗受试者的方法，包括将电流施加到从包括受试者的迷走神经，受试者的心外膜脂肪垫，受试者的肺静脉，颈动脉受试者的动脉，受试者的颈动脉窦，受试者的腔静脉和受试者的颈内静脉。该方法还包括配置电流以便治疗从以下列表中选择的受试者的状况：自身免疫疾病，自身免疫性炎性疾病，多发性硬化症，脑炎，脊髓炎，免疫介导的神经病，肌炎，皮肌炎，多发性肌炎，包涵体肌炎，炎性脱髓鞘多发性神经病，吉兰巴利综合征，重症肌无力，神经系统炎症，炎性肠病，克罗恩病，溃疡性结肠炎，SLE（系统性红斑狼疮），类风湿性关节炎，血管炎，结节性多动脉炎，干燥综合征，混合结缔组织病，肾小球性肾炎，甲状腺自身免疫性疾病，败血症，脑膜炎，细菌感染，病毒感染，真菌感染，结节病，肝炎和门静脉高血压。

53. 发明授权

US06600954B2 Method and apparatus for selective control of nerve fibers 有权
公开(公告)号：US06600954B2
公开(公告)日：2003-07-29
申请号：US09824682
申请日：2001-04-04
申请人： Ehud Cohen , Shai Ayal
发明人： Ehud Cohen , Shai Ayal
IPC分类号： A61N134
CPC分类号： A61N1/36071
摘要： A method and apparatus particularly useful for pain control by selectively blocking the propagation of body-generated action potentials travelling through a nerve bundle by using a tripolar electrode device to generate unidirectional action potentials to serve as collision blocks with the body-generated action potentials representing pain sensations in the small-diameter sensory fibers. In the described preferred embodiments there are a plurality of electrode devices spaced along the length of the nerve bundle which are sequentially actuated with delays corresponding to the velocity of propagation of the body-generated action potentials through the large-diameter fibers to produce a “green wave” effect which minimizes undesired anodal blocking of the large-diameter fibers while maximizing the collision blocking of the small-diameter fibers.

54. 发明授权

US08609082B2 Administering bone marrow progenitor cells or myoblasts followed by application of an electrical current for cardiac repair, increasing blood supply or enhancing angiogenesis 失效
标题翻译：管理骨髓祖细胞或成肌细胞，然后施加电流进行心脏修复，增加血液供应或增强血管生成
公开(公告)号：US08609082B2
公开(公告)日：2013-12-17
申请号：US11340156
申请日：2006-01-25
申请人： Tamir Ben-David , Omry Ben-Ezra , Ehud Cohen
发明人： Tamir Ben-David , Omry Ben-Ezra , Ehud Cohen
IPC分类号： A61N1/32 , A61N1/36 , A61N1/362 , A01N63/00
CPC分类号： A61N1/326 , A61N1/36121 , A61N1/36157
摘要： A method is provided including selecting a patient suffering from a condition, administering cells to the patient selected from the group consisting of: progenitor cells and genetically-modified cells, applying an electrical current to a site of the patient in a vicinity of nervous tissue, and configuring the current to stimulate the nervous tissue. Other embodiments are also described.
摘要翻译：提供了一种方法，包括选择患有病症的患者，向选自以下的患者施用细胞：祖细胞和遗传修饰的细胞，将电流施加到患者在神经组织附近的部位，并配置电流以刺激神经组织。还描述了其它实施例。

55. 发明授权

US08571651B2 Techniques for reducing pain associated with nerve stimulation 有权
标题翻译：降低神经刺激相关疼痛的技术
公开(公告)号：US08571651B2
公开(公告)日：2013-10-29
申请号：US13022199
申请日：2011-02-07
申请人： Omry Ben-Ezra , Tamir Ben-David , Ehud Cohen
发明人： Omry Ben-Ezra , Tamir Ben-David , Ehud Cohen
IPC分类号： A61N1/36
CPC分类号： A61N1/36071 , A61N1/36114
摘要： Apparatus is provided including an electrode device and a control unit. The electrode device is configured to be coupled to a site of a subject selected from the group consisting of: a vagus nerve, an epicardial fat pad, a pulmonary vein, a carotid artery, a carotid sinus, a coronary sinus, a vena cava vein, a right ventricle, a right atrium, and a jugular vein. The control unit is configured to drive the electrode device to apply to the site a current in at least first and second bursts, the first burst including a plurality of pulses, and the second burst including at least one pulse, and set (a) a pulse repetition interval (PRI) of the first burst to be on average at least 20 ms, (b) an interburst interval between initiation of the first burst and initiation of the second burst to be less than 10 seconds, (c) an interburst gap between a conclusion of the first burst and the initiation of the second burst to have a duration greater than the average PRI, and (d) a burst duration of the first burst to be less than a percentage of the interburst interval between, the percentage being less than 67%. Other embodiments are also described.
摘要翻译：提供了包括电极装置和控制单元的装置。电极装置被配置为耦合到选自以下的对象的部位：迷走神经，心外膜脂肪垫，肺静脉，颈动脉，颈动脉窦，冠状窦，腔静脉，右心室，右心房和颈静脉。所述控制单元被配置为驱动所述电极装置以至少第一和第二脉冲串向所述现场应用电流，所述第一脉冲串包括多个脉冲，所述第二脉冲串包括至少一个脉冲，并且设置（a）脉冲重复间隔（PRI）平均至少为20ms，（b）第一脉冲串的起始与第二脉冲串的起始之间的间歇间隔小于10秒，（c）突发间隙在第一突发的结论和第二突发的开始之间具有大于平均PRI的持续时间，以及（d）第一突发的突发持续时间小于突发间间隔的百分比，百分比为小于67％。还描述了其它实施例。

56. 发明授权

US08352683B2 Method and system to reduce the power consumption of a memory device 有权
标题翻译：降低存储器件功耗的方法和系统
公开(公告)号：US08352683B2
公开(公告)日：2013-01-08
申请号：US12823047
申请日：2010-06-24
申请人： Ehud Cohen , Oleg Margulis , Raanan Sade , Stanislav Shwartsman
发明人： Ehud Cohen , Oleg Margulis , Raanan Sade , Stanislav Shwartsman
IPC分类号： G06F12/00 , G06F13/00 , G06F13/28 , G06F1/00
CPC分类号： G06F12/0864 , G06F12/0859 , G06F2212/1028 , G06F2212/6082 , Y02D10/13
摘要： A method and system to reduce the power consumption of a memory device. In one embodiment of the invention, the memory device is a N-way set-associative level one (L1) cache memory and there is logic coupled with the data cache memory to facilitate access to only part of the N-ways of the N-way set-associative L1 cache memory in response to a load instruction or a store instruction. By reducing the number of ways to access the N-way set-associative L1 cache memory for each load or store request, the power requirements of the N-way set-associative L1 cache memory is reduced in one embodiment of the invention. In one embodiment of the invention, when a prediction is made that the accesses to cache memory only requires the data arrays of the N-way set-associative L1 cache memory, the access to the fill buffers are deactivated or disabled.
摘要翻译：一种降低存储器件功耗的方法和系统。在本发明的一个实施例中，存储器件是N路组合关联级（L1）高速缓冲存储器，并且存在与数据高速缓冲存储器耦合的逻辑，以便于仅访问N- 响应于加载指令或存储指令，单向设置关联L1高速缓冲存储器。通过减少针对每个加载或存储请求访问N路组合关联的L1高速缓冲存储器的方法的数量，在本发明的一个实施例中，减少了N路组合关联的L1高速缓冲存储器的功率需求。在本发明的一个实施例中，当预测到对高速缓存存储器的访问仅需要N路组关联的L1高速缓冲存储器的数据阵列时，对填充缓冲器的访问被去激活或禁用。

57. 发明授权

US08005542B2 Therapeutic maintenance of atrial fibrillation by electrical stimulation 有权
标题翻译：通过电刺激治疗房颤的治疗维持
公开(公告)号：US08005542B2
公开(公告)日：2011-08-23
申请号：US11978379
申请日：2007-10-29
申请人： Omry Ben-Ezra , Ehud Cohen , Tamir Ben-David
发明人： Omry Ben-Ezra , Ehud Cohen , Tamir Ben-David
IPC分类号： A61N1/362
CPC分类号： A61N1/0556 , A61B5/4035 , A61N1/36114 , A61N1/3621 , A61N1/395 , A61N1/3962
摘要： Apparatus for treating a subject suffering from spontaneous atrial fibrillation includes an electrode device, adapted to be coupled to a vagus nerve of the subject, and a control unit, adapted to drive the electrode device to apply an electrical current to the vagus nerve, and to configure the current to maintain the spontaneous AF for at least about 24 hours, so as to modify blood flow within the atria and reduce risk of thromboembolic events.
摘要翻译：用于治疗患有自发性心房颤动的受试者的装置包括适于耦合到受试者的迷走神经的电极装置和适于驱动电极装置向迷走神经施加电流的控制单元，以及配置电流以维持自发性AF至少约24小时，以便改变心房内的血流量并降低血栓栓塞事件的风险。

58. 发明授权

US07974693B2 Techniques for applying, configuring, and coordinating nerve fiber stimulation 有权
标题翻译：应用，配置和协调神经纤维刺激的技术
公开(公告)号：US07974693B2
公开(公告)日：2011-07-05
申请号：US11064446
申请日：2005-02-22
申请人： Tamir Ben-David , Shai Ayal , Omry Ben-Ezra , Ehud Cohen
发明人： Tamir Ben-David , Shai Ayal , Omry Ben-Ezra , Ehud Cohen
IPC分类号： A61N1/365
CPC分类号： A61B5/412 , A61B5/024 , A61B5/4029 , A61B5/4041 , A61B5/7217 , A61N1/0551 , A61N1/0556 , A61N1/36114 , A61N1/3621 , A61N1/3622 , A61N1/3627
摘要： Apparatus is provided including an implantable sensor, adapted to sense an electrical parameter of a heart of a subject, and a first control unit, adapted to apply pulses to the heart responsively to the sensed parameter, the pulses selected from the list consisting of: pacing pulses and anti-arrhythmic energy. The apparatus further includes an electrode device, adapted to be coupled to a site of the subject selected from the list consisting of: a vagus nerve of the subject, an epicardial fat pad of the subject, a pulmonary vein of the subject, a carotid artery of the subject, a carotid sinus of the subject, a coronary sinus of the subject, a vena cava vein of the subject, a right ventricle of the subject, and a jugular vein of the subject; and a second control unit, adapted to drive the electrode device to apply to the site a current that increases parasympathetic tone of the subject and affects a heart rate of the subject. The first and second control units are not under common control. At least one of the control units is adapted to coordinate an aspect of its operation with an aspect of operation of the other control unit. Other embodiments are also described.
摘要翻译：提供了包括适于感测对象的心脏的电参数的可植入传感器和适于响应于所感测的参数向心脏施加脉冲的第一控制单元，从列表中选择的脉冲包括：起搏脉冲和抗心律变能。所述装置还包括电极装置，适于耦合到选自以下列表的对象的部位：包括受试者的迷走神经，受试者的心外膜脂肪垫，受试者的肺静脉，颈动脉受试者的颈动脉窦，受试者的冠状窦，受试者的腔静脉，受试者的右心室和受试者的颈静脉; 以及第二控制单元，其适于驱动所述电极装置向所述部位施加增加所述受试者的副交感神经紧张并影响所述受试者的心率的电流。第一和第二控制单元不在一般控制之下。控制单元中的至少一个适于将其操作的一个方面与其他控制单元的操作的一个方面协调。还描述了其它实施例。

59. 发明授权

US07844346B2 Electrode assembly for nerve control 有权
标题翻译：用于神经控制的电极组件
公开(公告)号：US07844346B2
公开(公告)日：2010-11-30
申请号：US11347120
申请日：2006-02-02
申请人： Ehud Cohen , Tamir Ben-David , Shai Ayal , Omry Ben-Ezra
发明人： Ehud Cohen , Tamir Ben-David , Shai Ayal , Omry Ben-Ezra
IPC分类号： A61N1/375
CPC分类号： A61N1/0556
摘要： Apparatus is provided for applying current to a nerve, including a housing, that is adapted to be placed in a vicinity of the nerve. At least one electrode is fixed to the housing such that the at least one electrode does not come in direct physical contact with the nerve, and such that the electrode surrounds greater than 180 degrees of a circumference of the nerve after the placement of the housing. Two end insulating elements are fixed to the housing. The at least one electrode is between the end insulating elements. A characteristic closest end insulating element distance to a surface of the nerve is less than 0.5 mm.
摘要翻译：提供了用于将电流施加到神经的装置，包括适于放置在神经附近的壳体。至少一个电极被固定到壳体，使得至少一个电极不与神经直接物理接触，并且使得电极在放置壳体之后围绕大于180度的神经周围。两端绝缘元件固定在壳体上。至少一个电极在端部绝缘元件之间。距离神经表面最近的特征最接近的绝缘元件的距离小于0.5mm。

60. 发明授权

US07805203B2 Method for surgically implanting an electrode device 有权
标题翻译：手术植入电极装置的方法
公开(公告)号：US07805203B2
公开(公告)日：2010-09-28
申请号：US11975646
申请日：2007-10-19
申请人： Tamir Ben-David , Shai Ayal , Omry Ben-Ezra , Ehud Cohen
发明人： Tamir Ben-David , Shai Ayal , Omry Ben-Ezra , Ehud Cohen
IPC分类号： A61N1/05
CPC分类号： A61B5/412 , A61B5/024 , A61B5/4029 , A61B5/4041 , A61B5/7217 , A61N1/0551 , A61N1/0556 , A61N1/36114 , A61N1/3621 , A61N1/3622 , A61N1/3627
摘要： A method is provided that includes surgically implanting an electrode device having a cuff and one or more electrodes mounted in the cuff, by placing the electrode device around a nerve such that the electrodes face the nerve. Conductive solution is introduced into the electrode device such that the solution is in contact with both the electrodes and the nerve. During implantation of the electrode device, an impedance is measured between one or more of the electrodes and an electrical contact point in electrical communication with the electrode device. Responsively to the impedance measurement, it is determined whether the electrode device is correctly sized for the nerve, and, if not, the electrode device is removed and another electrode device having a different size is implanted. Other embodiments are also described.
摘要翻译：提供了一种方法，其包括通过将电极装置围绕神经放置以使得电极面向神经，手术地植入具有袖带的电极装置和安装在袖带中的一个或多个电极。将导电溶液引入电极装置，使得溶液与电极和神经接触。在植入电极装置期间，测量一个或多个电极之间的阻抗和与电极装置电连通的电接触点。响应于阻抗测量，确定电极装置是否具有适当尺寸的神经，如果不是，则去除电极装置，并植入具有不同尺寸的另一电极装置。还描述了其它实施例。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式