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    • 58. 发明授权
    • Quantifying autonomic tone with thoracic impedance
    • 量化自主神经与胸阻抗
    • US08435186B2
    • 2013-05-07
    • US12696753
    • 2010-01-29
    • Douglas A. HettrickDonald J. HefnerShantanu SarkarTodd M. Zielinski
    • Douglas A. HettrickDonald J. HefnerShantanu SarkarTodd M. Zielinski
    • A61B5/00
    • A61N1/36521A61B5/0031A61B5/0215A61B5/02405A61B5/053A61B5/08A61B5/11A61B5/1116A61B5/4035A61N1/36535A61N1/37247A61N1/37258
    • The disclosure describes techniques for quantifying the autonomic nervous system (ANS) health of a patient with thoracic impedance measurements. Thoracic impedance may be measured utilizing cardiac electrodes and an implantable medical device housing or other electrodes located on or within the patient. Since greater variability in thoracic impedance may indicate better health of the ANS, monitoring impedance changes in a patient may be used to quantify autonomic tone of the ANS, and ultimately, overall patient health. In some examples, thoracic impedance may be measured in response to a change in patient posture for acute monitoring or at predetermined times over several days, weeks, or months for more chronic monitoring of the patient. An implantable medical device may independently analyze the impedance measurements and transmit an alert to the patient or clinician when impedance changes indicate a change in patient health.
    • 本公开描述了用于量化具有胸部阻抗测量的患者的自主神经系统(ANS)健康的技术。 可以使用心电极和位于患者内部或内部的可植入医疗装置外壳或其它电极来测量胸腔阻抗。 由于胸部阻抗变化较大可能表明ANS的健康状况良好,所以监测患者的阻抗变化可用于量化ANS的自主音调,并最终对整体患者的健康状况进行量化。 在一些示例中,可以响应于用于急性监测的患者姿势的变化或在几天,几周或几个月的预定时间来测量胸部阻抗以进行更长期的患者监测。 当阻抗变化表示患者健康状况发生变化时,植入式医疗设备可以独立地分析阻抗测量结果并向患者或临床医生发送警报。