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51. 发明申请

US20070293667A1 4-Amino-quinazolines 有权
标题翻译： 4-氨基 - 喹唑啉
公开(公告)号：US20070293667A1
公开(公告)日：2007-12-20
申请号：US11300626
申请日：2005-12-14
申请人： Werner Mederski , Ralf Devant , Gerhard Barnickel , Sabine Bernotat-Danielowski , James Vickers , Bertram Cezanne , Daljit Dhanoa , Bao-Ping Zhao , James Rinker , Mark Player , Edward Jaeger , Richard Soll
发明人： Werner Mederski , Ralf Devant , Gerhard Barnickel , Sabine Bernotat-Danielowski , James Vickers , Bertram Cezanne , Daljit Dhanoa , Bao-Ping Zhao , James Rinker , Mark Player , Edward Jaeger , Richard Soll
IPC分类号： C07D239/72 , C07D403/02 , C07D413/02
CPC分类号： C07D239/94 , C07D403/12 , C07D405/12 , C07D409/10 , C07D409/14 , C07D413/12
摘要： Quinazolines of the formula I in which R, R1, R2, R3, R4 and Y have the meaning indicated in Patent Claim 1, and their salts or solvates as glycoprotein IbIX antagonists.
摘要翻译：其中R 1，R 2，R 2，R 3，R 4和Y 4的式I的喹唑啉具有专利权利要求1中所示的含义，并且其盐或溶剂合物作为糖蛋白IbIX拮抗剂。

52. 发明申请

US20060019974A1 4-Amino-quinazolines 有权
标题翻译： 4-氨基 - 喹唑啉
公开(公告)号：US20060019974A1
公开(公告)日：2006-01-26
申请号：US10380908
申请日：2001-09-17
申请人： Werner Mederski , Ralf Devant , Maria Devant , Gerhard Barnickel , Sabine Bernotat-Danielowski , James Vickers , Bertram Cezanne , Daljit Dhanoa , Bao-Ping Zhao , James Rinker , Mark Player , Edward Jaeger , Richard Soll
发明人： Werner Mederski , Ralf Devant , Maria Devant , Gerhard Barnickel , Sabine Bernotat-Danielowski , James Vickers , Bertram Cezanne , Daljit Dhanoa , Bao-Ping Zhao , James Rinker , Mark Player , Edward Jaeger , Richard Soll
IPC分类号： A61K31/517 , C07D403/02 , C07D239/94
CPC分类号： C07D239/94 , C07D239/95 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/04 , C07D409/14
摘要： Quinazolines of the formula (I) in which R, R1, R2, R3, R4 and Y have the meaning indicated in Patent claim 1, and their salts or solvates as glycoprotein IbIX antagonists.
摘要翻译：式（I）的喹唑啉其中R 1，R 2，R 2，R 3，R 4，并且Y具有专利权利要求1中所示的含义，并且其盐或溶剂合物作为糖蛋白IbIX拮抗剂。

53. 发明授权

US07060706B1 Quinazolinones 有权
标题翻译：喹唑啉酮
公开(公告)号：US07060706B1
公开(公告)日：2006-06-13
申请号：US10089167
申请日：2000-09-13
申请人： Werner Mederski , Ralf Devant , Gerhard Barnickel , Sabine Bernotat-Danielowski , Guido Melzer , Bertram Cezanne , Daljit Dhanoa , Bao-Ping Zhao , James Rinker , Mark Player , Richard Soll
发明人： Werner Mederski , Ralf Devant , Gerhard Barnickel , Sabine Bernotat-Danielowski , Guido Melzer , Bertram Cezanne , Daljit Dhanoa , Bao-Ping Zhao , James Rinker , Mark Player , Richard Soll
IPC分类号： C07D239/91 , A61K31/517 , A61P9/10
CPC分类号： C07D239/91
摘要： Quinazolinones of formula (I) in which R, R1, R2, R3, R4, Y, n and m have the meaning indicated in Patent claim 1, and their salts or solvates as glycoprotein IbIX antagonists
摘要翻译：式（I）的喹唑啉酮，其中R 1，R 2，R 2，R 3，R 4， Y，n和m具有专利权利要求1中所示的含义，其盐或溶剂合物作为糖蛋白IbIX拮抗剂

54. 发明申请

US20080306042A1 Triazole Derivatives 失效
标题翻译：三唑衍生物
公开(公告)号：US20080306042A1
公开(公告)日：2008-12-11
申请号：US12158344
申请日：2006-11-24
申请人： Bertram Cezanne , Christiane Amendt , Hartmut Greiner , Ulrich Graedler , Guenter Hoelzemann
发明人： Bertram Cezanne , Christiane Amendt , Hartmut Greiner , Ulrich Graedler , Guenter Hoelzemann
IPC分类号： A61K31/5517 , C07D487/04 , A61K31/554 , A61P35/00 , C07D513/04
CPC分类号： C07D513/04 , C07D471/14 , C07D487/04
摘要： Novel triazole derivatives are inhibitors of TGF-beta receptor I kinase, and can be employed, inter alia, for the treatment of tumours.
摘要翻译：新型的三唑衍生物是TGF-β受体I激酶的抑制剂，特别可用于治疗肿瘤。

55. 发明授权

US07977343B2 Adenine derivatives 有权
标题翻译：腺嘌呤衍生物
公开(公告)号：US07977343B2
公开(公告)日：2011-07-12
申请号：US12063384
申请日：2006-07-20
申请人： Hans-Peter Buchstaller , Hans-Michael Eggenweiler , Bertram Cezanne , Michael Wolf
发明人： Hans-Peter Buchstaller , Hans-Michael Eggenweiler , Bertram Cezanne , Michael Wolf
IPC分类号： A61K31/535
CPC分类号： C07D473/34
摘要： Novel adenine derivatives of the formula (I), in which R1, R2, R3, X and Y have the meanings indicated in Claim 1, are HSP90 inhibitors and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role.
摘要翻译：式（I）的新型腺嘌呤衍生物，其中R 1，R 2，R 3，X和Y具有权利要求1所示的含义，是HSP90抑制剂，可用于制备用于治疗疾病的药物 HSP90的抑制，调节和/或调节起着重要的作用。

56. 发明授权

US08093240B2 Triazole derivatives 失效
标题翻译：三唑衍生物
公开(公告)号：US08093240B2
公开(公告)日：2012-01-10
申请号：US12158344
申请日：2006-11-24
申请人： Bertram Cezanne , Christiane Amendt , Hartmut Greiner , Ulrich Graedler , Guenter Hoelzemann
发明人： Bertram Cezanne , Christiane Amendt , Hartmut Greiner , Ulrich Graedler , Guenter Hoelzemann
IPC分类号： A61P35/00 , A61K31/38 , A61K31/55 , C07D487/04 , C07D513/04
CPC分类号： C07D513/04 , C07D471/14 , C07D487/04
摘要： Novel triazole derivatives are inhibitors of TGF-beta receptor I kinase, and can be employed, inter alia, for the treatment of tumours.
摘要翻译：新型的三唑衍生物是TGF-β受体I激酶的抑制剂，特别可用于治疗肿瘤。

57. 发明申请

US20100160352A1 ADENINE DERIVATIVES 有权
标题翻译：腺嘌呤衍生物
公开(公告)号：US20100160352A1
公开(公告)日：2010-06-24
申请号：US12063384
申请日：2006-07-20
申请人： Hans-Peter Buchstaller , Hans-Michael Eggenweiler , Bertram Cezanne , Michael Wolf
发明人： Hans-Peter Buchstaller , Hans-Michael Eggenweiler , Bertram Cezanne , Michael Wolf
IPC分类号： A61K31/52 , C07D473/34 , A61P25/28
CPC分类号： C07D473/34
摘要： Novel adenine derivatives of the formula (I), in which R1, R2, R3, X and Y have the meanings indicated in Claim 1, are HSP90 inhibitors and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role.
摘要翻译：式（I）的新型腺嘌呤衍生物，其中R 1，R 2，R 3，X和Y具有权利要求1所示的含义，是HSP90抑制剂，可用于制备用于治疗疾病的药物 HSP90的抑制，调节和/或调节起着重要的作用。

58. 发明申请

US20080163701A1 Method and Device for the Taking and Analysis of Samples 审中-公开
标题翻译：采样和分析样品的方法和装置
公开(公告)号：US20080163701A1
公开(公告)日：2008-07-10
申请号：US11813477
申请日：2005-12-16
申请人： Michael Ukelis , Bertram Cezanne , Hanns Wurziger
发明人： Michael Ukelis , Bertram Cezanne , Hanns Wurziger
IPC分类号： G01N1/20
CPC分类号： G01N1/2035 , B01J19/0093 , B01J2219/00286 , B01J2219/00707 , B01J2219/00869 , B01J2219/00873 , B01J2219/00891 , B01J2219/0095 , C40B60/14 , G01N35/1095 , G01N2035/1034
摘要： In a method for the taking and analysis of samples from a microreaction system (3) having a suction line (9) arranged laterally alongside a discharge aperture (4) of the microreaction system (3), a reduced pressure is generated in the suction line (9) for the aspiration of substances exiting from the discharge aperture (4), causing the exiting substance stream to be divided into an aspirated substance stream and a free-falling substance stream, and one of the two divided substance streams is subsequently fed to an analytical device (10) for analysis. The reduced pressure in the suction line (9) can be influenced and thus the division of the exiting substance stream can be controlled as a function of a result of the analysis. Reaction parameters can also be pre-specified or controlled as a function of analytical results. A device for carrying out the method has an opening of the suction line (9) which is arranged laterally alongside the discharge aperture (4), where a reduced pressure can be generated in the suction line (9), and an analytical device (10) is either connected to the suction line (9) or arranged below the discharge aperture (4).
摘要翻译：在用于从具有沿着微反应系统（3）的排放孔（4）横向布置的吸入管线（9）的微反应系统（3）取样和分析样品的方法中，在吸入管线中产生减压（9），用于从排出孔（4）排出的物质的抽吸，使排出的物质流分成吸入物质流和自由落体物质流，然后将两个分开的物质流中的一个送入用于分析的分析装置（10）。可以影响吸入管线（9）中的减压，因此可以根据分析结果来控制排出物流的分配。反应参数也可以作为分析结果的函数进行预先指定或控制。用于执行该方法的装置具有沿排放孔（4）横向布置的吸入管线（9）的开口，其中在吸入管线（9）中可能产生减压，并且分析装置（10））或者连接到吸入管线（9）或者布置在排出孔（4）的下方。

59. 发明授权

US06441013B1 Sulphonyloxazolamines as therapeutic active ingredients 失效
标题翻译：磺酰氯唑胺作为治疗活性成分
公开(公告)号：US06441013B1
公开(公告)日：2002-08-27
申请号：US09868097
申请日：2001-06-14
申请人： Hartmut Greiner , Gerd Bartoszyk , Henning Böttcher , Gerhard Barnickel , Bertram Cezanne
发明人： Hartmut Greiner , Gerd Bartoszyk , Henning Böttcher , Gerhard Barnickel , Bertram Cezanne
IPC分类号： A61K3142
CPC分类号： C07D263/48
摘要： The present invention relates to sulphonylexazolamines of general formula (I), wherein R1, R2 represent independently from each other H, A, —(CH2)n—Ar or alkenyl with 2-6 C atoms, R1 and R2 together also represent a mononuclear saturated heterocycle with 1-2 N, O and/or S atoms, Z is H, A, CF3, NO2, Hal, OH, OA, NH2, NHA or NH2. A represents alkyl with 1-6 C atoms, Ar is Z-monosubstituted or Z-disubstituted phenyl, Hal is F, Cl, Br, or L n is 1 or 2 of the physiologically acceptable salts or solvates thereof. Said sulphonyloxazolamines are used as therapeutic active ingredients. The invention also relates to the use of sulphonyloxazolamines as therapeutic active ingredients and/or to the production of pharmaceutical preparations to combat diseases of the central nervous system. The invention further relates to a pharmaceutical preparation and the production thereof.
摘要翻译：本发明涉及通式（I）的磺酰基唑胺，其中R 1，R 2彼此独立地表示H，A， - （CH 2）n -Ar或具有2-6个C原子的烯基，R 1和R 2一起也表示单核具有1-2个N，O和/或S原子的饱和杂环，Z是H，A，CF 3，NO 2，Hal，OH，OA，NH 2，NHA或NH 2。 A表示具有1-6个C原子的烷基，Ar是Z-单取代或Z-二取代的苯基，Hal是F，Cl，Br或L n是其生理上可接受的盐或溶剂化物的1或2。所述磺酰基恶唑胺用作治疗活性成分。本发明还涉及磺酰氯唑胺作为治疗活性成分和/或用于制备用于对抗中枢神经系统疾病的药物制剂的用途。本发明还涉及药物制剂及其制备。

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