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51. 发明授权

US5330762A Tandospiaine antidepressive therapy 失效
标题翻译：坦度螺酮抗抑郁药治疗
公开(公告)号：US5330762A
公开(公告)日：1994-07-19
申请号：US10086
申请日：1993-01-27
申请人： Atul D. Ayer , Dana Ridzon
发明人： Atul D. Ayer , Dana Ridzon
IPC分类号： A61K9/00 , A61K9/52 , A61K31/495 , A61K31/496 , A61K31/505 , A61K31/506 , A61K47/34 , A61P25/20 , A61P25/24 , A61P25/26 , A61K9/24
CPC分类号： A61K31/496 , A61K31/495 , A61K31/505 , A61K31/506 , A61K9/0004
摘要： A dosage form is provided for administering a drug of the formula ##STR1## to a patient to produce an anxiolytic benefit in the patient.
摘要翻译：提供给患者施用式“IMAGE”的药物以在患者中产生抗焦虑益处的剂型。

52. 发明授权

US5030456A Dosage form for treating cardiovascular diseases 失效
标题翻译：用于治疗心血管疾病的剂型
公开(公告)号：US5030456A
公开(公告)日：1991-07-09
申请号：US516582
申请日：1990-04-30
申请人： Atul D. Ayer , David R. Swanson , Anthony L. Kuczynski
发明人： Atul D. Ayer , David R. Swanson , Anthony L. Kuczynski
IPC分类号： A61K9/00 , A61K9/22 , A61K31/44
CPC分类号： A61K31/44 , A61K9/0004
摘要： An osmotic device is disclosed comprising a first composition, and a second composition with the beneficial drug isradipine in the first composition.
摘要翻译：公开了一种渗透装置，其包含第一组合物，第二组合物在第一组合物中具有有益药物阿拉度铂。

53. 发明授权

US5024843A Oral hypoglycemic glipizide granulation 失效
标题翻译：口服降糖吡吡嗪颗粒
公开(公告)号：US5024843A
公开(公告)日：1991-06-18
申请号：US402314
申请日：1989-09-05
申请人： Anthony L. Kuczynski , Atul D. Ayer , Patrick S.-L. Wong
发明人： Anthony L. Kuczynski , Atul D. Ayer , Patrick S.-L. Wong
IPC分类号： A61K9/00 , A61K9/20 , A61K9/22 , A61K31/64 , A61K47/32 , A61K47/38
CPC分类号： A61K31/64 , A61K9/0004 , A61K9/2027 , A61K9/2031 , A61K9/2054 , Y10S514/866
摘要： A dosage form is disclosed comprising the antidiabetic drug glipizide for administering to a patient in need of glipizide therapy.
摘要翻译：公开了一种剂型，其包含用于给予需要格列吡嗪治疗的患者的抗糖尿病药物格列吡嗪。

54. 发明授权

US4915952A Composition comprising drug, HPC, HPMC and PEO 失效
标题翻译：组合物包含药物，HPC，HPMC和PEO
公开(公告)号：US4915952A
公开(公告)日：1990-04-10
申请号：US310167
申请日：1989-02-15
申请人： Atul D. Ayer , Lawrence G. Hamel
发明人： Atul D. Ayer , Lawrence G. Hamel
IPC分类号： A61K9/00 , A61K9/22 , A61K31/44
CPC分类号： A61K9/0004 , A61K31/44
摘要： A dosage form is disclosed for delivering the beneficial drugs pseudoephedrine and brompheniramine to a biological environment of use.
摘要翻译：公开了用于将有益药物伪麻黄碱和溴苯那敏递送到生物生物学环境的剂型。

55. 发明授权

US4847093A Dosage form with means for governing rate of gas formation 失效
标题翻译：用于形成气体排放率的方法
公开(公告)号：US4847093A
公开(公告)日：1989-07-11
申请号：US668761
申请日：1986-06-19
申请人： Atul D. Ayer , Patrick S. L. Wong
发明人： Atul D. Ayer , Patrick S. L. Wong
IPC分类号： A61K9/00 , A61K9/22
CPC分类号： A61K9/0004
摘要： An osmotic device is disclosed comprising a release rate controlling wall that surrounds a carbon dioxide generating compound.
摘要翻译：公开了一种渗透装置，其包括围绕产生二氧化碳的化合物的释放速率控制壁。

56. 发明授权

US4755180A Dosage form comprising solubility regulating member 失效
标题翻译：包含溶解性调节元件的剂型
公开(公告)号：US4755180A
公开(公告)日：1988-07-05
申请号：US874961
申请日：1986-06-16
申请人： Atul D. Ayer , Patrick S. L. Wong
发明人： Atul D. Ayer , Patrick S. L. Wong
IPC分类号： A61K9/00 , A61K9/22 , A61M31/00 , A01N25/12 , A61J3/00 , A61J3/10
CPC分类号： A61M31/002 , A61K9/0004
摘要： An osmotic dosage form is disclosed comprising a polymeric olefin, vinyl, condensation, addition or silicon film that surrounds a member selected from the group consisting of a buffer and osmogent which member is released by the film as a means for governing the solubility of a beneficial agent in the dosage form.

57. 发明授权

US4609374A Osmotic device comprising means for governing initial time of agent release therefrom 失效
标题翻译：渗透装置包括用于控制药剂从其释放的初始时间的装置
公开(公告)号：US4609374A
公开(公告)日：1986-09-02
申请号：US725961
申请日：1985-04-22
申请人： Atul D. Ayer
发明人： Atul D. Ayer
IPC分类号： A61K9/00 , A61K9/22 , A61K9/36 , A61K9/62
CPC分类号： A61K9/0004
摘要： An osmotic dispensing device is disclosed for delivering a medicine to a biological environment of use. The device comprises a semipermeable wall surrounding a compartment with an osmotic passageway in the semipermeable wall connecting the outside of the device with the compartment. The compartment house a medicine releasably held on a carrier member selected from the group consisting of cellulose esters, cellulose ethers and cellulose ester-ethers.
摘要翻译：公开了用于将药物递送到生物生物学环境的渗透分配装置。该装置包括围绕隔室的半透壁，该隔室具有连接设备外部与隔室的半透壁中的渗透通道。隔室装有一种可释放地保持在选自纤维素酯，纤维素醚和纤维素酯 - 醚的载体上的药物。

58. 发明授权

US4285987A Process for manufacturing device with dispersion zone 失效
标题翻译：具有分散区制造装置的方法
公开(公告)号：US4285987A
公开(公告)日：1981-08-25
申请号：US90492
申请日：1979-11-01
申请人： Atul D. Ayer , Felix Theeuwes
发明人： Atul D. Ayer , Felix Theeuwes
IPC分类号： A61K9/00 , A61M7/00
CPC分类号： A61K9/0004
摘要： An osmotic system is disclosed for dispensing a beneficial agent. The system comprises (1) a first wall of a semipermeable material that surrounds a compartment containing a drug formulation, and has a passageway through the wall for releasing agent from the compartment, (2) a second wall positioned distant from the first wall, said second wall a microporous or hydrogel material that extends around the first wall, and (3) a distribution zone interposed between the first and second wall and initially housing a compound soluble in an external fluid that enters the system.In operation, agent is dispensed from the system by fluid passing through the second wall into the zone from which fluid is further being imbibed through the first wall into the compartment forming a solution that is released through the passageway into the zone, and then through the second wall to the exterior of the system.
摘要翻译：公开了用于分配有益试剂的渗透系统。该系统包括（1）半透性材料的第一壁，该第一壁围绕包含药物制剂的隔室，并且具有通过所述壁的通道，用于从所述隔间释放剂，（2）位于远离所述第一壁的第二壁，所述第二壁第二壁是围绕第一壁延伸的微孔或水凝胶材料，以及（3）介于第一和第二壁之间的分配区，并且初始地容纳可溶于进入系统的外部流体的化合物。在操作中，通过流体通过第二壁将流体从系统中分配到进入区域中的流体进一步从第一壁吸入到隔室中，该隔室形成通过通道被释放到该区域中的溶液，然后通过第二个墙壁到系统的外部。

59. 发明授权

US4116241A Osmotic system with laminated wall comprising structurally different semipermeable lamina 失效
标题翻译：具有层压壁的渗透系统包括结构不同的半透膜
公开(公告)号：US4116241A
公开(公告)日：1978-09-26
申请号：US750773
申请日：1976-12-15
申请人： Felix Theeuwes , Atul D. Ayer
发明人： Felix Theeuwes , Atul D. Ayer
IPC分类号： A61F9/00 , A61K9/00 , A61K9/24 , A61K9/44
CPC分类号： A61K9/0004 , A61F9/0017
摘要： An osmotic system for delivering a beneficial agent to an environment of use is disclosed. The system comprises a laminate surrounding a compartment and has a passageway through the laminate for releasing agent from the compartment. The laminate comprises at least two laminae; one consisting of a semipermeable, polymeric material that is permeable to the passage of an external fluid and maintains its physical and chemical integrity in the environment of use, and one consisting of a semipermeable polymeric material that is permeable to the passage of fluid, substantially impermeable to the passage of agent and maintains its physical and chemical integrity in the presence of agent. The compartment comprises an active agent that is either soluble in the external fluid and exhibits an osmotic pressure gradient across the laminate against the fluid, or the agent has limited solubility in the fluid and it is mixed with an osmotically effective compound that is soluble in the fluid and exhibits an osmotic pressure gradient across the laminate against the fluid. In operation, agent is released from the system by fluid being imbibed through the laminate into the compartment at a rate controlled by the permeability of the laminate and the osmotic pressure gradient across the laminate producing a solution containing agent, or a solution of compound containing agent which solution in either operation is released through the passageway at a controlled and continuous rate over a prolonged period of time.
摘要翻译：公开了一种用于将有益剂递送到使用环境的渗透系统。该系统包括围绕隔室的层压板，并具有通过层压板的通道，用于将隔离物释放。层压体包括至少两层; 一种由可渗透外部流体通道并在使用环境中保持其物理和化学完整性的半透性聚合材料组成，并且由可渗透流体的半透性聚合材料构成，基本上不渗透代理人的通过，并在代理人的存在下保持其物理和化学完整性。隔室包含可溶于外部流体的活性剂，并且表现出横跨该层压体的流体的渗透压梯度，或者该试剂在流体中具有有限的溶解度，并且与渗透性有效的化合物混合，该化合物可溶于并且表现出跨过层压体抵抗流体的渗透压梯度。在操作中，通过流体通过层压体被吸收到隔室中的剂量从层压体的渗透性控制的速率和穿过层压体的渗透压梯度产生包含溶液的试剂或含化合物的溶液任何操作中的解决方案在长时间内以受控和连续的速率通过通道释放。

60. 发明授权

US4077407A Osmotic devices having composite walls 失效
标题翻译：具有复合壁的渗透装置
公开(公告)号：US4077407A
公开(公告)日：1978-03-07
申请号：US634859
申请日：1975-11-24
申请人： Felix Theeuwes , Atul D. Ayer
发明人： Felix Theeuwes , Atul D. Ayer
IPC分类号： A61M37/00 , A61K9/00 , A61M29/04 , A61M31/00
CPC分类号： A61K9/0036 , A61K9/0004
摘要： An osmotic device for delivering an active agent is disclosed. The device is comprised of a wall surrounding a compartment and has a passageway through the wall for releasing the agent. The wall is formed of a multiplicity of materials comprising a material permeable to an external fluid and substantially impermeable to agent and at least one additional material selected from a material that imparts stability to the wall, enhances the permeability of the wall to fluids, or aids in forming the wall. The compartment comprises an active agent that exhibits an osmotic pressure gradient against an external fluid, or the agent is mixed with an osmotically effective compound that exhibits an osmotic pressure gradient against the fluid. Agent is released from the device by fluid being imbibed through the wall into the compartment at a rate controlled by the permeability of the wall and the osmotic pressure gradient across the wall, to produce a solution containing agent that is released through the passageway at a controlled and continuous rate over a prolonged period of time.
摘要翻译：公开了用于递送活性剂的渗透装置。该装置包括围绕隔室的壁，并且具有通过壁的通道用于释放试剂。该壁由多种材料形成，包括可渗透外部流体的材料并且基本上不可渗透到试剂和至少一种附加材料，其选自赋予壁的稳定性的材料，增强壁对流体或助剂的渗透性在形成墙。所述隔室包含对外部流体显示渗透压梯度的活性剂，或者所述试剂与渗透压梯度相对于所述流体呈现渗透压的化合物混合。通过流体通过壁被吸入到隔室中的剂量通过壁的渗透性和穿过壁的渗透压梯度控制的速率从装置释放，以产生溶液包含试剂，其通过通道在受控的并持续延长时间。

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