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51. 发明授权

US08412326B2 Pacemaker with vagal surge monitoring and response 有权
标题翻译：起搏器与迷走神经浪涌监测和反应
公开(公告)号：US08412326B2
公开(公告)日：2013-04-02
申请号：US12709867
申请日：2010-02-22
申请人： Shantha Arcot-Krishnamurthy , Eric A. Mokelke , Allan C. Shuros
发明人： Shantha Arcot-Krishnamurthy , Eric A. Mokelke , Allan C. Shuros
IPC分类号： A61N1/00
CPC分类号： A61N1/3627 , A61N1/36514 , A61N1/36585
摘要： A pacemaker initiates and times a monitoring interval in response to an event such as a therapy delivery to a patient. The monitoring interval is specified to include a duration of an anticipated acute response to the event, such as vagal surge. One or more physiological parameters indicative of the acute response are detected during the monitoring interval for analyzing therapeutic effect of the event. In various embodiments, one or more pacing parameters are adjusted for a response interval specified to include the duration of the anticipated acute response to allow for the analysis and maximization of the therapeutic effect. In various embodiments, the event includes a session of pacing therapy delivered according to an intermittent cardiac stress augmentation pacing protocol, and the therapeutic effect is analyzed to adjust that protocol.
摘要翻译：起搏器响应于诸如向患者的治疗传递的事件而启动并且监视间隔时间。监测间隔被指定为包括对事件的预期急性反应的持续时间，例如迷走神经浪涌。在监视期间检测表示急性反应的一个或多个生理参数，以分析事件的治疗效果。在各种实施例中，针对指定为包括预期急性反应的持续时间的响应间隔调整一个或多个起搏参数，以允许治疗效果的分析和最大化。在各种实施例中，事件包括根据间歇性心脏应激增强起搏方案递送的起搏疗程，并且分析治疗效果以调整该方案。

52. 发明授权

US08412324B2 Method and device for treating myocardial ischemia 有权
标题翻译：治疗心肌缺血的方法和装置
公开(公告)号：US08412324B2
公开(公告)日：2013-04-02
申请号：US13103477
申请日：2011-05-09
申请人： Rodney W. Salo , Allan C. Shuros , Tamara Colette Baynham
发明人： Rodney W. Salo , Allan C. Shuros , Tamara Colette Baynham
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61N1/3684
摘要： A method and device for treating myocardial ischemia are described in which the stress experienced by a myocardial region identified as vulnerable to becoming ischemic is varied with pre-excitation pacing. In an unloading mode, pacing is applied in proximity to the vulnerable region to reduce stress and the metabolic demand of the region. In a loading mode, pacing is applied to a region remote from the vulnerable region in order to produce a conditioning effect.
摘要翻译：描述了一种用于治疗心肌缺血的方法和装置，其中被认为易于变得缺血的心肌区域所经受的压力随着预激发起搏而变化。在卸载模式下，起搏应用于脆弱区域附近，以减少该地区的压力和代谢需求。在加载模式中，起搏应用于远离脆弱区域的区域，以产生调节效果。

53. 发明申请

US20120296382A1 INTEGRATED CARDIAC RHYTHM MANAGEMENT SYSTEM WITH HEART VALVE 有权
标题翻译：整体心脏循环管理系统与心脏瓣膜
公开(公告)号：US20120296382A1
公开(公告)日：2012-11-22
申请号：US13564978
申请日：2012-08-02
申请人： Allan C. Shuros , Michael J. Kane
发明人： Allan C. Shuros , Michael J. Kane
IPC分类号： A61F2/24 , A61N1/39 , A61N1/365
CPC分类号： A61N1/3621 , A61F2/2403 , A61N1/36514 , A61N1/3962
摘要： Systems and methods using a heart valve and an implantable medical device, such as for event detection and optimization of cardiac output. The cardiac management system includes a heart valve, having a physiological sensor. The physiological sensor is adapted to measure at least one of an intrinsic electrical cardiac parameter, a hemodynamic parameter or the like. The system further includes an implantable electronics unit, such as a cardiac rhythm management unit, coupled to the physiological sensor of the heart valve to receive physiological information. The electronics unit is adapted to use the received physiological information to control delivery of an electrical output to the subject.
摘要翻译：使用心脏瓣膜和可植入医疗装置的系统和方法，例如用于事件检测和心输出量的优化。心脏管理系统包括具有生理传感器的心脏瓣膜。生理传感器适于测量本征电心脏参数，血液动力学参数等中的至少一个。该系统还包括可植入电子单元，例如心律管理单元，其耦合到心脏瓣膜的生理传感器以接收生理信息。电子单元适于使用所接收的生理信息来控制向对象的电输出的传递。

54. 发明申请

US20120239106A1 HIS CAPTURE VERIFICATION USING ELECTRO-MECHANICAL DELAY 有权
标题翻译：使用电子机械延迟的捕获验证
公开(公告)号：US20120239106A1
公开(公告)日：2012-09-20
申请号：US13404814
申请日：2012-02-24
申请人： Barun Maskara , Jiang Ding , Shantha Arcot-Krishnamurthy , Allan C. Shuros
发明人： Barun Maskara , Jiang Ding , Shantha Arcot-Krishnamurthy , Allan C. Shuros
IPC分类号： A61N1/37
CPC分类号： A61N1/36514 , A61N1/3627 , A61N1/365 , A61N1/36521 , A61N1/36564 , A61N1/36571 , A61N1/36578 , A61N1/371
摘要： Stimulation energy can be provided to a His-bundle to activate natural cardiac contraction mechanisms. Interval information can be used to describe a cardiac response to His-bundle stimulation, and the interval information can provide cardiac stimulation diagnostic information. For example, interval information can be used to discriminate between intrinsic conduction cardiac contractions and contractions responsive to His-bundle pacing.
摘要翻译：可以向His束提供刺激能量以激活自然心脏收缩机制。间隔信息可用于描述对His束刺激的心脏反应，间隔信息可提供心脏刺激诊断信息。例如，间隔信息可用于区分内在传导性心脏收缩和响应于His束起搏的收缩。

55. 发明申请

US20110319955A1 REDUCTION OF AV DELAY FOR TREATMENT OF CARDIAC DISEASE 有权
标题翻译：减少AV延迟治疗心脏病
公开(公告)号：US20110319955A1
公开(公告)日：2011-12-29
申请号：US13229948
申请日：2011-09-12
申请人： Joseph M. Pastore , Rodney W. Salo , Julio C. Spinelli , Allan C. Shuros , Andres Belalcazar
发明人： Joseph M. Pastore , Rodney W. Salo , Julio C. Spinelli , Allan C. Shuros , Andres Belalcazar
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/36521 , A61N1/36535 , A61N1/36542 , A61N1/36564 , A61N1/3688
摘要： An implantable pacing device for delivering ventricular pacing may be configured to intermittently reduce the AVD interval for beneficial effect in patients with compromised ventricular function (e.g., HF patients and post-MI patients). The AVD interval may be reduced in an AVD reduction mode, by shortening the AVD in an atrial triggered ventricular pacing mode or by switching to a non-atrial triggered ventricular pacing mode (e.g., VVI) and delivering paces at a rate above the intrinsic rate. The physiological effects of AVD reduction may be either positive or negative on cardiac output, depending upon the individual patient.
摘要翻译：用于输送心室起搏的可植入起搏装置可以被配置为间歇地减小AVD间隔，以在患有心室功能受损的患者（例如，HF患者和MI后患者）中产生有益效果。通过在心房触发的心室起搏模式中缩短AVD或者通过切换到非心房触发的心室起搏模式（例如，VVI）并以高于内在速率的速率递送步进，AVD间期可以减小AVD减小模式。取决于个体患者，AVD减少的生理作用可能是心输出量的正或负。

56. 发明申请

US20110319776A1 CARDIAC CONTRACTION DETECTION USING INFORMATION INDICATIVE OF LEAD MOTION 有权
标题翻译：使用指示铅运动的信息进行CARDIAC承包检测
公开(公告)号：US20110319776A1
公开(公告)日：2011-12-29
申请号：US13168507
申请日：2011-06-24
申请人： Robert J. Sweeney , Allan C. Shuros , Krzysztof Z. Siejko , David C. Olson , Frank Ingle
发明人： Robert J. Sweeney , Allan C. Shuros , Krzysztof Z. Siejko , David C. Olson , Frank Ingle
IPC分类号： A61B5/0245 , A61B5/042 , A61N1/365
CPC分类号： A61N1/36514 , A61B5/02133 , A61B5/026 , A61N1/08 , A61N1/36142 , A61N1/36578
摘要： Systems and methods for cardiac contraction detection using information indicative of lead motion are described. In an example, an implantable medical device can include a receiver circuit configured to be electrically coupled to conductor comprising a portion of an implantable lead and be configured to obtain information indicative of a movement of the implantable lead due at least in part to a motion of a heart. The device can include a processor circuit configured to determine whether a cardiac mechanical contraction occurred during a specified interval included in the obtained information indicative of the movement of the implantable lead. The processor circuit can be configured to determine information about the cardiac mechanical contraction using the obtained information indicative of the movement of the implantable lead.
摘要翻译：描述使用指示引导运动的信息进行心脏收缩检测的系统和方法。在一个示例中，可植入医疗设备可以包括被配置为电耦合到导体的接收器电路，该导体包括可植入引线的一部分，并被配置为获得指示可植入引线的运动的信息，至少部分地由一个心脏。该装置可以包括处理器电路，该处理器电路被配置为确定在所获得的指示可植入引线的运动的信息中包括的指定间隔期间是否发生心脏机械收缩。处理器电路可以被配置为使用获得的指示可植入引线的移动的信息来确定关于心脏机械收缩的信息。

57. 发明申请

US20110190840A1 SYMPATHETIC STIMULATION FOR IMPROVED MYOCARDIAL RELAXATION 有权
标题翻译：改善心肌松弛的同步刺激
公开(公告)号：US20110190840A1
公开(公告)日：2011-08-04
申请号：US13019818
申请日：2011-02-02
申请人： Allan C. Shuros , Shantha Arcot-Krishnamurthy , Guy Alvarez
发明人： Allan C. Shuros , Shantha Arcot-Krishnamurthy , Guy Alvarez
IPC分类号： A61N1/365
CPC分类号： A61N1/36564 , A61N1/3621 , A61N1/365
摘要： Described are methods and devices for improving diastolic function with electrostimulation in heart failure patients who exhibit relatively normal systolic function. Such patients are characterized by impaired myocardial relaxation during diastole that prevents adequate filling of the ventricles during diastole to thereby reduce cardiac output. An implantable device is described for effecting strategic and periodic stimulation of the sympathetic nervous system to elicit myocardial adrenergic activation for improved myocardial relaxation.
摘要翻译：描述了用于在呈现相对正常的收缩功能的心力衰竭患者中用电刺激改善舒张功能的方法和装置。这些患者的特征在于舒张期期间的心肌松弛受损，其在舒张期期间阻止充足的心室充盈，从而降低心输出量。描述了可植入装置，用于促进交感神经系统的战略和周期性刺激，以引发心肌肾上腺素能活化以改善心肌松弛。

58. 发明申请

US20110106197A1 PACEMAKER WITH VAGAL SURGE MONITORING AND RESPONSE 有权
标题翻译：具有VAGAL SURGE监测和响应的PACEMAKER
公开(公告)号：US20110106197A1
公开(公告)日：2011-05-05
申请号：US12709867
申请日：2010-02-22
申请人： Shantha Arcot-Krishnamurthy , Eric A. Mokelke , Allan C. Shuros
发明人： Shantha Arcot-Krishnamurthy , Eric A. Mokelke , Allan C. Shuros
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/36514 , A61N1/36585
摘要： A pacemaker initiates and times a monitoring interval in response to an event such as a therapy delivery to a patient. The monitoring interval is specified to include a duration of an anticipated acute response to the event, such as vagal surge. One or more physiological parameters indicative of the acute response are detected during the monitoring interval for analyzing therapeutic effect of the event. In various embodiments, one or more pacing parameters are adjusted for a response interval specified to include the duration of the anticipated acute response to allow for the analysis and maximization of the therapeutic effect. In various embodiments, the event includes a session of pacing therapy delivered according to an intermittent cardiac stress augmentation pacing protocol, and the therapeutic effect is analyzed to adjust that protocol.
摘要翻译：起搏器响应于诸如向患者的治疗传递的事件而启动并且监视间隔时间。监测间隔被指定为包括对事件的预期急性反应的持续时间，例如迷走神经浪涌。在监视期间检测表示急性反应的一个或多个生理参数，以分析事件的治疗效果。在各种实施例中，针对指定为包括预期急性反应的持续时间的响应间隔调整一个或多个起搏参数，以允许治疗效果的分析和最大化。在各种实施例中，事件包括根据间歇性心脏应激增强起搏方案递送的起搏疗程，并且分析治疗效果以调整该方案。

59. 发明申请

US20100268194A1 DEVICE AND METHOD FOR MODULATING RENAL FUNCTION 失效
标题翻译：用于调节肾功能的装置和方法
公开(公告)号：US20100268194A1
公开(公告)日：2010-10-21
申请号：US12825174
申请日：2010-06-28
申请人： Allan C. Shuros , M. Jason Brooke , Tasneem Poonawala
发明人： Allan C. Shuros , M. Jason Brooke , Tasneem Poonawala
IPC分类号： A61B17/122 , A61N1/36 , A61M25/00
CPC分类号： A61N1/3606 , A61M25/00 , A61N1/05 , A61N1/36007 , A61N1/36135
摘要： Renal function may be modulated by an implantable device having one or more leads or catheters disposed near the kidney via the lymphatic system. In one embodiment, lymphatic drainage from the kidney is modulated to increase or decrease tubular reabsorption of salt and water. The renal function modulation therapy may be delivered in an open-loop or closed-loop fashion, with the latter dependent upon a physiological variable such as blood pressure or cardiac output.
摘要翻译：肾功能可以由具有通过淋巴系统设置在肾附近的一个或多个引线或导管的可植入装置调节。在一个实施方案中，来自肾脏的淋巴引流被调节以增加或减少盐和水的管状再吸收。肾功能调节治疗可以以开环或闭环方式递送，后者取决于诸如血压或心输出量的生理变量。

60. 发明申请

US20100256700A1 METHOD AND APPARATUS FOR ORGAN SPECIFIC INFLAMMATION THERAPY 审中-公开
标题翻译：用于组织特异性炎症治疗的方法和装置
公开(公告)号：US20100256700A1
公开(公告)日：2010-10-07
申请号：US12755041
申请日：2010-04-06
申请人： Allan C. Shuros , Craig Stolen , Shantha Arcot-Krishnamurthy
发明人： Allan C. Shuros , Craig Stolen , Shantha Arcot-Krishnamurthy
IPC分类号： A61N1/365 , A61N1/39
CPC分类号： A61N1/36521 , A61N1/3627 , A61N1/365 , A61N1/3702
摘要： A method and device are described for delivering cardiac therapy in which an implantable device for delivering such cardiac therapy is additionally configured to detect the presence of inflammation. Upon detection of inflammation, the device may be configured to modify its delivery of therapy in various ways and/or to communicate the information to an external agent for other types of interventions.
摘要翻译：描述了用于递送心脏疗法的方法和装置，其中用于递送这种心脏治疗的可植入装置另外配置为检测炎症的存在。在检测到炎症时，该装置可以被配置为以各种方式修改其治疗递送和/或将信息传达给外部代理以用于其他类型的干预。

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