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51. 发明授权

US08754363B2 Method and apparatus for reducing noise in mass signal 有权
标题翻译：用于降低质量信号噪声的方法和装置
公开(公告)号：US08754363B2
公开(公告)日：2014-06-17
申请号：US13575600
申请日：2011-01-31
申请人： Koichi Tanji , Manabu Komatsu , Hiroyuki Hashimoto
发明人： Koichi Tanji , Manabu Komatsu , Hiroyuki Hashimoto
IPC分类号： H01J49/26 , G06F17/14 , H01J49/00
CPC分类号： H01J49/0036 , H01J49/0004
摘要： A more effective noise reduction method is provided. In the method, when mass spectrum information having a spatial distribution is processed, the whole data is taken as three-dimensional data (positional information is stored in an xy plane, and spectral information is stored along a z-axis direction), and three-dimensional wavelet noise reduction is performed by applying preferable basis functions to a spectral direction and a peak distribution direction (in-plane direction).
摘要翻译：提供了更有效的降噪方法。在该方法中，当处理具有空间分布的质谱信息时，将整个数据作为三维数据（位置信息存储在xy平面中，并且光谱信息沿z轴方向存储），并且三个通过对光谱方向和峰分布方向（面内方向）应用优选的基函数来进行维小波噪声降低。

52. 发明授权

US08704194B2 Information acquiring apparatus and information acquiring method for acquiring mass-related information 失效
标题翻译：信息获取装置和用于获取大量相关信息的信息获取方法
公开(公告)号：US08704194B2
公开(公告)日：2014-04-22
申请号：US13083510
申请日：2011-04-08
申请人： Manabu Komatsu , Hiroyuki Hashimoto
发明人： Manabu Komatsu , Hiroyuki Hashimoto
IPC分类号： H01J49/14 , H01J49/10
CPC分类号： H01J49/06 , H01J49/0463
摘要： Target molecules in a sample can be detected at an improved sensitivity by means of a mass spectrometer. A sample with or without a matrix is placed on a substrate and irradiated with a converged and pulsed primary beam selected from an ion beam, a neutral particle beam or a laser beam. Secondary ions and neutral molecules are emitted along with protons from the irradiated point of the sample as an electric field is applied between the substrate and an extraction electrode disposed above the substrate. A proton-control electrode is arranged in axial symmetry with the trajectory of the primary beam. A voltage is applied thereto so that the generated electric field decelerates the flying protons to raise their adhering efficiency to the flying neutral molecules.
摘要翻译：可以通过质谱仪以更高的灵敏度检测样品中的靶分子。将具有或不具有矩阵的样品放置在基底上并用从离子束，中性粒子束或激光束中选择的会聚且脉冲的一次束照射。随着电场施加在基板和设置在基板之上的引出电极之间，二次离子和中性分子与质子的辐射点一起被发射出来。质子控制电极与主光束的轨迹轴对称。施加电压使得所产生的电场使飞行质子减速，以提高它们对飞行中性分子的附着效率。

53. 发明授权

US07851749B2 Method for obtaining information and device therefor 有权
标题翻译：获取信息的方法及其设备
公开(公告)号：US07851749B2
公开(公告)日：2010-12-14
申请号：US12017584
申请日：2008-01-22
申请人： Manabu Komatsu , Hiroyuki Hashimoto , Yohei Murayama , Kazuhiro Ban
发明人： Manabu Komatsu , Hiroyuki Hashimoto , Yohei Murayama , Kazuhiro Ban
IPC分类号： H01J49/00
CPC分类号： H01J49/142
摘要： A method for obtaining information on a mass of an object by time-of-flight mass spectrometry. This method includes placing colloidal metal particles for promoting ionization of the object inside the object at a depth ranging from 0.1 nm to 100 nm in opposition to a primary beam for the ionization; irradiating the object with the primary beam selected from the group of ions, neutral particles, and electrons, which can be focused, pulsed, and are capable of scanning, and laser beams, which can be focused, pulsed, and are capable of scanning to ionize a constituent of the object and to allow the ionized constituent to fly out of the object; and obtaining information on the mass of the flying constituent of the object by time-of-flight mass spectrometry.
摘要翻译：一种通过飞行时间质谱法获得物体质量信息的方法。该方法包括将胶体金属颗粒放置在与离子化的主光束相反的0.1nm至100nm范围内的物体内部物体的离子化; 用可以被聚焦，脉冲和能够扫描的离子，中性粒子和电子组中选择的主要束照射物体，以及可以被聚焦，脉冲且能够扫描的激光束电离物体的成分并使离子化成分从物体飞出; 并通过飞行时间质谱法获得关于物体飞行成分质量的信息。

54. 发明授权

US07795579B2 Information obtaining method 有权
标题翻译：信息获取方法
公开(公告)号：US07795579B2
公开(公告)日：2010-09-14
申请号：US12120512
申请日：2008-05-14
申请人： Manabu Komatsu , Hiroyuki Hashimoto , Yohei Murayama , Kazuhiro Ban
发明人： Manabu Komatsu , Hiroyuki Hashimoto , Yohei Murayama , Kazuhiro Ban
IPC分类号： B01D59/44
CPC分类号： H01J49/145
摘要： An information obtaining method for obtaining information about a mass of a component of an analyte using a time of flight mass spectrometer and obtaining information about a distribution state of the component based on the obtained information about the mass includes the step of: (1) adding a self-reactive substance to the analyte on a base to facilitate ionization of the component; (2) irradiating the analyte with a primary beam in the presence of the self-reactive substance, thereby ionizing the components and allowing resulting ions to fly; (3) obtaining information about mass of the flying ions using the time of flight mass spectrometer; and (4) obtaining information about the distribution state of the component on the base based on the information about the mass.
摘要翻译：使用飞行时间质谱仪获取关于分析物的成分的质量的信息的信息获取方法，基于获得的关于质量的信息获得关于部件的分布状态的信息，包括以下步骤：（1）添加对基底上的分析物的自反应物质，以促进组分的离子化; （2）在存在自反应物质的情况下用主光束照射分析物，从而电离成分并允许所得离子飞行; （3）使用飞行时间质谱仪获取关于飞行离子质量的信息; 和（4）基于关于质量的信息获得关于组件在基础上的分布状态的信息。

55. 发明授权

US07643173B2 Image processing apparatus, image processing method, and printer driver 失效
标题翻译：图像处理装置，图像处理方法和打印机驱动程序
公开(公告)号：US07643173B2
公开(公告)日：2010-01-05
申请号：US11206130
申请日：2005-08-18
申请人： Manabu Komatsu
发明人： Manabu Komatsu
IPC分类号： G06F15/00
CPC分类号： G06F3/1284 , G06F3/1219 , G06F3/1244
摘要： An image processing apparatus is provided that processes image data to be output by an imaging apparatus. The image processing apparatus includes a target setting part for setting a target pertaining to imaging material saving that involves controlling the amount of imaging material used which target is set based on a designated condition, and a color reproducing condition adjusting part for adjusting a color reproducing condition for input color information based on the set target.
摘要翻译：提供一种处理由成像装置输出的图像数据的图像处理装置。图像处理装置包括：目标设定部，其用于设定与成像材料节约相关的目标，所述目标涉及根据指定条件来控制使用了所设定的成像材料的量;以及颜色再现条件调整部，用于调整颜色再现条件用于基于设定目标的输入颜色信息。

56. 发明申请

US20090251691A1 Liquid Immersion Microscope 失效
标题翻译：液体浸液显微镜
公开(公告)号：US20090251691A1
公开(公告)日：2009-10-08
申请号：US12083835
申请日：2006-10-18
申请人： Hiromasa Shibata , Manabu Komatsu , Toshio Uchikawa
发明人： Hiromasa Shibata , Manabu Komatsu , Toshio Uchikawa
IPC分类号： G01N21/01 , G01N21/88
CPC分类号： G02B21/33
摘要： To provide a liquid immersion microscope device enabling nondestructive liquid immersion observation of a substrate without deteriorating quality of the substrate. To attain this, a liquid immersion microscope device of the present invention includes a supporting unit supporting a substrate as an observation target, an objective lens of a liquid immersion type, a first supplying unit supplying ultrapure water as a liquid for observation to a gap between a tip of the objective lens and the substrate, a first draining unit draining the liquid for observation after observation of the substrate, a second supplying unit supplying a liquid for cleaning, which is different from the liquid for observation drained by the first draining unit, to an area, of the substrate, that has been in contact with the liquid for observation, and a second draining unit draining the liquid for cleaning after the substrate is cleaned.
摘要翻译：提供一种液晶显微镜装置，其能够对基板进行非破坏性液浸观察，而不会降低基板的质量。为此，本发明的液浸式显微镜装置包括：支撑单元，其支撑作为观察对象的基板，液浸型物镜;第一供给单元，其将超纯水作为观察用液体供给到第物镜的尖端和基板，在观察基板之后排出用于观察的液体的第一排水单元，供给与第一排水单元排出的观察用液体不同的清洗用液体的第二供给单元，与已经与用于观察的液体接触的基板的区域，以及在清洁基板之后排出用于清洁的液体的第二排出单元。

57. 发明授权

US07583859B2 Method, computer readable medium and apparatus for converting color image resolution 有权
标题翻译：方法，计算机可读介质和用于转换彩色图像分辨率的装置
公开(公告)号：US07583859B2
公开(公告)日：2009-09-01
申请号：US11157910
申请日：2005-06-22
申请人： Hiroaki Suzuki , Manabu Komatsu
发明人： Hiroaki Suzuki , Manabu Komatsu
IPC分类号： G06K9/00 , G06K9/32 , G09G5/00 , H04N1/393
CPC分类号： H04N1/3935 , G06T3/4015 , G09G5/02 , G09G2340/0407 , H04N1/40068 , H04N1/58
摘要： A method, computer readable medium and apparatus for converting color image resolution include inputting an image enlarging ratio, inputting target pixel data of an image in a first color space to be enlarged in a sequence, sampling reference pixels including the target pixel and pixels at least one of which links to the target pixel, and converting the reference pixel data into a second color space data. Other functions include extracting image feature quantities from the reference pixel data, selecting one of a plurality of pixel multiplying methods according to the extracted image feature quantities, multiplying the target pixel by the selected image multiplying method with an integer value based on the input image enlarging ratio, and outputting pixel data that have been generated by the target pixel multiplying step in a sequence.
摘要翻译：一种用于转换彩色图像分辨率的方法，计算机可读介质和装置，包括：输入图像放大率，输入第一颜色空间中的图像的目标像素数据以便按序列放大，至少包括目标像素和像素的参考像素其中一个链接到目标像素，并将参考像素数据转换为第二颜色空间数据。其他功能包括从参考像素数据提取图像特征量，根据提取的图像特征量选择多个像素乘法方法中的一个，根据所输入的图像放大将目标像素乘以所选择的图像乘法方法与整数值并按顺序输出由目标像素乘法步骤生成的像素数据。

58. 发明申请

US20080278706A1 METHOD FOR PRE-TREATING SPECIMEN AND METHOD FOR ANALYZING SPECIMEN 失效
标题翻译：预处理样本的方法和分析样本的方法
公开(公告)号：US20080278706A1
公开(公告)日：2008-11-13
申请号：US12113795
申请日：2008-05-01
申请人： Yohei Murayama , Hiroyuki Hashimoto , Manabu Komatsu , Kazuhiro Ban
发明人： Yohei Murayama , Hiroyuki Hashimoto , Manabu Komatsu , Kazuhiro Ban
IPC分类号： G01N1/28
CPC分类号： G01N1/30 , G01N1/31 , G01N2001/282 , G01N2001/317
摘要： A pre-treatment method for analyzing a specified portion in a specimen composed of a biological tissue includes the steps of preparing a specimen to be analyzed, determining a specified portion in the specimen; and applying an analysis inhibitor to a portion except the specified portion of the specimen using a droplet spray method.
摘要翻译：用于分析由生物组织构成的试样中的指定部位的预处理方法包括准备待分析试样的步骤，确定试样的规定部位; 并使用液滴喷雾法将分析抑制剂施加到除了特定部分的部分之外的部分。

59. 发明申请

US20080073509A1 HIGH-SENSITIVITY MASS SPECTROMETER AND METHOD 失效
标题翻译：高灵敏度质谱仪和方法
公开(公告)号：US20080073509A1
公开(公告)日：2008-03-27
申请号：US11682500
申请日：2007-03-06
申请人： Kazuhiro Ban , Hiroyuki Hashimoto , Manabu Komatsu , Norihiko Utsunomiya , Yohei Murayama
发明人： Kazuhiro Ban , Hiroyuki Hashimoto , Manabu Komatsu , Norihiko Utsunomiya , Yohei Murayama
IPC分类号： B01D59/44
CPC分类号： H01J49/0418
摘要： A sample is sliced obliquely with a blade provided with a metal thin film on the surface, and the slice of the sample adhering to the blade surface is subjected to mass spectrometry. As a result, the section of the sliced sample can be analyzed immediately by mass spectrometry with high sensitivity.
摘要翻译：将样品用表面上设置有金属薄膜的刀片倾斜切片，并且将附着在刀片表面上的样品切片进行质谱分析。因此，可以通过高灵敏度的质谱立即分析切片样品的部分。

60. 发明申请

US20070105087A1 Biological tissue processing substrate, processing apparatus, processing method and processing kit 有权
标题翻译：生物组织加工基材，加工设备，加工方法和加工工具
公开(公告)号：US20070105087A1
公开(公告)日：2007-05-10
申请号：US11592313
申请日：2006-11-03
申请人： Kazuhiro Ban , Miki Ogawa , Norihiko Utsunomiya , Hiroyuki Hashimoto , Manabu Komatsu , Yohei Murayama
发明人： Kazuhiro Ban , Miki Ogawa , Norihiko Utsunomiya , Hiroyuki Hashimoto , Manabu Komatsu , Yohei Murayama
IPC分类号： C12Q1/00 , C12M3/00
CPC分类号： G01N33/6848 , G01N33/5082
摘要： A biological tissue processing substrate for fixing proteins in a biological tissue or degradation products of the proteins, the substrate comprising: a porous body that forms a contact surface with the biological tissue, the porous body holding in pores an enzyme for obtaining the proteins or the degradation products of the proteins from the biological tissue, wherein the proteins or the degradation products obtained by the action of the enzyme are brought into contact with a member consisting of a metal.
摘要翻译：一种用于将蛋白质固定在生物组织中的生物组织处理底物或蛋白质的降解产物，所述底物包括：与生物组织形成接触表面的多孔体，多孔体在孔中保留用于获得蛋白质的酶或使来自生物组织的蛋白质的降解产物与由金属构成的构件接触，其中通过酶的作用获得的蛋白质或降解产物与金属接触。

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