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51. 发明申请

US20120122735A1 COMPOSITION, DEVICE AND ASSOCIATED METHOD 有权
标题翻译：组合物，装置和相关方法
公开(公告)号：US20120122735A1
公开(公告)日：2012-05-17
申请号：US11680652
申请日：2007-03-01
申请人： John Richard Nelson , Bahram Moasser , Anup Sood , Gregory Andrew Grossmann , Su Lu , Zhida Pan , Liangliang Qiang , John Yupeng Gui , Wei Cai , Zhixin Zheng
发明人： John Richard Nelson , Bahram Moasser , Anup Sood , Gregory Andrew Grossmann , Su Lu , Zhida Pan , Liangliang Qiang , John Yupeng Gui , Wei Cai , Zhixin Zheng
IPC分类号： G01N33/53 , C40B40/04 , G01N27/72 , G01N21/75 , G01N21/64 , G01N21/65
CPC分类号： G01N33/5308
摘要： A composition includes a first probe, a first initiator component bonded to the first probe, a second probe, and a second initiator component bonded to the second probe. The first probe and the second probe are capable of binding to a single analyte, and the first initiator component and the second initiator component are capable of forming an initiator when present in proximity to each other and when the first probe and the second probe are bonded to the analyte. An associated kit, device, and method are provided.
摘要翻译：组合物包括第一探针，结合到第一探针的第一引发剂组分，第二探针和结合到第二探针的第二引发剂组分。第一探针和第二探针能够结合单个分析物，并且第一引发剂组分和第二引发剂组分能够在彼此接近存在时形成引发剂，并且当第一探针和第二探针结合时分析物。提供相关的套件，设备和方法。

52. 发明申请

US20090155829A1 HEME CHOLINE ESTERS AND USES THEREOF 有权
标题翻译： HEME COLINE ESTERS及其用途
公开(公告)号：US20090155829A1
公开(公告)日：2009-06-18
申请号：US11958671
申请日：2007-12-18
申请人： Thomas Pirrie Treynor , Anup Sood , Sean Richard Dinn
发明人： Thomas Pirrie Treynor , Anup Sood , Sean Richard Dinn
IPC分类号： C12Q1/28 , C12N9/08 , C07D225/00
CPC分类号： C07D487/22 , G01N33/581
摘要： Methods of activating an apo-peroxidase are provided. The methods include the steps of providing a solution comprising an apo-peroxidase and a heme choline ester, hydrolyzing the heme choline ester with a choline esterase, and converting the apo-peroxidase to active peroxidase. The methods disclosed herein also provide for detecting the presence of an analyte in a sample. The methods include providing a binder capable of specifically binding the analyte wherein the binder is attached to a solid surface, applying the sample to the solid surface under conditions that permit binder-analyte binding, adding a choline esterase-conjugated binder that binds to the analyte, adding an apo-peroxidase, a heme choline ester, a peroxide, and a peroxide-activated signal generator, and detecting the signal produced by the peroxide-activated signal generator. An associated kit and components are also provided.
摘要翻译：提供了活化过氧化物酶的方法。所述方法包括提供包含过氧化物酶和血红素胆碱酯的溶液的步骤，用胆碱酯酶水解血红素胆碱酯，并将过氧化物酶转化成活性过氧化物酶。本文公开的方法还提供了检测样品中分析物的存在。所述方法包括提供能够特异性结合分析物的粘合剂，其中粘合剂连接到固体表面，在允许粘合剂分析物结合的条件下将样品施加到固体表面，加入与分析物结合的胆碱酯酶缀合的粘合剂，加入过氧化物酶，血红素胆碱酯，过氧化物和过氧化物激活的信号发生器，并检测由过氧化物激活的信号发生器产生的信号。还提供了相关的套件和组件。

53. 发明申请

US20080118944A1 SEQUENTIAL ANALYSIS OF BIOLOGICAL SAMPLES 有权
标题翻译：生物样品的序列分析
公开(公告)号：US20080118944A1
公开(公告)日：2008-05-22
申请号：US11864093
申请日：2007-09-28
申请人： Melinda Larsen , Anup Sood , Michael J. Gerdes , Michael Christopher Montalto , Zhengyu Pang , Fiona Ginty
发明人： Melinda Larsen , Anup Sood , Michael J. Gerdes , Michael Christopher Montalto , Zhengyu Pang , Fiona Ginty
IPC分类号： C12Q1/02 , G01N21/76 , G01N33/00 , G01N33/68
CPC分类号： G01N33/53 , C12Q1/68 , G01N33/542 , G01N33/582 , Y10T436/143333
摘要： Methods for probing multiple targets in a biological sample are provided. The methods include the steps of providing a biological sample containing multiple targets adhered to a solid support, binding at least one fluorescent probe to one or more target present in the sample, and observing a signal from the fluorescent probe. The method further includes the steps of oxidizing the bound fluorescent probe with a solution containing an oxidizing agent that substantially inactivates the fluorescent probe, binding at least one fluorescent probe to one or more target present in the sample, and observing a signal from the fluorescent probe. The methods disclosed herein also provide for multiple iterations of binding, observing, and oxidizing for deriving information about multiple targets in a single sample. An associated kit is also provided.
摘要翻译：提供了探测生物样品中多个靶标的方法。所述方法包括以下步骤：提供包含粘附到固体支持物上的多个靶的生物样品，将至少一种荧光探针结合到样品中存在的一种或多种靶，并观察来自荧光探针的信号。所述方法还包括以下步骤：用含有基本上灭活荧光探针的氧化剂的溶液氧化结合的荧光探针，将至少一种荧光探针结合到样品中存在的一种或多种靶，并观察来自荧光探针的信号。本文公开的方法还提供结合，观察和氧化的多次迭代，用于导出关于单个样本中的多个目标的信息。还提供了相关的套件。

54. 发明申请

US20070140967A1 Agents and methods for analyzing protein interactions 审中-公开
标题翻译：用于分析蛋白质相互作用的试剂和方法
公开(公告)号：US20070140967A1
公开(公告)日：2007-06-21
申请号：US11305970
申请日：2005-12-19
申请人： Nichole Wood , Mohan Amaratunga , Hans Grade , Faisal Syud , Anup Sood , Reginald Smith , Ayse Dinc , Amy Williams , Anthony Murray , Gregory Goddard
发明人： Nichole Wood , Mohan Amaratunga , Hans Grade , Faisal Syud , Anup Sood , Reginald Smith , Ayse Dinc , Amy Williams , Anthony Murray , Gregory Goddard
IPC分类号： A61K51/00
CPC分类号： G01N33/6845 , G01N33/6848
摘要： Agents and methods for qualitative and quantitative analysis a protein complex or protein complexes using isotope-labeled symmetrical bifunctional crosslinkers and mass spectrometry are provided. Targeting moieties, cell permeability moieties, or affinity moieties, may be appended to the bifunctional crosslinkers. The isotope-labeled symmetrical bifunctional crosslinkers may be used in a kit or as a library.
摘要翻译：提供了使用同位素标记的对称双功能交联剂和质谱定性和定量分析蛋白质复合物或蛋白质复合物的试剂和方法。靶向部分，细胞渗透性部分或亲和部分可附加到双功能交联剂上。同位素标记的对称双功能交联剂可用于试剂盒或文库。

55. 发明授权

US5659027A Boronated compounds 失效
标题翻译：硼化合物
公开(公告)号：US5659027A
公开(公告)日：1997-08-19
申请号：US334745
申请日：1994-11-04
申请人： Bernard F. Spielvogel , Anup Sood , Iris H. Hall , Barbara Ramsay Shaw , Jeno Tomasz
发明人： Bernard F. Spielvogel , Anup Sood , Iris H. Hall , Barbara Ramsay Shaw , Jeno Tomasz
IPC分类号： A61K31/70 , A61K31/7135 , A61P3/08 , A61P35/00 , A61P37/08 , C07D473/00 , C07D473/18 , C07D473/34 , C07F5/02 , C07H19/04 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C07H23/00 , C07H1/00
CPC分类号： C07D473/00 , C07D473/18 , C07D473/34 , C07F5/02 , C07H19/04 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C07H23/00 , Y10S514/824 , Y10S514/825 , Y10S514/886
摘要： A novel class of pharmaceutically active boronated compounds are provided. The boronated compounds include boronated purine and pyrimidine bases and boronated nucleosides, as well as phosphate esters and oligomers thereof. The compounds are boronated at the ring nitrogen of the purine or pyrimidine base, or at a 2', 3' or 5' amino substituent of the nucleoside sugar.
摘要翻译：提供了一类新颖的药物活性硼化合物。硼化化合物包括硼化嘌呤和嘧啶碱基和硼化核苷，以及其磷酸酯和低聚物。化合物在嘌呤或嘧啶碱基的环氮上或在核苷糖的2'，3'或5'氨基取代基处硼化。

56. 发明授权

US5362732A Boronated compounds 失效
标题翻译：硼化合物
公开(公告)号：US5362732A
公开(公告)日：1994-11-08
申请号：US909950
申请日：1992-07-07
申请人： Bernard F. Spielvogel , Anup Sood , Iris H. Hall , Barbara R. Shaw , Jeno Tomasz
发明人： Bernard F. Spielvogel , Anup Sood , Iris H. Hall , Barbara R. Shaw , Jeno Tomasz
IPC分类号： A61K31/70 , A61K31/7135 , A61P3/08 , A61P35/00 , A61P37/08 , C07D473/00 , C07D473/18 , C07D473/34 , C07F5/02 , C07H19/04 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C07H23/00 , A61K31/505 , A61K31/52 , C07D239/00
CPC分类号： C07D473/00 , C07D473/18 , C07D473/34 , C07F5/02 , C07H19/04 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C07H23/00 , Y10S514/824 , Y10S514/825 , Y10S514/886
摘要： A novel class of pharmaceutically active boronated compounds are provided. The boronated compounds include boronated purine and pyrimidine bases and boronated nucleosides, as well as phosphate esters and oligomers thereof. The compounds are boronated at the ring nitrogen of the purine or pyrimidine base, or at a 2', 3' or 5' amino substituent of the nucleoside sugar.
摘要翻译：提供了一类新颖的药物活性硼化合物。硼化化合物包括硼化嘌呤和嘧啶碱基和硼化核苷，以及其磷酸酯和低聚物。化合物在嘌呤或嘧啶碱基的环氮上或在核苷糖的2'，3'或5'氨基取代基处硼化。

57. 发明授权

US5286853A Boron-gadolinium compounds and method of conducting imaging and/or neutron capture therapy with same 失效
标题翻译：硼钆化合物及其相同方法进行成像和/或中子捕获治疗
公开(公告)号：US5286853A
公开(公告)日：1994-02-15
申请号：US943920
申请日：1992-09-11
申请人： Bernard F. Spielvogel , Anup Sood
发明人： Bernard F. Spielvogel , Anup Sood
IPC分类号： A61K41/00 , A61K49/06 , C07D257/02 , C07F5/02
CPC分类号： A61K49/06 , A61K41/009 , A61K41/0095 , C07D257/02 , C07F5/027
摘要： A gadolinium (3.sup.+) complex of polyamine polyacetate, comprising a polyamine nucleus having a pendant boron-containing substituent on one of the nitrogen or carbon atoms of the polyamine nucleus. The boron-gadolinium compound may suitably be of the formula: ##STR1## wherein: is a polyamine coordination structure capable of covalently bonding the substitutents R.sub.1, R.sub.2, R.sub.3 and R.sub.4 and of complexing with Gd;R.sub.1, R.sub.2, and R.sub.3 are independently selected from carboxyl, carboxylic salt groups, carboxylic ester groups, and carboxylate anion;R.sub.4 is a boron-containing group; andx is a number from zero to 4.Also disclosed is a method of treating a tumor-bearing mammalian subject by boron neutron capture therapy wherein the boron drug employed in such treatment comprises a boron-gadolinium compound, and a method of conducting sequential imaging and NCT treatment of a tumor tissue site in the corporeal structure of a mammalian subject, comprising administering to the mammalian subject an MRI imagingly- and NCT treatingly-effective amount of an effective boron-gadolinium compound, visualizing the tumor tissue site by MRI, and treating the tumor tissue by NCT.
摘要翻译：一种多胺聚乙酸钆（3+）配合物，其包含在多胺核的一个氮原子或碳原子上具有侧链含硼取代基的多胺核。硼 - 钆化合物可以合适地包含与包含三个羧基取代基（羧基，羧酸盐基团，羧酸酯基和羧酸根阴离子）的取代基共价结合的环化大环核和与钆络合的侧基含硼基团，并且任选地水合。本发明的化合物可用于中子捕获治疗以及磁共振成像。

58. 发明授权

US5260427A Nucleosidylphosphite-borane compounds and method of making the same 失效
标题翻译：亚磷酸核苷 - 硼烷化合物及其制备方法
公开(公告)号：US5260427A
公开(公告)日：1993-11-09
申请号：US908975
申请日：1992-07-06
申请人： Bernard F. Spielvogel , Anup Sood
发明人： Bernard F. Spielvogel , Anup Sood
IPC分类号： C07F9/141 , C07H19/10 , C07H19/20 , C07H23/00 , C12N9/99 , C12P19/34 , C07H15/04 , A61K31/69 , C07F9/06
CPC分类号： C07H23/00 , C07F9/141 , C07F9/1415 , C07H19/10 , C07H19/20 , C12N9/99 , C12P19/34
摘要： Nucleosidyl phosphite-borane compounds of the formula: ##STR1## wherein: Nucleoside is a natural or synthetic nucleoside connected to the phosphorus atom via a hydroxyl oxygen; each X is independently selected from O and BHR.sub.3 R.sub.4 ;R.sub.1 is selected from H, alkyl, aryl, alkyaryl, monovalent metal ions, and ammonium cation; R.sub.2 is selected from OR.sub.1 and N(R.sub.5).sub.2, wherein R.sub.5 is independently selected from H, C.sub.1 -C.sub.10 linear or branched alkyl or aryl; R.sub.3 is selected from H, CN, COOH, carboxyl salts, COOR.sub.6 and CONHR.sub.6, wherein R.sub.6 is selected from H, C.sub.1 -C.sub.10 alkyl, alkylaryl and aryl; R.sub.4 is selected from H and C.sub.1 -C.sub.10 alky; and n is 1 to 2.
摘要翻译：下式的核苷亚磷酸酯 - 硼烷化合物：其中：核苷是通过羟基氧与磷原子连接的天然或合成核苷; 每个X独立地选自O和BHR 3 R 4; R 1选自H，烷基，芳基，烷芳基，一价金属离子和铵阳离子; R2选自OR1和N（R5）2，其中R5独立地选自H，C1-C10直链或支链的烷基或芳基; R3选自H，CN，COOH，羧基盐，COOR6和CONHR6，其中R6选自H，C1-C10烷基，烷基芳基和芳基; R4选自H和C1-C10烷基; n为1〜2。

59. 发明授权

US5023513A Amine-alkylborane derivatives and methods 失效
标题翻译：胺 - 烷基硼烷衍生物和方法
公开(公告)号：US5023513A
公开(公告)日：1991-06-11
申请号：US364650
申请日：1989-06-09
申请人： Bernard F. Spielvogel , Anup Sood
发明人： Bernard F. Spielvogel , Anup Sood
IPC分类号： C07F5/02
CPC分类号： C07F5/027
摘要： Novel amine-alkylborane derivatives are disclosed which exhibit significant antineoplastic and antihyperlipidemic activities. Methods for preparing the compounds are disclosed as well as methods for utilizing the compounds to induce antineoplastic and antihyperlipidemic activity.

60. 发明授权

US09677125B2 Detection of plurality of targets in biological samples 有权
公开(公告)号：US09677125B2
公开(公告)日：2017-06-13
申请号：US12582745
申请日：2009-10-21
申请人： Anup Sood , John Richard Nelson , Michael John Gerdes
发明人： Anup Sood , John Richard Nelson , Michael John Gerdes
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6816 , C12Q2600/158 , C12Q2545/101 , C12Q2537/143
摘要： Methods for detecting a plurality of targets in a biological sample are provided. The method comprises contacting the biological sample with a plurality of target-binding probes to form a plurality of target-bound probes, covalently attaching at least one of the target-bound probes to the biological sample, and observing the signals from the target-bound probes sequentially. An associated kit and device for detection of the plurality of targets are also provided.

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