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51. 发明授权

US09820691B2 Fluid titration system 有权
公开(公告)号：US09820691B2
公开(公告)日：2017-11-21
申请号：US13287060
申请日：2011-11-01
申请人： Massi E. Kiani
发明人： Massi E. Kiani
IPC分类号： A61B5/00 , A61B5/0295 , A61B5/1455 , A61M5/142
CPC分类号： A61B5/6826 , A61B5/0295 , A61B5/14551 , A61B5/6838 , A61M5/142 , A61M2205/3306 , A61M2205/3313
摘要： A fluid titration system has an optical sensor, a physiological monitor, a titration controller and an infusion device. The optical sensor transmits multiple wavelengths of light into a tissue site of a person and detects the optical radiation after attenuation by pulsatile blood flowing within the tissue site. The physiological monitor receives a resulting sensor signal and derives a plethysmograph that corresponds to the pulsatile blood flow. The monitor also calculates a plethysmograph variability measure that is responsive to changes in perfusion at the tissue site. A titration controller generates a fluid control output according to the variability measure. The infusion device administers a liquid solution via an intravenous (IV) connection to the person according to the fluid control output so as to regulate at least one of a fluid flow start, rate and stop.

52. 发明授权

US08663107B2 Sepsis monitor 有权
标题翻译：脓毒症监测
公开(公告)号：US08663107B2
公开(公告)日：2014-03-04
申请号：US13100172
申请日：2011-05-03
申请人： Massi E. Kiani
发明人： Massi E. Kiani
IPC分类号： A61B5/00
CPC分类号： A61M5/1723 , A61B5/0205 , A61B5/022 , A61B5/02455 , A61B5/08 , A61B5/082 , A61B5/14551 , A61B5/412 , A61B5/6826 , A61B5/6838 , A61B7/04 , A61B2560/0276
摘要： Sensors are attached to a living being so as to generate corresponding sensor signals. A monitor is in communications with the sensors so as to derive physiological parameters responsive to the sensor signals. Predetermined limits are applied to the physiological parameters. At least one indicator responsive to the physiological parameters and the predetermined limits signal the onset of a sepsis condition in the living being.
摘要翻译：传感器连接在一起，以产生相应的传感器信号。监视器与传感器通信，以响应于传感器信号而导出生理参数。将预定极限应用于生理参数。响应于生理参数和预定限度的至少一个指示符表示生活中脓毒症状况的发作。

53. 发明申请

US20120227739A1 DRUG ADMINISTRATION CONTROLLER 有权
标题翻译：药物管理控制器
公开(公告)号：US20120227739A1
公开(公告)日：2012-09-13
申请号：US13475136
申请日：2012-05-18
申请人： Massi E. Kiani
发明人： Massi E. Kiani
IPC分类号： A61M5/168 , A61M16/10
CPC分类号： A61M5/1723 , A61M5/142 , A61M16/0057 , A61M16/12 , A61M2202/0208 , A61M2202/0233 , A61M2202/0241 , A61M2205/18 , A61M2205/3313 , A61M2205/3375 , A61M2205/3561 , A61M2205/3592 , A61M2205/502 , A61M2230/005 , A61M2230/04 , A61M2230/10 , A61M2230/204 , A61M2230/205 , A61M2230/207 , A61M2230/30 , A61M2230/42 , A61M2230/432 , A61M2230/50
摘要： A drug administration controller has a sensor that generates a sensor signal to a physiological measurement device, which measures a physiological parameter in response. A control output responsive to the physiological parameter or a metric derived from the physiological parameter causes a drug administration device to affect the treatment of a person, such as by initiating, pausing, halting or adjusting the dosage of drugs administered to the person.
摘要翻译：药物管理控制器具有向生理测量装置产生传感器信号的传感器，其响应于测量生理参数。响应于生理参数或来自生理参数的指标的控制输出导致药物施用装置影响人的治疗，例如通过引发，暂停，停止或调节施用于该人的药物的剂量。

54. 发明授权

US08145287B2 Manual and automatic probe calibration 有权
标题翻译：手动和自动探头校准
公开(公告)号：US08145287B2
公开(公告)日：2012-03-27
申请号：US12430049
申请日：2009-04-24
申请人： Mohamed Kheir Diab , Massi E. Kiani , Charles Robert Ragsdale , James M. Lepper, Jr.
发明人： Mohamed Kheir Diab , Massi E. Kiani , Charles Robert Ragsdale , James M. Lepper, Jr.
IPC分类号： A61B5/1455
CPC分类号： A61B5/1495 , A61B5/0205 , A61B5/02427 , A61B5/14552 , A61B5/6826 , A61B5/6838 , A61B2562/08 , G01J3/02 , G01J3/0254 , G01J3/027 , G01J3/0275 , G01J3/0291 , G01J3/10 , G01J2003/2866 , G01N21/255 , G01N21/274 , G01N21/31 , G01N21/3151 , G01N21/39 , G01N2021/3144 , G01N2201/0627
摘要： Embodiments of the present disclosure include an optical probe capable of communicating identification information to a patient monitor in addition to signals indicative of intensities of light after attenuation by body tissue. The identification information may indicate operating wavelengths of light sources, indicate a type of probe, such as, for example, that the probe is an adult probe, a pediatric probe, a neonatal probe, a disposable probe, a reusable probe, or the like. The information could also be utilized for security purposes, such as, for example, to ensure that the probe is configured properly for the oximeter, to indicate that the probe is from an authorized supplier, or the like. In one preferred embodiment, coding resistors could be provided across the light sources to allow additional information about the probe to be coded without added leads. However, any device could be used without it being used in parallel.
摘要翻译：本公开的实施例还包括能够向身体组织衰减之后除了表示光强度的信号之外，向患者监视器传送识别信息的光学探针。识别信息可以指示光源的操作波长，指示探针的类型，例如探针是成人探针，儿科探针，新生儿探针，一次性探针，可重复使用的探针等。该信息也可以用于安全目的，例如，以确保探针被适当地配置用于血氧计，以指示探针来自授权供应商等。在一个优选实施例中，编码电阻器可以跨越光源提供，以允许关于探针的附加信息被编码而没有添加引线。但是，任何设备都可以在没有并行使用的情况下使用。

55. 发明申请

US20110152645A1 PULSE OXIMETRY SENSOR ADAPTER 审中-公开
标题翻译：脉冲氧化传感器适配器
公开(公告)号：US20110152645A1
公开(公告)日：2011-06-23
申请号：US12955814
申请日：2010-11-29
申请人： Massi E. Kiani , Robert A. Smith , David R. Tobler
发明人： Massi E. Kiani , Robert A. Smith , David R. Tobler
IPC分类号： A61B5/1455
CPC分类号： A61B5/14551 , A61B5/14552 , A61B2562/222 , Y10S439/909
摘要： An adapter allows the interconnection of a sensor originating from one manufacturer to be coupled with conventionally incompatible monitors originating from other manufacturers to form a properly functioning pulse oximetry system. The adapter matches a sensor driver in a monitor to the current requirements and light source configuration of a sensor. The adapter also matches a sensor's light detector signal level to the dynamic range requirements of a monitor preamplifier. Further, the adapter provides compatible sensor calibration, sensor type and security information to a monitor. The adapter may have a self-contained power source or it may derive power from the monitor, allowing both passive and active adapter components. The adapter is particular suited as an adapter cable, replacing a conventional patient cable or sensor cable as the interconnection between a sensor to a monitor in a pulse oximetry system.
摘要翻译：适配器允许来自一个制造商的传感器的互连与来自其他制造商的常规不兼容的监视器耦合以形成正常工作的脉搏血氧饱和度系统。适配器将监视器中的传感器驱动器与传感器的当前要求和光源配置相匹配。适配器还将传感器的光检测器信号电平与监视器前置放大器的动态范围要求相匹配。此外，适配器向监视器提供兼容的传感器校准，传感器类型和安全信息。适配器可以具有独立的电源，或者可以从监视器获得电力，从而允许被动和主动适配器组件。适配器特别适合作为适配器电缆，替代传统的患者电缆或传感器电缆作为脉搏血氧测定系统中的传感器与监视器之间的互连。

56. 发明申请

US20090030330A1 DISPOSABLE ACTIVE PULSE SENSOR 有权
标题翻译：可选择的有源脉冲传感器
公开(公告)号：US20090030330A1
公开(公告)日：2009-01-29
申请号：US12147299
申请日：2008-06-26
申请人： Massi E. Kiani
发明人： Massi E. Kiani
IPC分类号： A61B5/02
CPC分类号： A61B5/02427 , A61B5/0048 , A61B5/0051 , A61B5/0261 , A61B5/14551 , A61B5/14552 , A61B5/6826 , A61B5/7221
摘要： A disposable active pulse sensor has an emitter that generates optical radiation having a plurality of wavelengths, a detector that is responsive to the optical radiation and an unbalanced electrical motor that vibrates when energized. A tape assembly removably attaches the emitter, the detector and the unbalanced electrical motor to a tissue site. The tape assembly also physically mounts the emitter, the detector and the unbalanced electrical motor in a spatial arrangement so that vibration from the unbalanced electrical motor induces pulsatile blood flow within the tissue site, the emitter transmits the optical radiation into the tissue site and the detector generates a sensor signal responsive to the intensity of the optical radiation after attenuation by the pulsatile blood flow within the tissue site.
摘要翻译：一次性有源脉冲传感器具有产生具有多个波长的光辐射的发射器，响应于光辐射的检测器和在通电时振动的不平衡电动机。胶带组件可拆卸地将发射器，检测器和不平衡电动机附接到组织部位。磁带组件还将发射器，检测器和不平衡电动机物理地安装在空间布置中，使得来自不平衡电动机的振动在组织部位内引起脉动血液流动，发射器将光学辐射器传输到组织部位和检测器通过在组织部位内的脉动血流衰减后响应于光辐射的强度产生传感器信号。

57. 发明授权

US06678543B2 Optical probe and positioning wrap 失效
标题翻译：光学探头和定位包装
公开(公告)号：US06678543B2
公开(公告)日：2004-01-13
申请号：US10005711
申请日：2001-11-08
申请人： Mohamed Kheir Diab , Massi E. Kiani , Charles Robert Ragsdale , James M. Lepper, Jr.
发明人： Mohamed Kheir Diab , Massi E. Kiani , Charles Robert Ragsdale , James M. Lepper, Jr.
IPC分类号： A61B500
CPC分类号： A61B5/1495 , A61B5/0205 , A61B5/02427 , A61B5/14552 , A61B5/6826 , A61B5/6838 , A61B2562/08 , G01J3/02 , G01J3/0254 , G01J3/027 , G01J3/0275 , G01J3/0291 , G01J3/10 , G01J2003/2866 , G01N21/255 , G01N21/274 , G01N21/31 , G01N21/3151 , G01N21/39 , G01N2021/3144 , G01N2201/0627
摘要： Embodiments of the present disclosure include an oximeter sensor system including a reusable portion including a substantially rigid connector connected to an end of a cable. The substantially rigid connector includes an electronic element housing at least one electronic component of a probe. The system also includes a disposable portion including a flexible wrap comprising a substantially rigid connection port shaped to receive the substantially rigid connector in a releasably securable manner.
摘要翻译：本公开的实施例包括血氧计传感器系统，其包括可重复使用部分，其包括连接到电缆端部的基本上刚性的连接器。基本刚性的连接器包括容纳探针的至少一个电子部件的电子元件。该系统还包括一次性部分，其包括柔性包装，其包括基本上刚性的连接端口，其形状为以可释放地固定的方式容纳基本上刚性的连接器。

58. 发明授权

US6088607A Low noise optical probe 失效
标题翻译：低噪声光探头
公开(公告)号：US6088607A
公开(公告)日：2000-07-11
申请号：US790674
申请日：1997-01-28
申请人： Mohamed Kheir Diab , Massi E. Kiani , James M. Lepper, Jr.
发明人： Mohamed Kheir Diab , Massi E. Kiani , James M. Lepper, Jr.
IPC分类号： A61B5/022 , A61B5/00 , A61B5/024 , A61B5/0245 , A61B5/145 , A61B5/1455 , G01N21/17 , G01N21/59 , H05K1/18
CPC分类号： A61B5/14552 , A61B5/02427 , A61B5/6826 , A61B5/6829 , A61B5/6838 , A61B2562/08 , A61B2562/12 , H05K1/189
摘要： An optical probe for measurements, which is particularly suited to reduce noise in measurements taken on an easily compressible material, such as a finger, a toe, a forehead, an earlobe, or a lip. The probe includes a base having an aperture which leads to a chamber. The base is placed adjacent a portion of the material, the chamber being placed directly adjacent any easily compressible portion of the material. A photodetector is located within the chamber and does not contact the material. A light emitting diode (LED) is affixed to the material, opposite the photodetector and above the chamber. The material which is supported by the aperture and therefore rests above or has intruded into the chamber is inhibited from compression since nothing comes in contact with this portion of the material, even when the material moves. Thus, light from the LED is directed through a stabilized portion of the material, i.e., the optical path length through which light travels is stabilized, even during motion of the material. This reduces noise in the signal measured by the photodetector. A scattering medium is interposed between the LED and the material, between the material and the photodetector, or between the LED and the material as well as between the material and the photodetector. The scattering medium is used to improve the signal-to-noise ratio of the received optical signal.
摘要翻译：用于测量的光学探针，其特别适用于减少在容易压缩的材料（例如手指，脚趾，额头，耳垂或唇部）上进行的测量中的噪声。探针包括具有通向腔室的孔的底座。基部放置在材料的一部分附近，该腔被直接放置在材料的任何容易压缩的部分附近。光电检测器位于室内并且不接触材料。发光二极管（LED）固定在材料上，与光电检测器相对并且在室上方。被孔支撑并且因此搁置在腔室中或已经入侵到腔室中的材料被抑制，因为即使当材料移动时也不会与材料的这一部分接触。因此，即使在材料的运动期间，来自LED的光被引导通过材料的稳定部分，即光行进的光路长度被稳定。这降低了由光电检测器测量的信号中的噪声。散射介质介于LED和材料之间，材料和光电检测器之间，或介于LED和材料之间以及材料与光电检测器之间。散射介质用于提高接收到的光信号的信噪比。

59. 发明授权

US5782757A Low-noise optical probes 失效
标题翻译：低噪声光探头
公开(公告)号：US5782757A
公开(公告)日：1998-07-21
申请号：US543789
申请日：1995-10-16
申请人： Mohamed Diab , Massi E. Kiani , David R. Tobler , Thomas J. Gerhardt , Eugene M. Mason , Mike A. Mills
发明人： Mohamed Diab , Massi E. Kiani , David R. Tobler , Thomas J. Gerhardt , Eugene M. Mason , Mike A. Mills
IPC分类号： A61B5/022 , A61B5/00 , A61B5/024 , A61B5/0245 , A61B5/145 , A61B5/1455 , G01N21/17 , G01N21/59 , H05K1/18
CPC分类号： A61B5/14552 , A61B5/02427 , A61B5/6826 , A61B5/6829 , A61B5/6838 , A61B2562/08 , A61B2562/12 , H05K1/189
摘要： An optical probe, which is particularly suited to reduce noise in measurements taken on an easily compressible material, such as a finger, a toe, a forehead, an earlobe, or a lip, measures characteristics of the material. A neonatal and adult disposable embodiment of the probe include adhesive coated surfaces to securely affix the probe onto the patient. In addition, the surface of the probe is specially constructed to minimize light piping effects. Furthermore, a flex circuit acts as a spring to absorb shock which may misalign the emitter and detector. One embodiment of the adult probe includes a cushioning pocket formed for a fingertip to align the probe and to absorb motion of the probe due to contact. The neonatal probe is formed with a unique V-configuration which provides multiple advantages.
摘要翻译：光学探头特别适用于减少在容易压缩的材料（例如手指，脚趾，额头，耳垂或唇部）上进行的测量中的噪音，测量材料的特性。探针的新生儿和成人一次性实施例包括粘合剂涂覆的表面以牢固地将探针附接到患者身上。此外，探针的表面是特别构造的，以最大限度地减少光线管道的影响。此外，柔性电路用作弹簧以吸收可能使发射器和检测器不对准的冲击。成人探针的一个实施例包括形成为指尖以对准探针并吸收由于接触而引起的探针运动的缓冲腔。新生儿探针形成了独特的V形结构，提供多种优点。

60. 发明授权

US08998809B2 Systems and methods for calibrating minimally invasive and non-invasive physiological sensor devices 有权
标题翻译：用于校准微创和非侵入性生理传感器设备的系统和方法
公开(公告)号：US08998809B2
公开(公告)日：2015-04-07
申请号：US11746451
申请日：2007-05-09
申请人： Massi E. Kiani
发明人： Massi E. Kiani
IPC分类号： A61B5/05 , G01N33/66 , A61B5/145 , A61B5/1495 , G06F19/00 , A61B5/1459 , A61B5/00
CPC分类号： G01N33/66 , A61B5/14532 , A61B5/14542 , A61B5/1459 , A61B5/1495 , A61B5/7275 , A61B2560/0223 , A61B2562/0295 , G06F19/00 , G06F19/3468 , G16H40/40 , Y10T436/144444
摘要： A calibration system is disclosed for calibrating a first physiological monitoring device using a second physiological monitoring device. The first physiological monitor measures a first indication of a physiological parameter. The second physiological monitor measures a second indication of the physiological parameter. The first and second indications are used to calibrate the first physiological monitoring device.
摘要翻译：公开了用于使用第二生理监测装置校准第一生理监测装置的校准系统。第一生理监测器测量生理参数的第一指示。第二生理监测器测量生理参数的第二指示。第一和第二指示用于校准第一生理监视装置。

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