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51. 发明授权

US4564364A Active agent dispenser 失效
标题翻译：活性剂分配器
公开(公告)号：US4564364A
公开(公告)日：1986-01-14
申请号：US498381
申请日：1983-05-26
申请人： Alejandro Zaffaroni , Patrick S. L. Wong
发明人： Alejandro Zaffaroni , Patrick S. L. Wong
IPC分类号： B01J4/00 , A61K9/20 , A61K9/26 , A61K9/70 , A61M31/00 , A61F15/00
CPC分类号： A61K9/7023 , A61K9/2086 , A61M31/002 , A61F2013/0296
摘要： The release pattern of a dispersion type active agent dispenser can be improved by forming the device from a depleted zone containing the agent at a concentration no greater than the saturation and a non-depleted zone containing the agent dispersed in the matrix at a uniform concentration greater than saturation. The depleted zone is disposed between the surface through which the agent is to be dispensed and at least a substantial portion of the non-depleted zone with the interface therebetween disposed at a non-uniform distance from the releasing surface. Certain embodiments are particularly useful for the transdermal administration of drugs.
摘要翻译：分散型活性剂分配器的释放模式可以通过从不含饱和度的含有试剂的贫化区形成装置，并且以均匀的浓度将含有分散在基质中的试剂的非贫化区形成，比饱和度。耗尽区设置在待分配试剂的表面和至少大部分的非耗尽区之间，其间的界面设置在与释放表面不均匀的距离处。某些实施方案对于透皮给药药物特别有用。

52. 发明授权

US4142526A Osmotic releasing system with means for changing release therefrom 失效
标题翻译：渗透释放系统，具有改变其释放的装置
公开(公告)号：US4142526A
公开(公告)日：1979-03-06
申请号：US775987
申请日：1977-03-09
申请人： Alejandro Zaffaroni , Alan S. Michaels , Felix Theeuwes
发明人： Alejandro Zaffaroni , Alan S. Michaels , Felix Theeuwes
IPC分类号： A61F6/14 , A61F9/00 , A61K9/00 , A61M31/00 , A61M37/00
CPC分类号： A61K9/0051 , A61F6/14 , A61F6/144 , A61F9/0017 , A61K9/0004 , A61K9/0039
摘要： An osmotic device for releasing a useful agent at different release rate patterns from the device in a selected environment is disclosed. The device is comprised of a wall surrounding and forming a compartment as a means for containing a useful agent and having a passageway for releasing the agent. The wall is comprised in at least a part of a material permeable to an external fluid and impermeable to the agent. A layer of a pattern rate controlling material that erodes in a selected environment for changing the release rate pattern of the device is carried on the semipermeable wall distant from the compartment. The agent is soluble in the fluid and exhibits an osmotic pressure gradient across the semipermeable wall against the fluid, or the agent has limited solubility and is admixed with an osmotically effective solute soluble in the fluid that exhibits an osmotic pressure gradient across the semipermeable wall against the fluid. In operation, agent is released from the device at different release rate patterns by the pattern rate controlling material eroding at a controlled rate to increase the amount of fluid available to the semipermeable wall for imbibition, which fluid is imbibed through the wall into the compartment producing a solution of the soluble agent or a solution of the osmotically effective solute containing the agent which is released through the passageway to the exterior of the device at a rate controlled by the permeability of the semipermeable wall and the osmotic pressure gradient across the wall of the device.
摘要翻译：公开了一种用于在所选环境中从设备以不同释放速率模式释放有用试剂的渗透装置。该装置包括围绕并形成隔室的壁，作为用于容纳有用试剂并具有用于释放试剂的通道的装置。所述壁包括在对外部流体可渗透并且对所述试剂不可渗透的材料的至少一部分中。在选择的环境中侵蚀以改变装置的释放速率图案的图案速率控制材料层被承载在远离隔室的半透壁上。该试剂可溶于流体并且表现出跨越半透性壁抵抗流体的渗透压梯度，或者该试剂具有有限的溶解度，并且与可溶于流体的渗透压有效溶质混合，该溶质表现出穿过半透壁的渗透压梯度，抵抗流体。在操作中，通过模式速率控制材料以受控的速率以不同的释放速率模式从设备释放试剂，以增加半渗透壁可用于吸入的流体的量，该流体通过壁被吸入隔室产生将可溶性试剂或含有该试剂的渗透有效溶质的溶液的溶液以通过该通道释放的渗透压力通过半透壁的渗透率和穿过该壁的渗透压梯度设备。

53. 发明授权

US3996934A Medical bandage 失效
标题翻译：医用绷带
公开(公告)号：US3996934A
公开(公告)日：1976-12-14
申请号：US169975
申请日：1971-08-09
申请人： Alejandro Zaffaroni
发明人： Alejandro Zaffaroni
IPC分类号： A61K9/00 , A61K9/70 , A61F7/02
CPC分类号： A61K9/7061 , A61K9/7069 , A61K9/7092 , A61K9/006
摘要： A bandage for continuously administering controlled quantities of systemically active drugs through the skin or mucosa is disclosed. This bandage has a backing member which defines one of its face surfaces and at least one reservoir containing the systemically active drug formulation which defines the other face surface. The reservoir can be a distinct layer of the bandage or can be a plurality of microcapsules distributed throughout a matrix. The material used to form the reservoir is drug release rate controlling and for a prolonged period continuously meters a controlled and predetermined flow of drug from the reservoir to the skin or mucosa of a patient.
摘要翻译：公开了通过皮肤或粘膜持续施用受控量的全身活性药物的绷带。该绷带具有限定其一个表面的背衬构件和至少一个包含限定另一个面部表面的系统活性药物制剂的容器。储存器可以是绷带的不同层，或者可以是分布在整个矩阵中的多个微胶囊。用于形成储层的材料是药物释放速率控制并且长时间连续地计量药物从储存器到患者的皮肤或粘膜的受控和预定的流动。

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