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51. 发明授权

US07332291B2 Methods of identifying modulators of ligand binding to ChemerinR polypeptides 有权
标题翻译：识别与ChemerinR多肽结合的配体调节剂的方法
公开(公告)号：US07332291B2
公开(公告)日：2008-02-19
申请号：US11134811
申请日：2005-05-20
申请人： Valérie Wittamer , Jean-Francois Mirjolet , Isabelle Migeotte , David Communi , Alberto Mantovani , Silvano Sozzani , Marisa Vulcano , Jean-Denis Franssen , Stéphane Brézillon , Michel Detheux , Gilbert Vassart , Marc Parmentier , Emmanuel Le Poul
发明人： Valérie Wittamer , Jean-Francois Mirjolet , Isabelle Migeotte , David Communi , Alberto Mantovani , Silvano Sozzani , Marisa Vulcano , Jean-Denis Franssen , Stéphane Brézillon , Michel Detheux , Gilbert Vassart , Marc Parmentier , Emmanuel Le Poul
IPC分类号： G01N33/53 , G01N33/566 , G01N33/567
CPC分类号： G01N33/74 , A61K38/00 , C07K14/47 , C07K14/4702 , C07K14/575 , C07K16/18 , C07K16/28 , C07K2317/34 , G01N2500/02
摘要： The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screeing assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.
摘要翻译：本发明涉及G蛋白偶联受体及其新型配体。本发明提供了用于鉴定调节G蛋白偶联受体的活性的候选化合物的screeing测定法，以及可用于诊断和治疗与G蛋白偶联受体信号传导调节异常相关的疾病或病症的测定法。

52. 发明申请

US20070238862A1 Compositions and methods comprising a ligand of ChemerinR 有权
公开(公告)号：US20070238862A1
公开(公告)日：2007-10-11
申请号：US11529867
申请日：2006-09-29
申请人： Valeria Wittamer , J.F. Mirjolet , Isabelle Migeotte , David Communi , Alberto Mantovani , Silvano Sozzani , Marisa Vulcano , Jean-Denis Franseen , Stephane Brezillon , Michel Detheux , Gilbert Vassart , Marc Parmentier , Emmanuel Le Poul , Cecile Loison , Frederic Ooms
发明人： Valeria Wittamer , J.F. Mirjolet , Isabelle Migeotte , David Communi , Alberto Mantovani , Silvano Sozzani , Marisa Vulcano , Jean-Denis Franseen , Stephane Brezillon , Michel Detheux , Gilbert Vassart , Marc Parmentier , Emmanuel Le Poul , Cecile Loison , Frederic Ooms
IPC分类号： C07K16/00
CPC分类号： C07K14/475 , A01K2217/075 , A61K38/00 , C07K14/705 , C07K16/24 , C07K16/2866 , C07K2317/34 , C12Q1/6876 , C12Q2600/136 , C12Q2600/158 , G01N33/566 , G01N2333/726 , G01N2500/02
摘要： The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screeing assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.

53. 发明授权

US06373377B1 Power supply with digital data coupling for power-line networking 有权
标题翻译：电源与数字数据耦合用于电力线网络
公开(公告)号：US06373377B1
公开(公告)日：2002-04-16
申请号：US09679414
申请日：2000-10-05
申请人： Frank Sacca , Alberto Mantovani
发明人： Frank Sacca , Alberto Mantovani
IPC分类号： H04M1104
CPC分类号： H04B3/54 , H04B2203/5445 , H04B2203/547
摘要： A power supply provides digital data coupling for power-line networking. The power supply includes a power supply side digital interface to transmit and receive a digital data passed through a digital coupler to and from a power-line network access circuitry side digital interface of power-line network access circuitry. The power supply further includes a digital-to-analog converter to process digital data into a high-frequency analog data carrier to provide to a power line of a power-line network. An analog-to-digital converter of the power supply converts a high-frequency analog data carrier from the power line into digital data for the power-line network access circuitry. A power-line analog front end of the power supply transmits and receives the high-frequency analog data carrier to and from the power line. Digital data exchanged between the power supply and the network access circuitry may include control signals for a control circuitry of the power supply. Control circuitry of the power supply may handle control of the digital-to-analog converter, the analog-to-digital converter and the analog front end.
摘要翻译：电源为电力线网络提供数字数据耦合。电源包括电源侧数字接口，用于发送和接收通过数字耦合器传送到电力线网络接入电路的电力线网络接入电路侧数字接口的数字数据。电源还包括数模转换器，用于将数字数据处理成高频模拟数据载体以提供给电力线网络的电力线。电源的模拟 - 数字转换器将来自电力线的高频模拟数据载体转换成用于电力线路网络接入电路的数字数据。电源的电源模拟前端向电力线发送和接收高频模拟数据载体。在电源和网络接入电路之间交换的数字数据可以包括用于电源的控制电路的控制信号。电源的控制电路可以处理数模转换器，模数转换器和模拟前端的控制。

54. 发明授权

US5837495A DNA encoding interleukin-1 antagonist 失效
标题翻译：编码白细胞介素-1拮抗剂的DNA
公开(公告)号：US5837495A
公开(公告)日：1998-11-17
申请号：US910733
申请日：1997-08-13
申请人： Francesco Colotta , Marta Muzio , Alberto Mantovani
发明人： Francesco Colotta , Marta Muzio , Alberto Mantovani
IPC分类号： A61K38/00 , C07K14/54 , C12N15/12 , C07K14/47
CPC分类号： C07K14/54 , A61K38/00
摘要： A novel interleukin-1 antagonist active against both IL-1.alpha. and IL-1.beta. and DNA encoding same are described. Antibodies specific for the novel IL-1 antagonist and prophylatic, therapeutic and diagnostic uses of the IL-1 antagonist in pathologies associated with IL-1 production are also described.
摘要翻译：描述了对IL-1α和IL-1β有活性的新型白细胞介素-1拮抗剂和编码它们的DNA。还描述了特异于新型IL-1拮抗剂的抗体和IL-1拮抗剂在与IL-1生成相关的病理学中的预防，治疗和诊断用途。

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