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51. 发明授权

US07659402B2 Piperidines as opioid receptor modulators 有权
标题翻译：哌啶类作为阿片受体调节剂
公开(公告)号：US07659402B2
公开(公告)日：2010-02-09
申请号：US11242763
申请日：2005-10-04
申请人： Henry J. Breslin , Wei He , Robert W. Kavash
发明人： Henry J. Breslin , Wei He , Robert W. Kavash
IPC分类号： C07D217/00
CPC分类号： C07D401/04 , C07D211/60 , C07D217/26 , C07D413/04
摘要： This invention is directed towards novel compounds as opioid receptor modulators, antagonists, and agonists useful for the treatment of opioid modulated disorders such as pain and gastrointestinal disorders.
摘要翻译：本发明涉及作为阿片样物质受体调节剂，拮抗剂和激动剂的新化合物，其可用于治疗阿片类调节障碍如疼痛和胃肠道疾病。

52. 发明申请

US20080294387A1 MARTINGALE CONTROL OF PRODUCTION FOR OPTIMAL PROFITABILITY OF OIL AND GAS FIELDS 有权
标题翻译： MARTINGALE控制生产油和油田的最佳利润
公开(公告)号：US20080294387A1
公开(公告)日：2008-11-27
申请号：US12019347
申请日：2008-01-24
申请人： Roger N. Anderson , Albert Boulanger , Wei He , Ulisses Mello , Liqing Xu
发明人： Roger N. Anderson , Albert Boulanger , Wei He , Ulisses Mello , Liqing Xu
IPC分类号： G06F17/50 , G06G7/50
CPC分类号： G01V11/00 , G01V2210/612 , G06Q10/04
摘要： A computer-aided lean management (CALM) controller system recommends actions and manages production in an oil and gas reservoir/field as its properties and conditions change with time. The reservoir/field is characterized and represented as an electronic-field (“e-field”). A plurality of system applications describe dynamic and static e-field properties and conditions. The application workflows are integrated and combined in a feedback loop between actions taken in the field and metrics that score the success or failure of those actions. A controller/optimizer operates on the combination of the application workflows to compute production strategies and actions. The controller/optimizer is configured to generate a best action sequence for production, which is economically “always-in-the-money.”
摘要翻译：计算机辅助精简管理（CALM）控制器系统建议在油气藏/油田中的生产进行动作和管理，因为其属性和条件随时间而变化。水库/油田被表征为电子场（“电场”）。多个系统应用程序描述动态和静态电场特性和条件。应用程序工作流程被集成在一起，并结合在现场采取的动作和衡量这些操作的成功或失败的指标之间的反馈循环中。一个控制器/优化器运行在应用程序工作流的组合上来计算生产策略和动作。控制器/优化器被配置为生成最佳的动作序列，这是经济上“永远在金钱”。

53. 发明申请

US20080287445A1 Prokineticin 2 receptor antagonists 审中-公开
标题翻译：原肌动蛋白2受体拮抗剂
公开(公告)号：US20080287445A1
公开(公告)日：2008-11-20
申请号：US11646957
申请日：2006-12-28
申请人： Steven J. Coats , Alexey B. Dyatkin , Wei He , Joseph Lisko , Tamara Miskowski , Janet L. Ralbovsky , Mark Schulz
发明人： Steven J. Coats , Alexey B. Dyatkin , Wei He , Joseph Lisko , Tamara Miskowski , Janet L. Ralbovsky , Mark Schulz
IPC分类号： A61K31/505 , A61K31/435 , A61P1/00 , A61K31/53
CPC分类号： A61K31/506 , A61K31/53
摘要： The present invention relates to certain novel compounds of Formula (I): and methods for the treatment of prokineticin 2 or prokinetin 2 receptor mediated disorders.
摘要翻译：本发明涉及某些新的式（I）化合物：以及用于治疗促动蛋白原2或原激素2受体介导的病症的方法。

54. 发明申请

US20080269225A1 Prokineticin 1 receptor antagonists 有权
标题翻译：原肌动蛋白1受体拮抗剂
公开(公告)号：US20080269225A1
公开(公告)日：2008-10-30
申请号：US11647091
申请日：2006-12-28
申请人： Steven J. Coats , Alexey B. Dyatkin , Wei He , Joseph Lisko , Tamara Miskowski , Janet L. Ralbovsky , Mark Schulz
发明人： Steven J. Coats , Alexey B. Dyatkin , Wei He , Joseph Lisko , Tamara Miskowski , Janet L. Ralbovsky , Mark Schulz
IPC分类号： A61K31/53 , C07D405/12 , A61P29/00 , A61P1/00
CPC分类号： C07D251/26 , C07D251/46 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/06 , C07D405/14 , C07D417/14 , C07D487/04
摘要： The present invention relates to certain novel compounds of Formula (I): and methods for preparing these compounds, compositions, intermediates and derivatives thereof and for the treatment of prokineticin 1 or prokinetin 1 receptor mediated disorders.
摘要翻译：本发明涉及某些新的式（I）化合物：以及制备这些化合物，组合物，中间体及其衍生物以及用于治疗促动蛋白原1或原激素1受体介导的病症的方法。

55. 发明申请

US20070197538A1 Anti-vascular and anti-proliferation methods, therapies, and combinations employing specific tyrosine kinase inhibitors 审中-公开
标题翻译：使用特异性酪氨酸激酶抑制剂的抗血管和抗增殖方法，疗法和组合
公开(公告)号：US20070197538A1
公开(公告)日：2007-08-23
申请号：US11519935
申请日：2006-09-13
申请人： Mark Nesbit , Alfred Spada , Wei He , Michael Myers
发明人： Mark Nesbit , Alfred Spada , Wei He , Michael Myers
IPC分类号： A61K31/498 , A61K31/47
CPC分类号： G01N33/5011 , A61K31/47 , A61K31/498 , A61K45/06 , A61K2300/00
摘要： This invention is directed to potent inhibitors of protein tyrosine kinase alone or in synergistic combination with antiangiogenic or chemotherapeutic agents for the abrogation of mature vasculature within chemotherapeutic refractory tumors, pharmaceutical compositions comprising these compounds, and to the use of these compounds for treating a patient suffering from or subject to disorders/conditions involving cell proliferation, and particularly treatment of brain cancer, ovarian cancer, pancreatic cancer prostate cancer, and human leukemias, such as CML, AML or ALL.
摘要翻译：本发明涉及单独的蛋白酪氨酸激酶的有效抑制剂或与抗血管生成或化学治疗剂协同组合以消除化学治疗难治性肿瘤内的成熟脉管系统，包含这些化合物的药物组合物以及这些化合物用于治疗患者的用途来自或受到涉及细胞增殖的病症/病症，特别是治疗脑癌，卵巢癌，胰腺癌前列腺癌和人类白血病，例如CML，AML或ALL。

56. 发明申请

US20060011701A1 Clamping device for processing electronic devices 有权
标题翻译：用于处理电子设备的夹紧装置
公开(公告)号：US20060011701A1
公开(公告)日：2006-01-19
申请号：US10894514
申请日：2004-07-19
申请人： Rong Duan , Wei He , Ka Kwan
发明人： Rong Duan , Wei He , Ka Kwan
IPC分类号： B23K37/00
CPC分类号： B23K37/0408 , B23K2101/40
摘要： A clamping device is provided for holding an electronic device, such as a semiconductor carrier in the form of a leadframe, during processing thereof. It includes a main body for covering the electronic device and an opening in the main body for providing access to a part of the electronic device to be worked upon. A support structure is attachable for coupling it to a periphery of the opening whereby the support structure is extended across the opening for supporting the part of the electronic device that is accessible through the opening.
摘要翻译：提供夹持装置，用于在其处理期间保持诸如引线框形式的半导体载体的电子装置。它包括用于覆盖电子设备的主体和主体中的开口，用于提供对待加工的电子设备的一部分的访问。支撑结构可附接到所述开口的周边，由此所述支撑结构延伸穿过所述开口以支撑可通过所述开口接近的所述电子设备的所述部分。

57. 发明申请

US20050203143A1 Novel compounds as opioid receptor modulators 有权
标题翻译：新型化合物作为阿片受体调节剂
公开(公告)号：US20050203143A1
公开(公告)日：2005-09-15
申请号：US11079647
申请日：2005-03-14
申请人： Henry Breslin , Chaozhong Cai , Wei He , Robert Kavash
发明人： Henry Breslin , Chaozhong Cai , Wei He , Robert Kavash
IPC分类号： A61K31/4172 , A61K31/4178 , A61K31/454 , C07D233/54 , C07D43/02
CPC分类号： A61K31/4164 , A61K9/20 , A61K9/2806 , A61K31/4174 , C07D233/64 , C07D275/06
摘要： The present invention is directed to novel opioid receptor modulators of Formula (I). The invention further relates to methods for preparing such compounds, pharmaceutical compositions containing them, and their use in the treatment of disorders that may be ameliorated or treated by the modulation of opioid receptors.
摘要翻译：本发明涉及式（I）的新型阿片受体调节剂。本发明还涉及制备这些化合物的方法，含有这些化合物的药物组合物，以及它们在治疗可通过调节阿片类受体而改善或治疗的病症中的用途。

58. 发明申请

US20050187252A1 Novel compounds as opioid receptor modulators 有权
标题翻译：新型化合物作为阿片受体调节剂
公开(公告)号：US20050187252A1
公开(公告)日：2005-08-25
申请号：US11079573
申请日：2005-03-14
申请人： Henry Breslin , Wei He , Robert Kavash
发明人： Henry Breslin , Wei He , Robert Kavash
IPC分类号： A61K31/4439 , A61K31/454 , A61K31/4725 , A61P1/00 , A61P1/04 , A61P1/10 , A61P25/04 , C07D211/60 , C07D217/26 , C07D401/04 , C07D413/04 , C07D413/02 , C07D43/02
CPC分类号： C07D401/04 , C07D211/60 , C07D217/26 , C07D413/04
摘要： This invention is directed towards novel compounds as opioid receptor modulators, antagonists, and agonists useful for the treatment of opioid modulated disorders such as pain and gastrointestinal disorders.
摘要翻译：本发明涉及作为阿片样物质受体调节剂，拮抗剂和激动剂的新化合物，其可用于治疗阿片类调节障碍如疼痛和胃肠道疾病。

59. 发明授权

US06852712B2 Quinoline and quinoxaline compounds which inhibit platelet-derived growth factor and/or p56lck tyrosine kinases 失效
标题翻译：抑制血小板衍生生长因子和/或p56lck酪氨酸激酶的喹啉和喹喔啉化合物
公开(公告)号：US06852712B2
公开(公告)日：2005-02-08
申请号：US10357882
申请日：2003-02-04
申请人： Michael R. Myers , Wei He , Alfred P. Spada , Martin P. Maguire
发明人： Michael R. Myers , Wei He , Alfred P. Spada , Martin P. Maguire
IPC分类号： A61F2/84 , A61K31/47 , A61K31/495 , A61K31/498 , A61K31/5377 , A61M25/00 , A61P9/00 , A61P9/10 , A61P17/06 , A61P19/08 , A61P29/00 , A61P35/00 , A61P35/02 , A61P43/00 , C07D215/20 , C07D215/38 , C07D241/42 , C07D241/44 , C07D241/52 , C07D241/54 , C07D403/04 , C07D405/10 , C07D405/12 , C07D453/06 , C07D471/08 , A61K31/33 , C07D241/36
CPC分类号： C07D215/38 , C07D215/20 , C07D241/42 , C07D241/44 , C07D241/52 , C07D241/54 , C07D403/04 , C07D405/12 , C07D453/06
摘要： This invention is directed to quinoline/quinoxaline compounds which inhibit platelet-derived growth factor or p56lck tyrosine kinase activity, to pharmaceutical compositions comprising these compounds, and to the use of these compounds for treating a patient suffering from or subject to disorders/conditions involving cellular differentiation, proliferation, extracellular matrix production or mediator release and/or T cell activation and proliferation.
摘要翻译：本发明涉及抑制血小板衍生生长因子或p56酪氨酸激酶活性的喹啉/喹喔啉化合物，包含这些化合物的药物组合物，以及这些化合物用于治疗患有或患有疾病/ 涉及细胞分化，增殖，细胞外基质产生或介体释放和/或T细胞活化和增殖的条件。

60. 发明申请

US20050021577A1 Applied estimation of eigenvectors and eigenvalues 审中-公开
标题翻译：特征向量和特征值的应用估计
公开(公告)号：US20050021577A1
公开(公告)日：2005-01-27
申请号：US10855174
申请日：2004-05-27
申请人： Nagabhushana Prabhu , Wei He
发明人： Nagabhushana Prabhu , Wei He
IPC分类号： G06F20060101 , G06F7/00 , G06F17/16 , G06K9/62
CPC分类号： G06F17/16 , G06K9/6232
摘要： Various applications are presented of a vector field method of computing one or more eigenvalues and eigenvectors of a symmetric matrix. The vector field method computes an eigenvector by computing a discrete approximation to the integral curve of a special tangent vector field on the unit sphere. The optimization problems embedded in each iteration of the vector field algorithms admit closed-form solutions making the vector field approach relatively efficient. Among the several vector fields discussed is a family of vector fields called the recursive vector fields. Numerical results are presented that suggest that in some embodiments the recursive vector field method yields implementations that are faster than those based on the QR method. Further, the vector field method preserves, and hence can fully exploit the sparseness on the given matrix to speed up computation even further. Preprocessing that contracts the spectral radius of the given matrix further accelerates the systems.
摘要翻译：呈现了用于计算对称矩阵的一个或多个特征值和特征向量的矢量场方法的各种应用。矢量场方法通过计算单位球上特殊切线矢量场的积分曲线的离散近似来计算特征向量。嵌入在矢量场算法的每次迭代中的优化问题承认封闭形式的解决方案，使得矢量场方法相对有效。在讨论的几个矢量场中，有一系列称为递归矢量场的矢量场。提出了数值结果，表明在一些实施例中，递归矢量场方法产生比基于QR方法的实现更快的实现。此外，矢量场方法保留，因此可以充分利用给定矩阵上的稀疏度，进一步加速计算。收缩给定矩阵的光谱半径的预处理进一步加速了系统。

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