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51. 发明授权

US08835376B2 Process for making particles for delivery of drug nanoparticles 有权
标题翻译：用于制备用于递送药物纳米颗粒的颗粒的方法
公开(公告)号：US08835376B2
公开(公告)日：2014-09-16
申请号：US13120146
申请日：2009-09-24
申请人： Zhigang Shen , Jimmy Sung Lai Yun , Jun Hu , Nital Arvind Jugade , Jiyao Zhang , Wenhao Chen , Zhe Wang , Lingyan Gao , William Glover , Jian Feng Chen
发明人： Zhigang Shen , Jimmy Sung Lai Yun , Jun Hu , Nital Arvind Jugade , Jiyao Zhang , Wenhao Chen , Zhe Wang , Lingyan Gao , William Glover , Jian Feng Chen
IPC分类号： A61K38/02 , A61K31/216 , A61K31/513 , A61K31/546 , A61K38/13 , A61K31/357 , A61K31/57 , A61K31/7052 , A61K31/277 , A61K31/197 , A61K47/38 , A61K47/24 , B01J2/06 , A61K9/16 , A61K9/20 , A61K9/14 , B01J19/00
CPC分类号： A61K9/14 , A61K9/1623 , A61K9/1652 , A61K9/1694 , A61K9/2077 , B01J2/06 , B01J19/0093 , B01J2219/00788 , B01J2219/00889
摘要： A process for making particles for delivery of drug nanoparticles is disclosed herein. The process comprises the steps of (a) forming a suspension of drug nanoparticles by mixing a precipitant solution with an anti-solvent solution under micro-mixing environment, where the formed nanoparticles have a narrow particle size distribution; (b) providing an excipient to at least one of the precipitant solution, the anti-solvent solution and the suspension of drug nanoparticles, the excipient being selected to maintain said drug nanoparticles in a dispersed state when in liquid form; and (c) drying the suspension of drug nanoparticles containing the excipient therein to remove solvent therefrom, wherein removal of the solvent causes the excipient to solidify and thereby form micro-sized matrix particles, each micro-sized particle being comprised of drug nanoparticles dispersed in a solid matrix of the excipient.
摘要翻译：本文公开了用于制备用于递送药物纳米颗粒的颗粒的方法。该方法包括以下步骤：（a）通过在微混合环境下将沉淀剂溶液与抗溶剂溶液混合形成药物纳米颗粒的悬浮液，其中所形成的纳米颗粒具有窄的粒度分布; （b）向沉淀剂溶液，抗溶剂溶液和药物纳米颗粒的悬浮液中的至少一种提供赋形剂，所述赋形剂被选择为当液体形式时将所述药物纳米颗粒维持在分散状态; 和（c）干燥其中含有赋形剂的药物纳米颗粒的悬浮液以从其中除去溶剂，其中去除溶剂导致赋形剂固化，从而形成微尺寸的基质颗粒，每个微尺寸颗粒由分散在赋形剂的固体基质。

52. 发明申请

US20140239352A1 CMOS COMPATIBLE SILICON DIFFERENTIAL CONDENSER MICROPHONE AND METHOD FOR MANUFACTURING THE SAME 有权
标题翻译： CMOS兼容硅差分冷凝器麦克风及其制造方法
公开(公告)号：US20140239352A1
公开(公告)日：2014-08-28
申请号：US13581882
申请日：2011-03-11
申请人： Zhe Wang
发明人： Zhe Wang
IPC分类号： B81B3/00 , H04R19/04 , B81C1/00
CPC分类号： B81B3/0078 , B81B2207/015 , B81C1/00246 , H04R19/005 , H04R19/04
摘要： The present invention provides a CMOS compatible silicon differential condenser microphone and a method of manufacturing the same. Said microphone comprises a silicon substrate, wherein a CMOS circuitry is accommodated thereon; a first rigid conductive perforated backplate supported on the silicon substrate with an insulating layer inserted therebetween; a second rigid perforated backplate formed above the first backplate, including CMOS passivation layers and a metal layer sandwiched between the CMOS passivation layers as an electrode plate of the second plate, wherein an air gap, with a spacer forming its boundary, is provided between the opposite perforated areas of the first backplate and the second backplate; a compliant diaphragm provided between the first backplate and the second backplate, wherein a back hole is formed to be open in the silicon substrate underneath the first backplate so as to allow sound pass through, and the diaphragm and the first backplate form a first variable condenser, the diaphragm and the second backplate form a second variable condenser, and the first variable condenser and the second variable condenser form differential condensers.
摘要翻译：本发明提供一种CMOS兼容的硅差分电容麦克风及其制造方法。所述麦克风包括硅衬底，其中容纳CMOS电路; 支撑在硅衬底上的第一刚性导电多孔背板，绝缘层插入其间; 形成在第一背板上方的第二刚性多孔背板，包括CMOS钝化层和夹在CMOS钝化层之间的金属层作为第二板的电极板，其中具有形成其边界的间隔件的气隙设置在第一背板和第二背板的相对穿孔区域; 设置在所述第一背板和所述第二背板之间的柔性隔膜，其中形成在所述第一背板下方的所述硅基板中开口的后孔，以允许声音通过，并且所述隔膜和所述第一背板形成第一可变冷凝器，隔膜和第二背板形成第二可变冷凝器，第一可变冷凝器和第二可变冷凝器形成差动冷凝器。

53. 发明授权

US08799645B2 Scalable distributed web-based authentication 有权
标题翻译：可扩展的基于分布式的Web认证
公开(公告)号：US08799645B2
公开(公告)日：2014-08-05
申请号：US13458979
申请日：2012-04-27
申请人： Yan-Zhe Wang , Sean Hou , Sridhar Devarapalli , Louis Yun
发明人： Yan-Zhe Wang , Sean Hou , Sridhar Devarapalli , Louis Yun
IPC分类号： H04L29/06 , H04L12/56 , H04L29/08
CPC分类号： H04L63/08 , H04L49/25 , H04L49/35 , H04L63/0485 , H04L63/166 , H04L67/02
摘要： Web-based authentication includes receiving a packet in a network switch having at least one associative store configured to forward packet traffic to a first one or more processors of the switch that are dedicated to cryptographic processing if a destination port of the packet indicates a secure transport protocol, and to a second one or more processors of the switch that are not dedicated to cryptographic processing if the destination port does not indicate a secure transport protocol. If a source of the packet is an authenticated user, the packet is forwarded via an output port of the switch, based on the associative store. If the source is an unauthenticated user, the packet is forwarded to the first one or more processors if the destination port indicates a secure transport protocol, and to the second one or more processors if the destination port does not indicate a secure transport protocol.
摘要翻译：基于网络的认证包括在具有至少一个关联存储器的网络交换机中接收分组，所述至少一个关联存储器配置成将分组业务转发到专用于密码处理的交换机的第一个或多个处理器，如果分组的目的地端口指示安全传输协议，以及如果目的地端口不指示安全传输协议，则交换机的第二个或多个处理器不专用于密码处理。如果分组的源是认证用户，则基于关联存储，分组经由交换机的输出端口转发。如果源是未经认证的用户，则如果目的地端口指示安全传输协议，则将分组转发到第一个或多个处理器，如果目的地端口不指示安全传输协议，则转发给第二个一个或多个处理器。

54. 发明授权

US08785377B2 Tetrazolyl macrocyclic hepatitis C serine protease inhibitors 失效
标题翻译：四唑基大环丙型肝炎丝氨酸蛋白酶抑制剂
公开(公告)号：US08785377B2
公开(公告)日：2014-07-22
申请号：US12016659
申请日：2008-01-18
申请人： Ying Sun , Dong Liu , Yat Sun Or , Zhe Wang
发明人： Ying Sun , Dong Liu , Yat Sun Or , Zhe Wang
IPC分类号： A61K38/00 , A01N37/18 , A61K31/41 , A61K31/13 , C07K5/083 , C07D487/04 , A61K38/21 , A61K31/7056 , A61K45/06
CPC分类号： C07K5/0804 , A61K31/13 , A61K31/41 , A61K31/7056 , A61K38/212 , A61K38/215 , A61K45/06 , C07D487/04 , A61K2300/00
摘要： The present invention relates to compounds of Formula I, II, III or IV, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising a compound of the present invention.
摘要翻译：本发明涉及式I，II，III或IV化合物或其药学上可接受的盐，酯或前药：其抑制丝氨酸蛋白酶活性，特别是丙型肝炎病毒（HCV）NS3-NS4A蛋白酶的活性。因此，本发明的化合物干扰丙型肝炎病毒的生命周期，也可用作抗病毒剂。本发明还涉及药物组合物，其包含用于给患有HCV感染的受试者施用的上述化合物。本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的HCV感染的方法。

55. 发明授权

US08737738B2 Parameters interpolation for high dynamic range video tone mapping 有权
标题翻译：高动态范围视频色调映射的参数插值
公开(公告)号：US08737738B2
公开(公告)日：2014-05-27
申请号：US13579401
申请日：2011-02-11
申请人： Zhe Wang , Jiefu Zhai
发明人： Zhe Wang , Jiefu Zhai
IPC分类号： G06K9/00
CPC分类号： G06T5/009 , G06T7/11 , G06T2207/10016 , G06T2207/20208
摘要： A method for toning mapping high dynamic range (HDR) video for display in low dynamic range display comprises accessing the HDR video; producing a luminance information for the individual frames; partitioning different consecutive groups of frames into segments responsive to the luminance information; classifying the segments into static luminance segments and transient luminance segments; producing a tone mapping parameter set for the static luminance segments; producing a tone mapping parameter set for at least one of the transient luminance segments responsive to the tone mapping parameter set of an adjacent static luminance segment; and tone mapping the static luminance segments and transient luminance segments according to the respective tone mapping parameter sets.
摘要翻译：用于色调映射高动态范围（HDR）视频以在低动态范围显示中显示的方法包括访问HDR视频; 产生各个帧的亮度信息; 响应于亮度信息将不同连续的帧组划分成段; 将段分为静态亮度段和瞬态亮度段; 产生用于静态亮度段的色调映射参数集; 响应于相邻静态亮度段的色调映射参数集，产生针对所述瞬态亮度段中的至少一个的色调映射参数集; 以及根据各个色调映射参数组对静态亮度段和瞬态亮度段进行色调映射。

56. 发明申请

US20130230532A1 MYOMEGALIN VARIANT 8 AND USES THEREOF 有权
标题翻译： MYOMEGALIN VARIANT 8及其用途
公开(公告)号：US20130230532A1
公开(公告)日：2013-09-05
申请号：US13825945
申请日：2011-11-15
申请人： Zhe Wang , Robert Zhong QI
发明人： Zhe Wang , Robert Zhong QI
IPC分类号： C07K14/47 , G01N33/68 , C12Q1/68
CPC分类号： C07K14/47 , A61K38/00 , C07K14/4716 , C07K16/18 , C12N15/113 , C12N2310/14 , C12Q1/6876 , G01N33/6887 , G01N33/6893 , G01N2500/00
摘要： The present invention provides a novel myomegalin isoform—myomegalin variant 8 (MMG8). The myomegalin variant 8 regulates microtubule organization at the Golgi apparatus, protein modification, secretion and trafficking, and cell proliferation. The present invention also provides nucleic acid molecules encoding the myomegalin isoforms, and vectors and host cells containing the nucleic acid molecules. Also provided are fusion constructs comprising the myomegalin isoform and antibodies that bind specifically to the myomegalin isoforms of the present invention. The present invention further provides uses of the myomegalin isoform as a diagnostic biomarker and as a target for screening for therapeutics for diseases such as cancer, diabetes, and lysosomal storage diseases.
摘要翻译：本发明提供了一种新型的大豆蛋白异构体 - 甲状腺球蛋白变体8（MMG8）。神经球蛋白变体8调节高尔基体上的微管组织，蛋白质修饰，分泌和运输以及细胞增殖。本发明还提供了编码大豆蛋白异构体的核酸分子以及含有核酸分子的载体和宿主细胞。还提供了包含myomegalin同种型和与本发明的myomegalin异构体特异性结合的抗体的融合构建体。本发明还提供了作为诊断性生物标志物的myomegalin同种型的用途，以及用于筛选疾病如癌症，糖尿病和溶酶体贮积病的治疗剂的靶标。

57. 发明授权

US08426360B2 Carbocyclic oxime hepatitis C virus serine protease inhibitors 有权
标题翻译：碳环肟丙型肝炎病毒丝氨酸蛋白酶抑制剂
公开(公告)号：US08426360B2
公开(公告)日：2013-04-23
申请号：US12269941
申请日：2008-11-13
申请人： Dong Liu , Yat Sun Or , Zhe Wang
发明人： Dong Liu , Yat Sun Or , Zhe Wang
IPC分类号： A61K38/00
CPC分类号： C07D471/04 , C07D225/04 , C07D245/04 , C07D401/12 , C07D405/12 , C07D409/12
摘要： The present invention discloses compounds of formula I, II, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. More specifically, the invention relates to oxime compounds containing a carbocyclic P2 unit. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
摘要翻译：本发明公开了式I，II的化合物或其药学上可接受的盐，酯或前药：其抑制丝氨酸蛋白酶活性，特别是丙型肝炎病毒（HCV）NS3-NS4A蛋白酶的活性。因此，本发明的化合物干扰丙型肝炎病毒的生命周期，也可用作抗病毒剂。更具体地，本发明涉及含有碳环P2单元的肟化合物。本发明还涉及药物组合物，其包含用于给患有HCV感染的受试者施用的上述化合物。本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的HCV感染的方法。

58. 发明申请

US20130027389A1 MAKING A TWO-DIMENSIONAL IMAGE INTO THREE DIMENSIONS 审中-公开
标题翻译：将二维图像制作成三维尺寸
公开(公告)号：US20130027389A1
公开(公告)日：2013-01-31
申请号：US13477308
申请日：2012-05-22
申请人： ZHE WANG
发明人： ZHE WANG
IPC分类号： G06T15/00
CPC分类号： H04N13/261
摘要： A 2D (two dimensional) image can be received that comprises at least one image layer. A depth value can be added to the image layer in the 2D image. The 2D image can be made into 3D (three dimensional) by using the added depth value.
摘要翻译：可以接收包括至少一个图像层的2D（二维）图像。深度值可以添加到2D图像中的图像层。通过使用添加的深度值，可以将2D图像制成3D（三维）。

59. 发明申请

US20120278068A1 VOICE ACTIVITY DETECTION METHOD AND APPARATUS, AND ELECTRONIC DEVICE 有权
标题翻译：语音活动检测方法和设备，以及电子设备
公开(公告)号：US20120278068A1
公开(公告)日：2012-11-01
申请号：US13546572
申请日：2012-07-11
申请人： Zhe Wang
发明人： Zhe Wang
IPC分类号： G10L11/06
CPC分类号： G10L25/78 , G10L25/09
摘要： A voice activity detection method and apparatus, and an electronic device are provided. The method includes: obtaining a time domain parameter and a frequency domain parameter from an audio frame; obtaining a first distance between the time domain parameter and a long-term slip mean of the time domain parameter in a history background noise frame, and obtaining a second distance between the frequency domain parameter and a long-term slip mean of the frequency domain parameter in the history background noise frame; and determining whether the audio frame is a foreground voice frame or a background noise frame according to the first distance, the second distance and a set of decision inequalities based on the first distance and the second distance. The above technical solutions enable the determination criterion to have an adaptive adjustment capability, thus improving the performance of the voice activity detection.
摘要翻译：提供语音活动检测方法和装置以及电子装置。该方法包括：从音频帧获得时域参数和频域参数; 在历史背景噪声帧中获得时域参数与时域参数的长期滑动平均值之间的第一距离，并获得频域参数与频域参数的长期滑动平均值之间的第二距离在历史背景噪声框架; 以及基于所述第一距离和所述第二距离，根据所述第一距离，所述第二距离和一组判定不等式来确定所述音频帧是前景语音帧还是背景噪声帧。上述技术解决方案使确定标准具有自适应调整能力，从而提高语音活动检测的性能。

60. 发明授权

US08273709B2 Triazole-containing macrocyclic HCV serine protease inhibitors 有权
标题翻译：含三唑的大环的HCV丝氨酸蛋白酶抑制剂
公开(公告)号：US08273709B2
公开(公告)日：2012-09-25
申请号：US12333458
申请日：2008-12-12
申请人： Yonghua Gai , Yat Sun Or , Zhe Wang
发明人： Yonghua Gai , Yat Sun Or , Zhe Wang
IPC分类号： A61K38/00
CPC分类号： C07K5/06165 , A61K38/00 , C07K5/0812
摘要： The present invention discloses compounds of formula I, II and III or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
摘要翻译：本发明公开了式I，II和III的化合物或其药学上可接受的盐，酯或前药：其抑制丝氨酸蛋白酶活性，特别是丙型肝炎病毒（HCV）NS3-NS4A蛋白酶的活性。因此，本发明的化合物干扰丙型肝炎病毒的生命周期，也可用作抗病毒剂。本发明还涉及药物组合物，其包含用于给患有HCV感染的受试者施用的上述化合物。本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的HCV感染的方法。

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