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    • 52. 发明申请
    • ASSAYS
    • 测定
    • US20150198604A1
    • 2015-07-16
    • US14564067
    • 2014-12-08
    • Eugen ErmantrautThomas KaiserJens TuchscheererVico BaierTorsten SchulzAnke Wostemeyer
    • Eugen ErmantrautThomas KaiserJens TuchscheererVico BaierTorsten SchulzAnke Wostemeyer
    • G01N33/58
    • G01N33/58B01L3/50273B01L2200/025B01L2200/0684B01L2300/0816B01L2300/0887B01L2300/123B01L2400/0481Y10T436/25
    • A method for assaying a sample for each of multiple analytes is described. The method includes contacting an array of spaced-apart test zones with a liquid sample (e.g., whole blood). The test zones disposed within a channel of a microfluidic device. The channel is defined by at least one flexible wall and a second wall which may or may not be flexible. Each test zone comprising a probe compound specific for a respective target analyte. The microfluidic device is compressed to reduce the thickness of the channel, which is the distance between the inner surfaces of the walls within the channel. The presence of each analyte is determined by optically detecting an interaction at each of multiple test zones for which the distance between the inner surfaces at the corresponding location is reduced. The interaction at each test zone is indicative of the presence in the sample of a target analyte. Capillary structures of the devices or used in the methods may comprise a matrix and the devices may comprise control elements and methods for assaying of sample may use corresponding controlling activities.
    • 描述了用于分析多种分析物中的每一种的样品的方法。 该方法包括使间隔开的测试区域的阵列与液体样品(例如全血)接触。 测试区域设置在微流体装置的通道内。 通道由至少一个柔性壁和可以是柔性的第二壁限定。 每个测试区域包含对各个目标分析物特异的探针化合物。 微流体装置被压缩以减小通道的厚度,其是通道内的壁的内表面之间的距离。 每个分析物的存在通过光学检测在相应位置处的内表面之间的距离减小的多个测试区域中的每一个处的相互作用来确定。 每个测试区域的相互作用表明样品中目标分析物的存在。 装置的毛细结构或方法中使用的毛细管结构可以包括基质,并且装置可以包括控制元件和用于测定样品的方法可以使用相应的控制活动。
    • 58. 发明申请
    • Assays
    • 测定
    • US20110124114A1
    • 2011-05-26
    • US12922383
    • 2009-03-16
    • Eugen ErmantrautThomas KaiserJens TuchscheererVico BeierTorsten SchulzAnke Wöstemeyer
    • Eugen ErmantrautThomas KaiserJens TuchscheererVico BeierTorsten SchulzAnke Wöstemeyer
    • G01N21/00G01N33/00G01N1/00
    • G01N33/58B01L3/50273B01L2200/025B01L2200/0684B01L2300/0816B01L2300/0887B01L2300/123B01L2400/0481Y10T436/25
    • A method for assaying a sample for each of multiple analytes is described. The method includes contacting an array of spaced-apart test zones with a liquid sample (e.g., whole blood). The test zones disposed within a channel of a microfluidic device. The channel is defined by at least one flexible wall and a second wall which may or may not be flexible. Each test zone comprising a probe compound specific for a respective target analyte. The microfluidic device is compressed to reduce the thickness of the channel, which is the distance between the inner surfaces of the walls within the channel. The presence of each analyte is determined by optically detecting an interaction at each of multiple test zones for which the distance between the inner surfaces at the corresponding location is reduced. The interaction at each test zone is indicative of the presence in the sample of a target analyte. Capillary structures of the devices or used in the methods may comprise a matrix and the devices may comprise control elements and methods for assaying of sample may use corresponding controlling activities.
    • 描述了用于分析多种分析物中的每一种的样品的方法。 该方法包括使间隔开的测试区域的阵列与液体样品(例如全血)接触。 测试区域设置在微流体装置的通道内。 通道由至少一个柔性壁和可以是柔性的第二壁限定。 每个测试区域包含对各个目标分析物特异的探针化合物。 微流体装置被压缩以减小通道的厚度,其是通道内的壁的内表面之间的距离。 每个分析物的存在通过光学检测在相应位置处的内表面之间的距离减小的多个测试区域中的每一个处的相互作用来确定。 每个测试区域的相互作用表明样品中目标分析物的存在。 装置的毛细结构或方法中使用的毛细管结构可以包括基质,并且装置可以包括控制元件和用于测定样品的方法可以使用相应的控制活动。