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51. 发明授权

US06316657B1 Process for purification or recovery of sweetener 失效
标题翻译：净化或回收甜味剂的方法
公开(公告)号：US06316657B1
公开(公告)日：2001-11-13
申请号：US09525319
申请日：2000-03-13
申请人： Tadashi Takemoto
发明人： Tadashi Takemoto
IPC分类号： C07C22900
CPC分类号： C07K5/06113 , C07C231/24 , C07C237/20
摘要： There is provided a process for purification of N-(3,3-dimethylbutyl)-&agr;-L-aspartyl-L-phenylalanine methyl ester comprising the step of contacting impure N-(3,3-dimethylbutyl)-&agr;-L-aspartyl-L-phenylalanine methyl ester containing at least &agr;-L-aspartyl-L-phenylalanine methyl ester as an impurity, with the mixed solvents having two layers of one layer given from at least one organic solvent which does not mix with water homogeneously and one layer of water to extract N-(3,3-dimethylbutyl)-&agr;-L-aspartyl-L-phenylalanine methyl ester in the organic solvent layer. In the present invention, the desired compound can be purified or recovered efficiently in a high yield without using burdensome steps or operations.
摘要翻译：提供了一种纯化N-（3,3-二甲基丁基）-α-L-天冬氨酰基-L-苯丙氨酸甲基酯的方法，该方法包括使不纯的N-（3,3-二甲基丁基）-α-L-天冬氨酰基至少含有α-L-天冬氨酰基-L-苯丙氨酸甲酯作为杂质的L-苯丙氨酸甲酯，其中混合溶剂具有两层由至少一种不与水均匀混合的有机溶剂提供的一层，在有机溶剂层中提取N-（3,3-二甲基丁基）-α-L-天冬氨酰基-L-苯丙氨酸甲酯的水。在本发明中，可以高产率有效地纯化或回收所需化合物没有使用繁重的步骤或操作。

52. 发明授权

US5958496A Aspartyl dipeptide amide derivatives and sweeteners 失效
标题翻译：天冬氨酰二肽酰胺衍生物和甜味剂
公开(公告)号：US5958496A
公开(公告)日：1999-09-28
申请号：US890993
申请日：1997-07-10
申请人： Yusuke Amino , Ryoichiro Nakamura , Tadashi Takemoto
发明人： Yusuke Amino , Ryoichiro Nakamura , Tadashi Takemoto
IPC分类号： A23L27/30 , C07K5/072 , C07K5/075 , A23L1/236 , C07C229/00
CPC分类号： C07K5/06113
摘要： Novel aspartyldipeptidoamides and salts thereof. The apartyldipeptides are useful as a low-calorie sweetener for food and beverage products and have excellent taste and chemical stability.
摘要翻译：新型天冬氨酰二肽酰胺及其盐。这种二十四碳四烯酸可用作食品和饮料产品的低热量甜味剂，具有极好的味道和化学稳定性。

53. 发明授权

US5763657A Phosphoric acid-amino acid-polyvalent metal composite salt and ruminant feed additive composition 失效
标题翻译：磷酸 - 氨基酸 - 多价金属复合盐和反刍动物饲料添加剂组成
公开(公告)号：US5763657A
公开(公告)日：1998-06-09
申请号：US894703
申请日：1997-08-28
申请人： Toyoto Hijiya , Toru Ikeda , Kenichi Mori , Toshihide Yukawa , Tadashi Takemoto , Hajime Kamada
发明人： Toyoto Hijiya , Toru Ikeda , Kenichi Mori , Toshihide Yukawa , Tadashi Takemoto , Hajime Kamada
IPC分类号： A23K1/00 , A23K1/16 , A23K1/175 , A23K1/18 , C07C229/26 , C07C279/14 , C07C229/00
CPC分类号： C07C229/26 , A23K20/142 , A23K20/147 , A23K20/26 , A23K40/10 , A23K40/35 , A23K50/10 , C07C279/14 , Y10S426/807
摘要： The present specification discloses a ruminant feed additive composition which contains as an active ingredient a phosphoric acid-amino acid-polyvalent metal composite salt (final composite salt) which is insoluble in neutral or alkaline water and is soluble in acidic water and which can be obtained by treating a composite salt composed of a basic amino acid, magnesium and phosphoric acid with a salt of a divalent or trivalent (polyvalent) metal other than magnesium, or by treating the above-mentioned composite salt with the polyvalent metal salt and a condensed phosphoric acid component (alone) or the condensed phosphoric acid component and a phosphoric acid component (in combination), this composition taking the form of a powder or granules. The above-mentioned final composite salt can exhibit the excellent stability to neutral or slightly acidic water, namely, the low solubility therein in comparison with the intermediate composite salt, and it can have both the excellent insolubility of the basic amino acid in a rumen of a ruminant and the excellent elution thereof in an abomasum and lower digestive organs.
摘要翻译： PCT No.PCT / JP96 / 03420 Sec。 371日期1997年8月28日 102（e）日期1997年8月28日PCT 1996年11月21日PCT公布。第WO97 / 24314号公报日本1997年7月10日本说明书公开了一种反刍动物饲料添加剂组合物，其含有不溶于中性或碱性水并且可溶于酸性水的磷酸 - 氨基酸 - 多价金属复合盐（最终复合盐）作为活性成分并且可以通过用碱性氨基酸，镁和磷酸组成的复合盐与除了镁以外的二价或三价（多价）金属的盐处理或通过用多价金属处理上述复合盐来获得盐和缩合磷酸组分（单独）或缩合磷酸组分和磷酸组分（组合），该组合物为粉末或颗粒形式。上述最终的复合盐可以显示出对中性或微酸性水的优异的稳定性，即与中间复合盐相比，其溶解度低，并且可以具有优异的碱性氨基酸在瘤胃的不溶性反刍动物和在皱胃和下消化器官中的优异洗脱。

54. 发明授权

US5723165A Aspartyldipeptide derivatives and sweetener compositions containing the same 失效
标题翻译：天冬氨酰二肽衍生物和含有它们的甜味剂组合物
公开(公告)号：US5723165A
公开(公告)日：1998-03-03
申请号：US500405
申请日：1995-07-10
申请人： Tadashi Takemoto , Yusuke Amino , Ryoichiro Nakamura
发明人： Tadashi Takemoto , Yusuke Amino , Ryoichiro Nakamura
IPC分类号： A23L27/30 , C07K5/072 , C07K5/075
CPC分类号： C07K5/06113 , Y10S530/801
摘要： Aspartyldipeptide compounds of the formula (I) L-Asp-X-NH-C*R.sub.1 R.sub.2 (I) where R.sub.1 is alkyl or alkoxymethyl, R.sub.2 is phenyl, benzyl, cyclohexyl or cyclohexylmethyl, C* has an (S) configuration when R.sub.1 is alkyl and an (R) configuration when R.sub.1 is alkoxymethyl and X is a residue of a D-.alpha.-amino acid, a DL-.alpha.-amino acid or a residue of a cyclic or acyclic .alpha.,.alpha.-diallylamino acid and the bond between L-Asp and X is an .alpha.-bond; and their use as active ingredients in sweetener compositions.
摘要翻译：式（I）L-Asp-X-NH-C * R1R2（I）的天冬氨酰二肽化合物，其中R 1是烷基或烷氧基甲基，R 2是苯基，苄基，环己基或环己基甲基，C *具有（S）烷基和（R）构型，当R 1为烷氧基甲基且X为D-α-氨基酸，DL-α-氨基酸或环状或非环状α，α-二烯丙基氨基酸的残基时， L-Asp和X是α键; 以及它们作为甜味剂组合物中的活性成分的用途。

55. 发明授权

US5616791A Method of preparing L-aspartyl-D-.alpha.-aminoalkane carboxylic acid-(S)-N-.alpha.-alkylbenzylamide 失效
标题翻译：制备L-天冬氨酰-D-α-氨基链烷羧酸 - （S）-N-甲基苄基酰胺的方法
公开(公告)号：US5616791A
公开(公告)日：1997-04-01
申请号：US524812
申请日：1995-09-07
申请人： Tadashi Takemoto , Toyoto Hijiya
发明人： Tadashi Takemoto , Toyoto Hijiya
IPC分类号： C07K1/06 , A23L27/30 , C07K5/072 , C07K5/075 , C07C229/08
CPC分类号： C07K5/06113 , A23L27/30 , Y02P20/55
摘要： The present invention provides a method of preparing L-aspartyl-D-.alpha.-aminoalkane carboxylic acid-(S)-N-.alpha.-alkylbenzylamide which is less expensive and more efficient than previous methods using N-protected-L-aspartic anhydride.
摘要翻译：本发明提供了一种制备L-天冬氨酰-D-α-氨基链烷羧酸 - （S）-N'-烷基苄基酰胺的方法，该方法比使用N-保护的L-天冬氨酸酐的先前方法更便宜且更有效。

56. 发明授权

US5173126A Aluminum brazing paste 失效
标题翻译：铝烧烤膏
公开(公告)号：US5173126A
公开(公告)日：1992-12-22
申请号：US879308
申请日：1992-05-07
申请人： Toshiaki Ogura , Tadashi Takemoto , Tatsuyuki Ujie
发明人： Toshiaki Ogura , Tadashi Takemoto , Tatsuyuki Ujie
IPC分类号： B23K35/22 , B23K35/36 , B23K35/363 , B23K103/10
CPC分类号： B23K35/3613 , B23K35/36 , B23K35/3605
摘要： Discloses an aluminium brazing paste which not only has excellent preservability and coating performance but also reveals excellent brazing characteristics; said aluminium brazing paste according to this invention comprises, per 100 parts by weight of aluminum-containing metal powder with 10 to 500 .mu.m of mean particle size for aluminium brazing, of 0.5 to 15 parts by weight of flux and 30 to 80 parts by weight of a liquid polyisobutylene with 300 to 1500 of average molecular weight and/or its hydrogenated product.

57. 发明授权

US4740616A Process for the production of an N-protected-L-.alpha.-aspartyl-L-phenylalanine 失效
标题翻译：用于生产N-保护的-L-α-天门冬酰基-L-苯丙氨酸的方法
公开(公告)号：US4740616A
公开(公告)日：1988-04-26
申请号：US883354
申请日：1986-07-01
申请人： Tadashi Takemoto , Toshihide Yukawa , Kunio Hisamitsu
发明人： Tadashi Takemoto , Toshihide Yukawa , Kunio Hisamitsu
IPC分类号： C07K5/075 , C07C101/20
CPC分类号： C07K5/0613 , Y10S530/801
摘要： A process is described for the synthesis of N-protected-L-.alpha.-aspartyl-L-phenylalanine by both (a) the reaction of an N-protected-L-aspartic anhydride and a R.sub.1 -L-phenylalanine, and (b) the reaction of an N-protected-L-aspartic anhydride and L-phenylalanine in an aqueous medium in the presence of R.sub.2, where R.sub.1 may be an alkali metal salt, alkaline earth metal salt, ammonium salt or organic amine salt, and R.sub.2 may be an ammonium salt or an alkali or alkaline earth metal salt of an inorganic or organic acid.
摘要翻译：描述了通过（a）N-保护的L-天冬氨酸酐和R1-L-苯丙氨酸的反应合成N-保护的-L-天冬酰胺-L-苯丙氨酸的方法，和（b）在R2的存在下，N-保护的L-天冬氨酸酐和L-苯丙氨酸在水性介质中的反应，其中R1可以是碱金属盐，碱土金属盐，铵盐或有机胺盐，R2可以是无机或有机酸的铵盐或碱金属或碱土金属盐。

58. 发明授权

US4680403A Process for producing N-protected-.alpha.-L-aspartyl-L-phenylalanine methyl ester 失效
标题翻译： N-保护-α-L-天冬氨酰-L-苯丙氨酸甲酯的制备方法
公开(公告)号：US4680403A
公开(公告)日：1987-07-14
申请号：US806811
申请日：1985-12-10
申请人： Kunio Hisamitsu , Tadashi Takemoto , Toyoto Hijiya , Satoji Takahashi
发明人： Kunio Hisamitsu , Tadashi Takemoto , Toyoto Hijiya , Satoji Takahashi
IPC分类号： C07K1/06 , C07K1/113 , C07K5/075 , C07D307/22
CPC分类号： C07K5/0613
摘要： The invention relates to a process for producing N-protected-.alpha.L-aspartyl-L-phenylalanine methyl ester, which comprises esterifying L-phenylalanine with methanol in the presence of a strong acid catalyst, adding, to the resulting solution, an aqueous alkaline solution to neutralize the acid catalyst and a water-immiscible organic solvent to extract the free L-phenylalanine methyl ester thus formed, collecting the organic layer, and reacting the L-phenylalanine methyl ester dissolved in said collected organic layer with N-protected-L-aspartic anhydride.
摘要翻译：本发明涉及一种生产N-保护-α-天冬氨酰基-L-苯丙氨酸甲酯的方法，该方法包括在强酸催化剂存在下用甲醇将L-苯丙氨酸酯化，向所得溶液中加入碱性水溶液用于中和酸催化剂和与水不混溶的有机溶剂以提取如此形成的游离L-苯丙氨酸甲酯的溶液，收集有机层，并将溶解在所述收集的有机层中的L-苯丙氨酸甲酯与N-保护的L - 天冬氨酸酐。

59. 发明授权

US4618695A Method of preparing methyl ester and its hydrochloride 失效
标题翻译：制备甲酯及其盐酸盐的方法
公开(公告)号：US4618695A
公开(公告)日：1986-10-21
申请号：US611548
申请日：1984-05-17
申请人： Yoichi Ozawa , Shinichi Kishimoto , Emiko Shinohara , Tadashi Takemoto , Chikahiko Eguchi
发明人： Yoichi Ozawa , Shinichi Kishimoto , Emiko Shinohara , Tadashi Takemoto , Chikahiko Eguchi
IPC分类号： C07K5/075 , C07C101/02
CPC分类号： C07K5/0613
摘要： A method of preparing .alpha.-L-phenylalanine methyl ester and its hydrochloride, which comprises dissolving .alpha.-L-aspartyl-L-phenylalanine .beta.-methyl ester in a methanol/hydrochloric acid mixture solvent which contains, when hydrochloric acid is expressed in terms of concentrated hydrochloric acid and water, 0 to 20% by volume of methanol, 8 to 55% by volume of concentrated hydrochloric acid and water (balance) in a concentration from 0.01 mol/dl to 0.3 mol/dl; holding the solution at 0.degree. to 60.degree. C. to effect intramolecular ester exchange reaction and crystallize out the formed .alpha.-L-aspartyl-L-phenylalanine methyl ester as its hydrochloride; isolating the hydrochloride; and obtaining, when required, the free ester by neutralization with an alkali, is disclosed.
摘要翻译：一种制备α-L-苯丙氨酸甲酯及其盐酸盐的方法，其包括将α--L-天冬氨酰基-L-苯丙氨酸β-甲酯溶于甲醇/盐酸混合物溶剂中，所述溶剂含有当盐酸以浓盐酸和水，0至20体积％甲醇，8至55体积％浓盐酸和水（余量），浓度为0.01mol / dl至0.3mol / dl; 将溶液保持在0〜60℃，进行分子内酯交换反应，结晶形成的α-L-天冬氨酰-L-苯丙氨酸甲酯为盐酸盐; 分离盐酸盐; 并且当需要时通过用碱中和获得游离酯。

60. 发明授权

US07951835B2 Crystals of non-natural-type stereoisomer salt of monatin and use thereof 有权
标题翻译：莫纳甜的非天然型立体异构体盐的晶体及其用途
公开(公告)号：US07951835B2
公开(公告)日：2011-05-31
申请号：US12825886
申请日：2010-06-29
申请人： Yusuke Amino , Kazuko Yuzawa , Kenichi Mori , Tadashi Takemoto
发明人： Yusuke Amino , Kazuko Yuzawa , Kenichi Mori , Tadashi Takemoto
IPC分类号： A61K31/40 , C07D209/18
CPC分类号： C07D209/20 , A23L2/60 , A23L27/30 , A23L27/32
摘要： The present invention provides salt crystals of non-natural stereoisomer forms of monatin and to the use thereof.
摘要翻译：本发明提供了莫纳甜的非天然立体异构形式的盐晶体及其用途。

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