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    • 53. 发明授权
    • Device and methods for non-invasive electrical stimulation and their use for vagal nerve stimulation
    • 用于非侵入性电刺激的装置和方法及其用于迷走神经刺激
    • US08874205B2
    • 2014-10-28
    • US13075746
    • 2011-03-30
    • Bruce SimonJoseph P. ErricoJohn T. Raffle
    • Bruce SimonJoseph P. ErricoJohn T. Raffle
    • A61N1/40A61N1/36
    • A61N1/40A61N1/36014A61N1/36017A61N1/36114
    • A non-invasive electrical stimulation device shapes an elongated electric field of effect that can be oriented parallel to a long nerve, such as a vagus nerve in a patient's neck, producing a desired physiological response in the patient. The stimulator comprises a source of electrical power, at least one electrode and a continuous electrically conducting medium in which the electrode(s) are in contact. The stimulation device is configured to produce a peak pulse voltage that is sufficient to produce a physiologically effective electric field in the vicinity of a target nerve, but not to substantially stimulate other nerves and muscles that lie between the vicinity of the target nerve and patient's skin. Current is passed through the electrodes in bursts of preferably five sinusoidal pulses, wherein each pulse within a burst has a duration of preferably 200 microseconds, and bursts repeat at preferably at 15-50 bursts per second.
    • 非侵入性电刺激装置形成可以平行于长神经(例如患者颈部的迷走神经)定向的细长的电场,在患者体内产生期望的生理反应。 刺激器包括电源,至少一个电极和连续导电介质,其中电极接触。 刺激装置被配置为产生峰值脉冲电压,该峰值脉冲电压足以在目标神经附近产生生理有效的电场,但是不能基本上刺激位于目标神经附近和患者皮肤之间的其它神经和肌肉 。 电流以优选五个正弦脉冲的脉冲串通过电极,其中脉冲串内的每个脉冲具有优选200微秒的持续时间,并且优选地以每秒15-50个突发重复突发。
    • 55. 发明申请
    • SYSTEMS AND METHODS FOR TREATMENT OF OBESITY AND TYPE 2 DIABETES
    • 用于治疗肥胖和2型糖尿病的系统和方法
    • US20140031738A1
    • 2014-01-30
    • US14042654
    • 2013-09-30
    • Joseph P. ErricoJohn T. RaffleJonathan David Gardiner
    • Joseph P. ErricoJohn T. RaffleJonathan David Gardiner
    • A61F5/00A61M27/00
    • A61M27/002A61F2/04A61F5/0076A61F2002/044
    • The present invention provides systems and methods for treating and controlling obesity and/or type II diabetes. In one aspect of the invention, a device comprises a hollow sleeve sized and shaped for positioning within a duodenum of the patient, an anchor coupled to the proximal end of the sleeve and being sized and shaped to inhibit distal migration of the sleeve and a plurality of elastomeric objects coupled to the distal end of the sleeve and being sized and shaped to inhibit proximal migration of the sleeve through a pylorus of the patient. The bypass device can be placed and removed endoscopically through the patient's esophagus in a minimally invasive outpatient procedure and it is “self-anchoring” and does not require invasive tissue fixation within the patient's GI tract, thereby reducing collateral tissue damage and minimizing its impact on the digestive process.
    • 本发明提供用于治疗和控制肥胖症和/或II型糖尿病的系统和方法。 在本发明的一个方面,一种装置包括尺寸和形状适于定位在患者的十二指肠内的中空套筒,联接到套筒的近端的锚固件,其尺寸和形状被设计成阻止套筒的远端移动,并且多个 耦合到套筒的远端的弹性体物体的尺寸和形状以阻止套管穿过患者幽门的近端迁移。 旁路装置可以通过患者的食管在微创门诊手术中内窥镜放置和移除,并且它是“自我锚定”的,并且不需要在患者胃肠道内进行侵入性组织固定,从而减少侧支组织损伤并使其对 消化过程。
    • 56. 发明授权
    • Systems and methods for treating obesity and type 2 diabetes
    • 用于治疗肥胖和2型糖尿病的系统和方法
    • US08591452B2
    • 2013-11-26
    • US12702411
    • 2010-02-09
    • Attila A. PriplataMarc GrahamJoseph P. ErricoJohn T. RaffleJonathan David Gardiner
    • Attila A. PriplataMarc GrahamJoseph P. ErricoJohn T. RaffleJonathan David Gardiner
    • A61M5/00A61F2/04
    • A61F5/0076A61B17/3468A61B2017/00557A61B2017/00818A61F5/004A61F5/0079A61F2002/045A61M25/04A61M27/002A61M39/00A61M39/10
    • The present invention provides systems and methods for treating and/or controlling obesity and type II diabetes. In one aspect of the invention, a device for treating obesity includes a flow restrictor and an anchor coupled to the flow restrictor. The flow restrictor is movable between a first or collapsed configuration sized and shaped for endoscopic advancement through the patient's esophagus and into a distal region of the stomach and a second or operative configuration sized and shaped for inhibiting a flow of chyme from the stomach to the pyloric sphincter. It is believed that this will cause the prolongation of satiety, and result in fewer meals being eaten and/or smaller meals being ingested. The anchor is movable between a first or collapsed configuration sized and shaped for advancement through the esophagus, stomach and pyloric sphincter and into the proximal region of the duodenum and a second or operative configuration sized and shaped to inhibit proximal movement of the anchor through the pyloric sphincter.
    • 本发明提供用于治疗和/或控制肥胖症和II型糖尿病的系统和方法。 在本发明的一个方面,一种用于治疗肥胖症的装置包括流量限制器和连接到限流器的锚固器。 限流器可在第一或塌陷构造之间移动,其尺寸和形状用于通过患者食道进入内窥镜前进并进入胃的远端区域,以及第二或可操作构造,其尺寸和形状用于抑制食糜从胃向幽门的流动 括约肌 相信这将导致饱腹感的延长,并且导致被摄入的食物减少和/或被摄入的较小的食物。 锚固件可以在尺寸和形状适于通过食道,胃和幽门括约肌进入并进入十二指肠的近端区域的第一或塌陷构型之间移动,以及尺寸和形状的第二或可操作构造,以阻止锚通过幽门的近端运动 括约肌