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51. 发明授权

US07345059B2 Diphenylpyridine derivatives, preparation and therapeutic application thereof 失效
标题翻译：二苯基吡啶衍生物，其制备及治疗应用
公开(公告)号：US07345059B2
公开(公告)日：2008-03-18
申请号：US11316510
申请日：2005-12-22
申请人： Francis Barth , Laurent Hortala , Murielle Rinaldi-Carmona
发明人： Francis Barth , Laurent Hortala , Murielle Rinaldi-Carmona
IPC分类号： A61K31/445 , C07D213/02 , C07D405/02
CPC分类号： C07D213/82 , C07D401/12 , C07D405/12
摘要： The invention relates to 5,6-diphenylpyridine-3-carboxamide derivatives of general formula (I): where: R1 represents hydrogen or a (C1-C4)alkyl; R2 represents: a monoazo saturated heterocycle of 5 to 7 atoms, the nitrogen atom being substituted with a (C1-C4)alkanoyl; NR10R11; a nonaromatic (C3-C10) carbocycle more than tri-substituted with (C1-C4)alkyl; a nonaromatic (C11-C12) carbocycle unsubstituted or mono- or polysubstituted with (C1-C4)alkyl; a monooxygenated saturated heterocycle with 5 to 7 atoms, more than tri-substituted with (C1-C4)alkyl; or R1 and R2, together with the nitrogen atom to which the above are bonded, form a 4-disubstituted piperidin-1-yl group; the salts, solvates and hydrates thereof. The invention further relates to a method for production and therapeutic application thereof.
摘要翻译：本发明涉及通式（I）的5,6-二苯基吡啶-3-甲酰胺衍生物：其中：R 1表示氢或（C 1 -C 3 -C > 4个）烷基; R 2表示：5至7个原子的单偶氮饱和杂环，氮原子被（C 1 -C 4 -C 4）烷酰基 ; NR 11 R 11; 与（C 1 -C 4 -C 4）三取代的非芳族（C 3 -C 10 - ）碳环，）烷基; 未取代或未被取代的（C 1 -C 4 -C 12）碳环的非芳族（C 1 -C 12 -C 12）碳环 >）烷基; 具有5至7个原子的单加成饱和杂环，多于（C 1 -C 4 -C 4）烷基的三取代基; 或R 1和R 2 2与上述键合的氮原子一起形成4-二取代的哌啶-1-基; 其盐，溶剂合物和水合物。本发明还涉及其生产方法及其治疗应用。

52. 发明授权

US07297710B1 Derivatives of N-[(1,5-diphenyl-1H-pyrazol-3-yl)methyl]sulfonamide, their preparation and their application in therapeutics 失效
标题翻译： N - [（1,5-二苯基-1H-吡唑-3-基）甲基]磺酰胺的衍生物及其制备及其在治疗中的应用
公开(公告)号：US07297710B1
公开(公告)日：2007-11-20
申请号：US11457014
申请日：2006-07-12
申请人： Francis Barth , Christian Congy , Serge Martinez , Philippe Pointeau , Murielle Rinaldi-Carmona
发明人： Francis Barth , Christian Congy , Serge Martinez , Philippe Pointeau , Murielle Rinaldi-Carmona
IPC分类号： A61K31/415 , C07D231/10
CPC分类号： C07D213/12 , C07D213/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12
摘要： The present invention relates to compounds corresponding to the formula (I): In which R1, R2, R3, R4 and R5 are as described herein. The invention also relates to the method of preparation of said compounds and their application in therapeutics.
摘要翻译：本发明涉及对应于式（I）的化合物：其中R 1，R 2，R 3，R 3， 4和R 5 5如本文所述。本发明还涉及所述化合物的制备方法及其在治疗中的应用。

53. 发明申请

US20070149596A1 PYRROLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE 失效
标题翻译：吡咯衍生物，其制备及其治疗用途
公开(公告)号：US20070149596A1
公开(公告)日：2007-06-28
申请号：US11625616
申请日：2007-01-22
申请人： Francis Barth , Christian Congy , Laurent Hortala , Murielle Rinaldi-Carmona
发明人： Francis Barth , Christian Congy , Laurent Hortala , Murielle Rinaldi-Carmona
IPC分类号： A61K31/40 , C07D207/46
CPC分类号： C07D409/12 , C07D207/34 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/12
摘要： The invention concerns compounds of formula (I): Wherein R1, R2, R3, R4, R5, R6, R7, R8 and R9 are as defined herein. The invention also concerns the method for preparing said compounds and their therapeutic use.
摘要翻译：本发明涉及式（I）的化合物：其中R 1，R 2，R 3，R 4， R 5，R 6，R 7，R 8和R 9，如本文所定义。本发明还涉及制备所述化合物的方法及其治疗用途。

54. 发明申请

US20060167049A1 Terphenly derivatives, preparation thereof, compositions containing same 失效
标题翻译：三苯并衍生物，其制备方法，含有它们的组合物
公开(公告)号：US20060167049A1
公开(公告)日：2006-07-27
申请号：US10511040
申请日：2003-04-10
申请人： Francis Barth , Serge Martinez , Murielle Rinaldi-Carmona
发明人： Francis Barth , Serge Martinez , Murielle Rinaldi-Carmona
IPC分类号： C07D211/06 , A61K31/445 , C07D207/02 , A61K31/401 , A61K31/165
CPC分类号： C07D295/32 , C07C69/76 , C07C233/65 , C07C233/69 , C07C233/78 , C07C2602/22 , C07D209/16 , C07D211/16 , C07D211/98
摘要： The invention relates to terphenyl derivatives of formula: and to their preparation and to the pharmaceutical compositions comprising them. These compounds exhibit an antagonist activity with respect to CB1 cannabinoid receptors.
摘要翻译：本发明涉及下式的三联苯衍生物及其制备方法及包含它们的药物组合物。这些化合物相对于CB1大麻素受体表现出拮抗剂活性。

55. 发明申请

US20060135776A1 4-Cyanopyrazole-3-carboxamide derivatives, preparation, and application thereof 有权
标题翻译： 4-氰基吡唑-3-甲酰胺衍生物，其制备及应用
公开(公告)号：US20060135776A1
公开(公告)日：2006-06-22
申请号：US11315774
申请日：2005-12-22
申请人： Francis Barth , Christian Congy , Serge Martinez , Murielle Rinaldi-Carmona
发明人： Francis Barth , Christian Congy , Serge Martinez , Murielle Rinaldi-Carmona
IPC分类号： A61K31/454 , A61K31/4152 , C07D403/02 , C07D231/14 , C07D231/54
CPC分类号： C07D401/12 , C07D231/14
摘要： The invention relates to 4-cyanopyrazole-3-carboxamide derivatives of formula (I): in which R1, R2, R3, R4, R5, R6, R7, R8 are as described herein. Also disclosed and claimed are the method of preparation and therapeutic application of compound of formula (I).
摘要翻译：本发明涉及式（I）的4-氰基吡唑-3-甲酰胺衍生物：其中R 1，R 2，R 3， R 4，R 5，R 6，R 7，R 8是如本文所述。还公开并要求保护的是式（I）化合物的制备和治疗应用的方法。

56. 发明授权

US07875646B2 Derivatives of N-[(1,5-diphenyl-1H-pyrazol-3-yl)methyl] sulfonamide, their preparation and their application in therapeutics 失效
标题翻译： N - [（1,5-二苯基-1H-吡唑-3-基）甲基]磺酰胺的衍生物及其制备及其在治疗中的应用
公开(公告)号：US07875646B2
公开(公告)日：2011-01-25
申请号：US11859010
申请日：2007-09-21
申请人： Francis Barth , Christian Congy , Serge Martinez , Philippe Pointeau , Murielle Rinaldi-Carmona
发明人： Francis Barth , Christian Congy , Serge Martinez , Philippe Pointeau , Murielle Rinaldi-Carmona
IPC分类号： A61K31/415 , C07D231/10
CPC分类号： C07D213/12 , C07D213/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12
摘要： The present invention relates to compounds corresponding to the formula (I): In which R1, R2, R3, R4 and R5 are as described herein. The invention also relates to the method of preparation of said compounds and their application in therapeutics.
摘要翻译：本发明涉及对应于式（I）的化合物：其中R 1，R 2，R 3，R 4和R 5如本文所述。本发明还涉及所述化合物的制备方法及其在治疗中的应用。

57. 发明申请

US20100144818A1 1-BENZYLPYRAZOLE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF 审中-公开
标题翻译： 1-苄氧基吡唑衍生物，其制备方法及其治疗方法
公开(公告)号：US20100144818A1
公开(公告)日：2010-06-10
申请号：US12630470
申请日：2009-12-03
申请人： Francis BARTH , Laurent BOULU , Joseph MILLAN , Murielle RINALDI-CARMONA
发明人： Francis BARTH , Laurent BOULU , Joseph MILLAN , Murielle RINALDI-CARMONA
IPC分类号： A61K31/415 , C07D231/12 , A61P41/00
CPC分类号： C07D231/12 , C07D405/12 , C07D409/12
摘要： The present invention relates to compounds corresponding to formula (I): in which Y, R1, R2, R3, R4, R5 and R6 are as defined herein. The present invention also relates to the methods of preparation and the therapeutic applications of the compounds of formula (I).
摘要翻译：本发明涉及对应于式（I）的化合物：其中Y，R 1，R 2，R 3，R 4，R 5和R 6如本文所定义。本发明还涉及式（I）化合物的制备方法和治疗应用。

58. 发明授权

US07687537B2 N-[(4,5-diphenyl-2-thienyl)methyl]amine derivatives, their preparation and their therapeutic application 失效
标题翻译： N - [（4,5-二苯基-2-噻吩基）甲基]胺衍生物及其制备方法及其应用
公开(公告)号：US07687537B2
公开(公告)日：2010-03-30
申请号：US11832162
申请日：2007-08-01
申请人： Jean-Philippe Ducoux , Francis Barth , Murielle Rinaldi-Carmona , Christian Congy
发明人： Jean-Philippe Ducoux , Francis Barth , Murielle Rinaldi-Carmona , Christian Congy
IPC分类号： A61K31/38 , C07D333/08
CPC分类号： C07D333/20
摘要： The subject of the present invention is compounds corresponding to formula (I): Wherein X, R1, R2, R3 and R4 are as described herein. The invention also relates to a method for the preparation and application of said compounds as cannabinoid CB1 receptor antagonists.
摘要翻译：本发明的主题是对应于式（I）的化合物：其中X，R 1，R 2，R 3和R 4如本文所述。本发明还涉及一种制备和应用所述化合物作为大麻素CB1受体拮抗剂的方法。

59. 发明授权

US07524971B2 1,5-diarylpyrrole derivatives, preparation method thereof and application of same in therapeutics 失效
标题翻译： 1,5-二芳基吡咯衍生物及其制备方法及其在治疗中的应用
公开(公告)号：US07524971B2
公开(公告)日：2009-04-28
申请号：US11832851
申请日：2007-08-02
申请人： Francis Barth , Christian Congy , Laurent Hortala , Murielle Rinaldi-Carmona
发明人： Francis Barth , Christian Congy , Laurent Hortala , Murielle Rinaldi-Carmona
IPC分类号： C07D207/30
CPC分类号： C07D207/323 , C07D207/335 , C07D403/12
摘要： The invention relates to compounds having formula (I): Wherein X, R1, R2, R3, R4, R5 and R6 are as defined herein. The invention also relates to a method of preparing said compounds and to die application thereof in therapeutics.
摘要翻译：本发明涉及具有式（I）的化合物：其中X，R 1，R 2，R 3，R 4，R 5和R 6如本文所定义。本发明还涉及一种制备所述化合物并将其在治疗中应用的方法。

60. 发明申请

US20080176867A1 N-[(4,5-DIPHENYLPYRIMIDIN-2-YL)METHYL]AMINE DERIVATIVES, THE PREPARATION THEREOF AND THEIR THERAPEUTIC USE 失效
标题翻译： N - [（4,5-二苯基嘧啶-2-基）甲基]胺衍生物及其制备方法及其治疗用途
公开(公告)号：US20080176867A1
公开(公告)日：2008-07-24
申请号：US11968855
申请日：2008-01-03
申请人： Francis BARTH , Christian CONGY , Patrick GUEULE , Murielle RINALDI-CARMONA
发明人： Francis BARTH , Christian CONGY , Patrick GUEULE , Murielle RINALDI-CARMONA
IPC分类号： A61K31/505 , C07D239/26 , A61P25/28 , A61P3/04 , A61P3/10 , A61P25/00 , A61P25/32 , A61P25/34 , A61P1/00 , A61P3/00 , A61P37/00
CPC分类号： C07D405/12 , C07D239/26 , C07D403/12 , C07D409/12
摘要： The invention relates to compounds of formula (I): Wherein X, R1, R2, R3, R4 and R5 are as defined herein. The invention also relates to a method for preparing the aforementioned compounds and to their therapeutic use.
摘要翻译：本发明涉及式（I）化合物：其中X，R 1，R 2，R 3，R 4， / SUB>和R 5'如本文所定义。本发明还涉及一种制备上述化合物及其治疗用途的方法。

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