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51. 发明授权

US06461823B1 Death domain containing receptor-4 antibodies 有权
标题翻译：含有受体-4抗体的死亡域
公开(公告)号：US06461823B1
公开(公告)日：2002-10-08
申请号：US09448868
申请日：1999-11-24
申请人： Jian Ni , Craig A. Rosen , James G. Pan , Reiner L. Gentz , Vishva M. Dixit
发明人： Jian Ni , Craig A. Rosen , James G. Pan , Reiner L. Gentz , Vishva M. Dixit
IPC分类号： G01N33567
CPC分类号： C07K14/70578
摘要： The present invention relates to novel Death Domain Containing Receptor-4 (DR4) proteins which are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR4 proteins. DR4 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of DR4 activity.
摘要翻译：本发明涉及作为肿瘤坏死因子（TNF）受体家族成员的新的含有死亡域的受体-4（DR4）蛋白。特别地，提供编码人DR4蛋白的分离的核酸分子。还提供了DR4多肽，载体，宿主细胞和用于制备它们的重组方法。本发明还涉及用于鉴定DR4活性的激动剂和拮抗剂的筛选方法。

52. 发明授权

US06451577B1 Human uridine disphosphate galactose-4-epimerase 失效
标题翻译：人尿苷磷酸半乳糖-4-差向异构酶
公开(公告)号：US06451577B1
公开(公告)日：2002-09-17
申请号：US09624183
申请日：2000-07-24
申请人： Hongjun Ji , Craig A. Rosen
发明人： Hongjun Ji , Craig A. Rosen
IPC分类号： C12N990
CPC分类号： C12N9/90
摘要： A human UDP galactose-4-epimerase polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the treatment of galactosemia. Also disclosed are diagnostic assays for the detection of mutations in the nucleic acid sequencing encoding human UDP galactose-4-epimerase protein and for detecting an altered level of human UDP galactose-4-epimerase protein in a sample derived from a host.
摘要翻译：公开了人类UDP半乳糖-4-差向异构酶多肽和编码这种多肽的DNA（RNA）以及通过重组技术产生这种多肽的方法。还公开了利用这种多肽治疗半乳糖血症的方法。还公开了用于检测编码人UDP半乳糖-4-差向异构酶蛋白的核酸测序中的突变的诊断测定，并用于检测源自宿主的样品中人UDP半乳糖-4-差向异构酶蛋白的水平的变化。

53. 发明授权

US06433147B1 Death domain containing receptor-4 有权
标题翻译：死亡域含受体4
公开(公告)号：US06433147B1
公开(公告)日：2002-08-13
申请号：US09565918
申请日：2000-05-05
申请人： Jian Ni , Craig A. Rosen , James G. Pan , Reiner L. Gentz , Vishva M. Dixit
发明人： Jian Ni , Craig A. Rosen , James G. Pan , Reiner L. Gentz , Vishva M. Dixit
IPC分类号： C07K14705
CPC分类号： C07K16/2878 , A61K38/00 , A61K39/39541 , C07K14/70578 , C07K14/7151 , C07K2319/30 , C12N2799/026 , A61K2300/00
摘要： The present invention relates to novel Death Domain Containing Receptor-4 (DR4) proteins which are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR4 proteins. DR4 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of DR4 activity and methods for using DR4 polynucleotides and polypeptides.
摘要翻译：本发明涉及作为肿瘤坏死因子（TNF）受体家族成员的新的含有死亡域的受体-4（DR4）蛋白。特别地，提供编码人DR4蛋白的分离的核酸分子。还提供了DR4多肽，载体，宿主细胞和用于制备它们的重组方法。本发明还涉及用于鉴定DR4活性的激动剂和拮抗剂的筛选方法以及使用DR4多核苷酸和多肽的方法。

54. 发明授权

US06433139B1 Secreted protein HPEAD48 失效
标题翻译：分泌蛋白HPEAD48
公开(公告)号：US06433139B1
公开(公告)日：2002-08-13
申请号：US09288143
申请日：1999-04-08
申请人： Steven M. Ruben , Craig A. Rosen , Henrik S. Olsen
发明人： Steven M. Ruben , Craig A. Rosen , Henrik S. Olsen
IPC分类号： C07K100
CPC分类号： C07K14/47 , A61K38/00 , A61K39/00 , A61K48/00 , C07K2319/00 , C12N2799/026
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。

55. 发明授权

US06403557B1 Fibroblast growth factor-13 失效
标题翻译：成纤维细胞生长因子-13
公开(公告)号：US06403557B1
公开(公告)日：2002-06-11
申请号：US08976315
申请日：1997-11-21
申请人： John M. Greene , Joachim R. Gruber , Craig A. Rosen
发明人： John M. Greene , Joachim R. Gruber , Craig A. Rosen
IPC分类号： A61K3818
CPC分类号： C07K14/50 , A01K67/027 , A61K38/00 , A61K48/00 , C07K2319/00 , C12N2799/026 , Y10S530/866
摘要： The present invention relates to a novel FGF-13 protein which is a member of the fibroblast growth factor (FGF) family. In particular, isolated nucleic acid molecules are provided encoding the human FGF-13 protein. FGF-13 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of FGF-13 activity. Also provided are diagnostic methods for detecting FGF-13-related disorders and therapeutic methods for treating FGF-13-related disorders. Disclosed is a method of prolonging dopaminergic neuron survival.
摘要翻译：本发明涉及作为成纤维细胞生长因子（FGF）家族成员的新型FGF-13蛋白。特别地，提供编码人FGF-13蛋白的分离的核酸分子。还提供FGF-13多肽，载体，宿主细胞以及用于制备其的重组方法。本发明还涉及用于鉴定FGF-13活性的激动剂和拮抗剂的筛选方法。还提供了用于检测FGF-13相关病症的诊断方法和用于治疗FGF-13相关疾病的治疗方法。公开了延长多巴胺能神经元存活的方法。

56. 发明授权

US06368822B1 Fibroblast growth factor 13 失效
标题翻译：成纤维细胞生长因子13
公开(公告)号：US06368822B1
公开(公告)日：2002-04-09
申请号：US09036985
申请日：1998-03-09
申请人： John M. Greene , Joachim R. Gruber , Craig A. Rosen
发明人： John M. Greene , Joachim R. Gruber , Craig A. Rosen
IPC分类号： C12P2106
CPC分类号： C07K14/50 , A61K38/00
摘要： Disclosed is a human Fibroblast growth factor-13 polypeptide and DNA(RNA) encoding such polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques. Also disclosed are methods for utilizing such polypeptide for promoting wound healing for example as a result of burns and ulcers, to prevent neuronal damage associated with stroke and due to neuronal disorders and promote neuronal growth, and to prevent skin aging and hair loss, to stimulate angiogenesis, mesodermal induction in early embryos and limb regeneration. Antagonists against such polypeptides and their use as a therapeutic to prevent abnormal cellular proliferation, hyper-vascular diseases and epithelial lens cell proliferation are also disclosed. Diagnostic methods for detecting mutations in the coding sequence and alterations in the concentration of the polypeptides in a sample derived from a host are also disclosed.
摘要翻译：公开了人成纤维细胞生长因子-13多肽和编码这种多肽的DNA（RNA）。还提供了通过重组技术产生这种多肽的方法。还公开了利用这种多肽促进伤口愈合的方法，例如作为烧伤和溃疡的结果，以防止与中风相关的神经元损伤以及由于神经元紊乱并促进神经元生长，并且防止皮肤老化和脱发，以刺激血管生成，早期胚胎中胚层诱导和肢体再生。还公开了抗这些多肽的拮抗剂及其作为预防异常细胞增殖，高血管疾病和上皮细胞增殖的治疗剂的用途。还公开了用于检测编码序列中的突变和衍生自宿主的样品中多肽浓度变化的诊断方法。

57. 发明授权

US06346246B1 Antibodies that bind human haemopoietic maturation factor 失效
标题翻译：结合人类造血成熟因子的抗体
公开(公告)号：US06346246B1
公开(公告)日：2002-02-12
申请号：US09333033
申请日：1999-06-15
申请人： Ewen F. Kirkness , Mark D. Adams , Henrik S. Olsen , Craig A. Rosen
发明人： Ewen F. Kirkness , Mark D. Adams , Henrik S. Olsen , Craig A. Rosen
IPC分类号： A61K39395
CPC分类号： C07K14/475 , A61K38/00
摘要： Disclosed is human haemopoietic maturation factor polypeptides and DNA (RNA) encoding such haemopoietic maturation factor polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and the use of such polypeptides for treating leukemia, auto-immune diseases and blood related disorders. Antagonists against such polypeptides and their use as a therapeutic to prevent expansion of T-cell populations is also disclosed. Diagnostic assays are also disclosed which detect the presence of mutations in the haemopoietic maturation factor nucleic acid sequences and altered levels of the protein.
摘要翻译：公开了人类造血成熟因子多肽和编码这种造血成熟因子多肽的DNA（RNA）。还提供了通过重组技术产生此类多肽的方法以及使用这些多肽来治疗白血病，自身免疫疾病和血液相关病症。还公开了抗这些多肽的拮抗剂及其作为预防T细胞群扩增的治疗剂的用途。还公开了诊断测定法，其检测造血成熟因子核酸序列中突变的存在和蛋白质的改变水平。

58. 发明授权

US06262233B1 Tissue factor pathway inhibitor-3 失效
标题翻译：组织因子途径抑制剂-3
公开(公告)号：US06262233B1
公开(公告)日：2001-07-17
申请号：US09013896
申请日：1998-01-27
申请人： Reiner L. Gentz , Tsu-An Hsu , Craig A. Rosen , Jian Ni
发明人： Reiner L. Gentz , Tsu-An Hsu , Craig A. Rosen , Jian Ni
IPC分类号： C07K400
CPC分类号： C07K14/8114 , A61K38/00 , C07K2319/00
摘要： The present invention relates to a novel TFPI-3 protein which is a member of the tissue factor protease inhibitor family. In particular, isolated nucleic acid molecules are provided encoding human TFPI-3 proteins. TFPI-3 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TFPI-3 activity. Also provided are diagnostic methods for detecting hemostasis system-related disorders and therapeutic methods for treating hemostatis system-related disorders.
摘要翻译：本发明涉及作为组织因子蛋白酶抑制剂家族成员的新型TFPI-3蛋白。特别地，提供编码人TFPI-3蛋白质的分离的核酸分子。还提供TFPI-3多肽，载体，宿主细胞和用于制备它们的重组方法。本发明还涉及用于鉴定TFPI-3活性的激动剂和拮抗剂的筛选方法。还提供了用于检测止血系统相关疾病的诊断方法和治疗止血系统相关疾病的治疗方法。

59. 发明授权

US06258777B1 Human B-cell translocation genes-2 and 3 有权
标题翻译：人B细胞易位基因-2和3
公开(公告)号：US06258777B1
公开(公告)日：2001-07-10
申请号：US09221844
申请日：1998-12-29
申请人： Charles A. Kunsch , Arvind Chopra , Craig A. Rosen
发明人： Charles A. Kunsch , Arvind Chopra , Craig A. Rosen
IPC分类号： C07K1400
CPC分类号： C07K14/82 , C12N2799/026
摘要： The present invention relates to novel antiproliferative genes. More specifically, isolated nucleic acid molecules are provided encoding the human B-cell translocation genes 2 and 3 (BTG-2 and BTG-3). BTG-2 and BTG-3 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same.
摘要翻译：本发明涉及新型抗增殖基因。更具体地，提供编码人B细胞易位基因2和3（BTG-2和BTG-3）的分离的核酸分子。还提供了BTG-2和BTG-3多肽，载体，宿主细胞以及用于制备它们的重组方法也是如此。

60. 发明授权

US6159469A Streptococcus pneumoniae antigens and vaccines 失效
公开(公告)号：US6159469A
公开(公告)日：2000-12-12
申请号：US961083
申请日：1997-10-30
申请人： Gil H. Choi , Charles A. Kunsch , Steven C. Barash , Patrick J. Dillon , Brian Dougherty , Michael R. Fannon , Craig A. Rosen
发明人： Gil H. Choi , Charles A. Kunsch , Steven C. Barash , Patrick J. Dillon , Brian Dougherty , Michael R. Fannon , Craig A. Rosen
IPC分类号： G01N33/53 , A01K67/027 , A61K38/00 , A61K39/00 , A61K39/09 , A61K48/00 , A61P31/04 , C07K14/315 , C07K16/12 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/00 , C12N5/10 , C12N5/18 , C12N15/09 , C12N15/31 , C12P21/02 , C12Q1/68 , G01N33/50 , G01N33/569 , G06F17/30 , A61K39/40 , A61K39/02 , A61K39/385
CPC分类号： C07K14/3156 , A61K38/00 , A61K39/00 , C07K14/315
摘要： The present invention relates to novel vaccines for the prevention or attenuation of infection by Streptococcus pneumoniae. The invention further relates to isolated nucleic acid molecules encoding antigenic polypeptides of Streptococcus pneumoniae. Antigenic polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention additionally relates to diagnostic methods for detecting Streptococcus nucleic acids, polypeptides and antibodies in a biological sample.

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