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51. 发明授权

US3867455A Preparation of phenylaminoethanols 失效
标题翻译：苯氨基乙醇的制备
公开(公告)号：US3867455A
公开(公告)日：1975-02-18
申请号：US42471173
申请日：1973-12-14
申请人： ALLEN & HANBURYS LTD
发明人： ATKINSON MICHAEL , HARTLEY DAVID
IPC分类号： C07C91/16
摘要： in which R1 and R2 have the meanings given above with formaldehyde or a formaldehyde yielding compound in the presence of a strong base and an alkali metal borate.

in which R1 represents a hydrogen atom or a benzyl group; AND R2 represents a hydrogen atom or a straight or branched chain alkyl radical containing from 1 to 6 carbon atoms or an arylalkyl radical which comprises treating a compound of the formula II:

A process for the preparation of phenylaminoethanol derivatives of the formula I:
摘要翻译：制备式I的苯基氨基乙醇衍生物的方法：

52. 发明授权

US3858583A Medicament inhalation device 失效
标题翻译：药物吸入装置
公开(公告)号：US3858583A
公开(公告)日：1975-01-07
申请号：US43699374
申请日：1974-01-28
申请人： ALLEN & HANBURYS LTD
发明人： HALLWORTH GERALD WYNN , SMITH SIDNEY WILLIAM
IPC分类号： A61M13/00 , A61M15/00 , A61M15/06
CPC分类号： A61M15/0028 , A61M15/0008 , A61M15/0033 , A61M2202/064
摘要： An inhalation device comprises a body with a dispersion chamber. A rotor is arranged in the chamber and is caused to rotate by passage of air through the chamber. One or more air inlet apertures open into the chamber around the rotor. A mouthpiece communicates with the chamber and air from the chamber can be inhaled through this mouthpiece. A capsule-retaining pocket is arranged to receive a pierced capsule and opens into the chamber. Inhalation of air through the mouthpiece will rotate the rotor, vibrate the capsule, draw medicament from the medicament containing capsule through the chamber and out through the mouthpiece.
摘要翻译：吸入装置包括具有分散室的主体。转子布置在腔室中，并通过空气通过腔室而转动。一个或多个空气入口孔围绕转子敞开进入腔室。接口与腔室连通，来自腔室的空气可以通过该接口管吸入。胶囊保持袋被布置成接收穿孔的胶囊并且通向腔室。通过接口管吸入空气将使转子旋转，使胶囊振动，从药物容纳胶囊中吸取药物通过腔室，并通过吸嘴吹出。

53. 发明授权

US3773746A 1,1'-azo bis(1h-imidazo(1,2-a)pyridinium dibromide compounds 失效
标题翻译： 1,1'-偶氮二（1H-咪唑（1,2-A）吡啶二酮化合物
公开(公告)号：US3773746A
公开(公告)日：1973-11-20
申请号：US3773746D
申请日：1971-05-13
申请人： ALLEN & HANBURYS LTD
发明人： JACK D , GLOVER E
IPC分类号： C07D213/77 , C07D233/54 , C07D235/22 , C07D471/04 , C07D519/00 , C07C115/00
CPC分类号： C07D213/77 , C07C243/00 , C07D233/54 , C07D235/22 , C07D471/04
摘要： THERE ARE PROVIDED COMPOUNDS OF THE GENERAL FORMULA

(2-R3,3-R4,4-R2,5-R1-1H-IMIDAZOL-1-YL)2-N2 (X(-))2

IN WHICH R1-R4 WHICH MAY BE THE SAME OR DIFFERENT REPRESENT LOWER ALKYL, LOWER ALKENYL, HALOGEN, ARALKYL OR ARYL IN WHICH THE ARYL GROUP MAY BE SUBSTITUTED WITH HYDROXY, LOWER ALKOXY, HALOGEN, NITRO OR TRIFLUOROMETHYL AND IN WHICH ANY TWO ADJACENT GROUPS R MAY TOGETHER WITH 2 ATOMS OF THE IMIDAZOLE RING FORM A 5, 6 OR 7 MEMBERED CARBOCYCLIC OR HETEROCYCLIC RING; AND X REPRESENTS A PHYSIOLOGICALLY ACCEPTABLE ANION. THESE COMPOUNDS HAVE A CURARE LIKE NEUROMUSCULAR BLOCKING ACTION.

54. 发明授权

US3755319A Xanthone derivatives 失效
标题翻译： XANTHONE衍生物
公开(公告)号：US3755319A
公开(公告)日：1973-08-28
申请号：US3755319D
申请日：1972-03-08
申请人： ALLEN & HANBURYS LTD
发明人： BAYS D
IPC分类号： C07D311/86 , C07D99/04
CPC分类号： C07D311/86 , Y10S514/826 , Y10S514/861
摘要： Xanthone derivatives of the formula:

IN WHICH X represents a carboxyl or 5-(1H)-tetrazolyl group; and R1 and R2 which may be the same or different each represent a hydrogen atom, an alkyl group containing from 1 to 4 carbon atoms, a nitro group, a halogen atom or a group of the formula NR3R4 or OR3 or NR5SO2R6, (in which the groups R3 and R4 which may be the same or different each represent a hydrogen atom, a phenyl group, a benzyl group or an alkyl group which may optionally be substituted by an alkoxy group containing from 1 to 6 carbon atoms, a phenoxy group, phenyl group, an amino, alkylamino or dialkylamino group or by one or more hydroxy groups; and in which R5 is a hydrogen atom or an alkyl group containing from 1 to 6 carbon atoms and R6 is an alkyl group containing from 1 to 6 carbon atoms); with the proviso that when X represents a carboxyl group R1 and R2 do not both represent hydrogen atoms; and pharmaceutically acceptable non-toxic salts and esters of such compounds. These derivatives have pharmacological activity and in particular inhibit the release of spasmogen mediators from antigen-antibody reactions.

55. 发明授权

US3706768A Xanthone derivatives 失效
标题翻译： XANTHONE衍生物
公开(公告)号：US3706768A
公开(公告)日：1972-12-19
申请号：US3706768D
申请日：1970-11-17
申请人： ALLEN & HANBURYS LTD
发明人： BAYS DAVID EDMUND
IPC分类号： C07D311/86 , C07D7/44
CPC分类号： C07D311/86 , Y10S514/826 , Y10S514/861
摘要： XANTHORNE DERIVATIVES OF THE FORMULA:

2-X,9-(O=),R1,R2-XANTHENE

IN WHICH X REPRESENTS A CARBOXYL OR 5-(1H)-TETRAZOLYL GROUP; AND R1 AND RI WHICH MAY BE THE SAME OR DIFFERENT EACH REPRESENT A HYDROGEN ATOM, AN ALKYL GROUP CONTAINING FROM 1 TO 4 CARBON ATOMS, A NITRO GROUP, A HALOGEN ATOM OR A GROUP OF THE FORMULA-NR3R4 OR OR3 OR NR5SO2R6 (IN WHICH THE GROUPS R2 AND R4 WHICH MAY BE THE SAME OR DIFFERENT EACH REPRESENT A HYDROGEN ATOM, A PHENYL GROUP, A BENZYL GROUP OR AN ALKYL GROUP WHICH MAY OPTIONALLY BE SUBSTITUTED BY AN ALKOXY GROUP CONTAINING FROM 1 TO 6 CARBON ATOMS, A PHENOXY GROUP, PHENYL GROUP, AN AMINO, ALKYLAMINO OR DIALKYLAMINO GROUP OR BY ONE OR MORE HYDROXY GROUPS; AND IN WHICH R5 IS A HYDROGEN ATOM OR AN ALKYL GROUP CONTAINING FROM 1 TO 6 CARBON ATOMS AND R6 IS AN ALKYL GROUP CONTAINING FROM 1 TO 6 CARBON ATOMS); WITH THE PROVISO THAT WHEN X REPRESENTS A CARBOXYL GROUP R1 AND R2 DO NOT BOTH REPRESENT HYDROGEN ATOMS; AND PHARMACEUTICALLY ACCEPTABLE NON-TONIX SALTS AND ESTERS OF SUCH COMPOUNDS. THESE DERIVATIVES HAVE PHARMACOLOGICAL ACTIVITY AND IT PARTICULAR INHIBIT THE RELEASE OF SPASMOGEN MEDIATORS FROM ANTIGEN-ANTIBODY REACTIONS.
摘要翻译：呫吨酮衍生物的配方：

56. 发明授权

US3644520A Phenylethanolamines 失效
标题翻译：苯乙醇胺
公开(公告)号：US3644520A
公开(公告)日：1972-02-22
申请号：US3644520D
申请日：1968-12-10
申请人： ALLEN & HANBURYS LTD
发明人： HARTLEY DAVID , JACK DAVID , LUNTS LAWRENCE H C
IPC分类号： C07C275/24 , C07C103/38 , C07C103/12
CPC分类号： C07C275/24 , Y02P20/55
摘要： COMPOUNDS HAVNG THE SKETETAL STRUCTURE

(1-(HO-),2-(>N-CH2-)PHENYL)-CH(OH)-CH(-)-N
AND PHYSIOLOGICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF. THE DISCLOSED COMPOUNDS POSSESS STIMULANT OR BLOCKING ACTIONS ON ADRENERGIC-RECEPTORS.

57. 发明授权

US3642896A Process for the preparation of alpha**1-tertiary butylaminomethyl - 4 - hydroxy-m-xylene-alpha**1 alpha**3-diol 失效
标题翻译：制备ALPHA ** 1-叔丁基氨基甲酰基-4-羟基-M-二甲基-AlpHA ** 1 ALPHA ** 3-DIOL的方法
公开(公告)号：US3642896A
公开(公告)日：1972-02-15
申请号：US3642896D
申请日：1968-04-15
申请人： ALLEN & HANBURYS LTD
发明人： COLLIN DAVID TREVOR
IPC分类号： C07C229/38 , C07C243/38 , C07D295/13 , C07C85/02
CPC分类号： C07D295/13 , C07C229/38 , C07C243/38
摘要： A MULT-STAGE PROCESS FOR THE PREPARATION OF COMPOUNDS OF THE GENERAL FORMULA:

R3-NH-CH(-R1)-CH(-OH)-),1-(HO-),2-(CH3-)BENZENE

IS DISCLOSED FROM THE PARENT KETONE OF THE FORMULA

(HO-),(R1-CH2-CO-)BENZENE

BY STEPS INCLUDING CHLOROMETHYLATION, ACETYLATION, BROMINATION, AMINATION WITH A COMPOUND OF THE FORMULA

PH-CH2-NH-R3

DEACETYLATION AND REDUCTION. THE PRODUCT MAY BE ISOLATED AS A PHARMACEUTICALLY ACCEPTABLE SALT.

58. 发明授权

US3577549A Treatment of pain or inflammation with p-benzoyl-phenylacetic acid or o-benzoyl-phenylacetic acid 失效
标题翻译：用对苯甲酰基 - 邻苯二甲酸或邻苯甲酰基苯酸处理疼痛或炎症
公开(公告)号：US3577549A
公开(公告)日：1971-05-04
申请号：US3577549D
申请日：1968-08-09
申请人： ALLEN & HANBURYS LTD
发明人： JACK DAVID , RHODES DERYCK
IPC分类号： A61K31/19 , A61K27/00
CPC分类号： A61K31/19
摘要： PHARMACEUTICAL COMPOSITIONS COMPRISING AS ACTIVE INGREDIENT EITHER P-BENZOYL-PHENYLACETIC ACID, OR O-BENZOYLPHENYLACETIC ACID, WHICH COMPOUNDS MAY BE USED IN THE FORM OF PHYSIOLOGICALLY ACCEPTABLE SALTS. THESE ACTIVE INGREDIENTS HAVE ANTI-INFLAMMATORY AND ANALGETIC ACTIVITY. THEY MAY BE ADMINISTERED IN DOSAGE UNIT FORM.

59. 发明授权

US3499748A Bacteria inoculated plaster of paris and agricultural seeds admixed therewith 失效
标题翻译：巴黎细菌细菌培养基和农业种子
公开(公告)号：US3499748A
公开(公告)日：1970-03-10
申请号：US3499748D
申请日：1966-08-10
申请人： ALLEN & HANBURYS LTD
发明人： FRASER MARGARET EVELYN
IPC分类号： A01C1/00 , A01N21/02
CPC分类号： A01C1/00 , Y10S435/831 , Y10S435/878

60. 发明授权

US3467657A As-triazino(5,6-b)indoles 失效
公开(公告)号：US3467657A
公开(公告)日：1969-09-16
申请号：US3467657D
申请日：1968-07-16
申请人： ALLEN & HANBURYS LTD
发明人： GLADYCH JAN MIECZYSLAW ZYGMUNT , HUNT JOHN HAROLD
IPC分类号： A61K31/00 , C07D209/38 , C07D55/10 , A01N9/22
CPC分类号： C07D209/38 , A61K31/00

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