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51. 发明申请

US20160027961A1 METHODS AND DEVICES FOR SOLID STATE NANOWIRE DEVICES 审中-公开
标题翻译：用于固态纳米器件的方法和装置
公开(公告)号：US20160027961A1
公开(公告)日：2016-01-28
申请号：US14776120
申请日：2014-03-14
申请人： THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
发明人： Zetian MI , Hieu Pham TRUNG , Songrui ZHAO
IPC分类号： H01L33/06
CPC分类号： H01L33/06 , H01L33/18
摘要： Solid state sources offers potential advantages including high brightness, electricity savings, long lifetime, and higher color rendering capability, when compared to incandescent and fluorescent light sources. To date however, many of these advantages, however, have not been borne out in providing white LED lamps for general lighting applications. The inventors have established that surface recombination through non-radiative processes results in highly inefficient electrical injection. Exploiting in-situ grown shells in combination with dot-in-a-wire LED structures to overcome this limitation through the effective lateral confinement offered by the shell the inventors have demonstrated core-shell dot-in-a-wire LEDs, with significantly improved electrical injection efficiency and output power, providing phosphor-free InGaN/GaN nanowire white LEDs operating with milliwatt output power and color rendering indices of 95-98. Additionally, the inventors demonstrate efficient UV nanowire LEDs for medical applications as well as the non-degraded growth of nanowire LEDs on amorphous substrates.
摘要翻译：与白炽灯和荧光灯相比，固态光源提供了高亮度，节电，长寿命和更高显色能力的潜在优势。然而，迄今为止，许多这些优点在为一般照明应用提供白色LED灯中尚未得到证实。发明人已经确定，通过非辐射过程的表面复合导致高度低效的电注入。利用现场生长的壳与点阵式LED结构相结合，以通过壳提供的有效的侧向限制来克服这个限制，本发明人已经证明了核 - 壳点对点LED的LED，其显着改进电喷射效率和输出功率，提供无磷的InGaN / GaN纳米线白光LED，以毫瓦输出功率和显色指数为95-98。此外，本发明人证明了用于医疗应用的有效的UV纳米线LED以及纳米线LED在非晶衬底上的非降解生长。

52. 发明授权

US09216045B2 Method of producing a porous bone screw 有权
标题翻译：多孔骨螺钉的制造方法
公开(公告)号：US09216045B2
公开(公告)日：2015-12-22
申请号：US14623280
申请日：2015-02-16
申请人： The Royal Institution for the Advancement of Learning / McGill University , National Research Council of Canada
发明人： Paul A. Martineau , Louis-Philippe Lefebvre , Edward J. Harvey
IPC分类号： A61B17/04 , A61B17/86 , B22F3/11 , B22F5/06 , B22F5/10 , B22F7/00 , A61B17/56 , A61B17/00
CPC分类号： A61B17/866 , A61B17/863 , A61B17/864 , A61B2017/00526 , A61B2017/561 , B22F3/11 , B22F5/06 , B22F5/10 , B22F7/008
摘要： A bone screw and method of producing the same is described. The method of producing a bone screw includes forming a one-piece headless screw body out of a rigid metallic foam that is entirely porous throughout and defines a plurality of inter-connected pores having a size of about 30 to about 500 microns in diameter. The method includes providing at least one thread on an external surface of the screw body, and forming a bore extending through an entire axial length of the screw body, the bore forming a cannula that defines an annular radial wall thickness of the screw body. The method further includes disposing the inter-connected pores throughout the radial wall thickness of the screw body such as to allow for bone in-growth through the full radial wall thickness and into the cannula.
摘要翻译：描述了骨螺钉及其制造方法。骨螺钉的制造方法包括：将整体无孔的刚性金属泡沫体形成为一体的无头螺钉体，并且限定出直径约30至约500微米尺寸的多个相互连接的孔。该方法包括在螺钉体的外表面上提供至少一个螺纹，以及形成延伸穿过螺钉体的整个轴向长度的孔，所述孔形成限定螺杆体的环形径向壁厚度的套管。该方法还包括将相互连接的孔布置在螺钉体的整个径向壁厚度上，以允许骨通过完整的径向壁厚进入生长并进入套管。

53. 发明授权

US09127035B2 Compounds for use in the treatment of bacterial infection 有权
标题翻译：用于治疗细菌感染的化合物
公开(公告)号：US09127035B2
公开(公告)日：2015-09-08
申请号：US13980364
申请日：2012-01-17
申请人： Karine Auclair , Kenward Vong
发明人： Karine Auclair , Kenward Vong
IPC分类号： A61K31/70 , C07H15/224 , A61K31/7036 , A61K45/06 , C07H15/23 , C07H15/234
CPC分类号： C07H15/224 , A61K31/7036 , A61K45/06 , A61P31/04 , C07H15/23 , C07H15/234 , A61K2300/00
摘要： This invention relates to a compound of Formula 1A: or a pharmaceutically acceptable salt thereof; wherein R1 to R4, R7, R9 to R12 and Y are as defined herein. The invention further relates to pharmaceutical composition comprising said compound or a pharmaceutically acceptable salt thereof; and method of using same for reducing or reversing bacterial resistance to at least one aminoglycoside antibiotic.
摘要翻译：本发明涉及式1A化合物或其药学上可接受的盐; 其中R 1至R 4，R 7，R 9至R 12和Y如本文所定义。本发明还涉及包含所述化合物或其药学上可接受的盐的药物组合物; 以及其用于减少或逆转对至少一种氨基糖苷类抗生素的细菌耐药性的方法。

54. 发明授权

US09085598B2 Compounds targeting the cell invasion protein complex, their pharmaceutical compositions and methods of use thereof 有权
标题翻译：靶向细胞侵袭蛋白复合物的化合物，其药物组合物及其使用方法
公开(公告)号：US09085598B2
公开(公告)日：2015-07-21
申请号：US14354871
申请日：2012-10-26
申请人： THE ROYAL INSTITUTE FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY , OCEAN UNIVERSITY OF CHINA
发明人： Moulay A. Alaoui-Jamali , Krikor Bijian , Jiang Tao
IPC分类号： C07H19/02 , C07H13/02 , C07H15/26 , C07H15/203 , C07H99/00
CPC分类号： C07H19/02 , C07H13/02 , C07H15/203 , C07H15/26 , C07H99/00
摘要： The present application relates to the compounds of formula I (I) as well as their use for inhibiting at least one of AKT-1, FAK and PKCα and in the treatment and/or prevention of metastatic diseases.
摘要翻译：本申请涉及式I（I）的化合物及其用于抑制AKT-1，FAK和PKCα中的至少一种以及治疗和/或预防转移性疾病的用途。

55. 发明申请

US20150157376A1 METHOD OF PRODUCING A POROUS BONE SCREW 有权
标题翻译：生产多孔骨螺钉的方法
公开(公告)号：US20150157376A1
公开(公告)日：2015-06-11
申请号：US14623280
申请日：2015-02-16
申请人： The Royal Institution for the Advancement of Learning / McGill University , National Research Council of Canada
发明人： Paul A. MARTINEAU , Louis-Philippe LEFEBVRE , Edward J. HARVEY
IPC分类号： A61B17/86 , B22F3/11 , B22F5/06 , B22F7/00 , B22F5/10
CPC分类号： A61B17/866 , A61B17/863 , A61B17/864 , A61B2017/00526 , A61B2017/561 , B22F3/11 , B22F5/06 , B22F5/10 , B22F7/008
摘要： A bone screw and method of producing the same is described. The method of producing a bone screw includes forming a one-piece headless screw body out of a rigid metallic foam that is entirely porous throughout and defines a plurality of inter-connected pores having a size of about 30 to about 500 microns in diameter. The method includes providing at least one thread on an external surface of the screw body, and forming a bore extending through an entire axial length of the screw body, the bore forming a cannula that defines an annular radial wall thickness of the screw body. The method further includes disposing the inter-connected pores throughout the radial wall thickness of the screw body such as to allow for bone in-growth through the full radial wall thickness and into the cannula.
摘要翻译：描述了骨螺钉及其制造方法。骨螺钉的制造方法包括：将整体无孔的刚性金属泡沫体形成为一体的无头螺钉体，并且限定出直径约30至约500微米尺寸的多个相互连接的孔。该方法包括在螺钉体的外表面上提供至少一个螺纹，以及形成延伸穿过螺钉体的整个轴向长度的孔，所述孔形成限定螺杆体的环形径向壁厚度的套管。该方法还包括将相互连接的孔布置在螺钉体的整个径向壁厚度上，以允许骨通过完整的径向壁厚进入生长并进入套管。

56. 发明申请

US20150110216A1 METHODS AND DEVICES FOR COMMUNICATIONS SYSTEMS USING MULTIPLIED RATE TRANSMISSION 有权
标题翻译：使用多路速率传输的通信系统的方法和设备
公开(公告)号：US20150110216A1
公开(公告)日：2015-04-23
申请号：US14396988
申请日：2013-04-29
申请人： The Royal Institution for the Advancement of Learning / McGill University
发明人： Jan Bajcsy , Yong-Jin Kim , Aminata Amadou Garba
IPC分类号： H04L25/03
CPC分类号： H04L25/03197 , H04B1/40 , H04L5/0044 , H04L25/03171 , H04L25/03343 , H04L25/06 , H04L27/264 , H04L27/34 , H04L2025/03414 , H04L2025/03426
摘要： Cost, electronic circuitry limitations, and communication channel behaviour yield communication systems with strict bandwidth constraints. Hence, maximally utilizing available bandwidth is crucial, for example in wireless networks, to supporting ever increasing numbers of users and their demands for increased data volumes, low latency, and high download speeds. Accordingly, it would be beneficial for such networks to support variable bandwidth allocations such that smaller frequency sub-bands are allocated to users, as their number increases, but the individual users/nodes insert more data-carrying signals in order to compensate pensate for the loss of operating bandwidth arising from the accommodation of more users. It would further be beneficial for transmitters and receivers according to embodiments of such a network architecture to be based upon low cost design methodologies allowing their deployment within a wide range of applications including high volume, low cost consumer electronics for example.
摘要翻译：成本，电子电路限制和通信信道行为产生具有严格带宽限制的通信系统。因此，最大限度地利用可用带宽是至关重要的，例如在无线网络中，以支持越来越多的用户以及对增加数据量，低延迟和高下载速度的需求。因此，这样的网络将有利于支持可变带宽分配，使得较小的频率子带被分配给用户，因为它们的数量增加，但是各个用户/节点插入更多的数据携带信号，以补偿针对由于更多用户的住宿而导致的业务带宽的损失。根据这种网络架构的实施例，发射机和接收机将进一步有利于基于低成本设计方法，从而允许其在包括大容量，低成本消费电子设备在内的宽范围的应用中部署。

57. 发明申请

US20150087072A1 SOIL ANALYSIS APPARATUS, METHOD, AND SYSTEM 有权
标题翻译：土壤分析装置，方法和系统
公开(公告)号：US20150087072A1
公开(公告)日：2015-03-26
申请号：US14494719
申请日：2014-09-24
申请人： The Royal Institution for the Advancement of Learning/McGill University
发明人： Viacheslav Adamchuk , Nandkishor Dhawale , Frédéric René-Laforest , Shiv Prasher , Antoine Pouliot
IPC分类号： G01N33/24
CPC分类号： G01N33/24 , G01N27/414 , G01N2033/245
摘要： A soil analysis apparatus includes at least one sensor element for measuring a property of the soil; a blade assembly having at least one blade and being displaceable between a raised position and an excavation position, the at least one blade being operable to excavate the soil at a test location when the blade assembly is in the excavation position, the blade assembly being further operable to enter a sensor permitting configuration; and a first actuator operable to displace the at least one sensor element between an initial position and a sensing position along a sensor displacement path, the sensor element being proximate the soil at the test location when in the sensing position.
摘要翻译：土壤分析装置包括至少一个用于测量土壤性质的传感器元件; 叶片组件，其具有至少一个叶片并且可在升高位置和挖掘位置之间移动，所述至少一个叶片可操作以在叶片组件处于挖掘位置时在测试位置挖掘土壤，叶片组件进一步可操作地进入允许配置的传感器; 以及第一致动器，其可操作以沿着传感器位移路径在初始位置和感测位置之间移位所述至少一个传感器元件，当处于所述感测位置时，所述传感器元件靠近所述测试位置处的土壤。

58. 发明授权

US08974795B2 Controlled release formulation based on hematin anhydride crystals for the induction of an innate immune reaction 有权
标题翻译：用于诱导先天免疫反应的基于血红素酐结晶的控释制剂
公开(公告)号：US08974795B2
公开(公告)日：2015-03-10
申请号：US13655602
申请日：2011-04-21
申请人： Martin Olivier , Marie-Josée Bellemare
发明人： Martin Olivier , Marie-Josée Bellemare
IPC分类号： A61K39/39 , A61K39/008 , A61K39/015 , C07D487/22 , C30B7/14 , C30B29/54 , C30B31/04
CPC分类号： A61K39/39 , A61K39/008 , A61K39/015 , C07D487/22 , C30B7/14 , C30B29/54 , C30B31/04
摘要： The present invention relates to a new process for producing a doped synthetic monodispersed hematin anhydride (HA) crystals useful as a slow release vehicle and immune modulator. As the preparation comprises embedded in the crystals one or more antigens and/or one or more biologically active entities, the preparation can be useful in numerous medical indications such as vaccine or any therapy where it is desired that a biologically active entity maintains its activity over time due to its slow-release. The process comprises the steps of (i) providing a substantially pure iron(III) protoporphyrin-IX, in solution in an alkaline solution substantially free of oxygen (ii) adjusting the pH of the solution to an acidic pH of between about 4.0, by slowly adding a medium strong organic acid, (iii) during step b) above, adding one or more antigens and/or one or entities having a biological activity, at a pH of about 5.0.
摘要翻译：本发明涉及用作缓释载体和免疫调节剂的掺杂的合成单分散血红素酐（HA）晶体的新方法。由于制剂包含嵌入晶体中的一种或多种抗原和/或一种或多种生物活性实体，所述制剂可用于许多医学适应症，例如疫苗或任何治疗，其中期望生物活性实体保持其活性超过时间由于缓释。该方法包括以下步骤：（i）在基本上不含氧的碱性溶液中的溶液中提供基本上纯的铁（III）原卟啉IX（ii）将溶液的pH调节至约4.0之间的酸性pH，通过缓慢添加中等强有机酸，（iii）在上述步骤b）中，在约5.0的pH下加入一种或多种抗原和/或具有生物活性的一种或多种物质。

59. 发明申请

US20140329894A1 COMBINATION THERAPY AND USES THEREOF FOR TREATMENT AND PREVENTION OF PARASITIC INFECTION AND DISEASE 有权
标题翻译：组合治疗及其用于治疗和预防PARASITIC感染和疾病的用途
公开(公告)号：US20140329894A1
公开(公告)日：2014-11-06
申请号：US14332829
申请日：2014-07-16
申请人： The Royal Institution for the advancement of Learning/McGill University
发明人： Philippe Gros , Gundula Min-Oo , Anny Fortin
IPC分类号： A61K31/357 , A61J1/00 , A61K31/145
CPC分类号： A61K31/357 , A61J1/00 , A61K31/145 , A61K31/35 , A61K2300/00 , Y02A50/411
摘要： The invention relates to compounds, methods, uses, compositions, combinations, kits and packages for the prevention and/or treatment of parasite infection (e.g., Plasmodium parasites) and/or disease (e.g., malaria) based on uses of (a) cystamine, cysteamine, and analogs, derivatives, prodrugs, precursors thereof; an agent capable of inducing their production; and/or salts thereof, and (b) artemisinin and functional derivative, analog, conjugate, metabolite, prodrug or precursor thereof, and/or salts thereof.
摘要翻译：本发明涉及基于（a）胱氨酸的用途的用于预防和/或治疗寄生虫感染（例如，疟原虫寄生虫）和/或疾病（例如疟疾）的化合物，方法，用途，组合物，组合，试剂盒和包装，半胱胺及其类似物，衍生物，前药，其前体; 能够诱导生产的代理人; 和/或其盐，和（b）青蒿素及其功能衍生物，类似物，缀合物，代谢物，前药或前体，和/或其盐。

60. 发明授权

US08855215B2 Phase/frequency synthesis using periodic sigma-delta modulated bit-stream techniques 有权
标题翻译：使用周期性Σ-Δ调制比特流技术的相位/频率合成
公开(公告)号：US08855215B2
公开(公告)日：2014-10-07
申请号：US13103325
申请日：2011-05-09
申请人： Gordon Roberts , Sadok Aouini
发明人： Gordon Roberts , Sadok Aouini
IPC分类号： H04B14/06 , H03L7/00 , G06F1/02
CPC分类号： G06F1/022 , H03L7/00
摘要： A method and a circuit are provided for providing phase or frequency synthesis using sigma-delta modulation bit-stream techniques in which data is encoded utilizing sigma-delta modulation and then digital-to-time conversion (DTC) or digital-to-frequency conversion (DFC). In some embodiments this encoded data stream is further subjected to phase or frequency domain filtering, which in some embodiments is carried out by a higher-order phase-locked loop (PLL).
摘要翻译：提供了一种方法和电路，用于使用Σ-Δ调制比特流技术提供相位或频率合成，其中使用Σ-Δ调制对数据进行编码，然后进行数字 - 时间转换（DTC）或数字 - 频率转换（DFC）。在一些实施例中，该编码数据流进一步经受相位或频域滤波，其在一些实施例中由高阶锁相环（PLL）执行。

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