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51. 发明授权

US08787641B2 Method and apparatus for quantitative analysis of a tree of recursively splitting tubular organs 有权
标题翻译：用于定量分析递归分裂管状器官的树的方法和装置
公开(公告)号：US08787641B2
公开(公告)日：2014-07-22
申请号：US13819891
申请日：2010-09-02
申请人： Jacobus Adrianus Engelbertus Johannes Hof , Sjoerd Diepen , Ron Hubertus Schormans
发明人： Jacobus Adrianus Engelbertus Johannes Hof , Sjoerd Diepen , Ron Hubertus Schormans
IPC分类号： G06K9/00
CPC分类号： G06F19/12 , G06T7/0012 , G06T7/12 , G06T7/149 , G06T17/00 , G06T2200/04 , G06T2207/30101 , G06T2207/30172
摘要： Method for quantitative analysis of a tree or part of a tree of recursively splitting tubular organs, the method comprising the following steps: —providing a 3D model of said tree or part of said tree, such 3D model giving a representation of the surface of the lumen wall of the tubular organs forming the tree or part of the tree; —defining the 3D centerlines of said tree or part of the tree; —identifying the branches of the tree; —identifying N-furcations of the tree or part of the tree, an N-furcation being a part of the tree where a proximal tubular organ branches into two or more distal tubular organs, further comprising the step of: —dividing, independently from the modality used for obtaining the 3D model, each branch in one or more regions, such regions being of two different types, named single vessel region and splitting region, different cross-section surfaces being defined in such regions, wherein the splitting regions can exist at the proximal side of a branch as well as at the distal side of said branch and each N-furcation comprises the distal splitting region of a branch and the proximal splitting regions of the N branches directly distal to said branch. A corresponding apparatus and computer program are also disclosed.
摘要翻译：用于定量分析递归分裂管状器官的树或部分树的方法，所述方法包括以下步骤： - 提供所述树或所述树的一部分的3D模型，所述3D模型给出所述树的表面的表示形成树或部分树的管状器官的管腔壁; - 定义所述树或树的一部分的3D中心线; - 识别树的分支; - 识别树或部分树的N分叉，N分叉是树的一部分，其中近端管状器官分支成两个或更多个远端管状器官，还包括以下步骤：独立于用于获得3D模型的模态，一个或多个区域中的每个分支，这样的区域是两种不同类型，称为单容器区域和分裂区域，在这些区域中定义不同的横截面，其中分割区域可以存在于分支的近侧以及所述分支的远侧，并且每个分叉包括分支的远侧分裂区域和直接在所述分支的远端的N个分支的近侧分裂区域。还公开了相应的装置和计算机程序。

52. 发明授权

US08155411B2 Method, apparatus and computer program for quantitative bifurcation analysis in 3D using multiple 2D angiographic images 有权
标题翻译：使用多维2D血管造影图像进行3D定量分岔分析的方法，装置和计算机程序
公开(公告)号：US08155411B2
公开(公告)日：2012-04-10
申请号：US12177850
申请日：2008-07-22
申请人： Jacobus Adrianus Engelbertus Johannes Hof , Bas Weijers , Jean-Paul Michel Maria Aben , Coenraad Christiaan Albert Lokkerbol
发明人： Jacobus Adrianus Engelbertus Johannes Hof , Bas Weijers , Jean-Paul Michel Maria Aben , Coenraad Christiaan Albert Lokkerbol
IPC分类号： G06K9/00
CPC分类号： G06T7/0012 , A61B6/481 , G06T7/12 , G06T2200/04 , G06T2207/30101
摘要： A computer-implemented method (and corresponding data processing facility and computer program) for creating a 3D bifurcation healthy model from multiple 2D angiographic images comprises the following: a. Creating a 3-D model based on said images; b. Defining a bifurcation region regarding said 3D model; c. Creating an area curve regarding said region; d. Creating a reference area curve regarding said region whilst reconstructing in 2D; e. Creating a healthy model regarding said area curves; and f. Computing quantitative analysis results regarding said healthy model based on the healthy cross-sectional areas of the bifurcation, obstruction boundaries and the diseased 3D model consisting of the bifurcation centerlines and cross-sections of the lumen on the centerline, the healthy centerline and cross-sections.
摘要翻译：用于从多个2D血管造影图像创建3D分叉健康模型的计算机实现的方法（以及相应的数据处理设备和计算机程序）包括以下：a。基于所述图像创建3维模型; b。定义关于所述3D模型的分叉区域; C。创建关于所述区域的区域曲线; d。在2D中重建时创建关于所述区域的参考区域曲线; e。创建关于所述区域曲线的健康模型; 和f。基于分叉，阻塞边界的健康横截面区域以及由分叉中心线和中心线，健康中心线和横截面上的管腔横截面组成的患病3D模型，计算所述健康模型的定量分析结果。

53. 发明授权

US08086000B2 Method, apparatus and computer program for quantitative bifurcation analysis on angiographic images 有权
标题翻译：血管造影图像定量分岔分析方法，装置和计算机程序
公开(公告)号：US08086000B2
公开(公告)日：2011-12-27
申请号：US11845154
申请日：2007-08-27
申请人： Bas Weijers , Jean-Paul Michel Maria Aben , Christian Consten , Jacobus Adrianus Engelbertus Johannes Hof
发明人： Bas Weijers , Jean-Paul Michel Maria Aben , Christian Consten , Jacobus Adrianus Engelbertus Johannes Hof
IPC分类号： G06K9/00
CPC分类号： G06T7/0012 , A61B90/37 , G06T7/13 , G06T7/62 , G06T2207/10116 , G06T2207/20044 , G06T2207/20101 , G06T2207/30048 , G06T2207/30101
摘要： A method, data processing facility and program storage device for quantitative analysis on medical image data of a bifurcated tubular organ which involves processing the medical image data to identify contours of the bifurcated tubular organ. The contours are used to determine a Polygon of Confluence amongst the bifurcated tubular organ. The Polygon of Confluence is used to determine at least one parameter value characterizing geometry of the bifurcated tubular organ. The at least one parameter value is outputted to a user for angiography purposes. The at least one parameter value can include at least one diameter value of the bifurcated tubular organ, at least one angle value between parts of the bifurcated tubular organ, and at least one reference diameter value for the bifurcated tubular organ, the at least one reference diameter value compensating for damage to the bifurcated tubular organ.
摘要翻译：一种用于对分叉管状器官的医学图像数据进行定量分析的方法，数据处理设备和程序存储装置，其涉及处理医学图像数据以识别分叉管状器官的轮廓。轮廓用于确定分叉管状器官之间的汇合多边形。 Confluence的Polygon用于确定表征分叉管状器官的几何的至少一个参数值。将至少一个参数值输出给用户用于血管造影目的。所述至少一个参数值可以包括所述分叉管状器官的至少一个直径值，所述分叉管状器官的部分之间的至少一个角度值和所述分叉管状器官的至少一个参考直径值，所述至少一个参考弥补分叉管状器官损伤的直径值。

54. 发明授权

US07970187B2 Method, apparatus and computer program for contour detection of vessels using x-ray densitometry 有权
标题翻译：使用X射线光密度测定的血管轮廓检测的方法，装置和计算机程序
公开(公告)号：US07970187B2
公开(公告)日：2011-06-28
申请号：US11220183
申请日：2005-09-06
申请人： Marcus Johannes Hubertus Puts , Jean-Paul Maria Michel Aben , Boudewijn Joseph Angelus Verstraelen
发明人： Marcus Johannes Hubertus Puts , Jean-Paul Maria Michel Aben , Boudewijn Joseph Angelus Verstraelen
IPC分类号： G06K9/00 , G06K9/36
CPC分类号： A61B5/1075 , A61B6/481 , A61B6/504 , G06K9/46 , G06K2009/00932 , G06K2209/05 , G06T7/12 , G06T7/62 , G06T2207/10116 , G06T2207/30101
摘要： A method has been described for deriving contour data in X-Ray images for vessels with differential absorption through applying a contour-finding algorithm on a shadow image and finding the vessel borders through segmentation based on image intensities. In particular, the method uses the following steps: finding a densitometric area of an above mentioned vessel, and displacing one or both of the borders inward until the densitometric measurement result between the borders after such displacing will start to change significantly. Furthermore, a specific procedure is introduced to automatically determine the conversion factor to equate the densitometrically based diameter to the contour based diameter of the vessel and to discriminate bifurcating or parallel vessels.
摘要翻译：已经描述了一种用于通过在阴影图像上应用轮廓寻找算法并基于图像强度的分割来找到血管边界来导出具有差异吸收的血管的X射线图像中的轮廓数据的方法。特别地，该方法使用以下步骤：找到上述容器的密度测量区域，并向内移动一个或两个边界，直到在这种移位之后边界之间的密度测量结果将开始显着变化。此外，引入特定的程序以自动确定转换因子以使基于密度的基于直径与容器的基于轮廓的直径相等并且区分分叉或平行的容器。

55. 发明授权

US07339585B2 Method and apparatus for visualization of biological structures with use of 3D position information from segmentation results 有权
标题翻译：使用分割结果的3D位置信息可视化生物结构的方法和装置
公开(公告)号：US07339585B2
公开(公告)日：2008-03-04
申请号：US10894202
申请日：2004-07-19
申请人： Boudewijn Joseph Angelus Verstraelen , Sebastiaan Paul Verstraelen
发明人： Boudewijn Joseph Angelus Verstraelen , Sebastiaan Paul Verstraelen
IPC分类号： G06T17/00
CPC分类号： G06T15/08 , G06T7/12 , G06T7/194 , G06T2200/04 , G06T2207/10081 , G06T2207/10132 , G06T2207/30048 , G06T2210/41
摘要： A data processing methodology and corresponding apparatus for visualizing the characteristics of a particular object volume in an overall medical/biological environment receives a source image data set pertaining to the overall environment. First and second contour surfaces within the environment are established which collectively define a target object volume. By way of segmenting, all information pertaining to structures outside the target object volume are excluded from the image data. A visual representation of the target object based on nonexcluded information is displayed. In particular, the method establishes i) the second contour surface through combining both voxel intensities and relative positions among voxel subsets, and ii) a target volume by excluding all data outside the outer surface and inside the inner surface (which allows non-uniform spacing between the first and second contour surfaces). The second contour surface is used as a discriminative for the segmenting.
摘要翻译：用于在整个医疗/生物环境中可视化特定对象体积的特征的数据处理方法和相应装置接收与整个环境有关的源图像数据集。建立环境中的第一和第二轮廓曲面，共同定义目标物体体积。通过分割，将与目标对象卷外的结构相关的所有信息从图像数据中排除。显示基于非包含信息的目标对象的视觉表示。特别地，该方法通过组合体素强度和体素子集中的相对位置来建立i）第二轮廓表面，以及ii）通过排除外表面外部和内表面内部的所有数据（允许非均匀间隔在第一和第二轮廓表面之间）。第二个轮廓表面被用作分割的区分。

56. 发明申请

US20060034511A1 Method and apparatus for visualization of biological structures with use of 3D position information from segmentation results 有权
标题翻译：使用分割结果的3D位置信息可视化生物结构的方法和装置
公开(公告)号：US20060034511A1
公开(公告)日：2006-02-16
申请号：US10894202
申请日：2004-07-19
申请人： Boudewijn Verstraelen , Sebastiaan Verstraelen
发明人： Boudewijn Verstraelen , Sebastiaan Verstraelen
IPC分类号： G06K9/34
CPC分类号： G06T15/08 , G06T7/12 , G06T7/194 , G06T2200/04 , G06T2207/10081 , G06T2207/10132 , G06T2207/30048 , G06T2210/41
摘要： A data processing methodology (and corresponding data processing apparatus) for visualizing the characteristics of a particular object volume in an overall medical/biological environment comprises the following computer operated steps: receiving a source image data set as pertaining to the overall environment; establishing a first contour surface within the environment, and through using the first contour surface as seed data, establishing a second contour surface within the environment, which contour surfaces collectively defining a target object volume; by way of segmenting, excluding from the image data set all information pertaining to structures outside the target object volume; and visualizing the target object as being based on nonexcluded information. In particular, the method establishes the second contour surface through combining both voxel intensities and relative positions among voxel subsets, a target volume by excluding all data outside the outer surface and inside the inner surface, thereby allowing non-uniform spacing between the first and second contour surfaces, and uses the second contour surface as being discriminative for the segmenting.
摘要翻译：用于在整个医疗/生物环境中可视化特定对象体积的特征的数据处理方法（和相应的数据处理装置）包括以下计算机操作步骤：接收与整个环境相关的源图像数据集; 在所述环境内建立第一轮廓表面，并且通过使用所述第一轮廓表面作为种子数据，在所述环境内建立第二轮廓表面，所述轮廓表示共同定义目标对象体积; 通过分割，从图像数据集中排除与目标对象体外的结构有关的所有信息; 并将目标对象可视化为基于非包含信息。特别地，该方法通过将体素强度和体素子集中的相对位置，目标体积通过排除外表面外部和内表面内的所有数据来组合第二轮廓表面，从而允许第一和第二轮廓之间的不均匀间隔轮廓表面，并且使用第二轮廓表面作为分割的区分。

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