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51. 发明申请

US20120276006A1 CONTRAST AGENTS FOR MYOCARDIAL PERFUSION IMAGING 有权
标题翻译：对比剂用于心肌灌注成像
公开(公告)号：US20120276006A1
公开(公告)日：2012-11-01
申请号：US13529756
申请日：2012-06-21
申请人： David S. Casebier , Simon P. Robinson , Ajay Purohit , Heike S. Radeke , Michael T. Azure , Douglas D. Dischino
发明人： David S. Casebier , Simon P. Robinson , Ajay Purohit , Heike S. Radeke , Michael T. Azure , Douglas D. Dischino
IPC分类号： A61K49/00 , A61K49/10 , A61K49/22 , A61P9/10 , C07D493/22 , C07D231/14 , C07D237/16 , C07D239/88 , A61K51/04 , C07D493/14
CPC分类号： C07D237/16 , A61K49/00 , A61K49/0002 , A61K49/0052 , A61K49/10 , A61K49/22 , A61K51/04 , A61K51/0421 , A61K51/0453 , A61K51/0459 , C07B59/002
摘要： The present disclosure is directed, in part, to compounds and methods for imaging myocardial perfusion, comprising administering to a patient a contrast agent which comprises a compound that binds MC-1, and an imaging moiety, and scanning the patient using diagnostic imaging.
摘要翻译：本公开部分地涉及用于成像心肌灌注的化合物和方法，包括向患者施用包含结合MC-1的化合物和成像部分的造影剂，以及使用诊断成像扫描患者。

52. 发明申请

US20120187308A1 RADIONUCLIDE GENERATOR AND METHOD OF STERILIZATION 有权
标题翻译：放射性核素发生器和灭菌方法
公开(公告)号：US20120187308A1
公开(公告)日：2012-07-26
申请号：US13320216
申请日：2009-05-13
申请人： John Henry Evers
发明人： John Henry Evers
IPC分类号： G21G1/00 , B21D51/16 , G21H5/00
CPC分类号： A61L2/20 , G21G1/0005 , G21G4/04 , G21G4/06 , Y10T29/494
摘要： A column assembly of a radionuclide generator includes a column that retains a parent radionuclide that spontaneouosly decays to a relatively short-lived daughter radionuclide. A fluid path extends from an inlet port to the column and then to an outlet port and allows daughter radionuclide to be eluted from the radionuclide generator for use. Improved retention of parent radionuclide in the column is accomplished by preventing fluid from entering the flow path in a liquid state, such as during sterilization. Proper column chemistry is also promoted by preventing excess moisture from coalescing in the column, which may promote a higher and/or more reliable yield of daughter radionuclide from a radionuclide generator.
摘要翻译：放射性核素发生器的列组件包括保留母体放射性核素的柱，该母体放射性核素自发地衰变到相对短寿命的子级放射性核素。流体路径从入口延伸到塔，然后延伸到出口，并允许子放射性核素从放射性核素发生器中洗脱使用。母体放射性核素在色谱柱中的保留率通过防止流体以液体状态（例如在灭菌期间）进入流路来实现。还通过防止柱中多余的水分聚集来促进适当的柱化学，这可以促进来自放射性核素发生器的子放射性核素的更高和/或更可靠的产率。

53. 发明申请

US20090252676A1 N-ALKOXYAMIDE CONJUGATES AS IMAGING AGENTS 有权
标题翻译： N-烷氧基酰胺作为成像剂
公开(公告)号：US20090252676A1
公开(公告)日：2009-10-08
申请号：US12350628
申请日：2009-01-08
申请人： Richard R. Cesati , Thomas D. Harris , Simon P. Robinson , Richard J. Looby , Edward H. Cheesman , Padmaja Yalamanchili , David S. Casebier
发明人： Richard R. Cesati , Thomas D. Harris , Simon P. Robinson , Richard J. Looby , Edward H. Cheesman , Padmaja Yalamanchili , David S. Casebier
IPC分类号： A61K49/00 , C07C229/36 , C07D257/02 , C07D213/56 , A61K51/04 , A61K49/04
CPC分类号： C07D257/02 , A61K49/103 , A61K49/106 , A61K51/04 , C07C53/18 , C07C259/06 , C07C259/14 , C07C271/22 , C07C2601/14 , C07D209/20 , C07D213/56 , C07D403/12
摘要： The present disclosure is directed to compounds, diagnostic agents, and related methods. In some cases, methods for treating patients are provided. More specifically, the disclosure provides compounds, diagnostic agents, and kits for detecting and/or imaging and/or monitoring elastin rich tissues. In addition, the disclosure provides methods of detecting and/or imaging and/or monitoring the presence of coronary plaque, carotid plaque, iliac/femoral plaque, aortic plaque, renal artery plaque, plaque of any arterial vessel, aneurism, vasculitis, other diseases of the arterial wall, and/or damage or structural changes in ligaments, uterus, lungs or skin, as indicated by changes in total vessel wall area, internal lumen size, and exterior arterial perimeter.
摘要翻译：本公开涉及化合物，诊断剂和相关方法。在某些情况下，提供了治疗患者的方法。更具体地，本公开提供了用于检测和/或成像和/或监测富含弹性蛋白的组织的化合物，诊断剂和试剂盒。此外，本公开提供了检测和/或成像和/或监测冠状动脉斑块，颈动脉斑块，髂骨/股骨斑块，主动脉斑块，肾动脉斑块，任何动脉血管的斑块，动脉瘤，血管炎，其他疾病的存在的方法的动脉壁，和/或韧带，子宫，肺或皮肤的损伤或结构变化，如总血管壁面积，内腔大小和外动脉周长的变化所示。

54. 发明申请

US20220395590A1 LIPID-ENCAPSULATED GAS MICROSPHERE COMPOSITIONS AND RELATED METHODS 有权
公开(公告)号：US20220395590A1
公开(公告)日：2022-12-15
申请号：US17849543
申请日：2022-06-24
申请人： Lantheus Medical Imaging, Inc.
发明人： Simon P. Robinson , Robert W. Siegler , David C. Onthank , Nhung Tuyet Nguyen
IPC分类号： A61K49/22 , A61K9/50 , A61K47/10 , A61K47/24
摘要： The invention provides, inter alia, improved lipid formulations used to generate lipid-encapsulated gas microspheres, and methods of their use.

55. 发明申请

US20220339303A1 COMPOSITIONS, METHODS, AND SYSTEMS FOR THE SYNTHESIS AND USE OF IMAGING AGENTS 有权
公开(公告)号：US20220339303A1
公开(公告)日：2022-10-27
申请号：US17724713
申请日：2022-04-20
申请人： Lantheus Medical Imaging, Inc.
发明人： Heike S. Radeke , Richard R. Cesati , Ajay Purohit , Thomas D. Harris , Simon P. Robinson , Ming Yu , David S. Casebier , Carol Hui Hu , Matthias Broekema , David C. Onthank
IPC分类号： A61K51/04 , C07C279/04 , C07D233/46 , C07D209/14 , C07C257/14 , C07C279/06 , C07C279/08 , C07C279/12 , C07C279/14 , C07C281/18 , C07C217/70
摘要： The present invention relates to systems, compositions, and methods for the synthesis and use of imaging agents, or precursors thereof. An imaging agent precursor may be converted to an imaging agent using the methods described herein. In some cases, the imaging agent is enriched in 18F. In some cases, an imaging agent may be used to image an area of interest in a subject, including, but not limited to, the heart, cardiovascular system, cardiac vessels, brain, and other organs. In some embodiments, methods and compositions for assessing perfusion and innervation mismatch in a portion of a subject are provided.

56. 发明申请

US20220193274A9 METHODS FOR MAKING ULTRASOUND CONTRAST AGENTS 有权
公开(公告)号：US20220193274A9
公开(公告)日：2022-06-23
申请号：US17325173
申请日：2021-05-19
申请人： Lantheus Medical Imaging, Inc.
发明人： Simon P. Robinson , Robert W. Siegler , Nhung Tuyet Nguyen , David C. Onthank , Tarakeshwar Vishwanath Anklekar , Charles Chester Van Kirk
IPC分类号： A61K49/22 , A61B8/08 , C07F9/09
摘要： Provided herein are improved methods for preparing phospholipid formulations including phospholipid UCA formulations.

57. 发明申请

US20220189651A1 PIERCEABLE PLUG FOR NEEDLE 有权
公开(公告)号：US20220189651A1
公开(公告)日：2022-06-16
申请号：US17607270
申请日：2020-05-01
申请人： Lantheus Medical Imaging, Inc.
发明人： Joseph Haepers , Jack N. Wentz, JR. , Virginia Ann Hankard , Khursida Shahidullah , Tricia D. Butland , Patricia A. Corosa , David P. Rice , Samantha Moran
IPC分类号： G21G4/08
摘要： A pierceable plug for closing off a piercing end of a needle is described herein. The plug has an end that is configured to be pierced by the needle to close off the piercing end of the needle. The plug may be radiation sterilizable and may be made of a material that includes an antimicrobial agent. The plug may be used to close off a needle end that is in fluid communication with a radioactive substance.

58. 发明申请

US20220165382A1 CONTROL SYSTEM FOR RADIOPHARMACEUTICALS 有权
公开(公告)号：US20220165382A1
公开(公告)日：2022-05-26
申请号：US17496646
申请日：2021-10-07
申请人： Lantheus Medical Imaging, Inc.
发明人： Derek F. Rhodes , Robert W. Siegler
IPC分类号： G16H20/10 , G06Q10/06 , G06Q30/00 , G16H70/40 , G05B15/02 , G05D21/02
摘要： Techniques for monitoring a pharmaceutical manufacturing process and making determinations regarding the release of radiopharmaceuticals to health care providers. A data processing system collects data across multiple batches of radiopharmaceuticals, across multiple entities, and/or across multiple stages of the manufacturing process, processes the data, and provides feedback to entities involved in the manufacturing process. In scenarios where quality assurance tests are conducted, data is collected from radiopharmaceutical products before they are shipped, and the data is analyzed to provide the recipients with an indication of whether the radiopharmaceutical products satisfy quality assurance standards. Techniques for analyzing information about a batch manufacturing process and, when a problem occurred during a manufacture of a batch, determining whether to continue to manufacture a next batch in time for delivering and administering to a patient. The detected problem may be investigated and remedied before or during the synthesis of the next batch.

59. 发明申请

US20220017459A1 COMPOSITIONS, METHODS, AND SYSTEMS FOR THE SYNTHESIS AND USE OF IMAGING AGENTS 有权
公开(公告)号：US20220017459A1
公开(公告)日：2022-01-20
申请号：US17387478
申请日：2021-07-28
申请人： Lantheus Medical Imaging, Inc.
发明人： Ajay Purohit , Pedro Benites , Heike S. Radeke , Joel Lazewatsky , L. Veronica Lee
IPC分类号： C07C303/30 , A61K51/04 , C07B59/00 , C07C53/06 , C07C217/58 , C07C255/54 , C07C279/10 , C07C279/24 , C07C309/65 , C07C309/66 , C07C309/73 , C07C277/08 , C07C53/10 , C07C53/18 , C07C63/08 , C07C213/02 , C07C303/28 , C07C309/04 , C07C309/30
摘要： The present invention generally relates to novel synthetic methods, systems, kits, salts, and precursors useful in medical imaging. In some embodiments, the present invention provides compositions comprising an imaging agent precursor, which may be formed using the synthetic methods described herein. An imaging agent may be converted to an imaging agent using the methods described herein. In some cases, the imaging agent is enriched in 18F. In some cases, an imaging agent including salt forms (e.g., ascorbate salt) may be used to image an area of interest in a subject, including, but not limited to, the heart, cardiovascular system, cardiac vessels, brain, and other organs.

60. 发明申请

US20200324002A1 RADIOPHARMACEUTICAL SYNTHESIS METHODS 审中-公开
公开(公告)号：US20200324002A1
公开(公告)日：2020-10-15
申请号：US16745446
申请日：2020-01-17
申请人： Lantheus Medical Imaging, Inc.
发明人： Richard R. Cesati , James F. Castner
IPC分类号： A61K51/12 , A61K51/04 , C07B59/00
摘要： The invention relates to products and methods that provide increased yields of certain radiopharmaceuticals.

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