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51. 发明授权

US07282203B2 Use of NOTCH pathway interfering agents for treatment of plasma cell disorders 失效
标题翻译：使用NOTCH途径干扰剂治疗浆细胞疾病
公开(公告)号：US07282203B2
公开(公告)日：2007-10-16
申请号：US10996651
申请日：2004-11-24
申请人： Lionel J. Coignet
发明人： Lionel J. Coignet
IPC分类号： A61K39/395 , C07K16/00
CPC分类号： C07K16/28 , A61K39/39541 , A61K2039/505 , C07K2317/76 , A61K2300/00
摘要： The present invention provides a method for reducing the severity of, or treatment of, plasma cell disorders. The method comprises the step of administering to an individual afflicted with a plasma cell disorder, a composition comprising an antibody directed to the extracellular portion of NOTCH or to JAG2.
摘要翻译：本发明提供了降低浆细胞病症的严重性或治疗其方法。该方法包括向患有浆细胞病症的个体施用包含针对NOTCH的细胞外部分的抗体或JAG2的组合物的步骤。

52. 发明申请

US20070149497A1 Water soluble tetrapyrollic photosensitizers for photodynamic therapy 失效
标题翻译：用于光动力疗法的水溶性四光镜光敏剂
公开(公告)号：US20070149497A1
公开(公告)日：2007-06-28
申请号：US11452511
申请日：2006-06-14
申请人： Ravindra Pandey , Amy Gryshuk , Lalit Goswami , William Potter , Allan Oseroff
发明人： Ravindra Pandey , Amy Gryshuk , Lalit Goswami , William Potter , Allan Oseroff
IPC分类号： A61K31/555 , C07D487/22 , A61K31/409
CPC分类号： C07D471/22 , A61K41/0071 , A61K41/0076 , C09B47/00 , C09B69/108
摘要： A tetrapyrollic photosensitizer compound having at least one pendant —CH2CH2CON(CH2CON(CH2COOH)2)2 or —N(CH2COOH)2 group or esters thereof said tetrapyrollic compound being a chlorin, bacteriochlorin, porphyrin, pyropheophorbide, purpurinimide, or bacteriopurpurinimide. Desirably the compound has the formula: or a pharmaceutically acceptable derivative thereof, wherein R1-R8 and R10 are various substituents and R9 is substituted or unsubstituted —CH2CH2CON(CH2CON(CH2COOH)2)2; or —N(CH2COOH)2. The invention also includes a method of treatment by photodynamic therapy by treatment with light after injecting the compound and a method of imaging by fluorescence after injection of the compound.
摘要翻译：具有至少一个侧基-CH 2 CH 2 CON（CH 2 CH 2）（CH 2）2 CH 3的四级光敏剂化合物， COOH）2）2或-N（CH 2 COOH）2个基团或其酯，所述四酯化合物为二氢卟酚，细菌二氢卟酚，卟啉，焦脱镁叶绿素，紫苏酰亚胺或细菌草甘膦酰亚胺。该化合物具有下式：或其药学上可接受的衍生物，其中R 1 -R 8和R 10是各种取代基，取代或未取代的-CH 2 CH 2 CON（CH 2 CH 2 CON（CH 2）2 CH 2） 2 CO 2）2）2

53. 发明申请

US20070053840A1 Multi DTPA conjugated tetrapyrollic compounds for phototherapeutic contrast agents 有权
标题翻译：用于光疗治疗造影剂的多DTPA共轭四氢化合物
公开(公告)号：US20070053840A1
公开(公告)日：2007-03-08
申请号：US11479524
申请日：2006-06-30
申请人： Ravindra Pandey , Lalit Goswami , Joseph Spernyak , Peter Kanter , Richard Mazurchuk
发明人： Ravindra Pandey , Lalit Goswami , Joseph Spernyak , Peter Kanter , Richard Mazurchuk
IPC分类号： A61K49/10 , C07F5/00 , C07D487/22
CPC分类号： C07D487/22 , A61K41/0071 , A61K41/0076 , A61K49/124
摘要： Novel tetrapyrollic water soluble photosensitizing and imaging compounds and the methods of treating and imaging hyperproliferative tissue, e.g. tumors and hypervacularized tissue such as found in macular degeneration. Broadly, the compounds are tetrapyrollic photosensitizer compounds where the tetrapyrollic compound is a chlorin, bacteriochlorin, porphyrin, pyropheophorbide, purpurinimide, or bacteriopurpurinimide having 3 to 6 —CH2CONHphenylCH2CH(N(CH2COOH)2))(CH2N(CH2COOH)(CH2CH2N(CH2COOH)2)) groups or esters thereof or complexes thereof with gadolinium(III).
摘要翻译：新型四级水溶性光敏剂和成像化合物以及治疗和成像过度增生组织的方法，例如，肿瘤和高血压组织，如发现于黄斑变性。广泛地说，这些化合物是四级光敏剂化合物，其中四溴化合物是二氢卟酚，细菌二氢卟酚，卟啉，焦脱镁叶绿素，嘌呤酰亚胺或具有3至6个-CH 2苯基CH 2 CH 2的细菌嘌呤酰亚胺（N（CH 2 COOH）2））（CH 2 N（CH 2 COOH）（CH 3）（CH 2 CO 2）2）其基团或其与钆（III）的络合物）。

54. 发明申请

US20060281708A1 Fluorinated glucosamine analogs useful for modulating post-translational glyscosylations on cells 审中-公开
标题翻译：氟化葡糖胺类似物可用于调节细胞上的翻译后糖基化
公开(公告)号：US20060281708A1
公开(公告)日：2006-12-14
申请号：US11508566
申请日：2006-08-23
申请人： Robert Sackstein , Charles Dimitroff , Ralph Bernacki , Moheswar Sharma , Khushi Matta , Brajeswar Paul
发明人： Robert Sackstein , Charles Dimitroff , Ralph Bernacki , Moheswar Sharma , Khushi Matta , Brajeswar Paul
IPC分类号： A61K31/7008
CPC分类号： A61K31/573 , A61K31/137 , A61K31/192 , A61K31/415 , A61K31/52 , A61K31/7008 , A61K31/704 , A61K31/7048 , A61K31/7068 , A61K2300/00
摘要： The present invention provides compositions and methods for inhibiting cell migration, e.g., lymphocytes and inflammation. The invention also provides an improved process for preparing fluorinated N-acetylglucosamines.
摘要翻译：本发明提供了抑制细胞迁移的组合物和方法，例如淋巴细胞和炎症。本发明还提供了制备氟化N-乙酰葡糖胺的改进方法。

55. 发明申请

US20060204437A1 Chlorin and bacteriochlorin-based difunctional aminophenyl DTPA and N2S2 conjugates for MR contrast media and radiopharmaceuticals 失效
公开(公告)号：US20060204437A1
公开(公告)日：2006-09-14
申请号：US11431275
申请日：2006-05-10
申请人： Ravindra Pandey , Zachary Grossman , Peter Kanter , Thomas Dougherty
发明人： Ravindra Pandey , Zachary Grossman , Peter Kanter , Thomas Dougherty
IPC分类号： A61K51/00 , C07F13/00 , C07F5/00 , C07D487/22 , A61K31/555 , A61K49/12
CPC分类号： A61K51/0485 , A61K41/0071 , A61K49/0002 , A61K49/085 , A61K49/10 , A61K51/0478 , C07D471/22 , C07D487/22
摘要： A compound comprising a chemical combination of a photodynamic tetra-pyrrolic compound with a plurality of radionuclide element atoms such that the compound may be used to enhance MR imaging and also be used as a photodynamic compound for use in photodynamic therapy to treat hyperproliferative tissue. The preferred compounds have the structural formula: where R1, R2, R2a R3, R3a R4, R5, R5a R6, R7, R7a, and R8 cumulatively contain at least two functional groups that will complex or combine with an MR imaging enhancing element or ion. The compound is intended to include such complexes and combinations and includes the use of such compounds for MR imaging and photodynamic therapy treatment of tumors and other hyperproliferative tissue.

56. 发明授权

US07097836B1 Method for increasing the efficacy of anti-tumor agents by anti-endoglin antibody 有权
标题翻译：通过抗内皮糖蛋白抗体增强抗肿瘤剂功效的方法
公开(公告)号：US07097836B1
公开(公告)日：2006-08-29
申请号：US10691051
申请日：2003-10-22
申请人： Ben K. Seon
发明人： Ben K. Seon
IPC分类号： A61K39/395
CPC分类号： A61K31/675 , A61K31/704 , A61K39/395 , C07K16/2896 , A61K2300/00
摘要： The present invention provides a method for enhancing the efficacy of chemotherapeutic agents for therapy of cancer and other angiogenesis-associated diseases such as rheumatoid arthritis. The method comprises the steps of administering to an individual in need of treatment, a combination of an anti-endoglin antibody and a chemotherapeutic agent. The anti-endoglin antibody and the chemotherapeutic agent may be administered sequentially or concurrently.
摘要翻译：本发明提供了一种用于增强化学治疗剂用于治疗癌症和其它血管生成相关疾病如类风湿性关节炎的功效的方法。该方法包括给予需要治疗的个体，抗内皮蛋白抗体和化学治疗剂的组合的步骤。抗内皮糖蛋白抗体和化学治疗剂可以顺序或同时施用。

57. 再颁专利

USRE38994E1 Pyropheophorbides conjugates and their use in photodynamic therapy 有权
标题翻译：焦磷偏共轭物及其在光动力疗法中的应用
公开(公告)号：USRE38994E1
公开(公告)日：2006-02-28
申请号：US10385378
申请日：2003-03-07
申请人： Ravindra K. Pandey , Thomas J. Dougherty
发明人： Ravindra K. Pandey , Thomas J. Dougherty
IPC分类号： A61K31/409 , C07D487/22
CPC分类号： A61K51/0485 , A61K41/0057 , A61K41/0076 , A61K2123/00 , C07D487/22 , C07D519/00
摘要： Conjugate are formed by covalently linking a target-specific compound to pyropheophorbide compound which conjugated are injected into a host and accumulate in tumor tissue to a higher degree than surrounding normal tissues. When the pyropheophorbide compound component of the conjugate is exposed to a particular wavelength of light the compound becomes cytotoxic destroying the tumor or diseased tissue without causing irreversible normal tissue damage. The pyropheophorbide compounds have been shown to have a variety of characteristics when used in photodynamic therapy. These characteristics are further improved when the compounds are bound to a target specific component such as a ligand capable of binding to a specific cellular receptor (e.g. growth hormones and growth factors) or an antibody capable of binding to a particular antigen.
摘要翻译：共轭体通过将靶特异性化合物与焦磷酸脱氢化合物共价连接而形成，所述化合物与缀合物注射入宿主中并在肿瘤组织中积聚到比周围正常组织更高的程度。当缀合物的焦偏心复合物组分暴露于特定波长的光时，该化合物变得细胞毒性破坏肿瘤或患病组织而不引起不可逆的正常组织损伤。已经显示焦磷酸脱氢化合物在用于光动力疗法中具有多种特征。当化合物结合到靶特异性组分如能够结合特定细胞受体的配体（例如生长激素和生长因子）或能够结合特定抗原的抗体时，这些特征进一步改善。

58. 发明授权

US06998237B1 GD3 peptide mimics 失效
标题翻译： GD3肽模拟物
公开(公告)号：US06998237B1
公开(公告)日：2006-02-14
申请号：US10618336
申请日：2003-07-11
申请人： Soldano Ferrone , Xinhui Wang , Jeff Chi-Feng Hsu , Chun-Yen Tsao , Wei Luo
发明人： Soldano Ferrone , Xinhui Wang , Jeff Chi-Feng Hsu , Chun-Yen Tsao , Wei Luo
IPC分类号： C12Q1/68 , A61K38/04 , C07K16/00
CPC分类号： C07K16/3084 , A61K38/00
摘要： The present invention provides peptide mimics for GD3 ganglioside. The peptide mimics were identified by panning phage display peptide libraries with an anti-GD3 monoclonal antibody. The peptide mimics inhibit the binding of an anti-GD3 antibody to GD3 positive cells and also elicit antibodies which can bind to GD3 positive cells. The identified peptide mimics can be used as immunogens for cancer therapy.
摘要翻译：本发明提供GD3神经节苷脂的肽模拟物。通过用抗GD3单克隆抗体淘选噬菌体展示肽文库来鉴定肽模拟物。肽模拟物抑制抗GD3抗体与GD3阳性细胞的结合，并引发可结合GD3阳性细胞的抗体。鉴定的肽模拟物可用作癌症治疗的免疫原。

59. 发明授权

US06991805B1 Temperature sensitive control of liposome-cell adhesion 失效
标题翻译：温度敏感控制脂质体细胞粘附
公开(公告)号：US06991805B1
公开(公告)日：2006-01-31
申请号：US10236345
申请日：2002-09-06
申请人： Sek Wen Hui , Arindam Sen
发明人： Sek Wen Hui , Arindam Sen
IPC分类号： A61K9/127
CPC分类号： A61K9/1271
摘要： The present invention provides a liposomal composition for targeted delivery of drugs. The composition comprises poloxamer molecules and liposomes encapsulating one or more delivery agents. At above the critical micellar temperature of the poloxamer, a fraction of the poloxamer molecules form micelles and another fraction becomes incorporated into the liposome surface, thereby inhibiting their adhesion to cells. At a temperature below the critical micellar temperature, the poloxamer molecules dissociate into monomers allowing the liposomes to adhere to adjacent cells and effecting retention of the liposomes in the surrounding tissue. A method is provided for delivery of agents to target site comprising administering the composition to an individual and cooling the target site to cause retention of the liposomes at or near the target site.
摘要翻译：本发明提供用于靶向递送药物的脂质体组合物。组合物包含泊洛沙姆分子和包封一种或多种递送剂的脂质体。在泊洛沙姆的临界胶束温度之上，一部分泊洛沙姆分子形成胶束，另一部分进入脂质体表面，从而抑制它们对细胞的粘附。在低于临界胶束温度的温度下，泊洛沙姆分子解离成单体，使脂质体粘附到相邻的细胞上，并使脂质体保留在周围的组织中。提供了一种用于将试剂递送至靶位点的方法，包括向个体施用组合物并冷却靶位点以使脂质体保留在靶位点附近或附近。

60. 发明授权

US06977271B1 Method for inhibition of angiogenesis and vasculogenesis 失效
标题翻译：抑制血管发生和血管发生的方法
公开(公告)号：US06977271B1
公开(公告)日：2005-12-20
申请号：US10232284
申请日：2002-08-30
申请人： Margot M. Ip , Patricia Masso-Welch , Clement Ip , Danilo Zangani
发明人： Margot M. Ip , Patricia Masso-Welch , Clement Ip , Danilo Zangani
IPC分类号： A61K31/20
CPC分类号： A61K31/20
摘要： The present invention provides a method for inhibiting or preventing angiogenesis in animals and humans comprising the steps of administering to the animal or human an effective amount of one or more isomers of conjugated linoleic acid (“CLA”). The CLA may be administered in the form of a free fatty acid, an ester, or as a salt, in a pill, or as a component of a natural or prepared food product.
摘要翻译：本发明提供了一种抑制或预防动物和人类血管生成的方法，包括以下步骤：向动物或人施用有效量的一种或多种共轭亚油酸异构体（“CLA”）。 CLA可以以游离脂肪酸，酯或盐的形式施用于丸剂，或作为天然或制备的食品的组分。

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