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41. 发明申请

US20080210320A1 MICROFABRICATED ELASTOMERIC VALVE AND PUMP SYSTEMS 审中-公开
公开(公告)号：US20080210320A1
公开(公告)日：2008-09-04
申请号：US11934192
申请日：2007-11-02
申请人： Marc A. Unger , Hou-Pu Chou , Todd A. Thorsen , Axel Scherer , Stephen R. Quake
发明人： Marc A. Unger , Hou-Pu Chou , Todd A. Thorsen , Axel Scherer , Stephen R. Quake
IPC分类号： F15C1/06
CPC分类号： B29C51/00 , B01L3/502707 , B01L3/50273 , B01L3/502738 , B01L2300/0861 , B01L2300/0887 , B01L2300/123 , B01L2400/046 , B01L2400/0481 , B01L2400/0655 , B33Y80/00 , B81B5/00 , B81B2201/036 , B81B2201/054 , B81C1/00119 , B81C2201/019 , B81C2201/034 , C12Q1/6874 , F04B43/043 , F15C1/06 , F15C5/00 , F16K11/20 , F16K13/00 , F16K31/126 , F16K99/0001 , F16K99/0015 , F16K99/0046 , F16K99/0048 , F16K99/0051 , F16K99/0059 , F16K2099/0074 , F16K2099/0076 , F16K2099/0078 , F16K2099/008 , F16K2099/0094 , Y10T137/0491 , Y10T137/0497 , Y10T137/2224 , Y10T137/87249 , Y10T156/10 , Y10T428/24479 , Y10T428/24744 , C12Q2535/125
摘要： A method of fabricating an elastomeric structure, comprising: forming a first elastomeric layer on top of a first micromachined mold, the first micromachined mold having a first raised protrusion which forms a first recess extending along a bottom surface of the first elastomeric layer; forming a second elastomeric layer on top of a second micromachined mold, the second micromachined mold having a second raised protrusion which forms a second recess extending along a bottom surface of the second elastomeric layer; bonding the bottom surface of the second elastomeric layer onto a top surface of the first elastomeric layer such that a control channel forms in the second recess between the first and second elastomeric layers; and positioning the first elastomeric layer on top of a planar substrate such that a flow channel forms in the first recess between the first elastomeric layer and the planar substrate.

42. 发明申请

US20080013092A1 Fluorescence detector, filter device and related methods 有权
标题翻译：荧光检测器，过滤装置及相关方法
公开(公告)号：US20080013092A1
公开(公告)日：2008-01-17
申请号：US11804112
申请日：2007-05-17
申请人： George Maltezos , John Lee , Axel Scherer , Emil Kartalov
发明人： George Maltezos , John Lee , Axel Scherer , Emil Kartalov
IPC分类号： G01N21/25 , B01D63/00 , F15C1/06 , F15C5/00
CPC分类号： G01N21/6456 , G01N21/6452 , Y10T137/2224
摘要： Microfluidic assay detectors and microfluidic assay detection methods are disclosed. A microfluidic chip is coupled to a light emitting device, emission filters and excitation filters. Excited fluorescent light is detected by a camera and a lens. The correspondent reading allows parallel detection of features such as antigens and biomarkers. A microfluidic filter and related methods are also disclosed. The filter can be used with on-chip fluid filtration such as whole blood filtration for microfluidic blood analysis. The filter is able to filter the necessary volume of fluid and in particular blood in an acceptable time frame.
摘要翻译：公开了微流控测定检测器和微流控测定检测方法。微流控芯片耦合到发光器件，发射滤光器和激发滤光器。激发的荧光灯由相机和透镜检测。通讯阅读允许并行检测抗原和生物标志物等特征。还公开了微流体过滤器和相关方法。过滤器可用于片上流体过滤，如全血过滤用于微流体血液分析。过滤器能够在可接受的时间范围内过滤所需体积的流体，特别是血液。

43. 发明申请

US20070259226A1 Fuel Cell System with Variable Coanda Amplifiers for Gas Recirculation and System Pressure Regulation 失效
标题翻译：用于气体再循环和系统压力调节的可变扩散放大器的燃料电池系统
公开(公告)号：US20070259226A1
公开(公告)日：2007-11-08
申请号：US10589199
申请日：2005-02-10
申请人： Jochen Sang , Andreas Knoop
发明人： Jochen Sang , Andreas Knoop
IPC分类号： H01M8/04 , F15C1/06
CPC分类号： F15C1/003 , F02M26/19 , F02M26/34 , F04F5/18 , F04F5/54 , F15C1/08 , H01M8/04089 , H01M8/04097 , H01M8/04201 , H01M8/04223 , H01M8/04231 , Y02E60/50 , Y10T137/2224
摘要： A Coanda flow amplifier has a suction intake, an outlet, a fluid channel extending between the suction intake and the outlet, and a drive-flow inlet, which is fluidly connected to the fluid channel via a drive-flow discharge slit, whereby the flow cross section of the drive-flow discharge slit is variably adjustable. In a method to operate the Coanda flow amplifier, the variably adjustable flow cross section of the drive-flow discharge slit is chosen such that a pressure ratio between an output pressure of the drive flow when it leaves the drive-flow discharge slit, and an intake pressure of the drive flow when it enters the drive-flow discharge slit, does not exceed a critical pressure ratio. A fuel cell system comprises at least one fuel cell, a fluid source, a fluid line, and a Coanda flow amplifier arranged in the fluid line, whereby the Coanda flow amplifier is equipped with a drive-flow discharge slit with a variably adjustable flow cross section.
摘要翻译：柯达流量放大器具有吸入口，出口，在吸入口和出口之间延伸的流体通道，以及驱动流入口，其通过驱动流放电狭缝流体地连接到流体通道，由此流动驱动流量放电狭缝的横截面是可变的。在一种用于操作柯安达流量放大器的方法中，驱动流量放电狭缝的可变流量横截面被选择为使得当离开驱动流放电狭缝时驱动流的输出压力与当驱动流进入驱动流量放电狭缝时的进气压力不超过临界压力比。燃料电池系统包括布置在流体管线中的至少一个燃料电池，流体源，流体管线和柯安达流量放大器，由此柯恩达流量放大器配备有可变流量交叉的驱动流放电狭缝部分。

44. 发明授权

US07282705B2 Microdevice having an annular lining for producing an electrospray emitter 失效
标题翻译：微型设备具有用于产生电喷雾发射器的环形衬里
公开(公告)号：US07282705B2
公开(公告)日：2007-10-16
申请号：US10741901
申请日：2003-12-19
申请人： Reid A. Brennen
发明人： Reid A. Brennen
IPC分类号： H01J49/04 , F15C1/06
CPC分类号： B81B1/00 , G01N30/6095 , G01N30/7266 , H01J49/167 , Y10T137/2191 , Y10T137/2224
摘要： A microdevice is constructed from a substrate having a microchannel formed therein and a cover plate arranged over the substrate. The cover plate in combination with the microchannel at least partially defines a conduit within the microdevice. The conduit has a surface that extends from an upstream region toward a downstream region and terminates at an opening. The microdevice also includes an annular lining that conforms to the conduit surface at the downstream region and extends from the opening toward the upstream region in the conduit. An emitter may be produced in situ by depositing an emitter material on the annular lining. In addition, material may be removed from the cover plate and/or substrate about the opening. As a result, an exterior microdevice surface is formed and a downstream portion of the emitter is exposed that protrudes from the exterior surface.
摘要翻译：微型器件由其中形成有微通道的衬底和布置在衬底上的盖板构成。与微通道组合的盖板至少部分地限定了微型装置内的导管。导管具有从上游区域向下游区域延伸并终止在开口处的表面。微型装置还包括在下游区域处符合导管表面并且从开口朝向导管中的上游区域延伸的环形衬里。可以通过在环形衬里上沉积发射体材料来原位产生发射极。此外，可以围绕开口从盖板和/或基板移除材料。结果，形成外部微器件表面，并且从外表面露出发射体的下游部分。

45. 发明申请

US20060054228A1 Microfabricated elastomeric valve and pump systems 有权
公开(公告)号：US20060054228A1
公开(公告)日：2006-03-16
申请号：US11111264
申请日：2005-04-20
申请人： Marc Unger , Hou-Pu Chou , Todd Thorsen , Axel Scherer , Stephen Quake , Jian Liu , Mark Adams , Carl Hansen
发明人： Marc Unger , Hou-Pu Chou , Todd Thorsen , Axel Scherer , Stephen Quake , Jian Liu , Mark Adams , Carl Hansen
IPC分类号： F15C1/06
CPC分类号： B29C39/02 , B01J2219/00355 , B01J2219/00378 , B01J2219/00396 , B01J2219/00398 , B01J2219/00439 , B01J2219/005 , B01J2219/00527 , B01J2219/00605 , B01J2219/00612 , B01J2219/00621 , B01J2219/00659 , B01J2219/00707 , B01J2219/00722 , B01J2219/00725 , B01L3/502707 , B01L3/50273 , B01L3/502738 , B01L7/54 , B01L9/527 , B01L2200/025 , B01L2200/027 , B01L2200/0605 , B01L2200/10 , B01L2300/0681 , B01L2300/0861 , B01L2300/0887 , B01L2300/123 , B01L2300/14 , B01L2300/18 , B01L2400/046 , B01L2400/0481 , B01L2400/0655 , B01L2400/0688 , B32B2037/1081 , B81B2201/036 , B81B2201/054 , B81C1/00119 , B81C2201/019 , C12Q1/6874 , F04B43/043 , F15C5/00 , F16K31/126 , F16K99/0001 , F16K99/0015 , F16K99/0026 , F16K99/0046 , F16K99/0051 , F16K99/0055 , F16K99/0059 , F16K2099/0074 , F16K2099/0076 , F16K2099/0078 , F16K2099/008 , F16K2099/0094 , Y10T137/2174 , Y10T137/2224 , Y10T137/7879 , Y10T137/87877 , C12Q2535/125
摘要： A method of fabricating an elastomeric structure, comprising: forming a first elastomeric layer on top of a first micromachined mold, the first micromachined mold having a first raised protrusion which forms a first recess extending along a bottom surface of the first elastomeric layer; forming a second elastomeric layer on top of a second micromachined mold, the second micromachined mold having a second raised protrusion which forms a second recess extending along a bottom surface of the second elastomeric layer; bonding the bottom surface of the second elastomeric layer onto a top surface of the first elastomeric layer such that a control channel forms in the second recess between the first and second elastomeric layers; and positioning the first elastomeric layer on top of a planar substrate such that a flow channel forms in the first recess between the first elastomeric layer and the planar substrate.

46. 发明授权

US06899137B2 Microfabricated elastomeric valve and pump systems 有权
公开(公告)号：US06899137B2
公开(公告)日：2005-05-31
申请号：US09826583
申请日：2001-04-06
申请人： Marc A. Unger , Hou-Pu Chou , Todd A. Thorsen , Axel Scherer , Stephen R. Quake , Markus M. Enzelberger , Mark L. Adams , Carl L. Hansen
发明人： Marc A. Unger , Hou-Pu Chou , Todd A. Thorsen , Axel Scherer , Stephen R. Quake , Markus M. Enzelberger , Mark L. Adams , Carl L. Hansen
IPC分类号： B01L3/00 , B01L7/00 , B01L9/00 , B67D99/00 , B81B1/00 , B81B3/00 , B81C1/00 , C12Q1/68 , F04B43/04 , F15C5/00 , F16K7/00 , F16K31/126 , F16K99/00 , F15C1/06
CPC分类号： B05D3/04 , B01J2219/00355 , B01J2219/00378 , B01J2219/00396 , B01J2219/00398 , B01J2219/00439 , B01J2219/005 , B01J2219/00527 , B01J2219/00605 , B01J2219/00612 , B01J2219/00621 , B01J2219/00659 , B01J2219/00707 , B01J2219/00722 , B01J2219/00725 , B01L3/502707 , B01L3/50273 , B01L3/502738 , B01L7/54 , B01L9/527 , B01L2200/025 , B01L2200/027 , B01L2200/0605 , B01L2200/10 , B01L2300/0681 , B01L2300/0861 , B01L2300/0887 , B01L2300/123 , B01L2300/14 , B01L2300/18 , B01L2400/046 , B01L2400/0481 , B01L2400/06 , B01L2400/0655 , B01L2400/0688 , B32B2037/1081 , B65B31/00 , B81B2201/036 , B81B2201/054 , B81C1/00119 , B81C2201/019 , C12Q1/6832 , C12Q1/6874 , C30B29/54 , F04B43/043 , F15C1/06 , F15C3/00 , F15C5/00 , F16K99/0001 , F16K99/0015 , F16K99/0046 , F16K99/0051 , F16K99/0059 , F16K2099/0074 , F16K2099/0076 , F16K2099/0078 , F16K2099/008 , F16K2099/0084 , F16K2099/0094 , Y10T137/0324 , Y10T137/0379 , Y10T137/0424 , Y10T137/206 , Y10T137/2082 , Y10T137/2164 , Y10T137/2169 , Y10T137/2174 , Y10T137/2202 , Y10T137/2224 , Y10T137/3084 , Y10T137/7837 , Y10T137/86027 , Y10T156/10 , Y10T428/24479 , Y10T428/24612 , C12Q2535/125
摘要： A method of fabricating an elastomeric structure, comprising: forming a first elastomeric layer on top of a first micromachined mold, the first micromachined mold having a first raised protrusion which forms a first recess extending along a bottom surface of the first elastomeric layer; forming a second elastomeric layer on top of a second micromachined mold, the second micromachined mold having a second raised protrusion which forms a second recess extending along a bottom surface of the second elastomeric layer; bonding the bottom surface of the second elastomeric layer onto a top surface of the first elastomeric layer such that a control channel forms in the second recess between the first and second elastomeric layers; and positioning the first elastomeric layer on top of a planar substrate such that a flow channel forms in the first recess between the first elastomeric layer and the planar substrate.

47. 发明授权

US4275767A Fluid resistor 失效
标题翻译：流体电阻器
公开(公告)号：US4275767A
公开(公告)日：1981-06-30
申请号：US736069
申请日：1976-10-27
申请人： Norman R. Westfall
发明人： Norman R. Westfall
IPC分类号： F16L55/027 , F15C1/06
CPC分类号： F16L55/027 , Y10T29/494 , Y10T29/49885
摘要： A fluid resistor with a fluid tight structure including two planar members having a surface of each contacting in close proximity. One of the planar members has a laminated structure including a substrate and at least one thin layer of substantially uniform thickness formed on the substrate. A groove extends through the layer. The groove and the surface of the other planar member define a capilliary passageway of substantially constant depth for restricted fluid flow.
摘要翻译：一种具有流体密封结构的流体电阻器，包括两个平面构件，每个平面构件的表面各自接近。平面构件中的一个具有层压结构，其包括衬底和形成在衬底上的至少一个基本均匀厚度的薄层。凹槽延伸穿过该层。凹槽和另一个平面构件的表面限定了用于限制流体流动的基本恒定深度的毛细通道。

48. 发明授权

US4065839A Method and apparatus for the production of stacked, etched patterned metal foils for component elements 失效
标题翻译：用于生产用于组件元件的层叠的蚀刻图案化金属箔的方法和装置
公开(公告)号：US4065839A
公开(公告)日：1978-01-03
申请号：US705692
申请日：1976-07-15
申请人： Martin Pointner
发明人： Martin Pointner
IPC分类号： B21D47/00 , B21D43/22 , C23C18/20 , F15C1/06 , F15C5/00 , B21D33/00 , B65G57/04
CPC分类号： C23C18/20 , B21D43/22 , F15C5/00 , Y10S414/113 , Y10T29/301 , Y10T83/207
摘要： A method and apparatus for the production of a stack of etched, patterned metal foils for component elements, such as fluid plates and nozzle plates, is disclosed. Individual patterned foils are cut free from a mat having a group of patterned foils and also edge foils. The patterned foils are examined and unwanted foils together with the edge foils are discarded. The approved foils are individually stacked at stacking positions in a stacking station. A number of foil stacks corresponds to the number of individual patterned foils in the mat with the patterned foils being placed on the foil stacks in correspondence with their arrangement in the mat. Additional patterned foils from additional mats are stacked onto the individual foil stacks until a counter for each of the stacks determines that a predetermined number of stacked foils has occurred. The stack is removed and a new stack is begun until the counter again arrives at the predetermined number of foils for a given stack.
摘要翻译：公开了一种用于生产用于组件元件（例如流体板和喷嘴板）的蚀刻图案化金属箔的叠层的方法和装置。单独的图案化的箔被切割成具有一组图案化箔和边缘箔的垫。检查图案箔，并且丢弃与边缘箔一起的不需要的箔。批准的箔片在叠放台的堆放位置单独堆放。多个箔堆叠对应于垫中的单个图案化箔的数量，其中图案化的箔根据其在垫中的布置而放置在箔堆上。来自附加垫的附加图案箔层叠在单独的箔堆叠上，直到每个堆叠的计数器确定已经发生了预定数量的堆叠箔。堆叠被移除，并且开始新的堆栈，直到计数器再次到达给定堆栈的预定数量的箔片。

49. 发明授权

US3786831A Valve with modular manifold body 失效
标题翻译：带模块化管体的阀
公开(公告)号：US3786831A
公开(公告)日：1974-01-22
申请号：US3786831D
申请日：1973-04-05
申请人： CLIPPARD INSTR LABOR INC
发明人： CLIPPARD W
IPC分类号： F15B13/00 , F15B13/08 , F16K11/00 , F15C1/06
CPC分类号： F15B13/0814 , F15B13/0835 , F15B2013/006 , Y10T137/2224 , Y10T137/5109
摘要： A valve having a modular, multi-passage manifold or body. Different types of valve mechanisms are insertable axially through an open end of a cavity formed within the manifold and are sealed therein by a closure. Fluid connections for the valve mechanism are provided by a plurality of passages which extend parallel to the cavity but within the wall of the manifold, from a common end of the manifold. Each passage extends longitudinally in the manifold parallel to the cavity over substantially all of the effective length of the cavity, and is selectively ported to the cavity at one or more positions along its length to serve the particular valve mechanism with which the manifold is used. The valve mechanism has circumferential grooves with which the respective manifold cavity ports communicate.
摘要翻译：具有模块化多通道歧管或阀体的阀。不同类型的阀机构可轴向地插入通过形成在歧管内的空腔的开口端，并通过封闭件密封在其中。用于阀机构的流体连接件由多个通道平行延伸，从歧管的公共端平行于腔而在歧管的壁内延伸。每个通道在歧管中在空腔的基本上全部有效长度上在歧管中纵向延伸，并且在沿其长度的一个或多个位置处选择性地移动到空腔，以用于使用歧管的特定阀机构。阀机构具有各自的歧管腔端口连通的周向槽。

50. 发明授权

US3752187A Laminated flow element 失效
标题翻译：层压流量元件
公开(公告)号：US3752187A
公开(公告)日：1973-08-14
申请号：US3752187D
申请日：1971-11-10
申请人： RETALLICK D
发明人： RETALLICK D
IPC分类号： F15C1/06 , F17D1/00 , F15C5/00
CPC分类号： F15C1/06 , Y10T137/2224
摘要： The invention concerns a flow element and method of making which consists of several plates stacked (layered) on top of each other having flow channels arranged therein and in which the number of layers is reduced by providing at least one channel completely enclosing a section of a plate. The above is accomplished by etching such a channel from both surfaces of a plate in which the channel is to be formed except in one region which is etched from one side only. A connecting web remains at this latter region and if a restriction is not desired in this region of the channel, the channel is made wider than the rest of the channel to the extent necessary to compensate for the lesser depth thereat.
摘要翻译：本发明涉及一种流动元件及其制造方法，该流动元件和方法由几个彼此顶部叠置（层叠）的板组成，其中排列有流动通道，并且通过提供至少一个通道来完全包围一部分盘子。以上是通过从要形成通道的板的两个表面蚀刻这种通道来实现的，除了仅从一侧蚀刻的一个区域中。连接纤维网保留在后一区域，并且如果在该通道的该区域中不需要限制，则通道被制成比通道的其余部分更宽，以补偿其中较小深度所必需的程度。

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