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41. 发明申请

US20040063192A1 Process for decreasing the reducing sugars content of light steepwater 失效
标题翻译：降低轻质水中还原糖含量的方法
公开(公告)号：US20040063192A1
公开(公告)日：2004-04-01
申请号：US10259035
申请日：2002-09-27
发明人： Roman J. Blaszczyk , Lawrence A. Trickey
IPC分类号： C07H001/00 , C07K001/00
CPC分类号： C08B30/02 , C08B30/044 , C08B30/10
摘要： A process for decreasing the reducing sugars content of light steepwater comprising complementary incubation of light steepwater from a corn steeping process having sulfur dioxide (SO2) content at between about 20 ppm and about 220 ppm for at least about 5 hours. The process is particularly useful for obtaining Pharmaceutical Industry Grade Steepwater.
摘要翻译：一种用于降低轻质水的还原糖含量的方法，其包括在二氧化硫（SO2）含量为约20ppm至约220ppm之间的玉米浸渍方法的轻质浸水的互补孵育至少约5小时。该方法对于获得制药工业级陡峭水是特别有用的。

42. 发明申请

US20030144488A1 Novel saccharide, process for preparation of the same and use thereof 审中-公开
标题翻译：新型糖类，其制备方法及其用途
公开(公告)号：US20030144488A1
公开(公告)日：2003-07-31
申请号：US10296628
申请日：2002-11-26
发明人： Susumu Hizukuri , Junichi Abe , Kenkou Muroya , Kazuhiro Yoshinaga , Mami Fujisue , Hideto Ishiba
IPC分类号： C07H001/00
CPC分类号： C07H3/02
摘要： There is provided a novel carbohydrate: having neither a carbon-carbon double bond nor a carbonyl group and represented by a molecular formula C6H10O5; showing a retention time of 11.0null0.2 minutes when maltose and fructose as reference materials show retention times of 8.8 minutes and 12.5 minutes, respectively, the retention times being measured by high performance liquid chromatography using a column having, as a filler, a strongly acidic ion exchange resin which is a styrene-divinylbenzene copolymer with a degree of crosslinkage of 8% and has a sulfonic group bonded to sodium as an ion exchange group, at a column temperature of 40null C. and a flow rate of water as an eluent of 1 ml/min, and; showing intramolecular carbon chemical shift values obtained by carbon nuclear magnetic resonance of 70.54null1 ppm, 95.37null1 ppm, 75.09null1 ppm, 68.86null1 ppm, 77.99null1 ppm and 64.15null1 ppm. This novel carbohydrate is useful as an antioxidant.
摘要翻译：提供了一种新颖的碳水化合物：既不具有碳 - 碳双键也不具有羰基并由分子式C6H10O5表示; 显示出麦芽糖和果糖作为参考物质的保留时间分别为11.0±0.2分钟，保留时间为8.8分钟和12.5分钟，保留时间通过高效液相色谱法测定，使用具有强酸性离子交换树脂，其为交联度为8％并具有与钠作为离子交换基团键合的磺酸基的苯乙烯 - 二乙烯基苯共聚物，柱温40℃，水作为洗脱剂的流速为1ml / min，显示通过碳核磁共振获得的分子内碳化学位移值为70.54±1ppm，95.37±1ppm，75.09±1ppm，68.86±1ppm，77.99±1ppm和64.15±1ppm。这种新型碳水化合物可用作抗氧化剂。

43. 发明申请

US20030105306A1 Transition metal oxo, sulfido and amido complexes as catalysts of nucleophilic addition reactions 有权
标题翻译：过渡金属氧代，硫代和酰胺配合物作为亲核加成反应的催化剂
公开(公告)号：US20030105306A1
公开(公告)日：2003-06-05
申请号：US10152957
申请日：2002-05-21
发明人： Robert H. Grubbs , F. Dean Toste
IPC分类号： C07H001/00 , C07C029/04 , C07C041/05
CPC分类号： B01J31/182 , B01J23/36 , B01J31/1805 , B01J31/184 , B01J31/2226 , B01J31/24 , B01J31/2409 , B01J31/2452 , B01J2231/323 , B01J2231/643 , B01J2231/645 , B01J2531/0266 , B01J2531/64 , B01J2531/66 , B01J2531/74 , B01J2531/821 , B01J2531/825 , C07B53/00 , C07B2200/07 , C07C29/143 , C07C41/20 , C07C67/303 , C07F13/005 , C07C69/24 , C07C43/2055 , C07C33/22
摘要： Methods are provided for carrying out nucleophilic addition reactions using oxo, sulfido or amido complexes of transition metals as reaction catalysts. Exemplary catalysts are oxo complexes of Group 7 transition metals, with rhenium (V) oxo complexes, including dioxo complexes, preferred. Nucleophilic addition reactions that can be catalyzed using the present methods include silylation, hydrosilylation, hydroamination, silylmetalation, carbometalation, aldol reactions, hydro- and carbometalation initiated cyclization/polymerization, and epoxide/aziridine opening. The invention also pertains to novel transition metal complexes that have utility in catalyzing such reactions.
摘要翻译：提供了使用过渡金属的氧代，硫代或酰氨基配合物作为反应催化剂进行亲核加成反应的方法。示例性催化剂是第7族过渡金属的氧代络合物，优选铼（V）氧代络合物，包括二氧化合物。可以使用本发明方法催化的亲核加成反应包括甲硅烷基化，氢化硅烷化，水解，甲硅烷基金属化，碳金属化，醛醇反应，水解和金属催化引发的环化/聚合和环氧化物/氮丙啶开口。本发明还涉及可用于催化这种反应的新型过渡金属配合物。

44. 发明申请

US20030105305A1 Methods for the separation of isomers 失效
公开(公告)号：US20030105305A1
公开(公告)日：2003-06-05
申请号：US10005434
申请日：2001-12-05
发明人： Phillipa M. Wiggins
IPC分类号： C07H001/00 , C07C29/88
CPC分类号： H03K19/00346
摘要： Methods for the separation of chaotropic and kosmotropic enantiomers within a racemic mixture are provided. Such methods comprise differentially partitioning the enantiomers into stabilized microdomains of low density water and high density water abutting a porous surface.

45. 发明申请

US20030050437A1 Electrochemical solid phase synthesis 审中-公开
公开(公告)号：US20030050437A1
公开(公告)日：2003-03-13
申请号：US10233208
申请日：2002-08-30
发明人： Donald D. Montgomery
IPC分类号： C07K001/04 , C25B003/00 , C07H001/00
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00641 , B01J2219/00653 , B01J2219/00659 , B01J2219/00713 , B01J2219/0072 , B01J2219/00722 , B82B3/00 , B82Y40/00 , C07K1/047 , C40B40/06 , H01L23/585 , H01L2924/0002 , H01L2924/09701 , H01L2924/12044 , H01M4/00 , H01L2924/00
摘要： A solid phase synthesis method for the preparation of diverse sequences of separate polymers or nucleic acid sequences using electrochemical placement of monomers or nucleic acids at a specific location on a substrate containing at least one electrode that is preferably in contact with a buffering or scavenging solution to prevent chemical crosstalk between electrodes due to diffusion of electrochemically generated reagents.

46. 发明申请

US20030023080A1 Synthesis of allofuranose 有权
标题翻译：异戊二烯的合成
公开(公告)号：US20030023080A1
公开(公告)日：2003-01-30
申请号：US10165768
申请日：2002-06-07
发明人： Troels Koch , Henrik Frydenlund Hansen
IPC分类号： C07H001/00
CPC分类号： C07H1/00
摘要： The present invention provides a novel strategy for the synthesis of allofuranose using glucofuranose as starting material in a one-pot reaction. The novel finding is that it is possible to carry out the oxidation of 1,2:5,6-di-O-isopropylidene-null-D-glucofuranose with DMSO/acetic anhydride and a reduction reaction in one pot obtaining high yields of recrystallised and analytical pure 1,2:5,6-di-O-isopropylidene-null-D-allofuranose.
摘要翻译：本发明提供了在一锅反应中使用呋喃糖作为原料合成异戊二醛的新策略。该新发现是可以用DMSO /乙酸酐进行1,2：5,6-二-O-异亚丙基-α-D-吡喃葡萄糖的氧化，并在一锅中进行还原反应，得到高产率的重结晶和分析纯的1,2：5,6-二-O-异亚丙基-α-D-异戊二醛。

47. 发明申请

US20030022844A1 Process for manufacturing of tagatose 失效
标题翻译：塔格糖的制造方法
公开(公告)号：US20030022844A1
公开(公告)日：2003-01-30
申请号：US10194295
申请日：2002-07-15
发明人： Hans Bertelsen , Kristian Eriknauer , Karen Bottcher , Hans Jorgen Singel Christensen , Peter Stougaard , Ole Cai Hansen , Flemming Jorgensen
IPC分类号： A61K031/70 , C12P019/02 , C07H001/00
CPC分类号： C12P19/02 , C12N9/2402 , C12N9/90 , C12Y302/01108 , C12Y503/01004
摘要： Tagatose is manufactured by hydrolyzing lactose to galactose and glucose and isomerizing galactose to tagatose and chromatographic separation and recycling any unconverted compounds. Thereby high yields of pure tagatose are obtained.
摘要翻译：塔高糖通过将乳糖水解成半乳糖和葡萄糖并将半乳糖异构化为塔格糖并进行色谱分离和再循环任何未转化的化合物来制备。从而获得纯的塔格糖的高产率。

48. 发明申请

US20020169232A1 Saccharide-alkyleneoxy derivative and ink 审中-公开
标题翻译：糖 - 亚烷基氧基衍生物和油墨
公开(公告)号：US20020169232A1
公开(公告)日：2002-11-14
申请号：US09909417
申请日：2001-07-19
申请人： SEIKO EPSON CORPORATION
发明人： Masahiro Yatake
IPC分类号： C03C017/00 , C07H001/00
CPC分类号： C09D11/30 , C07H15/08
摘要： A saccharide-alkyleneoxy derivative comprising a compound represented by the following formula (1): Anull(EP)nnullOH nullnull(1)wherein A represents a skeleton of a saccharide selected from the group consisting of C3 to C12 aldoses, ketoses and sugar alcohols; EP represents an ethyleneoxy group and/or a propyleneoxy group; and n represents an average number of the repeating units. Also disclosed are a method for producing the saccharide alkyleneoxy derivative, and an ink containing the saccharide-alkyleneoxy derivative.
摘要翻译：包含由下式（1）表示的化合物的糖 - 亚烷基氧基衍生物： A-（EP）n-OH（1）其中A表示选自C3至C12醛糖，酮糖和糖醇的糖的骨架; EP表示乙烯氧基和/或丙烯氧基; n表示重复单元的平均数。还公开了制备糖类亚烷基氧基衍生物的方法和含有糖 - 亚烷基氧基衍生物的油墨。

49. 发明申请

US20020161136A1 Polylactide/dextran graft co-polymers for biomaterial and tissue engineering applications 失效
标题翻译：用于生物材料和组织工程应用的聚丙交酯/葡聚糖接枝共聚物
公开(公告)号：US20020161136A1
公开(公告)日：2002-10-31
申请号：US09857157
申请日：2001-05-31
发明人： Matthew R. Gevaert , Stephen Massia
IPC分类号： C08F251/00 , C07H001/00 , A01N043/04 , A61K009/14
CPC分类号： C08L51/02 , A61K9/1647 , A61K9/1652 , A61L27/18 , A61L27/20 , A61L27/52 , A61L27/54 , A61L2300/00 , A61L2300/406 , A61L2300/43 , A61L2300/45 , A61L2300/602 , C08F251/00 , C08F263/00 , C08F267/00 , C08F290/14 , A61L27/58 , C08L67/04 , C08L5/02
摘要： A biocompatible, biodegradable, copolymer is prepared from cross-linking a polylactic acid with a polysaccharide such as dextran. The resulting copolymer is a biodegradable hydrogel or solid having both hydrophobic and hydrophilic properties and provides for a mechanism in which biologically active agents may be covalently bonded to the dextran prior to incorporation of the dextran into a copolymer, and the subsequent release of the biologically active agents as the copolymer degrades.
摘要翻译：通过将聚乳酸与多糖例如葡聚糖交联制备生物相容的可生物降解的共聚物。所得共聚物是具有疏水性和亲水性的生物可降解水凝胶或固体，并且提供了一种机制，其中生物活性剂可以在将葡聚糖掺入共聚物之前共价键合到葡聚糖上，并且随后释放生物活性作为共聚物的试剂降解。

50. 发明申请

US20020137903A1 C-aryl glucoside SGLT2 inhibitors and method 有权
标题翻译： C-芳基葡糖苷SGLT2抑制剂及方法
公开(公告)号：US20020137903A1
公开(公告)日：2002-09-26
申请号：US10151436
申请日：2002-05-20
发明人： Bruce Ellsworth , William N. Washburn , Philip M. Sher , Gang Wu , Wei Meng
IPC分类号： C07H001/00 , A61K031/70
CPC分类号： C07C43/225 , A61K31/70 , A61K31/7034 , A61K45/06 , C07C45/46 , C07C49/84 , C07H7/04 , C07H15/203 , A61K2300/00
摘要： An SGLT2 inhibiting compound is provided having the formula 1 A method is also provided for treating diabetes and related diseases employing an SGLT2 inhibiting amount of the above compound alone or in combination with another antidiabetic agent or other therapeutic agent.
摘要翻译：提供了具有式A的SGLT2抑制化合物还提供了用于治疗糖尿病和相关疾病，其使用单独的SGLT2抑制量的上述化合物或与另一种抗糖尿病剂或其它治疗剂组合。

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