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41. 发明申请

US20010011090A1 Pyrazole derivative 失效
标题翻译：吡唑衍生物
公开(公告)号：US20010011090A1
公开(公告)日：2001-08-02
申请号：US09773736
申请日：2001-02-02
发明人： Hirokazu Kubota , Yasuhiro Yonetoku , Keizo Sugasawa , Masashi Funatsu , Souichirou Kawazoe , Akira Toyoshima , Yoshinori Okamoto , Jun Ishikawa , Makoto Takeuchi
IPC分类号： A61K031/535 , A61K031/497 , A61K031/445 , A01N043/40 , A61K031/415 , A01N043/56
CPC分类号： C07D231/12 , C07D231/14 , C07D233/56 , C07D249/08 , C07D401/12 , C07D403/12 , C07D409/04 , C07D409/12 , C07D409/14 , C07D417/04 , C07D417/12 , C07D417/14
摘要： Drugs, in particular, pyrazole derivatives represented by the following general formula (I) which have a calcium release-dependent calcium channel inhibitory effect and medicinal compositions, in particular, calcium release-dependent calcium channel inhibitors containing the above compounds as the active ingredient, 1 (in the formula, each symbol has the following meaning: B: phenylene, a nitrogen-containing, divalent, saturated ring group, or a monocyclic, divalent heteroaromatic ring group which may be substituted with Alk, X: nullNR1nullCR2R3null, nullCR2R3nullNR1null, nullNR1SO2null, nullSO2nullNR1null or nullCR4nullCR5null, and A: benzene ring which may have one or more substituents; mono-, di- or tricyclic fused heteroaryl which may have one or more substituents; cycloalkyl which may have one or more substituents; a nitrogen-containing, saturated ring group which may have one or more substituents; lower alkenyl which may have one or more substituents; lower alkynyl which may have one or more substituents; or Alk which may have one or more substituents).
摘要翻译：药物，特别是具有钙释放依赖性钙通道抑制作用的药物组合物，特别是含有上述化合物作为活性成分的钙释放依赖性钙通道抑制剂的下述通式（I）表示的吡唑衍生物，（在该式中，每个符号具有以下含义：B：亚苯基，含氮，二价饱和环基或可被Alk，X：-NR1-CR2R3-取代的单环，二价杂芳族环基团， -CR2R3-NR1-，-NR1SO2-，-SO2-NR1-或-CR4 = CR5-，和A：可具有一个或多个取代基的苯环;可具有一个或多个取代基的单 - ，二 - 或三环稠合杂芳基取代基;可具有一个或多个取代基的环烷基;可具有一个或多个取代基的含氮饱和环基;可具有一个或多个取代基的低级烯基;可具有一个或多个取代基的低级炔基;或Alk，可能具有一个或多个取代基）。

42. 发明申请

US20010011064A1 Herbicidal 3,5-difluoropyridines 失效
标题翻译：除草剂3,5-二氟吡啶
公开(公告)号：US20010011064A1
公开(公告)日：2001-08-02
申请号：US09759564
申请日：2001-01-12
申请人： American Cyanamid Company
发明人： Thomas Maier , Stefan Scheiblich , Helmut S. Baltruschat
IPC分类号： A01N043/40
CPC分类号： A01N43/40 , A01N43/56
摘要： The invention relates to novel compounds of formula I: 1 wherein R, A, B and X have the meaning given in claim 1; and the agronomically acceptable salts or N-oxides thereof, and to herbicidal compositions containing such compounds as active ingredients.
摘要翻译：本发明涉及式I的新化合物：其中R，A，B和X具有权利要求1中给出的含义; 和其农学上可接受的盐或N-氧化物，以及含有这些化合物作为活性成分的除草组合物。

43. 发明申请

US20010006974A1 COMBINATION THERAPY FOR LYMPHOPROLIFERATIVE DISEASES 有权
标题翻译：联合治疗淋巴瘤性疾病
公开(公告)号：US20010006974A1
公开(公告)日：2001-07-05
申请号：US09256666
申请日：1999-02-24
发明人： JOHN C. BYRD , MICHAEL R. GREVER , IAN W. FLINN , JAMIE K. WASELENKO
IPC分类号： A61K031/445 , A01N043/40
CPC分类号： A61K31/675 , A61K31/52 , A61K31/55 , A61K31/565 , A61K31/70 , A61K33/24 , A61K45/06 , A61K31/415 , A61K31/255 , A61K31/195 , A61K31/17 , A61K31/13 , A61K2300/00
摘要： Disclosed are methods and kits for treating lymphoproliferative diseases in a host including (co)administering to the host pentostatin, at least one alkylating agent and at least one methylated xanthine.
摘要翻译：公开了用于在宿主中治疗淋巴组织增生性疾病的方法和试剂盒，其包括（共）施用所述宿主叶喷司他丁，至少一种烷化剂和至少一种甲基化黄嘌呤。

44. 发明申请

US20010005511A1 Insect control by insect growth regulators broadcast by volatilization 审中-公开
公开(公告)号：US20010005511A1
公开(公告)日：2001-06-28
申请号：US09767614
申请日：2001-01-22
申请人： Wellmark International
发明人： Robin Rudolph , Eric Duffey
IPC分类号： A01N043/40 , A61K031/44
CPC分类号： A01N43/40 , A01M1/2083 , A01M2200/011 , A01N49/00 , A01N25/18 , A01N2300/00
摘要： Insect control through the use of an insect growth regulators is achieved by volatilization of the active compound from a point source in a spatial region such as a room, to diffuse through the air in the region toward objects in the region such as a carpet or a piece of furniture. The ability of the insect growth regulator to retain its activity when applied in this manner, even after periods of time in excess of one month following volatilization, is surprising in view of pre-existing methods of application that involved application of the insect growth regulator directly to the surface or object of interest in liquid form.

45. 发明申请

US20040266829A1 Fungicidal composition based on at least one pyridylmethylbenzamide derivatives and at least on dithiocarbamate derivative 有权
标题翻译：基于至少一种吡啶基甲基苯甲酰胺衍生物和至少二硫代氨基甲酸酯衍生物的杀真菌组合物
公开(公告)号：US20040266829A1
公开(公告)日：2004-12-30
申请号：US10493591
申请日：2004-04-23
发明人： Richard Mercer , Thomas Wegmann
IPC分类号： A01N055/00 , A01N043/40
CPC分类号： A01N43/40 , A01N2300/00
摘要： 1) Fungicidal compositions comprising: a) at least one pyridylmethylbenzamide derivative of formula (I), in which the various radicals are as defined in the description, and b) at least one compound (II) chosen from dithiocarbamates, preferably fungicidal dithiocarbamates, and, still more preferably from the following active agents: ferbam, mancopper, mancozeb, maneb, metiram, nabam, nickel bis(dimethyldithio-carbamate), propineb, zineb and mixtures thereof.; and their agriculturally acceptable isomers and addition salts with an acid. 2) Method for the curative or preventive control of phytopathogenic fungi of crops using an effective and non-phytotoxic quantity of one of these fungicidal compositions.
摘要翻译： 1）杀真菌组合物，其包含：a）至少一种式（I）的吡啶基甲基苯甲酰胺衍生物，其中各种基团如说明书中所定义，和b）至少一种选自二硫代氨基甲酸盐，优选杀真菌二硫代氨基甲酸盐的化合物（II）和，还更优选来自以下活性剂：ferbam，mancopper，代森锰锌，芒硝，metiram，纳巴姆，双（二甲基二硫代氨基甲酸镍）镍，丙炔，吖嗪及其混合物。及其农业上可接受的异构体和与酸的加成盐。 2）使用有效和非植物毒性量的这些杀真菌组合物之一治疗或预防控制作物的植物病原真菌的方法。

46. 发明申请

US20040242456A1 Herbicidal n-alkysulfonamino derivatives 审中-公开
标题翻译：除草剂n-烷基磺酰氨基衍生物
公开(公告)号：US20040242456A1
公开(公告)日：2004-12-02
申请号：US10488562
申请日：2004-03-02
发明人： Christoph Luthy , Andrew Edmunds , Roger Graham Hall
IPC分类号： A01N041/06 , A01N043/40 , A01N043/80
CPC分类号： C07D213/70 , A01N43/40 , C07C311/07 , C07C317/24 , C07D213/50 , C07D213/80 , C07D213/82 , C07D409/12
摘要： The present invention relates to novel, herbicidally active N-alkylsulfonamino derivatives of Formula (I), wherein the substituents are as defines in claim 1, to processes for their preparation, to compositions comprising those compounds, and to their use in controlling weeds, especially in crops of useful plants, or in inhibiting plant growth. 1
摘要翻译：本发明涉及式（I）的新型除草活性N-烷基磺酰氨基衍生物，其中取代基如权利要求1所定义，其制备方法，包含那些化合物的组合物及其在控制杂草中的用途，特别是在有用植物的作物中，或抑制植物生长。

47. 发明申请

US20040224847A1 Method for improving plant growth 审中-公开
标题翻译：改善植物生长的方法
公开(公告)号：US20040224847A1
公开(公告)日：2004-11-11
申请号：US10859929
申请日：2004-06-03
发明人： Robert Senn , Dieter Hofer , Thomas Thieme , Larry Zang
IPC分类号： A01N043/40 , A01N043/08
CPC分类号： A01N51/00 , A01N43/40 , A01N47/40
摘要： Disclosed is a method of improving the growth of plants wherein at least one compound of formula (I) 1 wherein A is 2-chloropyrid-5-yl, 2-methylpyrid-5-yl, 1-oxido-3-pyridinio, 2-chloro-1-oxido-5-pyridinio, 2,3-dichloro-1-oxido-5-pyridinio, tetrahydrofuran-3-yl, 5-methyl-tetrahydrofuran-3-yl or 2-chlorothiazol-5-yl group, R is hydrogen, C1-C6alkyl, phenyl-C1-C4alkyl, C3-C6cycloalkyl, C2-C6alkenyl or C2-C6alkynyl; Y is nullN(R)(R2) or SR2; R1 and R2 are independently of each other C1-C4-alkyl, C1-C4-alkenyl, C1-C4-alkinyl nullC(nullO)nullCH3 or benzyl; or together form a group nullCH2nullCH2null, nullCH2nullCH2nullCH2null, nullCH2nullOnullCH2null, nullCH2nullSnullCH2null, nullCH2nullNHnullCH2null or nullCH2nullN(CH3)nullCH2null; and X is NnullNO2 or NnullCN or CHnullNO2; or, where appropriate, a tautomer thereof, in each case in free from or in salt form; is applied to the plant or the locus thereof.
摘要翻译：公开了一种改善植物生长的方法，其中至少一种式（I）化合物，其中A是2-氯吡啶-5-基，2-甲基吡啶-5-基，1-氧化-3-吡啶并吡啶，2-氯 -1-氧化-5-吡啶鎓，2,3-二氯-1-氧化-5-吡啶并，四氢呋喃-3-基，5-甲基 - 四氢呋喃-3-基或2-氯噻唑-5-基，R为氢，C 1 -C 6烷基，苯基-C 1 -C 4烷基，C 3 -C 6环烷基，C 2 -C 6烯基或C 2 -C 6炔基; Y是-N（R）（R2）或SR2; R 1和R 2彼此独立地为C 1 -C 4 - 烷基，C 1 -C 4 - 烯基，C 1 -C 4 - 炔基-C（= O）-CH 3或苄基; 或一起形成基团-CH 2 -CH 2 - ， - CH 2 -CH 2 - ， - CH 2 -O-CH 2 - ， - CH 2 -S-CH 2 - ， - CH 2 -NH-CH 2 - 或-CH 2 -N（CH 3） -CH 2 - ; X为N-NO 2或N-CN或CH-NO 2; 或在适当情况下，其互变异构体在每种情况下不含或以盐形式存在; 施用于植物或其基因座。

48. 发明申请

US20040220833A1 System and method for monitoring efficacy of web-based online behavioral clinical study 审中-公开
标题翻译：基于网络的在线行为临床研究监测功效的系统和方法
公开(公告)号：US20040220833A1
公开(公告)日：2004-11-04
申请号：US10823114
申请日：2004-04-13
发明人： Joseph A. Matthias
IPC分类号： A61K031/44 , A01N043/40 , G06F017/60 , G09B019/18
CPC分类号： G09B23/28 , G06Q30/02 , G06Q50/22 , G09B7/00 , G16H10/20
摘要： A system and method which evaluates the efficacy of tailored online health related behavioral materials provided to a human subject. More particularly, a method of evaluating the efficacy of online behavioral material in a clinical study including enrolling a plurality of customers, performing a computerized initial, randomly segregating the plurality of customers into a first group which accesses tailored behavioral material online and a second group which accesses non-tailored behavioral material online, providing the first group with tailored behavioral material, providing the second group with non-tailored behavioral material, providing the first group and the second group with a computerized first and second series of questions, analyzing the responses of the first group and the second group to the first and second series of questions according to predetermined factors, and evaluating the efficacy of the behavioral material.
摘要翻译：评估提供给人类受试者的定制在线健康相关行为材料的功效的系统和方法。更具体地，涉及一种在临床研究中评估在线行为材料的功效的方法，包括登记多个顾客，执行计算机化的初始，将多个顾客随机分离成在线访问定制行为材料的第一组，以及第二组，在线访问非定制的行为材料，为第一组提供量身定制的行为材料，为第二组提供非定制的行为材料，为第一组和第二组提供计算机化的第一和第二系列问题，分析第一组和第二组根据预定因素对第一和第二系列问题进行评估，并评估行为材料的功效。

49. 发明申请

US20040176424A1 Insecticide and method of controlling insects 失效
标题翻译：杀虫剂及防治昆虫的方法
公开(公告)号：US20040176424A1
公开(公告)日：2004-09-09
申请号：US10674196
申请日：2003-09-29
申请人： Nufarm Australia Limited , La Trobe University
发明人： Richard Mark Sandeman , David Spencer Chandler , Ann Maree Duncan , Phillip Maxwell Hay
IPC分类号： A01N043/40 , A01N043/36 , A01N037/12 , A01N037/44 , A01N037/28
CPC分类号： C07F9/3808 , A01N37/44 , A01N37/46 , A01N43/36 , A01N43/80 , A01N57/20 , A01N57/24 , A01N57/28 , C07F9/4006 , A01N47/22 , A01N43/90 , A01N43/24 , A01N57/16 , A01N2300/00
摘要： An insecticide of formula 1 1 and the agriculturally acceptable salts thereof, wherein: R1 is selected from the group consisting of: the group OR5 wherein R5 is selected from the group consisting of hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, cycloalkyl, substituted cycloalkyl, heterocyclic and substituted heterocyclic; the group nullNR6OH wherein R6 is selected from the group consisting of hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, carbocyclic and substituted carbocyclic; the group NR7R8 wherein R7 and R8 are independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, aryl, substituted aryl and carbocyclic; and the group wherein R1 is linked to R2 to form a diradical bridging group; R2 and R3 are independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, carbocyclic, substituted carbocyclic, aryl, substituted aryl, acyl and substituted acyl; and A is a diradical linking group which has a molecular weight of preferably less than 200 and more preferably less than 100.
摘要翻译：式1的杀虫剂及其农业上可接受的盐，其中：R 1选自：OR 5，其中R 5选自氢，烷基，取代的烷基，芳基，取代的芳基，环烷基，取代的环烷基，杂环和取代的杂环; 基团-NR 6 OH，其中R 6选自氢，烷基，取代的烷基，芳基，取代的芳基，碳环和取代的碳环; 基团NR 7 R 8其中R 7和R 8独立地选自氢，烷基，取代的烷基，芳基，取代的芳基和碳环; 和其中R 1连接到R 2的基团以形成双价桥联基团; R 2和R 3独立地选自氢，烷基，取代的烷基，碳环，取代的碳环，芳基，取代的芳基，酰基和取代的酰基; 并且A是分子量优选小于200，更优选小于100的双价连接基团。

50. 发明申请

US20040157741A1 Benzoylsulfonamides and sulfonylbenzamidines for use as antitumour agents 失效
标题翻译：苯甲酰基磺酰胺和磺酰基苯甲脒用作抗肿瘤剂
公开(公告)号：US20040157741A1
公开(公告)日：2004-08-12
申请号：US10478389
申请日：2003-11-18
发明人： Chuan Shih , Cora Grossman , Karen Lobb , Thomas Hughes Corbett , Ho-Shen Lin
IPC分类号： A01N043/40 , A01N043/42 , A01N043/653 , A01N043/10
CPC分类号： C07D307/38 , A61K31/18 , C07C311/51 , C07C323/67 , C07D213/34 , C07D215/12 , C07D231/12 , C07D233/56 , C07D249/08 , C07D333/18
摘要： The present invention provides antitumor compounds of the formula (I), and antitumor methods. 1
摘要翻译：本发明提供式（I）的抗肿瘤化合物和抗肿瘤方法。

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