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41. 发明授权

US07314598B2 Dispenser and dispensing device 有权
标题翻译：分配器和分配装置
公开(公告)号：US07314598B2
公开(公告)日：2008-01-01
申请号：US10776162
申请日：2004-02-12
申请人： Mitsuo Nishino
发明人： Mitsuo Nishino
IPC分类号： B01L3/02
CPC分类号： B01L3/0227 , B01L2200/146 , G01N2035/1018 , Y10T436/119163
摘要： A dispenser has a pressure sensor enabled to detect a pressure precisely by forming a pressure sensor integrally with a syringe constructing a nozzle to thereby eliminate a pipeline or the like. The dispenser is provided for sucking and discharging a liquid from a nozzle by slidably moving a piston sliding in the inside of a syringe by a motor mounted in a body. A detection sensor for detecting the internal pressure of the inside of the syringe is integrally formed by connecting its air inlet directly to a through hole formed to extend to the inner face of the syringe.
摘要翻译：分配器具有能够通过与构造喷嘴的注射器一体地形成压力传感器来精确地检测压力从而消除管道等的压力传感器。分配器被设置用于通过滑动地移动通过安装在体内的电动机在注射器的内部滑动的活塞而从喷嘴吸取和排出液体。用于检测注射器内部的内部压力的检测传感器通过将其空气入口直接连接到形成为延伸到注射器的内表面的通孔而一体地形成。

42. 发明授权

US07312068B2 Capillary pins for high-efficiency microarray printing device 有权
标题翻译：用于高效微阵列打印设备的毛细管引脚
公开(公告)号：US07312068B2
公开(公告)日：2007-12-25
申请号：US10456943
申请日：2003-06-06
申请人： Daniel Pinkel , Donna G. Albertson , Joe W. Gray , Greg Hamilton , Nils W. Brown , Steven M. Clark , John Hanson
发明人： Daniel Pinkel , Donna G. Albertson , Joe W. Gray , Greg Hamilton , Nils W. Brown , Steven M. Clark , John Hanson
IPC分类号： C12M3/00 , C12Q1/68 , G01N33/00 , C07H21/04
CPC分类号： B41J2/25 , B41J2/005 , C12Q1/6837 , Y10T436/119163 , Y10T436/143333 , Y10T436/2575 , C12Q2565/507
摘要： This invention provides improved components (e.g. array “pins”, print head, substrate platen, print head platen, and the like) for microarray printing devices as well as microarray printing devices incorporating such components. In one embodiment, this invention provides a microarray print head comprising a plurality of glass or quartz spotting capillaries disposed in a support that maintains a fixed spacing between the spotting capillaries and that permits the spotting capillaries to move in a direction parallel to the long axis of the capillaries.
摘要翻译：本发明提供了用于微阵列打印装置的改进的组件（例如，阵列“针”，打印头，基板压板，打印头压板等）以及并入这些组件的微阵列打印装置。在一个实施方案中，本发明提供了一种微阵列打印头，其包括设置在支撑体中的多个玻璃或石英斑点毛细管，其在斑点毛细管之间保持固定的间隔，并且允许斑点毛细管沿平行于长轴的方向移动毛细血管

43. 发明授权

US07285422B1 Systems and methods for preparing and analyzing low volume analyte array elements 失效
标题翻译：用于制备和分析低体积分析物阵列元件的系统和方法
公开(公告)号：US07285422B1
公开(公告)日：2007-10-23
申请号：US08786988
申请日：1997-01-23
申请人： Daniel P. Little , Maryanne J. O'Donnell-Maloney , Charles R. Cantor , Hubert Köster
发明人： Daniel P. Little , Maryanne J. O'Donnell-Maloney , Charles R. Cantor , Hubert Köster
IPC分类号： G01N1/10
CPC分类号： H01J49/0418 , B01J19/0046 , B01J2219/00315 , B01J2219/00317 , B01J2219/00378 , B01J2219/00387 , B01J2219/00468 , B01J2219/00497 , B01J2219/005 , B01J2219/00504 , B01J2219/00511 , B01J2219/0052 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00637 , B01J2219/00641 , B01J2219/00648 , B01J2219/00659 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01L3/0244 , B01L3/0262 , B01L3/0268 , C07B2200/11 , C07F9/2408 , C07F9/2429 , C07H21/00 , C40B40/06 , C40B40/10 , C40B60/14 , G01N35/1067 , G01N35/1074 , G01N2035/1037 , G01N2035/1069 , Y10T428/26 , Y10T428/31678 , Y10T428/31855 , Y10T436/119163 , Y10T436/24 , Y10T436/25 , Y10T436/2575
摘要： The invention provides methods for dispensing tools that can be employed to generate multi-element arrays of sample material on a substrate surface. The substrates surfaces can be flat or geometrically altered to include wells of receiving material. The tool can dispense a spot of fluid to a substrate surface by spraying the fluid from the pin, contacting the substrate surface or forming a drop that touches against the substrate surface. The tool can form an array of sample material by dispensing sample material in a series of steps, while moving the pin to different locations above the substrate surface to form the sample array. The invention then passes the prepared sample arrays to a plate assembly that disposes the sample arrays for analysis by mass spectrometry. To this end, a mass spectrometer is provided that generates a set of spectra signal which can be understood as indicative of the composition of the sample material under analysis.
摘要翻译：本发明提供了用于分配工具的方法，该工具可用于在衬底表面上产生样品材料的多元件阵列。衬底表面可以是平坦的或几何上的改变以包括接收材料的孔。该工具可以通过喷射来自销的流体，与基板表面接触或形成与基板表面接触的液滴来将流体点分配到基板表面。该工具可以通过在一系列步骤中分配样品材料来形成样品材料阵列，同时将销移动到衬底表面上方的不同位置以形成样品阵列。然后，本发明将所制备的样品阵列传递到通过质谱法分离样品阵列以进行分析的板组件。为此，提供质谱仪，其产生一组光谱信号，其可以被理解为指示分析下的样品材料的组成。

44. 发明申请

US20070202608A1 AUTOMATED FLUID HANDLING SYSTEM AND METHOD 有权
标题翻译：自动化流体处理系统及方法
公开(公告)号：US20070202608A1
公开(公告)日：2007-08-30
申请号：US11679289
申请日：2007-02-27
申请人： KENNETH UFFENHEIMER , Arthur Hunt
发明人： KENNETH UFFENHEIMER , Arthur Hunt
IPC分类号： G01N1/10 , B01L11/00
CPC分类号： G01N35/1002 , G01N15/1404 , G01N35/109 , G01N2001/383 , G01N2015/1409 , G01N2015/1411 , G01N2015/149 , Y10T436/11 , Y10T436/113332 , Y10T436/114165 , Y10T436/119163 , Y10T436/2575
摘要： An automated fluid handling system configured to prepare fluid samples and to introduce them into an analytical instrument, such as a particle analyzer, flow cytometer or sorter flow cell, and that is capable of analyzing both accurately and quickly.
摘要翻译：一种自动化流体处理系统，其被配置为制备流体样品并将其引入分析仪器，例如粒子分析仪，流式细胞仪或分选器流动池，并且能够准确且快速地分析。

45. 发明授权

US07250301B2 In situ heat induced antigen recovery and staining method 有权
标题翻译：原位热诱导抗原回收和染色方法
公开(公告)号：US07250301B2
公开(公告)日：2007-07-31
申请号：US10245035
申请日：2002-09-13
申请人： Lee Angros
发明人： Lee Angros
IPC分类号： G01N35/00
CPC分类号： G01N1/30 , B01L9/52 , G01N1/312 , G01N1/44 , G01N33/52 , G01N33/521 , G01N33/53 , G01N33/5306 , G01N35/00029 , G01N35/00584 , G01N2035/00138 , G01N2035/00346 , Y10T436/11 , Y10T436/110833 , Y10T436/111666 , Y10T436/112499 , Y10T436/114165 , Y10T436/114998 , Y10T436/119163 , Y10T436/25 , Y10T436/2575
摘要： An automated in situ heat induced antigen recovery and staining method and apparatus for treating a plurality of microscope slides. The process of heat induced antigen recovery and the process of staining the biological sample on the microscope slide are conducted in the same apparatus, wherein the microscope slides do not need to by physically removed from one apparatus to another. Each treatment step occurs within the same reaction compartment. The reaction conditions of each reaction compartment for treating a slide can preferably be controlled independently, including the individualized application of reagents to each slide and the individualized treatment of each slide. The reagents are preferably held in a reagent dispensing strip similar to a “blister pack”.
摘要翻译：一种用于处理多个显微镜载片的自动原位热诱导抗原恢复和染色方法和装置。在相同的装置中进行热诱导的抗原恢复过程和生物样品染色的过程，其中显微镜载片不需要通过物理上从一个装置移除到另一个装置。每个处理步骤发生在相同的反应室内。用于处理载玻片的每个反应室的反应条件可以独立地进行控制，包括各载玻片的各种试剂的应用以及各载玻片的个体化处理。试剂优选保持在类似于“泡罩包装”的试剂分配条中。

46. 发明授权

US07182916B2 Method and the device for micro-particle array fabrication 有权
标题翻译：微粒子阵列制造方法及装置
公开(公告)号：US07182916B2
公开(公告)日：2007-02-27
申请号：US10321589
申请日：2002-12-18
申请人： Hideyuki Noda , Yoshinobu Kohara , Kazunori Okano
发明人： Hideyuki Noda , Yoshinobu Kohara , Kazunori Okano
IPC分类号： B01L3/02
CPC分类号： B01L3/021 , B01J19/0046 , B01J2219/00315 , B01J2219/00317 , B01J2219/00353 , B01J2219/00414 , B01J2219/00463 , B01J2219/00468 , B01J2219/00497 , B01J2219/005 , B01J2219/00576 , B01J2219/00585 , B01J2219/00599 , B01J2219/00648 , B01J2219/00657 , B01J2219/00659 , B01J2219/00689 , B01J2219/00704 , B01J2219/00707 , B01J2219/00722 , B01J2219/00725 , B01L3/502707 , B01L3/502761 , B01L2200/0657 , B01L2200/0668 , B01L2300/0838 , B01L2400/0487 , B01L2400/049 , G01N35/028 , G01N2035/00574 , Y10T436/119163 , Y10T436/2575
摘要： There are provided a novel method and technology for arraying micro-particles. Micro-particle trapping capillaries each having an inner diameter smaller than the outer diameter of probe-immobilized micro-particles are prepared. By vacuuming the inside of each micro-particle trapping capillary, only one of the micro-particles is vacuumed onto an opening at the tip thereof and taken out from holders holding a plurality of the micro-particles. The micro-particle vacuumed onto the opening at the tip of each micro-particle trapping capillary is positioned at the opening of the capillary or the edge of each channel provided in a chip, the channels each having an inlet and an outlet with a slightly larger width than the outer diameter of the micro-particle so as to allow passage of only one micro-particle. The micro-particle vacuumed onto the opening at the capillary tip is injected into the capillary from the opening of the capillary or the channel edge of the chip.
摘要翻译：提供了一种用于排列微粒子的新颖方法和技术。制备各自具有小于探针固定的微粒外径的内径的微粒捕集毛细管。通过抽吸每个微粒捕获毛细管的内部，只有一个微粒被抽吸到其尖端的开口上并从保持多个微粒的保持器中取出。抽吸到每个微粒捕获毛细管尖端的开口处的微粒定位在毛细管的开口处或设置在芯片中的每个通道的边缘，每个通道具有入口和出口略大宽度小于微粒的外径，以允许仅仅一个微粒通过。被抽吸到毛细管尖端的开口上的微粒子从毛细管的开口或芯片的通道边缘注入毛细管中。

47. 发明授权

US07118892B2 Automated process for preparing and amplifying a target nucleic acid sequence 有权
标题翻译：用于制备和扩增靶核酸序列的自动化方法
公开(公告)号：US07118892B2
公开(公告)日：2006-10-10
申请号：US10263939
申请日：2002-10-03
申请人： Kelly G. Ammann , Ralph E. Burns , Ernest V. Hansberry , Glenn A. Horner , Cheryl A. Jakub , John E. Kling , Donald J. Nieglos , Robert E. Schneider , Robert J. Smith
发明人： Kelly G. Ammann , Ralph E. Burns , Ernest V. Hansberry , Glenn A. Horner , Cheryl A. Jakub , John E. Kling , Donald J. Nieglos , Robert E. Schneider , Robert J. Smith
IPC分类号： C12P19/34 , C12Q1/68 , C12M1/34 , C07H21/02 , C07H21/04
CPC分类号： C12Q1/6834 , B01F9/0001 , B01F9/0014 , B01F9/0021 , B01F2009/0074 , B01L7/52 , B01L7/5255 , B01L9/06 , B01L2200/147 , B01L2300/1822 , B01L2300/1827 , B03C1/282 , B03C1/288 , B03C1/30 , B03C2201/26 , C12Q1/6813 , C12Q1/6832 , C12Q2537/10 , G01N35/0098 , G01N35/0099 , G01N35/025 , G01N35/1065 , G01N2035/00356 , G01N2035/00524 , G01N2035/0437 , G01N2035/0455 , G01N2035/103 , Y10T29/53657 , Y10T29/53683 , Y10T29/53843 , Y10T156/1105 , Y10T156/1906 , Y10T436/11 , Y10T436/111666 , Y10T436/113332 , Y10T436/114998 , Y10T436/119163 , Y10T436/2575
摘要： An automated process for preparing and amplifying a target nucleic acid sequence within a stand-alone unit.
摘要翻译：用于在独立单元内制备和扩增靶核酸序列的自动化方法。

48. 发明授权

US07037470B2 System and method for biochemical assay 失效
公开(公告)号：US07037470B2
公开(公告)日：2006-05-02
申请号：US10618923
申请日：2003-07-14
申请人： Clayton M. Hardman , Jaspal Mahal , Sanjay R. Mishra , Kuldip Sra
发明人： Clayton M. Hardman , Jaspal Mahal , Sanjay R. Mishra , Kuldip Sra
IPC分类号： G01N27/00
CPC分类号： G01N27/745 , G01N35/0098 , Y10T436/11 , Y10T436/113332 , Y10T436/119163
摘要： A system for making a biochemical assay of each of plurality of provided specimens, comprising: a plurality of receptacles, a sensor for providing a resistance, a mechanism and a controller.

49. 发明申请

US20050266489A1 Automated process for isolating and amplifying a target nucleic acid sequence using a rotatable transport mechanism 有权
标题翻译：使用可旋转传送机构分离和扩增靶核酸序列的自动化方法
公开(公告)号：US20050266489A1
公开(公告)日：2005-12-01
申请号：US11168374
申请日：2005-06-29
申请人： Kelly Ammann , Ralph Burns , Ernest Hansberry , Glenn Horner , Cheryl Jakub , John Kling , Donald Nieglos , Robert Schneider , Robert Smith
发明人： Kelly Ammann , Ralph Burns , Ernest Hansberry , Glenn Horner , Cheryl Jakub , John Kling , Donald Nieglos , Robert Schneider , Robert Smith
IPC分类号： B01L99/00 , B01F9/00 , B01F15/00 , B01L7/00 , C12M1/00 , C12M1/34 , C12M1/36 , C12P19/34 , C12Q1/68 , G01N35/00 , G01N35/02 , G01N35/04 , G01N35/10
CPC分类号： C12Q1/6834 , B01F9/0001 , B01F9/0014 , B01F9/0021 , B01F2009/0074 , B01L7/52 , B01L7/5255 , B01L9/06 , B01L2200/147 , B01L2300/1822 , B01L2300/1827 , B03C1/282 , B03C1/288 , B03C1/30 , B03C2201/26 , C12Q1/6813 , C12Q1/6832 , C12Q2537/10 , G01N35/0098 , G01N35/0099 , G01N35/025 , G01N35/1065 , G01N2035/00356 , G01N2035/00524 , G01N2035/0437 , G01N2035/0455 , G01N2035/103 , Y10T29/53657 , Y10T29/53683 , Y10T29/53843 , Y10T156/1105 , Y10T156/1906 , Y10T436/11 , Y10T436/111666 , Y10T436/113332 , Y10T436/114998 , Y10T436/119163 , Y10T436/2575
摘要： An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample, incubating the sample at prescribed temperatures for prescribed periods, preforming an analyte isolation procedure, and ascertaining the presence of a target analyte. An automated receptacle transporting system moves the reaction receptacles from one station to the next. The analyzer further includes devices for carrying a plurality of specimen tubes and disposable pipette tips in a machine-accessible manner, a device for agitating containers of target capture reagents comprising suspensions of solid support material and for presenting the containers for machine access thereto, and a device for holding containers of reagents in a temperature controlled environment and presenting the containers for machine access thereto. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte. The process is performed by automatically moving each of a plurality of reaction receptacles containing a solid support material and a fluid sample between stations for incubating the contents of the reaction receptacle and for separating the target analyte bound to the solid support from the fluid sample. An amplification reagent is added to the separated analyte after the analyte separation step and before a final incubation step.
摘要翻译：用于执行多个诊断测定的自动分析仪同时包括多个站或模块，其中对反应容器中包含的流体样品进行分析方面的分析。分析仪包括用于自动准备标本样品，在规定温度下规定时间孵育样品，预处理分析物分离程序以及确定目标分析物的存在的站。自动插座输送系统将反应容器从一个站移动到另一个站。分析仪还包括用于以机器可接近的方式携带多个样本管和一次性移液管尖端的装置，用于搅拌包含固体支持材料的悬浮液并用于提供用于机器通入的容器的靶捕获试剂的容器的装置，以及用于在温度受控的环境中容纳试剂容器的装置，并且提供用于机器通入的容器。执行自动诊断测定的方法包括用于分离和扩增靶分析物的自动化方法。该过程通过在站之间自动移动包含固体支持材料和流体样品的多个反应容器中的每一个来进行，用于孵育反应容器的内容物并将与固体支持物结合的目标分析物与流体样品分离。在分析物分离步骤之后和最终孵育步骤之前，将分离的分析物加入扩增试剂。

50. 发明申请

US20050244303A1 Device for aspirating and dispensing liquid samples 失效
标题翻译：用于吸取和分配液体样品的装置
公开(公告)号：US20050244303A1
公开(公告)日：2005-11-03
申请号：US11056696
申请日：2005-02-11
申请人： Nikolaus Ingenhoven , Noa Schmid , Stefano Fornito
发明人： Nikolaus Ingenhoven , Noa Schmid , Stefano Fornito
IPC分类号： G01N1/00 , B01J4/00 , B01L3/02 , B01L99/00 , G01F25/00 , G01N35/02 , G01N35/10 , G01N37/00
CPC分类号： B01L3/022 , B01L3/021 , B01L3/0241 , B01L99/00 , B01L2400/025 , B01L2400/0439 , B01L2400/0478 , G01F25/0092 , G01N35/10 , G01N2035/1006 , G01N2035/103 , G01N2035/1039 , Y10T436/114998 , Y10T436/119163 , Y10T436/2575
摘要： A device for aspirating and dispensing liquid samples comprising a pump that comprises a cylindrical chamber, a piston movable in this cylindrical chamber, and a piston drive that engages the piston. The device further comprises a tip connected to the cylindrical chamber with a line, and a channel system that discharges into the cylindrical chamber for flushing or rinsing the latter. The device is characterized in that the piston entirely seals this cylindrical chamber from the channel system, if the piston is positioned in the cylindrical chamber in such a way that a free piston end comes to rest between the channel system and the line. Preferably, the cylindrical chamber is located in a cylinder block, which comprises two parts that are separated by and enclosing an intermediate channel system. The channel system most preferably is implemented as a coherent cavity. According to a first embodiment, the cylindrical chamber is implemented as a sleeve that is inserted in a boring located in a cylinder block. According to a second embodiment, the cylindrical chamber is implemented as a boring located in a cylinder block. Furthermore, the invention also concerns systems with, for example, 384 or more such devices that are arranged in an array.
摘要翻译：用于抽吸和分配液体样品的装置，包括包括圆柱形腔室的泵，可在该圆柱形腔室中移动的活塞以及与活塞接合的活塞驱动器。该装置还包括连接到具有管线的圆柱形腔室的尖端，以及排出到圆柱形室中用于冲洗或冲洗其的通道系统。该装置的特征在于，如果活塞以这样的方式定位在柱形腔室中，则活塞将该圆柱形腔室与通道系统完全密封，使得自由活塞端部在通道系统和管线之间搁置。优选地，圆柱形腔室位于气缸体中，该气缸体包括由中间通道系统分隔并包围中间通道系统的两个部件。通道系统最优选地被实现为相干腔。根据第一实施例，圆柱形腔室被实施为插入位于气缸体中的钻孔中的套筒。根据第二实施例，圆柱形室被实现为位于气缸体中的钻孔。此外，本发明还涉及具有例如384个或更多个以阵列排列的这种装置的系统。

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