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41. 发明申请

US20040197383A1 High calcium foodstuffs for weight loss 审中-公开
标题翻译：高钙食品减肥
公开(公告)号：US20040197383A1
公开(公告)日：2004-10-07
申请号：US10827353
申请日：2004-04-20
申请人： University of Tennessee Research Foundation
发明人： Michael B. Zemel , Hang Shi , Paula C. Zemel
IPC分类号： A61K047/00 , A61K031/19
CPC分类号： A61K31/00 , A23L33/16 , A23L33/30 , Y10S514/905
摘要： The subject invention provides methods of inducing the loss of adipose tissue by providing a diet high in calcium. In one aspect of the invention, the calcium is provided in the form of dairy products. In yet another aspect of the invention, calcium is provided in the form of a dietary supplement, such as calcium carbonate, of vitamin supplements. Methods of suppressing nullCa2nullnulli levels in individuals are also provided. The subject invention also provides methods of stimulating lipolysis, inhibiting lipogenesis, and increasing the expression of white adipose tissue uncoupling protein 2 (UCP2). The subject invention also provides methods of increasing the core temperature of an individual.
摘要翻译：本发明提供通过提供高钙饮食来诱导脂肪组织损失的方法。在本发明的一个方面，钙以乳制品的形式提供。在本发明的另一方面，钙以维生素补充剂的膳食补充剂如碳酸钙的形式提供。还提供了抑制个体中[Ca 2+] i水平的方法。本发明还提供了刺激脂肪分解，抑制脂肪生成并增加白色脂肪组织解偶联蛋白2（UCP2）的表达的方法。本发明还提供了增加个体的核心温度的方法。

42. 发明授权

US06669966B1 Compositions for facilitating skin growth and methods and articles using same 失效
标题翻译：用于促进皮肤生长的组合物和使用其的方法和制品
公开(公告)号：US06669966B1
公开(公告)日：2003-12-30
申请号：US09692127
申请日：2000-10-20
申请人： Marvin S. Antelman
发明人： Marvin S. Antelman
IPC分类号： A61K3334
CPC分类号： A61K8/0208 , A01N59/16 , A01N59/20 , A61K8/19 , A61K9/0014 , A61K9/06 , A61K33/24 , A61K33/245 , A61K33/26 , A61K33/32 , A61K33/34 , A61K33/38 , A61K47/06 , A61L15/26 , A61L15/44 , A61L2300/10 , A61Q1/12 , A61Q19/00 , C01G3/02 , Y10S424/06 , Y10S424/13 , Y10S514/836 , Y10S514/904 , Y10S514/905 , Y10S514/925 , Y10S514/928 , Y10S514/95 , C08L71/02
摘要： Skin-growth-enhancing compounds and compositions including a therapeutically effective amount of at least one electron active compound, or a pharmaceutically acceptable derivative thereof, that has at least two polyvalent cations, at least one of which has a first valence state and at least one of which has a second, different valence state. Preferred compounds include Bi(III,V) oxide, Co(II,III) oxide, Cu(I,III) oxide, Fe(II,III) oxide, Mn(II,III) oxide, and Pr(III,IV) oxide, and Ag(I,III) oxide, or a combination thereof. These compounds may be in a crystalline state having metallic cations of two different valences, or electronic states, in the inorganic crystal. Also included are articles containing such compositions, such as wound dressings, and methods for facilitating or enhancing skin growth using these compounds, compositions, and articles, such as for the treatment or management of burns or skin grafts.
摘要翻译：皮肤生长增强化合物和组合物，其包含治疗有效量的至少一种电子活性化合物或其药学上可接受的衍生物，其具有至少两种多价阳离子，其中至少一种具有第一价态和至少一种其中具有第二种不同的价态。优选的化合物包括氧化物Bi（III），氧化物（II），氧化物（I），氧化物（III），氧化物（II），氧化物（III）），氧化物（II）氧化物和Ag（I，III）氧化物，或其组合。这些化合物可以是在无机晶体中具有两种不同价态的金属阳离子或电子态的结晶状态。还包括含有这种组合物的制品，例如伤口敷料，以及使用这些化合物，组合物和制品促进或增强皮肤生长的方法，例如用于治疗或治疗烧伤或皮肤移植物的方法。

43. 发明授权

US06660777B2 Comprehensive pharmacologic therapy for treatment of obesity 失效
公开(公告)号：US06660777B2
公开(公告)日：2003-12-09
申请号：US09942188
申请日：2001-08-29
申请人： Martin C. Hinz
发明人： Martin C. Hinz
IPC分类号： A61K31137
CPC分类号： A61K31/34 , A61K31/198 , A61K31/343 , A61K31/375 , A61K31/405 , A61K31/4415 , A61K33/06 , Y10S514/905 , Y10S514/909 , Y10S514/91 , A61K31/44 , A61K31/195 , A61K31/135 , A61K2300/00
摘要： The comprehensive pharmacologic therapy for treatment of obesity is a procedure which involves the administration of a desired therapeutic range of Diethylpropion and/or Phentermine in combination with a SSRI medication and nutritional supplementation for brief and long durations which may be 12 months or more. The preferred procedure involves the administration of drugs in combination which are identified as: Citalopram (Celexa) and Phentermine; Citalopram (Celexa) and Diethylpropion; Citalopram (Celexa), Phentermine, and Diethylpropion. In addition nutritional supplementation such as a multivitamin, 5-Hydroxytryptophan, vitamin B6, vitamin C, Tyrosine, Calcium, and Lysine may be used to enhance the performance of the weight loss treatment program.

44. 发明授权

US06592908B1 Nutritional or therapeutic compositions 有权
标题翻译：营养或治疗组合物
公开(公告)号：US06592908B1
公开(公告)日：2003-07-15
申请号：US10252957
申请日：2002-09-23
申请人： Albert Crum
发明人： Albert Crum
IPC分类号： A61K31095
CPC分类号： A61K31/197 , A23L33/16 , A23L33/175 , A23V2002/00 , A61K9/2018 , A61K31/095 , A61K31/198 , A61K33/04 , A61K45/06 , Y10S514/836 , Y10S514/905 , A61K2300/00 , A23V2250/1626 , A23V2250/06
摘要： Nutritional or therapeutic compositions containing glutamic acid, cystine, glycine and a selenium precursor and methods for their utilization to increase glutathione synthesis and thereby enhance the immune system are described.
摘要翻译：描述了包含谷氨酸，胱氨酸，甘氨酸和硒前体的营养或治疗组合物及其用于增加谷胱甘肽合成从而增强免疫系统的方法。

45. 发明授权

US06565891B1 Nutritional supplement for children 有权
标题翻译：儿童营养补品
公开(公告)号：US06565891B1
公开(公告)日：2003-05-20
申请号：US10226195
申请日：2002-08-23
申请人： Ranjit Kumar Chandra
发明人： Ranjit Kumar Chandra
IPC分类号： A61K31315
CPC分类号： A23L33/16 , A23L33/15 , A23V2002/00 , Y10S426/80 , Y10S514/905 , A23V2250/1608 , A23V2250/1618 , A23V2250/1626 , A23V2250/1642 , A23V2250/211 , A23V2250/70 , A23V2250/702 , A23V2250/708 , A23V2250/71 , A23V2250/712 , A23V2250/7046 , A23V2250/704 , A23V2250/1578 , A23V2250/1586 , A23V2250/1588 , A23V2250/159 , A23V2250/1598 , A23V2250/161 , A23V2250/1612
摘要： A multinutrient nutritional supplement is provided that is designed to be most effective in optimizing health, increasing the immunity and decreasing the instances and severity of infection particularly among children.
摘要翻译：提供多种营养补充剂，旨在最有效地优化健康，增加免疫力，减少感染的实例和严重程度，特别是儿童。

46. 发明授权

US06548551B2 Comprehensive pharmacologic therapy for treatment of obesity 失效
公开(公告)号：US06548551B2
公开(公告)日：2003-04-15
申请号：US09943462
申请日：2001-08-30
申请人： Martin C. Hinz
发明人： Martin C. Hinz
IPC分类号： A61K31137
CPC分类号： A61K31/34 , A61K31/198 , A61K31/343 , A61K31/375 , A61K31/405 , A61K31/4415 , A61K33/06 , Y10S514/905 , Y10S514/909 , Y10S514/91 , A61K31/44 , A61K31/195 , A61K31/135 , A61K2300/00
摘要： The comprehensive pharmacologic therapy for treatment of obesity is a procedure which involves the administration of a desired therapeutic range of Diethylpropion and/or Phentermine in combination with a SSRI medication and nutritional supplementation for brief and long durations which may be 12 months or more. The preferred procedure involves the administration of drugs in combination which are identified as: Citalopram (Celexa) and Phentermine; Citalopram (Celexa) and Diethylpropion; Citalopram (Celexa), Phentermine, and Diethylpropion. In addition nutritional supplementation such as a multivitamin, 5-Hydroxytryptophan, vitamin B6, vitamin C, Tyrosine, Calcium, and Lysine may be used to enhance the performance of the weight loss treatment program.

47. 发明授权

US06495168B2 Nutritional supplements formulated from bioactive materials 失效
标题翻译：营养补充剂由生物活性材料配制
公开(公告)号：US06495168B2
公开(公告)日：2002-12-17
申请号：US09817831
申请日：2001-03-26
申请人： Jon K. West , David Greenspan , James L. Meyers
发明人： Jon K. West , David Greenspan , James L. Meyers
IPC分类号： A61K3300
CPC分类号： C03C3/097 , A23K20/28 , A23L33/29 , C03C4/0007 , C03C12/00 , Y10S514/905
摘要： This invention relates, generally, to nutritional supplements which contain bioactive glass. These supplements are useful in both veterinary and human contexts. The compositions of the subject invention can be used to achieve a number of advantageous results including: enhancing the growth rates of young animals, osteogenic stimulation, strengthening the skeletal structure, and treating osteoporosis.
摘要翻译：本发明一般涉及含有生物活性玻璃的营养补充剂。这些补充剂在兽医和人类环境中都是有用的。本发明的组合物可用于实现许多有利的结果，包括：增强幼动物的生长速率，成骨刺激，加强骨骼结构和治疗骨质疏松症。

48. 发明授权

US06465517B1 Composition for the treatment of migraine 有权
标题翻译：用于治疗偏头痛的组合物
公开(公告)号：US06465517B1
公开(公告)日：2002-10-15
申请号：US09613573
申请日：2000-07-11
申请人： Luutsche Van Der Zee
发明人： Luutsche Van Der Zee
IPC分类号： A61K31185
CPC分类号： A61K45/06 , A23L33/15 , A23L33/16 , A23L33/175 , A23V2002/00 , A61K31/122 , A61K31/185 , A61K33/04 , Y10S514/904 , Y10S514/905 , A61K2300/00 , A23V2250/708 , A23V2250/712 , A23V2250/7042 , A23V2250/314 , A23V2250/0644 , A23V2250/306 , A23V2250/0612 , A23V2250/1626 , A23V2250/5114 , A23V2250/70 , A23V2250/161 , A23V2250/1642
摘要： The present invention describes a novel composition for the treatment of migraine, a common neurovascular syndrome, which can be elicited by functional and/or structural (symptomatic) disorders. This composition comprises taurine, coenzyme Q10 and additionally creatine, L-carnitine, certain vitamins and minerals, carbohydrates, proteins, fats and herbal extracts. Furthermore, the invention describes a method for the treatment of migraine.
摘要翻译：本发明描述了用于治疗偏头痛的新型组合物，其是可由功能性和/或结构性（症状性）障碍引起的常见的神经血管综合征。该组合物包含牛磺酸，辅酶Q10和另外的肌酸，左旋肉碱，某些维生素和矿物质，碳水化合物，蛋白质，脂肪和草药提取物。此外，本发明描述了治疗偏头痛的方法。

49. 发明授权

US06461634B1 Food-based delivery of HGH-stimulating and other nutritional supplements 失效
标题翻译：基于食物的HGH刺激和其他营养补充剂的输送
公开(公告)号：US06461634B1
公开(公告)日：2002-10-08
申请号：US09641614
申请日：2000-08-17
申请人： Edward Marshall
发明人： Edward Marshall
IPC分类号： A61K4700
CPC分类号： A23L33/175 , A23L33/40 , A23V2002/00 , Y10S514/904 , Y10S514/905 , Y10S514/948 , A23V2250/062 , A23V2250/0622 , A23V2250/0606 , A23V2250/063 , A23V2250/70 , A23V2250/156
摘要： A food, or ready-to-drink beverage, delivery system for increasing the production and release of human growth hormone (HGH) for anti-aging effects and/or to improve a condition of HGH deficiency. A food bar, powder, other food forms, or ready-to-drink beverage that contains the full range and optimal dosages of vitamins, minerals, non-prescription hormonal and herbal supplements most desired by individuals who regularly take such supplements from numerous bottles or other packages. HGH stimulation and the above-described supplementation may be delivered for oral ingestion separately or together in the same aliquot, said aliquot providing a pleasant-tasting and convenient snack or mini-meal in addition to the specific HGH stimulation and supplementation. L-glutamine, glycine and melatonin are sufficient to boost HGH up to age 60, and it is preferred to add L-arginine and L-lysine for individuals of age 60 and older. The single food or beverage aliquot makes unnecessary the inconvenient ingestion of numerous pills from numerous bottles, or ill-tasting powders that must be mixed with water. Calories are kept under about 300, and carbohydrate is kept generally below about 5 grams per aliquot in order to permit the stimulation of HGH when the stimulating ingredients are consumed in the form of food or nutritional ready-to-drink beverage. Ingredients are included as needed for optimal flavor and texture choices, and to prevent spoilage.
摘要翻译：用于增加人类生长激素（HGH）的生产和释放以用于抗衰老作用和/或改善HGH缺乏症状的食物或即饮饮料的递送系统。一种食物棒，粉末，其他食物形式或即饮饮料，其中含有全部范围和最佳剂量的维生素，矿物质，非处方荷尔蒙和草药补充剂，这些补充剂是经常从许多瓶子或其他包装 HGH刺激和上述补充可以单独或一起在相同的等分试样中进行口服摄入，除了特异性HGH刺激和补充之外，所述等分试样还提供令人愉快的品尝和方便的零食或微型餐。 L-谷氨酰胺，甘氨酸和褪黑激素足以将HGH升高至60岁，并且对于60岁及以上的个体，优选加入L-精氨酸和L-赖氨酸。单个食物或饮料等分试样不需要从许多瓶中吸收许多药丸，或者必须与水混合的不合适的粉末。卡路里保持在300左右，碳水化合物通常保持在每等份5克以下，以便当刺激成分以食物或营养即饮饮料的形式消耗时，可以刺激HGH。根据需要包括成分，以获得最佳的风味和质地选择，并防止腐败。

50. 发明授权

US06436446B1 Composition for increasing bone density 有权
标题翻译：用于增加骨密度的组合物
公开(公告)号：US06436446B1
公开(公告)日：2002-08-20
申请号：US09365156
申请日：1999-07-30
申请人： Samuel L. Forusz , Hanlan Liu , Rose M. Muatine
发明人： Samuel L. Forusz , Hanlan Liu , Rose M. Muatine
IPC分类号： A61K3306
CPC分类号： A61K33/06 , A23L33/10 , A23L33/16 , A23L33/17 , A23V2002/00 , A61K9/0095 , Y10S514/904 , Y10S514/905 , Y10S514/97 , A61K31/715 , A61K31/59 , A61K31/35 , A61K31/12 , A61K2300/00 , A23V2250/1578 , A23V2250/2116 , A23V2250/7106 , A23V2250/714 , A23V2250/708 , A23V2250/1642 , A23V2250/5062 , A23V2250/5086 , A23V2250/5036 , A23V2250/5114
摘要： A method including administering a beverage composition suitable for human consumption including effective amounts of the following solubilized components, a calcium compound, an organic acid in an amount up to the equivalent amount of a calcium of the calcium compound, an isoflavone, and inulin wherein the effective amounts are sufficient to reduce the risk of bone density loss and are solubilized by a stabilizing agent including one or more of maltol, carrageenan and maltodextrin, and xanthan gum.
摘要翻译：一种方法，包括施用适合人类消费的饮料组合物，包括有效量的以下溶解组分，钙化合物，至少等于钙化合物钙，异黄酮和菊粉的量的有机酸，其中有效量足以降低骨密度损失的风险，并通过包括麦芽醇，角叉菜胶和麦芽糖糊精中的一种或多种的稳定剂和黄原胶溶解。

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