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41. 发明授权

US09646815B2 Integrated nanospray system 有权
公开(公告)号：US09646815B2
公开(公告)日：2017-05-09
申请号：US14409233
申请日：2014-06-05
申请人： NEW OBJECTIVE, INC.
发明人： Gary Valaskovic , Ben Ngo , John P. Devlin , Kurt M. Maw , Ian Schon
IPC分类号： H01J49/16 , G01N30/72 , H01J27/02 , H01J27/26 , H01J49/06
CPC分类号： H01J49/165 , G01N30/7266 , H01J27/022 , H01J27/26 , H01J49/068
摘要： Integrated nanospray ionization package, comprising a nanospray emitter, a push button carriage with button element projecting through a bore in said package, an integral high voltage contact pin, a bore in said package for reversible protrusion of the nanospray emitter, a push-and-retract spring mechanism in which the range of forward motion of the emitter is not dependent on range of travel of the said button, and then upon actuation of said button element and spring element for retraction of said nanospray emitter, said nanospray emitter is pushed forward to establish electrical contact, and upon release of said button retracts and breaks the electrical contact.

42. 发明申请

US20170110307A1 SOLID PHASE EXTRACTION WITH CAPILLARY ELECTROPHORESIS 有权
公开(公告)号：US20170110307A1
公开(公告)日：2017-04-20
申请号：US15079541
申请日：2016-03-24
申请人： The University of North Carolina at Chapel Hill
发明人： John Scott Mellors , William A. Black , John Michael Ramsey
IPC分类号： H01J49/04 , H01J49/16 , G01N27/447
CPC分类号： H01J49/0459 , G01N27/4473 , G01N27/44743 , G01N27/44791 , H01J49/165
摘要： Methods, systems and devices that provide fluid devices with at least one SPE bed adjacent (upstream of) a separation channel which may be in communication with an inlet of a Mass Spectrometer. The fluid device can be configured to operate using independently applied pressures to a BGE reservoir and a sample reservoir for pressure-driven injection that can inject a discrete sample plug into a separation channel that does not require voltage applied to the sample reservoir and can allow for in-channel focusing methods to be used. The methods, systems and devices are particularly suitable for use with a mass spectrometer but optical or other electronic detectors may also be used with the fluidic devices.

43. 发明申请

US20170097320A1 MULTI-SEGMENT INJECTION-CAPILLARY ELECTROPHORESIS-MASS SPECTROMETRY (MSI-CE-MS): A MULTIPLEXED SCREENING PLATFORM AND DATA WORKFLOW FOR CHEMICAL ANALYSIS 审中-公开
公开(公告)号：US20170097320A1
公开(公告)日：2017-04-06
申请号：US15293775
申请日：2016-10-14
申请人： McMaster University
发明人： Philip Britz-McKibbin
IPC分类号： G01N27/447 , H01J49/04 , H01J49/16 , H01J49/00
CPC分类号： G01N27/44782 , G01N27/447 , G01N27/4473 , G01N27/44743 , G01N30/7266 , H01J49/0027 , H01J49/0404 , H01J49/165
摘要： Various embodiments illustrating a multiplexed method for high throughput screening of ions in biological samples within a single capillary when using capillary electrophoresis mass spectrometry (CE-MS) are illustrated. The method includes sequential injection of multiple sample segments in series within a single capillary, the sample segments being separated by a spacer plug of buffer, and multiplexed analysis of the sample segments simultaneously within a single capillary electrophoresis (CE) run. The method also includes application of voltage to the single capillary subsequent to sequential injection and zonal separation of polar metabolites within each sample segment by CE such that each analyte zone migrates within its characteristic electrophoretic mobility offset in time by the spacer. The incorporation of a quality control/reference sample and the use of dilution patterning with specific injection configurations also enables encoding of information temporally for enhanced data processing with quality assurance.

44. 发明申请

US20160363513A1 Atmospheric Condensate Collector and Electrospray Source 审中-公开
公开(公告)号：US20160363513A1
公开(公告)日：2016-12-15
申请号：US14578897
申请日：2014-12-22
申请人： California Institute of Technology
发明人： Fedor D. Kossakovski , Dmitri A. Kossakovski , Jesse L. Beauchamp , Monika E. Freiser
IPC分类号： G01N1/22 , B05B5/057 , H01J49/16 , H01J49/00 , G01N1/40
CPC分类号： G01N1/2273 , B05B5/057 , G01N1/4022 , G01N2001/2282 , G01N2001/4033 , H01J49/0031 , H01J49/165
摘要： An atmospheric condensate collector and electrospray source apparatus. The apparatus has a cooler having a surface with a sharp point. The cooler generates a condensate from ambient atmosphere exposed to the cooler. A ground electrode is electrically and mechanically separated from the cooler. A high voltage power supply switchably provides a high voltage between the sharp point of the cooler and the ground electrode. A controller is electrically connected to the cooler power supply and the high voltage power supply. The controller controls the operation of the cooler power supply and the high voltage power supply. The atmospheric condensate collector and electrospray ionizer apparatus generates the condensate and generates particulate spray from the condensate in response to command signals issued from the controller. In some embodiments, an analyzer is provided to analyze particles of the spray to determine the chemical composition of the condensate.

45. 发明授权

US09500621B2 Leakage current sense circuit for error detection in an improved capillary electrophoresis-electrospray ionization-mass spectrometry system 有权
标题翻译：用于在改进的毛细管电泳 - 电喷雾离子化 - 质谱系统中进行误差检测的泄漏电流检测电路
公开(公告)号：US09500621B2
公开(公告)日：2016-11-22
申请号：US13908861
申请日：2013-06-03
申请人： Beckman Coulter, Inc.
发明人： Peter S. Kotowski , Sunil S. Deliwala , Stephen A. Frye
IPC分类号： G01N27/447 , G01R31/02 , H01J49/02 , H01J49/16
CPC分类号： G01N27/44704 , G01N27/44713 , G01R31/025 , H01J49/022 , H01J49/165
摘要： Aspects of the present innovations relate to improved systems that may perform capillary electrophoresis (CE) and CE in conjunction with electrospray ionization (ESI) as an input to a mass spectrometry system (MS). Embodiments may use a current sense circuit at a high voltage output from an MS-ESI power supply in conjunction with additional elements to identify fault conditions associated with leakage current, to confirm the continuity of CE connections, and to provide improved system protection.
摘要翻译：本发明的方面涉及可以将电喷雾离子化（ESI）作为质谱系统（MS）的输入进行毛细管电泳（CE）和CE的改进系统。实施例可以使用来自MS-ESI电源的高电压输出的电流感测电路以及附加元件来识别与泄漏电流相关联的故障状况，以确认CE连接的连续性并提供改进的系统保护。

46. 发明申请

US20160307744A1 Atmospheric Interface for Electrically Grounded Electrospray 审中-公开
标题翻译：电接地电喷雾的大气界面
公开(公告)号：US20160307744A1
公开(公告)日：2016-10-20
申请号：US15102910
申请日：2014-12-22
申请人： WATERS TECHNOLOGIES CORPORATION
发明人： Joseph A. Jarrell
IPC分类号： H01J49/04 , H01J49/16
CPC分类号： H01J49/0404 , H01J49/044 , H01J49/165
摘要： An interface for a mass spectrometer system is provided. The interface can include an inner ceramic tube fabricated from a first ceramic material and an outer tube fabricated from a second ceramic material surrounding the inner ceramic tube. The inner ceramic tube can have high electrical resistivity and high thermal conductivity and the intermediate ceramic tube can have an electrical resistivity that is at least an order of magnitude higher than the electrical resistivity of the first ceramic material and a thermal conductivity that is at least an order of magnitude higher than the thermal conductivity of the first ceramic material.
摘要翻译：提供了用于质谱仪系统的界面。界面可以包括由第一陶瓷材料制成的内陶瓷管和由围绕内陶瓷管的第二陶瓷材料制成的外管。内部陶瓷管可以具有高电阻率和高导热性，并且中间陶瓷管可以具有比第一陶瓷材料的电阻率高至少一个数量级的电阻率和至少为数量级高于第一陶瓷材料的热导率。

47. 发明授权

US09466470B2 Systems and methods for acquiring data for mass spectrometry images 有权
公开(公告)号：US09466470B2
公开(公告)日：2016-10-11
申请号：US14965960
申请日：2015-12-11
申请人： DH Technologies Development Pte. Ltd.
发明人： Ronald F. Bonner , Stephen A. Tate
IPC分类号： H01J49/00 , H01J49/16 , H01J49/04
CPC分类号： H01J49/0004 , H01J49/0027 , H01J49/0031 , H01J49/0036 , H01J49/004 , H01J49/0045 , H01J49/0418 , H01J49/164 , H01J49/165
摘要： Systems and methods are provided for maximizing the data acquired from a sample in a mass spectrometry imaging experiment. An ion source device is instructed to produce and transmit to a tandem mass spectrometer a plurality of ions for each location of two or more locations of a sample. A mass range is divided into two or more mass window widths. For each location of the two or more locations, the tandem mass spectrometer is instructed to fragment the plurality of ions received for each location using each mass window width of the two or more mass window widths and to analyze resulting product ions. A product ion spectrum is produced for each mass window width, and a plurality of product ion spectra are produced for each location of the two or more locations.

48. 发明申请

US20160268113A1 Charge-Stripping of Multiply-Charged Ions 有权
标题翻译：多重带电离子的电荷剥离
公开(公告)号：US20160268113A1
公开(公告)日：2016-09-15
申请号：US15031015
申请日：2014-10-23
申请人： MICROMASS UK LIMITED , THE UNIVERSITY OF BRITISH COLUMBIA
发明人： Jeffery Mark Brown , Damon Robb
IPC分类号： H01J49/00 , H01J49/16
CPC分类号： H01J49/0077 , H01J49/00 , H01J49/165
摘要： A method of mass spectrometry or ion mobility spectrometry is disclosed wherein a sample is ionised by an electrified sprayer so as to produce multiply charged analyte ions of a first polarity in gas-phase. A reaction region is provided downstream of the electrified sprayer, wherein the reaction region is maintained substantially at atmospheric pressure and is maintained substantially free of electric-fields. A gas flow is provided from said electrified sprayer to said reaction region such that the gas flow carries the analyte ions from the electrified sprayer into the reaction region. Free electrons or reagent ions of a second polarity are generated in the reaction region, wherein the second polarity is opposite to said first polarity. The free electrons or reagent ions are then reacted with the analyte ions in the reaction region so as to reduce the charge state of the multiply charged analyte ions and thereby produce charge-reduced analyte ions.
摘要翻译：公开了一种质谱法或离子迁移光谱法，其中通过带电的喷雾器对样品进行电离，从而在气相中产生具有第一极性的多电荷分析物离子。反应区域设置在带电喷雾器的下游，其中反应区域基本保持在大气压力并且基本上没有电场。从所述带电喷雾器向所述反应区域提供气流，使得气流将来自带电喷雾器的分析物离子进入反应区域。在反应区域中产生具有第二极性的自由电子或试剂离子，其中第二极性与所述第一极性相反。然后自由电子或试剂离子与反应区域中的分析物离子反应，以便减少多电荷分析离子的电荷状态，从而产生电荷减少的分析物离子。

49. 发明申请

US20160233071A1 Automated Adjustment of Capillary Voltage Based on the Elution Conditions to Retain Optimal Ionization Conditions 有权
标题翻译：基于洗脱条件自动调整毛细管电压以保持最佳电离条件
公开(公告)号：US20160233071A1
公开(公告)日：2016-08-11
申请号：US15022576
申请日：2014-09-17
申请人： MICROMASS UK LIMITED
发明人： David Gordon , Alexander Hooper , Daniel James Kenny , Richard Barrington Moulds , David Pugh , Kate Whyatt
IPC分类号： H01J49/16 , G01N30/72 , H01J49/00
CPC分类号： H01J49/167 , G01N30/7266 , H01J49/0031 , H01J49/165
摘要： A method of Electrospray ionisation is disclosed comprising passing a sample liquid through a liquid chromatography column, monitoring a liquid chromatography back pressure and varying a voltage applied to an Electrospray ionisation source electrode in dependence upon said monitored liquid chromatography back pressure.
摘要翻译：公开了一种电喷雾离子化方法，其包括使样品液体通过液相色谱柱，监测液相色谱背压并根据所监测的液相色谱背压改变施加到电喷雾电离源极的电压。

50. 发明授权

US09401267B2 Use of cryogenic ion chemistry to add a structural characterization capability to mass spectrometry through linear action spectroscopy 有权
标题翻译：使用低温离子化学法通过线性动力学光谱法增加质谱的结构表征能力
公开(公告)号：US09401267B2
公开(公告)日：2016-07-26
申请号：US14513724
申请日：2014-10-14
申请人： YALE UNIVERSITY
发明人： Mark A. Johnson , Michael Z. Kamrath , Etienne Garand
IPC分类号： H01J49/00 , H01J49/16 , G01N21/31 , H01J49/42 , G01N21/3504 , G01J3/42 , H01J49/10 , G01N21/35 , H01J49/40 , G01N21/33
CPC分类号： H01J49/165 , G01J3/42 , G01N21/31 , G01N21/33 , G01N21/35 , G01N21/3504 , G01N2201/06113 , H01J49/0031 , H01J49/0045 , H01J49/10 , H01J49/40 , H01J49/424
摘要： The present invention relates to mass spectrometry and infrared spectrometry and in particular, to a method of providing highly resolved infrared spectra of mass-selected, complex (e.g., biopolymer, polypeptide, organic chemical, an organometallic compound, a carbohydrate, a polynucleotide or oligonucleotide compound) ions to be obtained in a general fashion.
摘要翻译：本发明涉及质谱法和红外光谱法，特别涉及提供质量选择复合物（例如生物聚合物，多肽，有机化学品，有机金属化合物，碳水化合物，多核苷酸或寡核苷酸）的高分辨红外光谱的方法化合物）离子以一般方式获得。

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