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41. 发明授权

US08982454B2 Microscope and filter inserting method 有权
标题翻译：显微镜和滤芯插入法
公开(公告)号：US08982454B2
公开(公告)日：2015-03-17
申请号：US13210057
申请日：2011-08-15
申请人： Takashi Yamamoto , Norihiro Tanabe
发明人： Takashi Yamamoto , Norihiro Tanabe
IPC分类号： G02B21/18
CPC分类号： G02B21/18
摘要： A microscope includes a first imaging optical system that images light beams from a cell tissue sample, a second imaging optical system having a light beam splitting element which splits a portion of the light beams from the cell tissue sample from the first imaging optical system, an imaging element which captures phase contrast images of a portion of the light beams, which have been split, from the cell tissue sample, and one or a plurality of optical elements which forms the phase contrast images on the imaging element, and a filter inserting unit that inserts an optical filter absorbing light of a predetermined wavelength into an optical path of the second imaging optical system, wherein the filter inserting unit inserts the optical filter absorbing light of a wavelength corresponding to a complementary color of a color of an observed target according to the color of the observed target.
摘要翻译：显微镜包括：第一成像光学系统，其对来自细胞组织样本的光束进行成像;第二成像光学系统，具有将来自第一成像光学系统的细胞组织样本的一部分光束分裂的光束分离元件; 成像元件，其捕获已经从细胞组织样本分离的一部分光束的相位对比图像，以及在成像元件上形成相位图像的一个或多个光学元件，以及滤光器插入单元其将吸收预定波长的光的滤光器插入到第二成像光学系统的光路中，其中滤光器插入单元插入吸收与观察目标的颜色的互补色相对应的波长的光学滤光器，根据观察目标的颜色。

42. 发明申请

US20150054937A1 Light microscope and method for image recording using a light microscope 审中-公开
标题翻译：光学显微镜和使用光学显微镜进行图像记录的方法
公开(公告)号：US20150054937A1
公开(公告)日：2015-02-26
申请号：US14390165
申请日：2013-05-16
申请人： Carl Zeiss Microscopy GmbH
发明人： Helmut Lippert , Ralf Netz , Tiemo Anhut , Nils Langholz , Matthias Langhorst
IPC分类号： G02B21/00 , G02B21/18 , G01B9/02 , G02B21/36 , G01B9/04 , G02B21/08 , G02B21/14
CPC分类号： G02B21/008 , G01B9/02042 , G01B9/04 , G01B2210/50 , G01N2021/6419 , G01N2021/6421 , G01N2021/6463 , G02B21/0028 , G02B21/0032 , G02B21/0036 , G02B21/0044 , G02B21/006 , G02B21/0064 , G02B21/0068 , G02B21/0092 , G02B21/08 , G02B21/14 , G02B21/18 , G02B21/24 , G02B21/367
摘要： The invention relates to a light microscope comprising a polychromatic light source for emitting illumination light in the direction of a sample, focussing means for focussing illumination light onto the sample, wherein the focussing means, for generating a depth resolution, have a longitudinal chromatic aberration, and a detection device, which comprises a two-dimensional array of detector elements, for detecting sample light coming from the sample. According to the invention, the light microscope is characterized in that, for detecting both confocal portions and non-confocal portions of the sample light, a beam path from the sample to the detection device is free of elements for completely masking out non-confocal portions. In addition, the invention relates to a method for image recording using a light microscope.
摘要翻译：本发明涉及一种光学显微镜，其包括用于在样品方向上发射照明光的多色光源，用于将照明光聚焦到样品上的聚焦装置，其中用于产生深度分辨率的聚焦装置具有纵向色差，以及检测装置，其包括用于检测来自样品的样本光的检测器元件的二维阵列。根据本发明，光学显微镜的特征在于，为了检测样品光的共焦部分和非共焦部分，从样品到检测装置的光束路径没有用于完全掩蔽非共焦部分的元件。此外，本发明涉及一种使用光学显微镜进行图像记录的方法。

43. 发明授权

US08928887B2 Characteristic parameters of cells and tissue from quantitative phase imaging 有权
标题翻译：来自定量相位成像的细胞和组织的特征参数
公开(公告)号：US08928887B2
公开(公告)日：2015-01-06
申请号：US13775788
申请日：2013-02-25
申请人： The Board of Trustees of the University of Illinois
发明人： Gabriel Popescu , Huafeng Ding , Zhuo Wang
IPC分类号： G01B9/02 , G01N21/47 , G01N15/14 , G02B21/00 , G01N15/10 , G02B21/18
CPC分类号： G01N21/47 , G01N15/1434 , G01N2015/1006 , G01N2015/1445 , G01N2015/1454 , G02B21/0004 , G02B21/18
摘要： Methods mapping a characteristic parameter of a specimen, such as a scattering mean free path and a scattering anisotropy factor, based on a quantitative phase shift measurement. The methods have steps of using spatial light interference microscopy (SLIM) to determine a quantitative phase shift as a function of position in a sample, and applying a generalized scatter-phase transformation to derive at least one of a scattering mean free path (MFP), a scattering anisotropy factor, and a thickness-independent parameter as a function of position in the sample. In some cases, the sample may be a slice of tissue or a cell.
摘要翻译：基于定量相移测量法，将样品的特征参数，如散射平均自由程和散射各向异性因子进行映射。所述方法具有使用空间光干涉显微镜（SLIM）来确定作为样品中位置的函数的定量相移的步骤，以及应用广义散射相位变换以导出散射平均自由路径（MFP）中的至少一个，，散射各向异性因子和与厚度无关的参数，作为样品中位置的函数。在一些情况下，样品可以是组织或细胞的切片。

44. 发明申请

US20140323325A1 Molecular imaging and related methods 审中-公开
标题翻译：分子成像及相关方法
公开(公告)号：US20140323325A1
公开(公告)日：2014-10-30
申请号：US13999508
申请日：2014-03-04
申请人： Marc Beal , Ronald M. Cook , Peter Jay Coassin , Arturo Orjalo , Jekwan Ryu
发明人： Marc Beal , Ronald M. Cook , Peter Jay Coassin , Arturo Orjalo , Jekwan Ryu
IPC分类号： C12Q1/68 , G01N21/64
CPC分类号： C12Q1/6841 , C12Q1/6883 , C12Q1/6886 , C12Q2600/158 , G01N21/6428 , G01N21/6458 , G02B21/0004 , G02B21/0096 , G02B21/082 , G02B21/16 , G02B21/18 , C12Q2537/143 , C12Q2543/10 , C12Q2563/107 , C12Q2565/601
摘要： The present invention generally relates to imaging single molecules, or one or more collections of single molecules, and methods related to the imaging. In a method aspect, the present invention provides a method of imaging single molecules. The method comprises the steps of: a) exposing a test sample to a probe, wherein the probe comprises a first portion that specifically binds to a target molecule and a second portion that is detectable as the result of one or more chemical groups that interact with light at one or more wavelengths, wherein the probe binds to a target molecule to provide a complex; b) exposing the complex to one or more wavelengths of light that interact with the one or more chemical groups; c) detecting a result from the interacting of one or more wavelengths of light that interact with the one or more chemical groups to provide an image of one or more single molecules. The image possesses a resolution better than 450 nm over a view field area of at least 1×105 μm2, and wherein the image is obtained in a single detection step without variation of any detection settings.
摘要翻译：本发明一般涉及成像单分子，或单个分子的一个或多个集合，以及与成像有关的方法。在方法方面，本发明提供了单分子成像的方法。该方法包括以下步骤：a）将测试样品暴露于探针，其中所述探针包含特异性结合靶分子的第一部分和作为一个或多个化学基团相互作用的结果可检测的第二部分一个或多个波长的光，其中所述探针结合靶分子以提供复合物; b）将所述复合物暴露于与所述一个或多个化学基团相互作用的一个或多个波长的光; c）检测与一个或多个化学基团相互作用的一种或多种波长的光的相互作用的结果，以提供一个或多个单个分子的图像。该图像在至少1×105μm2的视野区域中的分辨率优于450nm，并且其中在单个检测步骤中获得图像而不改变任何检测设置。

45. 发明授权

US08625201B2 Optical element for distributing light 有权
标题翻译：用于分配光的光学元件
公开(公告)号：US08625201B2
公开(公告)日：2014-01-07
申请号：US13296689
申请日：2011-11-15
申请人： Frank Eisenkraemer , Steffen Guenther , Hans-Martin Heuck
发明人： Frank Eisenkraemer , Steffen Guenther , Hans-Martin Heuck
IPC分类号： G02B27/14
CPC分类号： G02B27/145 , G02B21/18 , G02B27/0025 , G02B27/1066 , G02B27/142 , G02B27/144
摘要： An optical element for distributing light has a predefined spectral energy distribution in a predetermined working wavelength range. The optical element encompasses a transparent body into which the light enters, and a beam splitter layer embodied inside the transparent body, which layer has in the working wavelength range a predefined wavelength-dependent reflectance with which it reflects the light entering the transparent body in order to generate a reflected exit light bundle, and a wavelength-dependent transmittance with which it transmits the light entering the transparent body to generate a transmitted exit light bundle. The optical element encompasses a compensation layer arrangement, embodied on the transparent body separately from the beam splitter layer, whose transmittance with regard to the light passing through the compensation layer arrangement is defined as a function of the reflectance and transmittance of the beam splitter layer.
摘要翻译：用于分配光的光学元件在预定工作波长范围内具有预定的光谱能量分布。光学元件包括光入射到其中的透明体，以及在透明体内部实现的分束器层，该层在工作波长范围内具有预定的波长相关反射率，依次反射进入透明体的光以产生反射的出射光束和透射进入透明体的光的波长相关透射率，以产生透射的出射光束。光学元件包括补偿层布置，该透明体与分束器层分开实现，透射体相对于通过补偿层布置的光的透射率被定义为分束器层的反射率和透射率的函数。

46. 发明申请

US20130229494A1 MICROSCOPIC DEVICE AND MICROSCOPIC METHOD FOR THE THREE-DIMENSIONAL LOCALIZATION OF POINT-LIKE OBJECTS 有权
标题翻译：用于点对象物体的三维局部化的微观器件和微观方法
公开(公告)号：US20130229494A1
公开(公告)日：2013-09-05
申请号：US13600463
申请日：2012-08-31
申请人： Marcus Dyba
发明人： Marcus Dyba
IPC分类号： G02B21/36
CPC分类号： G02B21/367 , G02B21/18
摘要： A microscopic device provides three-dimensional localization of point-like objects and includes two imaging optics, each configured to image a same point-like object located in an object space into two separate image spaces as a focused light distribution. Two detector units are respectively associated with the imaging optics and configured to capture an analyzable light spot in detection points of a detection surface disposed in the respective image space. Each imaging optics includes an optical device that orients the focused light distributions obliquely to a detection axis such that, taking into account the detection point correspondence, the two light spots shift in opposite directions based on a z-position of the point-like object. An evaluation unit brings the detection points of the two detection surfaces into mutual pairwise correspondence and analyzes the two light spots so as to ascertain a lateral x-y position and an axial z-position of the point-like object.
摘要翻译：微观装置提供点样物体的三维定位，并且包括两个成像光学元件，每个成像光学元件被配置为将位于物体空间中的相同点样物体成像为聚焦光分布的两个分开的图像空间。两个检测器单元分别与成像光学元件相关联，并且被配置为在设置在各个图像空间中的检测表面的检测点中捕获可分析的光斑。每个成像光学器件包括光学装置，其将聚焦光分布倾斜于检测轴定向，使得考虑到检测点对应，基于点状物体的z-位置，两个光点在相反方向上移动。评估单元将两个检测表面的检测点相互成对地对应，并分析两个光点，以确定点状物体的横向x-y位置和轴向z位置。

47. 发明申请

US20130094071A1 FAST, MODULAR PORT SWITCHER FOR AN OPTICAL MICROSCOPE USING A GALVANOMETER 有权
标题翻译：快速模块化端口切换器，用于使用GALVANOMETER的光学显微镜
公开(公告)号：US20130094071A1
公开(公告)日：2013-04-18
申请号：US13648340
申请日：2012-10-10
申请人： INTELLIGENT IMAGING INNOVATIONS, INC.
发明人： Glen Ivan Redford
IPC分类号： G02B21/18 , G02F1/33 , G02B26/08
CPC分类号： G02B21/18 , G02B26/007 , G02B26/0816
摘要： A fast modular port switching device is described. The device can be used with an optical microscope to facilitate using multiple devices with the microscope. The port switching is done with a galvanometer for switching very fast. The device is modular so it can be combined with any number of similar devices for building a complex, multi-modal imaging system. Also described is the combination of a port switcher with automated spherical aberration correction. Even further described is a similar device where the outputs are recombined, thus making the device a fast filter switcher.
摘要翻译：描述了一种快速的模块化端口交换设备。该设备可以与光学显微镜一起使用，以便于使用显微镜使用多个设备。端口切换使用电流计进行切换非常快。该设备是模块化的，因此它可以与任何数量的类似设备组合，以构建复杂的多模态成像系统。还描述了具有自动球面像差校正的端口切换器的组合。甚至进一步描述了类似的装置，其中输出被重组，从而使装置成为快速的过滤器切换器。

48. 发明授权

US08300309B2 OCT measuring method and system 有权
标题翻译： OCT测量方法和系统
公开(公告)号：US08300309B2
公开(公告)日：2012-10-30
申请号：US13072840
申请日：2011-03-28
申请人： Michael Haisch , Christoph Hauger , Harmut Wolf , Joachim Hug , Schwarz Brigitta
发明人： Michael Haisch , Christoph Hauger , Harmut Wolf , Joachim Hug , Schwarz Brigitta
IPC分类号： G02B21/06
CPC分类号： G02B27/0172 , A61B5/0066 , A61B5/0071 , A61B5/0086 , G01N21/35 , G01N21/3563 , G01N21/359 , G01N21/4795 , G01N21/6428 , G01N21/6458 , G01N2021/1782 , G01N2021/6421 , G02B7/002 , G02B21/16 , G02B21/18 , G02B21/22 , G02B21/361 , G02B21/365 , G02B21/367 , G02B21/368 , G02B2027/0134 , G02B2027/0138 , G02B2027/014
摘要： A microscopy system and method allow observing a fluorescent substance accumulated in a tissue. The tissue can be observed at a same time both with visible light and with fluorescent light. It is possible to observe a series of previously recorded fluorescent light images in superposition with the visible light images. An end of the series of images may be automatically determined. A thermal protective filter may be inserted into a beam path of an illuminating system at such automatically determined end of the series. Further, the fluorescent light image may be analyzed for identifying a coherent fluorescent portion thereof. A representation of a periphery line of the coherent portion may be generated, and depths profile data may be obtained only from the coherent portion. An illuminating light beam for exciting the fluorescence may be modulated for improving a contrast of fluorescent images.
摘要翻译：显微镜系统和方法允许观察积聚在组织中的荧光物质。可以在可见光和荧光的同时观察组织。可以观察到与可见光图像重叠的一系列先前记录的荧光图像。可以自动确定一系列图像的结束。可以在系列的这种自动确定的端部将热保护过滤器插入到照明系统的光束路径中。此外，可以分析荧光图像以识别其相干荧光部分。可以生成相干部分的外围线的表示，并且可以仅从相干部分获得深度轮廓数据。用于激发荧光的照明光束可以被调制以改善荧光图像的对比度。

49. 发明授权

US08217992B2 Microscopic imaging techniques 有权
标题翻译：显微成像技术
公开(公告)号：US08217992B2
公开(公告)日：2012-07-10
申请号：US12008661
申请日：2008-01-11
申请人： Joerg Bewersdorf , Michael Darin Mason , Sam T. Hess
发明人： Joerg Bewersdorf , Michael Darin Mason , Sam T. Hess
IPC分类号： H04N13/02
CPC分类号： G02B21/0076 , G02B21/16 , G02B21/18 , G02B21/367 , G02B27/58
摘要： A method of performing 3D photoactivation microscope imaging includes providing a sample having a plurality of probes, each of the plurality of probes including a photo-activatable material. Probes from the plurality of probes are activated to form a sparse subset of probes, the sparse subset of probes having probes that are spatially separated by at least a microscope resolution. The sample is illuminated with a readout light source, and light emitted from activated probes is detected. Based on the light emission detected from the activated probes, localized three-dimensional positions of the activated probes are obtained.
摘要翻译：执行3D光活化显微镜成像的方法包括提供具有多个探针的样品，所述多个探针中的每一个包括可光活化的材料。来自多个探针的探针被激活以形成探针的稀疏子集，探针的稀疏子集具有通过至少显微镜分辨率在空间上分离的探针。用读出光源照射样品，检测到从激活的探针发出的光。基于从激活的探针检测到的光发射，获得激活的探针的局部三维位置。

50. 发明申请

US20120169862A1 Digital Microscope System 有权
标题翻译：数字显微镜系统
公开(公告)号：US20120169862A1
公开(公告)日：2012-07-05
申请号：US13325800
申请日：2011-12-14
申请人： Jin-Wug SON , Jin-Whan Yun
发明人： Jin-Wug SON , Jin-Whan Yun
IPC分类号： H04N7/18
CPC分类号： G02B21/365 , G02B6/0006 , G02B6/3514 , G02B6/3598 , G02B21/18
摘要： Disclosed is a digital microscope system capable of controlling two or more microscope units with a controlling unit. The digital microscope system includes (i) two or more microscope units, (ii) a camera interface, (iii) a controlling unit and (iv) a light output device. The microscope unit includes a lens tube, a digital camera, a light terminator and a stand. The camera interface includes two or more camera interface (I/F) channels and a camera interface channel selector. The controlling unit includes a memory, a display device, a CPU (Central Processing Unit) and a power supply.
摘要翻译：公开了一种能够用控制单元控制两个或更多个显微镜单元的数字显微镜系统。数字显微镜系统包括（i）两个或更多个显微镜单元，（ii）照相机接口，（iii）控制单元和（iv）光输出装置。显微镜单元包括透镜管，数字照相机，光终端器和支架。相机接口包括两个或更多个摄像机接口（I / F）通道和摄像机接口通道选择器。控制单元包括存储器，显示装置，CPU（中央处理单元）和电源。

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